Abstract: Before performing polymerase chain reactions (PCR), a feasible primer set is required. Many primer design methods have been proposed for design a feasible primer set. However, the majority of these methods require a relatively long time to obtain an optimal solution since large quantities of template DNA need to be analyzed. Furthermore, the designed primer sets usually do not provide a specific PCR product. In recent years, evolutionary computation has been applied to PCR primer design and yielded promising results. In this paper, a particle swarm optimization (PSO) algorithm is proposed to solve primer design problems associated with providing a specific product for PCR experiments. A test set of the gene CYP1A1, associated with a heightened lung cancer risk was analyzed and the comparison of accuracy and running time with the genetic algorithm (GA) and memetic algorithm (MA) was performed. A comparison of results indicated that the proposed PSO method for primer design finds optimal or near-optimal primer sets and effective PCR products in a relatively short time.
Abstract: The overriding goal of software engineering is to
provide a high quality system, application or a product. To achieve
this goal, software engineers must apply effective methods coupled
with modern tools within the context of a mature software process
[2]. In addition, it is also must to assure that high quality is realized.
Although many quality measures can be collected at the project
levels, the important measures are errors and defects. Deriving a
quality measure for reusable components has proven to be
challenging task now a days. The results obtained from the study are
based on the empirical evidence of reuse practices, as emerged from
the analysis of industrial projects. Both large and small companies,
working in a variety of business domains, and using object-oriented
and procedural development approaches contributed towards this
study. This paper proposes a quality metric that provides benefit at
both project and process level, namely defect removal efficiency
(DRE).
Abstract: Zinc borates can be used as multi-functional
synergistic additives with flame retardant additives in polymers. Zinc
borate is white, non-hygroscopic and powder type product. The most
important properties are low solubility in water and high dehydration
temperature. Zinc borates dehydrate above 290°C and anhydrous zinc
borate has thermal resistance about 400°C. Zinc borates can be
synthesized using several methods such as hydrothermal and solidstate
processes. In this study, the solid-state method was applied at
low temperatures of 600oC and 700oC using the starting materials of
ZnO and H3BO3 with several mole ratios. The reaction time was
determined as 4 hours after some preliminary experiments. After the
synthesis, the crystal structure and the morphology of the products
were examined by X-Ray Diffraction (XRD) and Fourier Transform
Infrared Spectroscopy (FT-IR). As a result the forms of ZnB4O7,
Zn3(BO3)2, ZnB2O4 were synthesized and obtained along with the
unreacted ZnO.
Abstract: The aim of the study was to investigate whether there
is the promotion of product ecodesign measures as a result of
adopting ISO 14001 certification in manufacturing companies in the
Republic of Slovenia. Companies gave the most of their product
development attention to waste and energy reduction during
manufacturing process and reduction of material consumption per
unit of product. Regarding the importance of different ecodesign
criteria reduction of material consumption per unit of product was
reported as the most important criterion. Less attention is paid to endof-
life issues considering recycling or packaging. Most
manufacturing enterprises considered ISO 14001 standard as a very
useful tool or at least a useful tool helping them to accelerate and
establish product ecodesign activities. Two most frequently
considered ecodesign drivers are increased competitive advantage
and legal requirements and two most important barriers are high
development costs and insufficient market demand.
Abstract: Product Data Management (PDM) systems for Computer
Aided Design (CAD) file management are widely established
in design processes. This management system is indispensable for
design collaboration or when design task distribution is present. It is
thus surprising that engineering design curricula has not paid much
attention in the education of PDM systems. This is also the case
for eduction of ecodesign and environmental evaluation of products.
With the rise of sustainability as a strategic aspect in companies,
environmental concerns are becoming a key issue in design. This
paper discusses the establishment of a PDM platform to be used
among technical and vocational schools in Austria. The PDM system
facilitates design collaboration among these schools. Further, it will
be discussed how the PDM system has been prepared in order to
facilitate environmental evaluation of parts, components and subassemblies
of a product. By integrating a Business Intelligence
solution, environmental Life Cycle Assessment and communication
of results is enabled.
