Abstract: Poor ability of cartilage tissue when experiencing a damage leads scientists to use tissue engineering as a reliable and effective method for regenerating or replacing damaged tissues. An artificial tissue should have some features such as biocompatibility, biodegradation and, enough mechanical properties like the original tissue. In this work, a composite hydrogel is prepared by using natural and synthetic materials that has high porosity. Mechanical properties of different combinations of polymers such as modulus of elasticity were tested, and a hydrogel with good mechanical properties was selected. Bone marrow derived mesenchymal stem cells were also seeded into the pores of the sponge, and the results showed the adhesion and proliferation of cells within the hydrogel after one month. In comparison with previous works, this study offers a new and efficient procedure for the fabrication of cartilage like tissue and further cartilage repair.
Abstract: Commercialization method is a means to make inventions available at the market for final consumption. It is described as an important tool for keeping business enterprises sustainable and improving national economic growth. Thus, there are several scholarly publications on it, either presenting or testing different methods for commercialization. However, young entrepreneurs, technologists and scientists would like to know the best method to commercialize their innovations. Then, this question arises: What is the best commercialization method? To answer the question, a systematic literature review was conducted, and practitioners were interviewed. The literary results revealed that there are many methods but new methods are needed to improve commercialization especially during these times of economic crisis and political uncertainty. Similarly, the empirical results showed there are several methods, but the best method is the one that reduces costs, reduces the risks associated with uncertainty, and improves customer participation and acceptability. Therefore, it was concluded that new commercialization method is essential for today's high technologies and a method was presented.
Abstract: A high quality crack-free film of Bi2Te3 material has been deposited for the first time using electrophoretic deposition (EPD) and microstructures of various films have been investigated. One of the most important thermoelectric (TE) applications is Bi2Te3 to manufacture TE generators (TEG) which can convert waste heat into electricity targeting the global warming issue. However, the high cost of the manufacturing process of TEGs keeps them expensive and out of reach for commercialization. Therefore, utilizing EPD as a simple and cost-effective method will open new opportunities for TEG’s commercialization. This method has been recently used for advanced materials such as microelectronics and has attracted a lot of attention from both scientists and industry. In this study, the effect of media of suspensions has been investigated on the quality of the deposited films as well as their microstructure. In summary, finding an appropriate suspension is a critical step for a successful EPD process and has an important effect on both the film’s quality and its future properties.
Abstract: Animal nutritionists and scientists have searched for alternative measures to improve the production. One of such alternative is use of organic acids as feed additive in animal nutrition. The study was conducted to investigate the impact of butyric acids, calcium formate, organic acids, and its salts (BCOS) additives on rabbit’s productive performance, carcass traits and meat quality. The study was conducted with 14 Californian breed rabbits. The rabbits were assigned to two treatment groups (seven rabbits per each treatment group). The dietary treatments were 1) control diet, 2) diet supplemented with a mixture BCOS - 2 kg/t of feed. Growth performance characteristics (body weight, daily weight gain, daily feed intake, feed conversion ratio, mortality) were evaluated. Rabbits were slaughtered; carcass characteristics and meat quality were evaluated. Samples loin and hind leg meat were analysed to determine carcass characteristics, pH and colour measurements, cholesterol, and malonyldialdehyde (MDA) content in loin and hind leg meat. Differences between treatments were significant for body weight (1.30 vs. 1.36 kg; P
Abstract: Freeze-thaw cycles are one of the greatest threats to concrete durability. Lately, protection against this threat excites scientists’ attention. Air-entraining admixtures have been widely used to produce freeze-thaw resistant at concretes. The use of air-entraining agents (AEAs) enhances not only freeze-thaw endurance but also the properties of fresh concrete such as segregation, bleeding and flow ability. This paper examines the effects of air-entraining on compressive strength of concrete. Air-entraining is used between 0.05% and 0.4% by weight of cement. One control and four fiber reinforced concrete mixes are prepared and three specimens are tested for each mix. It is concluded from the test results that when air entraining is increased the compressive strength of concrete reduces for all mixes with AEAs.
