Abstract: Risperidone (RISP) is an antipsychotic agent and has
low water solubility and nontargeted delivery results in numerous
side effects. Hence, an attempt was made to develop SLNs hydrogel
for intranasal delivery of RISP to achieve maximum bioavailability
and reduction of side effects. RISP loaded SLNs composed of 1.65%
(w/v) lipid mass were produced by high shear homogenization (HSH)
coupled ultrasound (US) method using glycerylmonostearate (GMS)
or Imwitor 900K (solid lipid). The particles were loaded with 0.2%
(w/v) of the RISP & surface-tailored with a 2.02% (w/v) non-ionic
surfactant Tween® 80. Optimization was done using 32 factorial
design using Design Expert® software. The prepared SLNs
dispersion incorporated into Polycarbophil AA1 hydrogel (0.5%
w/v). The final gel formulation was evaluated for entrapment
efficiency, particle size, rheological properties, X ray diffraction, in
vitro diffusion, ex vivo permeation using sheep nasal mucosa and
histopathological studies for nasocilliary toxicity. The entrapment
efficiency of optimized SLNs was found to be 76 ± 2%,
polydispersity index
Abstract: This work is focused on the study of valuation of
recycled concrete aggregates, by measuring certain properties of
concrete in the fresh and hardened state. In this study, rheological
tests and physic-mechanical characterization on concretes and
mortars were conducted with recycled concrete whose geometric
properties were identified aggregates. Mortars were elaborated with
recycled fine aggregate (0/5mm) and concretes were manufactured
using recycled coarse aggregates (5/12.5 mm and 12.5/20 mm). First,
a study of the mortars was conducted to determine the effectiveness
of polycarboxylate superplasticizer on the workability of these and
their action deflocculating of the recycled sand. The rheological
behavior of mortars based on fine aggregate recycled was
characterized. The results confirm that the mortars composed of
different fractions of recycled sand (0 /5) have a better mechanical
properties (compressive and flexural strength) compared to normal
mortar. Also, the mechanical strengths of concretes made with
recycled aggregates (5/12.5 mm and 12.5/20 mm), are comparable to
those of conventional concrete with conventional aggregates,
provided that the implementation can be improved by the addition of
a superplasticizer.
Abstract: Cement-based grouts has been used successfully to
repair cracks in many concrete structures such as bridges, tunnels,
buildings and to consolidate soils or rock foundations. In the present
study the rheological characterization of cement grout with
water/binder ratio (W/B) is fixed at 0.5. The effect of the replacement
of cement by bentonite (2 to 10% wt) in presence of superplasticizer
(0.5% wt) was investigated. Several rheological tests were carried out
by using controlled-stress rheometer equipped with vane geometry in
temperature of 20°C. To highlight the influence of bentonite and
superplasticizer on the rheological behavior of grout cement, various
flow tests in a range of shear rate from 0 to 200 s-1 were observed.
Cement grout showed a non-Newtonian viscosity behavior at all
concentrations of bentonite. Three parameter model Herschel-
Bulkley was chosen for fitting of experimental data. Based on the
values of correlation coefficients of the estimated parameters, The
Herschel-Bulkley law model well described the rheological behavior
of the grouts. Test results showed that the dosage of bentonite
increases the viscosity and yield stress of the system and introduces
more thixotropy. While the addition of both bentonite and
superplasticizer with cement grout improve significantly the fluidity
and reduced the yield stress due to the action of dispersion of SP.
Abstract: Fluid rheology may have essential impact on sound propagation in a liquid-filled pipe, especially, in a low frequency range. Rheological parameters of liquid are temperature-sensitive, which ultimately results in a temperature dependence of the wave speed and attenuation in the waveguide. The study is devoted to modeling of this effect at sound propagation in an elastic pipe with polymeric liquid, described by generalized Maxwell model with non-zero high-frequency viscosity. It is assumed that relaxation spectrum is distributed according to the Spriggs law; temperature impact on the liquid rheology is described on the basis of the temperature-superposition principle and activation theory. The dispersion equation for the waveguide, considered as a thin-walled tube with polymeric solution, is obtained within a quasi-one-dimensional formulation. Results of the study illustrate the influence of temperature on sound propagation in the system.