Abstract: On the basis of questionnaires and interviews of two samples of subjects (French and Anglo-Saxon) for which two food products were presented (one of the subject’s country and one of the foreign country), we have shown how consumers could be sensitive to the label or brand written on the package of the food product. Furthermore, in the light of Intersubjectivity theory, we have shown the necessity for the consumer to find congruence between the direct and meta perspective towards the product for which the producer and especially the marketer is responsible. Taking into account these findings may help to avoid the commercial failure of a brand while exported abroad.
Abstract: This is an application research presenting the
improvement of production quality using the six sigma solutions and
the analyses of benefit-cost ratio. The case of interest is the
production of tile-concrete. Such production has faced with the
problem of high nonconforming products from an inappropriate
surface coating and had low process capability based on the strength
property of tile. Surface coating and tile strength are the most critical
to quality of this product. The improvements followed five stages of
six sigma solutions. After the improvement, the production yield was
improved to 80% as target required and the defective products from
coating process was remarkably reduced from 29.40% to 4.09%. The
process capability based on the strength quality was increased from
0.87 to 1.08 as customer oriented. The improvement was able to save
the materials loss for 3.24 millions baht or 0.11 million dollars. The
benefits from the improvement were analyzed from (1) the reduction
of the numbers of non conforming tile using its factory price for
surface coating improvement and (2) the materials saved from the
increment of process capability. The benefit-cost ratio of overall
improvement was high as 7.03. It was non valuable investment in
define, measure, analyses and the initial of improve stages after that
it kept increasing. This was due to there were no benefits in define,
measure, and analyze stages of six sigma since these three stages
mainly determine the cause of problem and its effects rather than
improve the process. The benefit-cost ratio starts existing in the
improve stage and go on. Within each stage, the individual benefitcost
ratio was much higher than the accumulative one as there was an
accumulation of cost since the first stage of six sigma. The
consideration of the benefit-cost ratio during the improvement
project helps make decisions for cost saving of similar activities
during the improvement and for new project. In conclusion, the
determination of benefit-cost ratio behavior through out six sigma
implementation period provides the useful data for managing quality
improvement for the optimal effectiveness. This is the additional
outcome from the regular proceeding of six sigma.
Abstract: The use of electronic sensors in the electronics
industry has become increasingly popular over the past few years,
and it has become a high competition product. The frequency
adjustment process is regarded as one of the most important process
in the electronic sensor manufacturing process. Due to inaccuracies
in the frequency adjustment process, up to 80% waste can be caused
due to rework processes; therefore, this study aims to provide a
preliminary understanding of the role of parameters used in the
frequency adjustment process, and also make suggestions in order to
further improve performance. Four parameters are considered in this
study: air pressure, dispensing time, vacuum force, and the distance
between the needle tip and the product. A full factorial design for
experiment 2k was considered to determine those parameters that
significantly affect the accuracy of the frequency adjustment process,
where a deviation in the frequency after adjustment and the target
frequency is expected to be 0 kHz. The experiment was conducted on
two levels, using two replications and with five center-points added.
In total, 37 experiments were carried out. The results reveal that air
pressure and dispensing time significantly affect the frequency
adjustment process. The mathematical relationship between these
two parameters was formulated, and the optimal parameters for air
pressure and dispensing time were found to be 0.45 MPa and 458 ms,
respectively. The optimal parameters were examined by carrying out
a confirmation experiment in which an average deviation of 0.082
kHz was achieved.
Abstract: Typically thermal power plants are located near to
surface coal mines that produce huge amount of fly ash as a waste
byproduct. Disposal of fly ash causes significant economic and
environmental problems. Now-a-days, research is going on for bulk
utilization of fly ash. In order to increase its percentage utilization, an
investigation was carried out to evaluate its potential for haul road
construction. This paper presents the laboratory California bearing
ratio (CBR) tests and evaluates the effect of lime on CBR behavior of
fly ash - mine overburden mixes. Tests were performed with different
percentages of lime (2%, 3%, 6%, and 9%). The results show that the
increase in bearing ratio of fly ash-overburden mixes was achieved
by lime treatment. Scanning electron microscopy (SEM) analyses
were conducted on 28 days cured specimens. The SEM study showed
that the bearing ratio development is related to the microstructural
development.
