Abstract: The present study is aim to prepare and evaluate the selfnanoemulsifying drug delivery (SNEDDS) system of a poorly water soluble drug valsartan in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. The present research work describes a SNEDDS of valsartan using labrafil M 1944 CS, Tween 80 and Transcutol HP. The pseudoternary phase diagrams with presence and absence of drug were plotted to check for the emulsification range and also to evaluate the effect of valsartan on the emulsification behavior of the phases. The mixtures consisting of oil (labrafil M 1944 CS) with surfactant (tween 80), co-surfactant (Transcutol HP) were found to be optimum formulations. Prepared formulations were evaluated for its particle size distribution, nanoemulsifying properties, robustness to dilution, self emulsication time, turbidity measurement, drug content and invitro dissolution. The optimized formulations are further evaluated for heating cooling cycle, centrifugation studies, freeze thaw cycling, particle size distribution and zeta potential were carried out to confirm the stability of the formed SNEDDS formulations. The prepared formulation revealed t a significant improvement in terms of the drug solubility as compared with marketed tablet and pure drug.
Abstract: The elimination of ranitidine (a pharmaceutical
compound) has been carried out in the presence of UV-C radiation.
After some preliminary experiments, it has been experienced the no
influence of the gas nature (air or oxygen) bubbled in photolytic
experiments. From simple photolysis experiments the quantum yield
of this compound has been determined. Two photolytic
approximation has been used, the linear source emission in parallel
planes and the point source emission in spherical planes. The
quantum yield obtained was in the proximity of 0.05 mol Einstein-1
regardless of the method used. Addition of free radical promoters
(hydrogen peroxide) increases the ranitidine removal rate while the
use of photocatalysts (TiO2) negatively affects the process.
Abstract: The dynamics of Min proteins plays a center role in
accurate cell division. Although the nucleoids may presumably play
an important role in prokaryotic cell division, there is a lack of
models to account for its participation. In this work, we apply the
lattice Boltzmann method to investigate protein oscillation based on a
mesoscopic model that takes into account the nucleoid-s role. We
found that our numerical results are in reasonably good agreement
with the previous experimental results On comparing with the other
computational models without the presence of nucleoids, the
highlight of our finding is that the local densities of MinD and MinE
on the cytoplasmic membrane increases, especially along the cell
width, when the size of the obstacle increases, leading to a more
distinct cap-like structure at the poles. This feature indicated the
realistic pattern and reflected the combination of Min protein
dynamics and nucleoid-s role.
Abstract: In this paper a novel method for multiple one dimensional real valued sinusoidal signal frequency estimation in the presence of additive Gaussian noise is postulated. A computationally simple frequency estimation method with efficient statistical performance is attractive in many array signal processing applications. The prime focus of this paper is to combine the subspace-based technique and a simple peak search approach. This paper presents a variant of the Propagator Method (PM), where a collaborative approach of SUMWE and Propagator method is applied in order to estimate the multiple real valued sine wave frequencies. A new data model is proposed, which gives the dimension of the signal subspace is equal to the number of frequencies present in the observation. But, the signal subspace dimension is twice the number of frequencies in the conventional MUSIC method for estimating frequencies of real-valued sinusoidal signal. The statistical analysis of the proposed method is studied, and the explicit expression of asymptotic (large-sample) mean-squared-error (MSE) or variance of the estimation error is derived. The performance of the method is demonstrated, and the theoretical analysis is substantiated through numerical examples. The proposed method can achieve sustainable high estimation accuracy and frequency resolution at a lower SNR, which is verified by simulation by comparing with conventional MUSIC, ESPRIT and Propagator Method.
Abstract: The main objective of this research was to investigate
the biosorption capacity for biofilms of sulphate reducing bacteria
(SRB) to remove heavy metals, such as Zn, Pb and Cd from
rainwater using laboratory-scale reactors containing mixed support
media. Evidence showed that biosorption had contributed to removal
of heavy metals including Zn, Pb and Cd in presence of SRB and
SRB were also found in the aqueous samples from reactors.
However, the SRB and specific families (Desulfobacteriaceae and
Desulfovibrionaceae) were found mainly in the biomass samples
taken from all reactors at the end of the experiment. EDX-analysis
of reactor solids at end of experiment showed that heavy metals Zn,
Pb and Cd had also accumulated in these precipitates.