Abstract: Volterra integro-differential equations appear in many models for real life phenomena. Since analytical solutions for this type of differential equations are hard and at times impossible to attain, engineers and scientists resort to numerical solutions that can be made as accurately as possible. Conventionally, numerical methods for ordinary differential equations are adapted to solve Volterra integro-differential equations. In this paper, numerical solution for solving Volterra integro-differential equation using extended trapezoidal method is described. Formulae for the integral and differential parts of the equation are presented. Numerical results show that the extended method is suitable for solving first order Volterra integro-differential equations.
Abstract: The paper analyses the usage of the Internet by university students in Visegrad Countries (4V Countries) who study economic fields in their formal and informal financial education and captures the areas of untapped potential of Internet in educational processes. Higher education and training, technological readiness, and the financial market development are in the group of pillars, that are key for efficiency driven economies. These three pillars have become an inspiration to the research on using the Internet in the financial education among economic university students as the group of the best educated people in finance. The financial education is a process that allows for improving the level of financial literacy. In turn, the financial literacy it is the set of financial knowledge, skills, awareness and patterns influencing the financial decisions. The level of financial literacy influences the level of financial well-being of individuals, determines the scale of saving of households and at the same time gives the greater chance for sustainable and more predictable development of the financial market with the positive impact on economy. The financial literacy is necessary for each group of society but its appropriate level is desirable especially in respect of economics students as future participants of financial markets as well as the experts and advisors in financial decision making. The low level of financial literacy is the great problem of many target groups in both developing and developed countries and the financial education is seen as the best way of improving this situation. Also the financial inclusion plays the special role in enhancing the level of financial literacy in the aspect of education by practice as well as due to interrelation between level of financial literacy and degree of financial inclusion. Despite many initiatives under financial education, the level of financial literacy is still very low. Scientists still search for new ways of solving this problem. One of the proposal is more effective usage of the new technology in financial education, especially the Internet, because of the growing popularity of e-learning and the increasing number of Internet users, especially among young people who are called the Generation Net. Due to special role of the university students studying the economics fields for the future financial markets, students of four universities from Visegrad Countries (Czech Republic, Hungary, Poland and Slovakia) were invited to participate in the survey. The aim of the article is to present the level and ways of using the Internet technology in financial education and indicating the so far unused or underused opportunities.
Abstract: Reservoirs are being contaminated all around the world with point source and Non-Point Source (NPS) pollution. The most common NPS pollutants are sediments and nutrients. Krishnagiri Reservoir (KR) has been chosen for the present case study, which is located in the tropical semi-arid climatic zone of Tamil Nadu, South India. It is the main source of surface water in Krishnagiri district to meet the freshwater demands. The reservoir has lost about 40% of its water holding capacity due to sedimentation over the period of 50 years. Hence, from the research and management perspective, there is a need for a sound knowledge on the spatial and seasonal variations of KR water quality. The present study encompasses the specific objectives as (i) to investigate the longitudinal heterogeneity and seasonal variations of physicochemical parameters, nutrients and biological characteristics of KR water and (ii) to examine the extent of degradation of water quality in KR. 15 sampling points were identified by uniform stratified method and a systematic monthly sampling strategy was selected due to high dynamic nature in its hydrological characteristics. The physicochemical parameters, major ions, nutrients and Chlorophyll a (Chl a) were analysed. Trophic status of KR was classified by using Carlson's Trophic State Index (TSI). All statistical analyses were performed by using Statistical Package for Social Sciences programme, version-16.0. Spatial maps were prepared for Chl a using Arc GIS. Observations in KR pointed out that electrical conductivity and major ions are highly variable factors as it receives inflow from the catchment with different land use activities. The study of major ions in KR exhibited different trends in their values and it could be concluded that as the monsoon progresses the major ions in the water decreases or water quality stabilizes. The inflow point of KR showed comparatively higher concentration of nutrients including nitrate, soluble reactive phosphorus (SRP), total phosphors (TP), total suspended phosphorus (TSP) and total dissolved phosphorus (TDP) during monsoon seasons. This evidently showed the input of significant amount of nutrients from the catchment side through agricultural runoff. High concentration of TDP and TSP at the lacustrine zone of the reservoir during summer season evidently revealed that there was a significant release of phosphorus from the bottom sediments. Carlson’s TSI of KR ranged between 81 and 92 during northeast monsoon and summer seasons. High and permanent Cyanobacterial bloom in KR could be mainly due to the internal loading of phosphorus from the bottom sediments. According to Carlson’s TSI classification Krishnagiri reservoir was ranked in the hyper-eutrophic category. This study provides necessary basic data on the spatio-temporal variations of water quality in KR and also proves the impact of point and NPS pollution from the catchment area. High TSI warrants a greater threat for the recovery of internal P loading and hyper-eutrophic condition of KR. Several expensive internal measures for the reduction of internal loading of P were introduced by many scientists. However, the outcome of the present research suggests for the innovative algae harvesting technique for the removal of sediment nutrients.