Abstract: This paper argues that a product development exercise
involves in addition to the conventional stages, several decisions
regarding other aspects. These aspects should be addressed
simultaneously in order to develop a product that responds to the
customer needs and that helps realize objectives of the stakeholders
in terms of profitability, market share and the like. We present a
framework that encompasses these different development
dimensions. The framework shows that a product development
methodology such as the Quality Function Deployment (QFD) is the
basic tool which allows definition of the target specifications of a
new product. Creativity is the first dimension that enables the
development exercise to live and end successfully. A number of
group processes need to be followed by the development team in
order to ensure enough creativity and innovation. Secondly,
packaging is considered to be an important extension of the product.
Branding strategies, quality and standardization requirements,
identification technologies, design technologies, production
technologies and costing and pricing are also integral parts to the
development exercise. These dimensions constitute the proposed
framework. The paper also presents a mathematical model used to
calculate the design targets based on the target costing principle. The
framework is used to study a case of a new product development in
the telecommunications services sector.
Abstract: The article presents findings from the study and
analysis of the results of an experimental programme focused on the
production of concrete and fibre reinforced concrete in which natural
aggregate has been substituted with brick or concrete recyclate. The
research results are analyzed to monitor the effect of mechanicalphysical
characteristics on the durability properties of tested
cementitious composites. The key parts of the fibre reinforced
concrete mix are the basic components: aggregates – recyclate,
cement, fly ash, water and fibres. Their specific ratios and the
properties of individual components principally affect the resulting
behaviour of fresh fibre reinforced concrete and the characteristics of
the final product. The article builds on the sources dealing with the
use of recycled aggregates from construction and demolition waste in
the production of fibre reinforced concrete. The implemented
procedure of testing the composite contributes to the building
sustainability in environmental engineering.
Abstract: The present work consecutively on synthesis and
characterization of composites, Al/Al alloy A 384.1 as matrix in
which the main ingredient as Al/Al-5% MgO alloy based metal
matrix composite. As practical implications the low cost processing
route for the fabrication of Al alloy A 384.1 and operational
difficulties of presently available manufacturing processes based in
liquid manipulation methods. As all new developments, complete
understanding of the influence of processing variables upon the final
quality of the product. And the composite is applied comprehensively
to the acquaintance for achieving superiority of information
concerning the specific heat measurement of a material through the
aid of thermographs. Products are evaluated concerning relative
particle size and mechanical behavior under tensile strength.
Furthermore, Taguchi technique was employed to examine the
experimental optimum results are achieved, owing to effectiveness of
this approach.
Abstract: Product customization is an essential requirement for
manufacturing firms to achieve higher customers- satisfaction and
fulfill business target. In order to achieve these objectives, firms need
to handle both external varieties such as customer preference,
government regulations, cultural considerations etc and internal
varieties such as functional requirements of product, production
efficiency, quality etc. Both of the varieties need to be accumulated
and integrated together for the purpose of producing customized
product. These varieties are presented and discussed in this paper
along with the perspectives of modular product design and
development process. Other development strategies such as
modularity, component commonality, product family design and
product platform are presented with a view to achieve product variety
quickly and economically. A case example both for the concept of
modular design and platform based product development process is
also presented with the help of design structure matrix (DSM) tool.
This paper is concluded with several managerial implications and
future research direction.
Abstract: The study was conducted to evaluate the quality
characteristics of cookies produced from sweet potato-fermented
soybean flour. Cookies were subjected to proximate and sensory
analysis to determine the acceptability of the product. Protein, fat and
ash increased as the proportion of soybean flour increased, ranging
from 13.8-21.7, 1.22-5.25 and 2.20-2.57 respectively. The crude fibre
content was within the range of 3.08-4.83%. The moisture content of
the cookies decreased with increase in soybean flour from 3.42-
2.13%. Cookies produced from whole sweet potato flour had the
highest moisture content of 3.42% while 30% substitution had the
lowest moisture content 2.13%. A nine point hedonic scale was used
to evaluate the organoleptic characteristics of the cookies. The
sensory analysis indicated that there was no significant difference
between the cookies produced even when compared to the control
100% sweet potato cookies. The overall acceptance of the cookies
was ranked to 20% soybean flour substitute.