Abstract: Solid lipid nanoparticles (SLNs) have gained great attention for the topical treatment of skin associated fungal infection as they facilitate the skin penetration of loaded drugs. Our work deals with the preparation of nystatin loaded solid lipid nanoparticles (NystSLNs) using the hot homogenization and ultrasonication method. The prepared NystSLNs were characterized in terms of entrapment efficiency, particle size, zeta potential, transmission electron microscopy, differential scanning calorimetry, rheological behavior and in vitro drug release. A stability study for 6 months was performed. A microbiological study was conducted in male rats infected with Candida albicans, by counting the colonies and examining the histopathological changes induced on the skin of infected rats. The results showed that SLNs dispersions are spherical in shape with particle size ranging from 83.26±11.33 to 955.04±1.09 nm. The entrapment efficiencies are ranging from 19.73±1.21 to 72.46±0.66% with zeta potential ranging from -18.9 to -38.8 mV and shear-thinning rheological Behavior. The stability studies done for 6 months showed that nystatin (Nyst) is a good candidate for topical SLN formulations. A least number of colony forming unit/ ml (cfu/ml) was recorded for the selected NystSLN compared to the drug solution and the commercial Nystatin® cream present in the market. It can be fulfilled from this work that SLNs provide a good skin targeting effect and may represent promising carrier for topical delivery of Nyst offering the sustained release and maintaining the localized effect, resulting in an effective treatment of cutaneous fungal infection.
Abstract: Despite of few research works on municipal sludge, still there is a lack of actual data. Thus, this work was focused on the conditioning and rheology of fresh activated sludge. The effect of cationic polyelectrolyte has been investigated at different concentrations and pH values in a comparative fashion. Yield stress is presented in all results indicating the minimum stress that necessary to reach flow conditions. Connections between particle-particle is the reason for this yield stress, also, the addition of polyelectrolyte causes strong bonds between particles and water resulting in the aggregation of particles which required higher shear stress in order to flow. The results from the experiments indicate that the cationic polyelectrolytes have significant effluence on the sludge characteristic and water quality such as turbidity, SVI, zone settling rate and shear stress.
Abstract: Semi-active Fuzzy control of quarter car system having three degrees of freedom and assembled with magneto-rheological (MR) shock absorber is studied in present paper. First, experimental work was performed on an MR shock absorber under different excitation conditions to obtain force-displacement and force-velocity curves. Then, for the application of experimental data in semi-active quarter car system, a polynomial model was selected. Finally, Fuzzy logic controller was designed having the combination of Forward fuzzy controller and Inverse fuzzy controller for integration in secondary suspension system of concerned model. The proposed controlled quarter car model was compared with uncontrolled system using simulation work under bump type of road excitation. Results obtained by simulation work shows the effectiveness of fuzzy controlled suspension system in improving the ride comfort and safety of travelling passengers compared to uncontrolled suspension system.
Abstract: The development of vehicles having best ride comfort and safety of travelling passengers is of great interest for automotive manufacturers. The effect of transmitted vibrations from car body to passenger seat is required to be controlled for achieving the same. The application of magneto-rheological (MR) shock absorber in suspension system has been considered to achieve significant benefits in this regard. This paper introduces a secondary suspension controlled semi-active quarter car system using MR shock absorber for effective vibration control. Fuzzy logic control system is used for design of controller for actual damping force generation by MR shock absorber. Performance evaluations are done related to passenger seat acceleration and displacement in time and frequency domains, in order to see the effectiveness of the proposed semi-active suspension system. Simulation results show that the semi-active suspension system provides better results compared to passive suspension system in terms of passenger ride comfort improvement.
Abstract: By planning this experimental work to investigate the effect of zeolitic waste on rheological and technological properties of self-compacting fiber reinforced concrete, we had an intention to draw attention to the environmental factor. Large amount of zeolitic waste, as secondary raw materials are not in use properly and large amount of it is collected without a clear view of its usage in future. The principal aim of this work is to assure, that zeolitic waste admixture takes positive effect to the self-compacting fiber reinforced concrete mixes stability, flowability and other properties by using the experimental research methods. In addition to that a research on cement and zeolitic waste mortars were implemented to clarify the effect of zeolitic waste on properties of cement paste and stone. Primary studies indicates that zeolitic waste characterizes clear pozzolanic behavior, do not deteriorate and in some cases ensure positive rheological and mechanical characteristics of self-compacting concrete mixes.
Abstract: In this paper, an magnetorheological (MR) mount with
fuzzy sliding mode controller (FSMC) is studied for vibration
suppression when the system is subject to base excitations. In recent
years, magnetorheological fluids are becoming a popular material in
the field of the semi-active control. However, the dynamic equation of
an MR mount is highly nonlinear and it is difficult to identify. FSMC
provides a simple method to achieve vibration attenuation of the
nonlinear system with uncertain disturbances. This method is capable
of handling the chattering problem of sliding mode control effectively
and the fuzzy control rules are obtained by using the Lyapunov
stability theory. The numerical simulations using one-dimension and
two-dimension FSMC show effectiveness of the proposed controller
for vibration suppression. Further, the well-known skyhook control
scheme and an adaptive sliding mode controller are also included in
the simulation for comparison with the proposed FSMC.