Abstract: Cultural setup is varied from country to country and nation to nation, but the ability to adapt successfully to the new cultural setup may pave the way toward the development of cultural intelligence. Overcoming differences may require to build up our personality with the ability to learn, exchange thoughts, and have a constructive dream. Adaptation processes can be accelerated if we effectively utilize our cultural diversity. This can be done through a unified body or society; people with common goals can collectively work to satisfy their values. Narrowing the gap between developed and developing countries is of prime importance. Many international organizations are trying to resolve these issues by rational and peaceful means. Failing to understand the cultural differences, mentalities, strengths and weaknesses of developed and developing countries led to the collapse of many partnerships. Establishment of a neutral body influenced by developed countries intellectuality and developing countries personality may offer a better understanding and reasonable solutions, suggestions, advice that may assist in narrowing gaps and promote-strengthening relationship between developed and developing countries. The key issues, goals, and potential concepts associated with initiating Swiss scientific society for developing countries as a model to facilitate integration of highly skilled scientists are discussed.
Abstract: In the situation of great acceleration of changes and the need for new developments in the cities on one hand and conservation and regeneration approaches on the other hand, place identity and its relation with heritage context have taken on new importance. This relation is generally mutual and complex one. The significant point in this relation is that the process of identifying something as heritage rather than just historical phenomena, brings that which may be inherited into the realm of identity. In planning and urban design as well as environmental psychology and phenomenology domain, place identity and its attributes and components were studied and discussed. However, the relation between physical environment (especially heritage) and identity has been neglected in the planning literature. This article aims to review the knowledge on this field and develop a model on the influence and relation of these two major concepts (heritage and identity). To build this conceptual model, we draw on available literature in environmental psychology as well as planning on place identity and heritage environment using a descriptive-analytical methodology to understand how they can inform the planning strategies and governance policies. A cross-disciplinary analysis is essential to understand the nature of place identity and heritage context and develop a more holistic model of their relationship in order to be employed in planning process and decision making. Moreover, this broader and more holistic perspective would enable both social scientists and planners to learn from one another’s expertise for a fuller understanding of community dynamics. The result indicates that a combination of these perspectives can provide a richer understanding—not only of how planning impacts our experience of place, but also how place identity can impact community planning and development.
Abstract: A DNA microarray technology is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. Elucidating the patterns hidden in gene expression data offers a tremendous opportunity for an enhanced understanding of functional genomics. However, the large number of genes and the complexity of biological networks greatly increase the challenges of comprehending and interpreting the resulting mass of data, which often consists of millions of measurements. It is handled by clustering which reveals the natural structures and identifying the interesting patterns in the underlying data. In this paper, gene based clustering in gene expression data is proposed using Cuckoo Search with Differential Evolution (CS-DE). The experiment results are analyzed with gene expression benchmark datasets. The results show that CS-DE outperforms CS in benchmark datasets. To find the validation of the clustering results, this work is tested with one internal and one external cluster validation indexes.