Abstract: This paper deals with rheological behavior of tomato
paste from the view point of time independent properties inclusive of
processing variables such as sample temperature which influence on
rheological properties as well as breaking temperature and
concentration which beside the rheological properties, influence on
the quality of final product. With this aim 10 tomato paste samples at
various concentrations (17-25%) and breaking temperatures (65-
85 C o ) have been produced. The experimental results showed tomato
paste behaves as a non-Newtonian semi-fluid which follows power
law model that consistency coefficient (K) is supposed function of
breaking temperature, concentration and sample temperature with
consideration to superimpose function.
Abstract: Apart from geometry, functionality is one of the most
significant hallmarks of a product. The functionality of a product can
be considered as the fundamental justification for a product
existence. Therefore a functional analysis including a complete and
reliable descriptor has a high potential to improve product
development process in various fields especially in knowledge-based
design. One of the important applications of the functional analysis
and indexing is in retrieval and design reuse concept. More than 75%
of design activity for a new product development contains reusing
earlier and existing design know-how. Thus, analysis and
categorization of product functions concluded by functional
indexing, influences directly in design optimization. This paper
elucidates and evaluates major classes for functional analysis by
discussing their major methods. Moreover it is finalized by
presenting a noble hybrid approach for functional analysis.
Abstract: In this paper we will develop further the sequential
life test approach presented in a previous article by [1] using an
underlying two parameter Weibull sampling distribution. The
minimum life will be considered equal to zero. We will again provide
rules for making one of the three possible decisions as each
observation becomes available; that is: accept the null hypothesis H0;
reject the null hypothesis H0; or obtain additional information by
making another observation. The product being analyzed is a new
type of a low alloy-high strength steel product. To estimate the shape
and the scale parameters of the underlying Weibull model we will use
a maximum likelihood approach for censored failure data. A new
example will further develop the proposed sequential life testing
approach.
Abstract: This paper mathematically analyses the varying
magnitude of production loss, which may occur due to idle time (inprocess
waiting time and traveling time) on a linear walking worker
assembly line. Within this flexible and reconfigurable assembly
system, each worker travels down the line carrying out each
assembly task at each station; and each worker accomplishes the
assembly of a unit from start to finish and then travels back to the
first station to start the assembly of a new product. This strategy of
system design attempts to combine the flexibility of the U-shaped
moving worker assembly cell with the efficiency of the conventional
fixed worker assembly line. The paper aims to evaluate the effect of
idle time that may offset the labor efficiency of each walking worker
providing an insight into the mechanism of such a flexible and
reconfigurable assembly system.
Abstract: Prickly pear fruit (Opuntia ficus indica L. Miller) belongs to the Cactaceae family. This species is very sensitive to low storage temperatures (< 5°C) which cause damages. The fruits can be peeled, suitably packaged and successfully commercialized as a ready-to-eat product. The main limit to the extension of the shelf life is the production of off-flavors due to different factors, the growth of microorganisms and the action of endogenous enzymes. Lipoxygenase (LOX) and Pectinesterase (PE) are involved in fruit degradation. In particular, LOX pathway is directly responsible for lipid oxidation, and the subsequent production of off-flavours, while PE causes the softening of fruit during maturation. They act on the texture and shelf-life of post-harvest, packaged fruits, as a function of the the grown of microorganisms and packaging technologies used. The aim of this work is to compare the effect of different packaging technologies on the shelf life extension of ready-to-eat prickly pear fruits with regards for the enzymes activities.
Abstract: The paper proposes the novel design of a 3T XOR gate combining complementary CMOS with pass transistor logic. The design has been compared with earlier proposed 4T and 6T XOR gates and a significant improvement in silicon area and power-delay product has been obtained. An eight transistor full adder has been designed using the proposed three-transistor XOR gate and its performance has been investigated using 0.15um and 0.35um technologies. Compared to the earlier designed 10 transistor full adder, the proposed adder shows a significant improvement in silicon area and power delay product. The whole simulation has been carried out using HSPICE.