Abstract: According to Rostler method (ASTM D 2006), saturates content of bitumen is determined based on its reactivity to sulphuric acid. While Corbett method (ASTM D 4124) based on its polarity level. This paper presents results from the study on the effect of saturates content determined by two different fractionation methods on the rheological and aging characteristics of bitumen. The result indicated that the increment of saturates content tended to reduce all the rheological characteristics concerned. Bitumen became less elastic, less viscous, and less resistant to plastic deformation, but became more resistant to fatigue cracking. After short and long term aging process, the treatment effect coefficients of saturates decreased, saturates became thicker due to aging process. This study concludes that saturates is not really stable or reactive in aging process. Therefore, the reactivity of saturates should be considered in bitumen aging index
Abstract: Use of a sliding joint is an effective method to
decrease the stress in foundation structure where there is a horizontal
deformation of subsoil (areas afflicted with underground mining) or
horizontal deformation of a foundation structure (pre-stressed
foundations, creep, shrinkage, temperature deformation). A
convenient material for a sliding joint is a bitumen asphalt belt.
Experiments for different types of bitumen belts were undertaken at
the Faculty of Civil Engineering - VSB Technical University of
Ostrava in 2008. This year an extension of the 2008 experiments is in
progress and the shear resistance of a slide joint is being tested as a
function of temperature in a temperature controlled room. In this
paper experimental results of temperature dependant shear resistance
are presented. The result of the experiments should be the sliding
joint shear resistance as a function of deformation velocity and
temperature. This relationship is used for numerical analysis of
stress/strain relation between foundation structure and subsoil. Using
a rheological slide joint could lead to a decrease of the reinforcement
amount, and contribute to higher reliability of foundation structure
and thus enable design of more durable and sustainable building
structures.
Abstract: Homogeneous composites of alumina and zirconia
with a small amount of MgO (99%) were obtained for ZTA ceramic containing 0.05 wt% MgO in
1500 °C.
Abstract: The influence of lactulose and inulin on rheological
properties of fermented milk during storage was studied.Pasteurized
milk, freeze-dried starter culture Bb-12 (Bifidobacterium lactis, Chr.
Hansen, Denmark), inulin – RAFTILINE®HP (ORAFI, Belgium) and
syrup of lactulose (Duphalac®, the Netherlands) were used for
experiments. The fermentation process was realized at 37 oC for 16
hours and the storage of products was provided at 4 oC for 7 days.
Measurements were carried out by BROOKFIELD standard methods
and the flow curves were described by Herschel-Bulkley model.
The results of dispersion analysis have shown that both the
concentration of prebiotics (p=0.04
Abstract: The simulation of extrusion process is studied widely
in order to both increase products and improve quality, with broad
application in wire coating. The annular tube-tooling extrusion was
set up by a model that is termed as Navier-Stokes equation in
addition to a rheological model of differential form based on singlemode
exponential Phan-Thien/Tanner constitutive equation in a twodimensional
cylindrical coordinate system for predicting the
contraction point of the polymer melt beyond the die. Numerical
solutions are sought through semi-implicit Taylor-Galerkin pressurecorrection
finite element scheme. The investigation was focused on
incompressible creeping flow with long relaxation time in terms of
Weissenberg numbers up to 200. The isothermal case was considered
with surface tension effect on free surface in extrudate flow and no
slip at die wall. The Stream Line Upwind Petrov-Galerkin has been
proposed to stabilize solution. The structure of mesh after die exit
was adjusted following prediction of both top and bottom free
surfaces so as to keep the location of contraction point around one
unit length which is close to experimental results. The simulation of
extrusion process is studied widely in order to both increase products
and improve quality, with broad application in wire coating. The
annular tube-tooling extrusion was set up by a model that is termed
as Navier-Stokes equation in addition to a rheological model of
differential form based on single-mode exponential Phan-
Thien/Tanner constitutive equation in a two-dimensional cylindrical
coordinate system for predicting the contraction point of the polymer
melt beyond the die. Numerical solutions are sought through semiimplicit
Taylor-Galerkin pressure-correction finite element scheme.