Abstract: Problem of food preservation is extremely important
for mankind. Viscous damage ("illness") of bread results from
development of Bacillus spp. bacteria. High temperature resistant
spores of this microorganism are steady against 120°C) and remain in
bread during pastries, potentially causing spoilage of the final
product. Scientists are interested in further characterization of bread
spoiling Bacillus spp. species. Our aim was to find weather yeast
Saccharomyces cerevisiae strains that are able to produce natural
antimicrobial killer factor can preserve bread illness. By diffusion
method, we showed yeast antagonistic activity against spore-forming
bacteria. Experimental technological parameters were the same as for
bakers' yeasts production on the industrial scale. Risograph test
during dough fermentation demonstrated gas production. The major
finding of the study was a clear indication of the presence of killer
yeast strain antagonistic activity against rope in bread causing
bacteria. After demonstrating antagonistic effect of S. cerevisiae on
bacteria using solid nutrient medium, we tested baked bread under
provocative conditions. We also measured formation of carbon
dioxide in the dough, dough-making duration and quality of the final
products, when using different strains of S. cerevisiae. It is
determined that the use of yeast S. cerevisiae RCAM 01730 killer
strain inhibits appearance of rope in bread. Thus, natural yeast
antimicrobial killer toxin, produced by some S. cerevisiae strains is
an anti-rope in bread protector.
Abstract: With the advancement of knowledge about the utility
and impact of sustainability, its feasibility has been explored into
different walks of life. Scientists, however; have established their
knowledge in four areas viz environmental, economic, social and
cultural, popularly termed as four pillars of sustainability. Aspects of
environmental and economic sustainability have been rigorously
researched and practiced and huge volume of strong evidence of
effectiveness has been founded for these two sub-areas. For the social
and cultural aspects of sustainability, dependable evidence of
effectiveness is still to be instituted as the researchers and
practitioners are developing and experimenting methods across the
globe. Therefore, the present research aimed to identify globally used
practices of social and cultural sustainability and through evidence
synthesis assess their outcomes to determine the effectiveness of
those practices. A PICO format steered the methodology which
included all populations, popular sustainability practices including
walkability/cycle tracks, social/recreational spaces, privacy, health &
human services and barrier free built environment, comparators
included ‘Before’ and ‘After’, ‘With’ and ‘Without’, ‘More’ and
‘Less’ and outcomes included Social well-being, cultural coexistence,
quality of life, ethics and morality, social capital, sense of
place, education, health, recreation and leisure, and holistic
development. Search of literature included major electronic
databases, search websites, organizational resources, directory of
open access journals and subscribed journals. Grey literature,
however, was not included. Inclusion criteria filtered studies on the
basis of research designs such as total randomization, quasirandomization,
cluster randomization, observational or single studies
and certain types of analysis. Studies with combined outcomes were
considered but studies focusing only on environmental and/or
economic outcomes were rejected. Data extraction, critical appraisal
and evidence synthesis was carried out using customized tabulation,
reference manager and CASP tool. Partial meta-analysis was carried
out and calculation of pooled effects and forest plotting were done.
As many as 13 studies finally included for final synthesis explained
the impact of targeted practices on health, behavioural and social
dimensions. Objectivity in the measurement of health outcomes
facilitated quantitative synthesis of studies which highlighted the
impact of sustainability methods on physical activity, Body Mass
Index, perinatal outcomes and child health. Studies synthesized
qualitatively (and also quantitatively) showed outcomes such as
routines, family relations, citizenship, trust in relationships, social
inclusion, neighbourhood social capital, wellbeing, habitability and
family’s social processes. The synthesized evidence indicates slight
effectiveness and efficacy of social and cultural sustainability on the
targeted outcomes. Further synthesis revealed that such results of this
study are due weak research designs and disintegrated implementations. If architects and other practitioners deliver their
interventions in collaboration with research bodies and policy
makers, a stronger evidence-base in this area could be generated.
Abstract: Microcantilevers are the basic MEMS devices, which
can be used as sensors, actuators and electronics can be easily built
into them. The detection principle of microcantilever sensors is based
on the measurement of change in cantilever deflection or change in its
resonance frequency. The objective of this work is to explore the
analogies between mechanical and electrical equivalent of
microcantilever beams. Normally scientists and engineers working in
MEMS use expensive software like CoventorWare, IntelliSuite,
ANSYS/Multiphysics etc. This paper indicates the need of developing
electrical equivalent of the MEMS structure and with that, one can
have a better insight on important parameters, and their interrelation of
the MEMS structure. In this work, considering the mechanical model
of microcantilever, equivalent electrical circuit is drawn and using
force-voltage analogy, it is analyzed with circuit simulation software.
By doing so, one can gain access to powerful set of intellectual tools
that have been developed for understanding electrical circuits Later
the analysis is performed using ANSYS/Multiphysics - software based
on finite element method (FEM). It is observed that both mechanical
and electrical domain results for a rectangular microcantlevers are in
agreement with each other.
Abstract: The fundamental issue in understanding the origin and
growth mechanism of nanomaterials, from a fundamental unit is a big
challenging problem to the scientists. Recently, an immense attention
is generated to the researchers for prediction of exceptionally stable
atomic cluster units as the building units for future smart materials.
The present study is a systematic investigation on the stability and
electronic properties of a series of bimetallic (semiconductor-alkaline
earth) clusters, viz., BxMg3 (x=1-5) is performed, in search for
exceptional and/ or unusual stable motifs. A very popular hybrid
exchange-correlation functional, B3LYP along with a higher basis
set, viz., 6-31+G[d,p] is employed for this purpose under the density
functional formalism. The magic stability among the concerned
clusters is explained using the jellium model. It is evident from the
present study that the magic stability of B4Mg3
cluster arises due to
the jellium shell closure.
Abstract: Typical load-bearing biological materials like bone,
mineralized tendon and shell, are biocomposites made from both
organic (collagen) and inorganic (biomineral) materials. This
amazing class of materials with intrinsic internally designed
hierarchical structures show superior mechanical properties with
regard to their weak components from which they are formed.
Extensive investigations concentrating on static loading conditions
have been done to study the biological materials failure. However,
most of the damage and failure mechanisms in load-bearing
biological materials will occur whenever their structures are exposed
to dynamic loading conditions. The main question needed to be
answered here is: What is the relation between the layout and
architecture of the load-bearing biological materials and their
dynamic behavior? In this work, a staggered model has been
developed based on the structure of natural materials at nanoscale and
Finite Element Analysis (FEA) has been used to study the dynamic
behavior of the structure of load-bearing biological materials to
answer why the staggered arrangement has been selected by nature to
make the nanocomposite structure of most of the biological materials.
The results showed that the staggered structures will efficiently
attenuate the stress wave rather than the layered structure.
Furthermore, such staggered architecture is effectively in charge of
utilizing the capacity of the biostructure to resist both normal and
shear loads. In this work, the geometrical parameters of the model
like the thickness and aspect ratio of the mineral inclusions selected
from the typical range of the experimentally observed feature sizes
and layout dimensions of the biological materials such as bone and
mineralized tendon. Furthermore, the numerical results validated with
existing theoretical solutions. Findings of the present work emphasize
on the significant effects of dynamic behavior on the natural
evolution of load-bearing biological materials and can help scientists
to design bioinspired materials in the laboratories.
Abstract: Plasmin plays an important role in the human
circulatory system owing to its catalytic ability of fibrinolysis. The
immediate injection of plasmin in patients of strokes has intrigued
many scientists to design vectors that can transport plasmin to the
desired location in human body. Here we predict the structure of
human plasmin and investigate the interaction of plasmin with the
gold-nanoparticle.