The investigation was focused on incompressible creeping flow with
long relaxation time in terms of Weissenberg numbers up to 200. The
isothermal case was considered with surface tension effect on free
surface in extrudate flow and no slip at die wall. The Stream Line
Upwind Petrov-Galerkin has been proposed to stabilize solution. The
structure of mesh after die exit was adjusted following prediction of
both top and bottom free surfaces so as to keep the location of
contraction point around one unit length which is close to
experimental results.
Abstract: This paper made an attempt to investigate the problem associated with enhancement of emulsions of light crude oil-water recovery in an oil field of Algerian Sahara. Measurements were taken through experiments using RheoStress (RS600). Factors such as shear rate, temperature and light oil concentration on the viscosity behavior were considered. Experimental measurements were performed in terms of shear stress–shear rate, yield stress and flow index on mixture of light crude oil–water. The rheological behavior of emulsion showed Non-Newtonian shear thinning behavior (Herschel-Bulkley). The experiments done in the laboratory showed the stability of some water in light crude oil emulsions form during consolidate oil recovery process. To break the emulsion using additives may involve higher cost and could be very expensive. Therefore, further research should be directed to find solution of these problems that have been encountered.
Abstract: In the present study, the incorporation of graphene
into blends of acrylonitrile-butadiene-styrene terpolymer with
polypropylene (ABS/PP) was investigated focusing on the
improvement of their thermomechanical characteristics and the effect
on their rheological behavior. The blends were prepared by melt
mixing in a twin-screw extruder and were characterized by measuring
the MFI as well as by performing DSC, TGA and mechanical tests.
The addition of graphene to ABS/PP blends tends to increase their
melt viscosity, due to the confinement of polymer chains motion.
Also, graphene causes an increment of the crystallization temperature
(Tc), especially in blends with higher PP content, because of the
reduction of surface energy of PP nucleation, which is a consequence
of the attachment of PP chains to the surface of graphene through the
intermolecular CH-π interaction. Moreover, the above nanofiller
improves the thermal stability of PP and increases the residue of
thermal degradation at all the investigated compositions of blends,
due to the thermal isolation effect and the mass transport barrier
effect. Regarding the mechanical properties, the addition of graphene
improves the elastic modulus, because of its intrinsic mechanical
characteristics and its rigidity, and this effect is particularly strong in
the case of pure PP.
Abstract: This paper deals with the evaluation of flow properties
of polymeric matrix with natural animal fillers. Technical university
of Liberec cooperates on the long-term development of “green
materials“ that should replace conventionally used materials
(especially in automotive industry). Natural fibres (of animal and
plant origin) from all over the world are collected and adapted
(drying, cutting etc.) for extrusion processing. Inside the extruder
these natural additives are blended with polymeric (synthetic and
biodegradable - PLA) matrix and created compound is subsequently
cut for pellets in the wet way. These green materials with unique
recipes are then studied and their mechanical, physical and
processing properties are determined. The main goal of this research
is to develop new ecological materials very similar to unfilled
polymers. In this article the rheological behaviour of chosen natural
animal fibres is introduced considering their shape and surface that
were observed with use of SEM microscopy.
Abstract: Magneto-rheological (MR) fluid damper is a semiactive
control device that has recently received more attention by the
vibration control community. But inherent hysteretic and highly
nonlinear dynamics of MR fluid damper is one of the challenging
aspects to employ its unique characteristics. The combination of
artificial neural network (ANN) and fuzzy logic system (FLS) have
been used to imitate more precisely the behavior of this device.
However, the derivative-based nature of adaptive networks causes
some deficiencies. Therefore, in this paper, a novel approach that
employ genetic algorithm, as a free-derivative algorithm, to enhance
the capability of fuzzy systems, is proposed. The proposed method
used to model MR damper. The results will be compared with
adaptive neuro-fuzzy inference system (ANFIS) model, which is one
of the well-known approaches in soft computing framework, and two
best parametric models of MR damper. Data are generated based on
benchmark program by applying a number of famous earthquake
records.
Abstract: Asphalt surfaces are exposed to various weather
conditions and dynamic loading caused by passing trucks and
vehicles. In such situations, asphalt cement shows so different
rheological-mechanical behavior. If asphalt cement isn-t compatible
enough, asphalt layer will be damaged immediately and expensive
repairing procedures should be performed then. To overcome this
problem, researchers study on mechanical improved asphalt cement.
In this study, bentonite was used in order to modify bitumen
characteristics and the modified bitumen's characteristics were
investigated by asphalt cement tests. Then, the optimal bitumen
content in various compounds was determined and asphalt samples
with different contents of additives were prepared and tested. Results
show using this kind of additive not only has caused improvement in
bitumen mechanical properties, but also improvement in Marshall
Parameters was achieved.