Because the crystal structure of plasminogen has been solved, we
deleted N-terminal domain (Pan-apple domain) of plasminogen and
generate a mimic of the active form of this enzyme (plasmin). We
conducted a simulated annealing process on plasmin and discovered a
very large conformation occurs. Kringle domains 1, 4 and 5 had been
observed to leave its original location relative to the main body of the
enzyme and the original doughnut shape of this enzyme has been
transformed to a V-shaped by opening its two arms. This observation
of conformational change is consistent with the experimental results of
neutron scattering and centrifugation.
We subsequently docked the plasmin on the simulated gold surface
to predict their interaction. The V-shaped plasmin could utilize its
Kringle domain and catalytic domain to contact the gold surface.
Our findings not only reveal the flexibility of plasmin structure but
also provide a guide for the design of a plasmin-gold nanoparticle.
Abstract: The arm length, hand length, hand breadth and middle
finger length of 1540 right-handed industrial workers of Haryana
state was used to assess the relationship between the upper limb
dimensions and stature. Initially, the data were analyzed using basic
univariate analysis and independent t-tests; then simple and multiple
linear regression models were used to estimate stature using SPSS
(version 17). There was a positive correlation between upper limb
measurements (hand length, hand breadth, arm length and middle
finger length) and stature (p < 0.01), which was highest for hand
length. The accuracy of stature prediction ranged from ± 54.897 mm
to ± 58.307 mm. The use of multiple regression equations gave better
results than simple regression equations. This study provides new
forensic standards for stature estimation from the upper limb
measurements of male industrial workers of Haryana (India). The
results of this research indicate that stature can be determined using
hand dimensions with accuracy, when only upper limb is available
due to any reasons likewise explosions, train/plane crashes, mutilated
bodies, etc. The regression formula derived in this study will be
useful for anatomists, archaeologists, anthropologists, design
engineers and forensic scientists for fairly prediction of stature using
regression equations.
Abstract: Modeling and forecasting dynamics of rainfall
occurrences constitute one of the major topics, which have been
largely treated by statisticians, hydrologists, climatologists and many
other groups of scientists. In the same issue, we propose, in the
present paper, a new hybrid method, which combines Extreme
Values and fractal theories. We illustrate the use of our methodology
for transformed Emberger Index series, constructed basing on data
recorded in Oujda (Morocco).
The index is treated at first by Peaks Over Threshold (POT)
approach, to identify excess observations over an optimal threshold u.
In the second step, we consider the resulting excess as a fractal object
included in one dimensional space of time. We identify fractal
dimension by the box counting. We discuss the prospect descriptions
of rainfall data sets under Generalized Pareto Distribution, assured by
Extreme Values Theory (EVT). We show that, despite of the
appropriateness of return periods given by POT approach, the
introduction of fractal dimension provides accurate interpretation
results, which can ameliorate apprehension of rainfall occurrences.
Abstract: Surface modification and functionalization has been
an important tool for scientists in order to open new frontiers in
nanoscience and nanotechnology. Desired surface characteristics for
the intended applications can be achieved with surface
functionalization.
In this work, the effect of water soluble ligands on the adsorption
capabilities of silver nanoparticles onto AC which was synthesized
from German beech wood was investigated. Sodium borohydride
(NaBH4) and polyvinyl alcohol (PVA) were used as the ligands.
Silver nanoparticles with different surface coatings have average
sizes range from 10 to 13 nm. They were synthesized in aqueous
media by reducing Ag (I) ion in the presence of ligands. These
particles displayed adsorption tendencies towards AC when they
were mixed together and shaken in distilled water.
Silver nanoparticles (NaBH4-AgNPs) reduced and stabilized by
NaBH4 adsorbed onto AC with a homogenous dispersion of
aggregates with sizes in the range of 100-400 nm. Beside, silver
nanoparticles, which were prepared in the presence of both NaBH4
and PVA (NaBH4/PVA-Ag NPs), demonstrated that NaBH4/PVA-Ag
NPs adsorbed and dispersed homogenously but, they aggregated with
larger sizes on the AC surface (range from 300 to 600 nm). In
addition, desorption resistance of Ag nanoparticles were investigated
in distilled water. According to the results AgNPs were not desorbed
on the AC surface in distilled water.