Abstract: Support Vector Machine (SVM) is a statistical
learning tool developed to a more complex concept of
structural risk minimization (SRM). In this paper, SVM is
applied to signal detection in communication systems in the
presence of channel noise in various environments in the form
of Rayleigh fading, additive white Gaussian background noise
(AWGN), and interference noise generalized as additive color
Gaussian noise (ACGN). The structure and performance of
SVM in terms of the bit error rate (BER) metric is derived and
simulated for these advanced stochastic noise models and the
computational complexity of the implementation, in terms of
average computational time per bit, is also presented. The
performance of SVM is then compared to conventional binary
signaling optimal model-based detector driven by binary
phase shift keying (BPSK) modulation. We show that the
SVM performance is superior to that of conventional matched
filter-, innovation filter-, and Wiener filter-driven detectors,
even in the presence of random Doppler carrier deviation,
especially for low SNR (signal-to-noise ratio) ranges. For
large SNR, the performance of the SVM was similar to that of
the classical detectors. However, the convergence between
SVM and maximum likelihood detection occurred at a higher
SNR as the noise environment became more hostile.
Abstract: Films of pure tin oxide SnO2 and in presence of
antimony atoms (SnO2-Sb) deposited onto glass substrates have
shown a sufficiently high energy gap to be transparent in the visible
region, a high electrical mobility and a carrier concentration which
displays a good electrical conductivity [1]. In this work, the effects of
polycrystalline silicon substrate on the optical properties of pure and
Sb doped tin oxide is investigated.
We used the APCVD (atmospheric pressure chemical vapour
deposition) technique, which is a low-cost and simple technique,
under nitrogen ambient, for growing this material. A series of SnO2
and SnO2-Sb have been deposited onto polycrystalline silicon
substrates with different contents of antimony atoms at the same
conditions of deposition (substrate temperature, flow oxygen,
duration and nitrogen atmosphere of the reactor). The effect of the
substrate in terms of morphology and nonlinear optical properties,
mainly the reflectance, was studied. The reflectance intensity of the
device, compared to the reflectance of tin oxide films deposited
directly on glass substrate, is clearly reduced on the overall
wavelength range. It is obvious that the roughness of the poly-c
silicon plays an important role by improving the reflectance and
hence the optical parameters.
A clear shift in the minimum of the reflectance upon doping level
is observed. This minimum corresponds to strong free carrier
absorption, resulting in different plasma frequency. This effect is
followed by an increase in the reflectance depending of the antimony
doping. Applying the extended Drude theory to the combining
optical and electrical obtained results these effects are discussed.
Abstract: Since the 1940s, many promising telepresence
research results have been obtained. However, telepresence
technology still has not reached industrial usage. As human
intelligence is necessary for successful execution of most manual
assembly tasks, the ability of the human is hindered in some cases,
such as the assembly of heavy parts of small/medium lots or
prototypes. In such a case of manual assembly, the help of industrial
robots is mandatory. The telepresence technology can be considered
as a solution for performing assembly tasks, where the human
intelligence and haptic sense are needed to identify and minimize the
errors during an assembly process and a robot is needed to carry
heavy parts. In this paper, preliminary steps to integrate the
telepresence technology into industrial robot systems are introduced.
The system described here combines both, the human haptic sense
and the industrial robot capability to perform a manual assembly task
remotely using a force feedback joystick. Mapping between the
joystick-s Degrees of Freedom (DOF) and the robot-s ones are
introduced. Simulation and experimental results are shown and future
work is discussed.
Abstract: The aim of this work was to study the in vitro effects
of δ-lactam 1 and its 4-chlorophenyl derivative 2, on the proliferative
responses of human lymphocytes and Th1 and Th2 cytokine
secretion. The possible protective role of vitamin E on intracellular
stress oxidative induced by these compounds was also investigated.
Peripheral blood lymphocytes were isolated using differential
centrifugation on a density gradient of Histopaque. They were
cultured with mitogen concanavalin A, vitamin E (10 μM) and with
different concentrations of the compounds 1 and 2 (0.1 to 10 μM).
Proliferation (MTT assay), IL-2, INFγ and IL-4 (Elisa kits),
intracellular superoxide anion were determined. 1 and 2 were
immunostimulant and increased cytokine secretion with a shift away
from Th1 response to Th2. These properties were however
accompanied by an increase in intracellular oxidative stress. The
presence of vitamin E exhibited protective effects by reducing δ-
lactam-induced superoxide anion generation in lymphocytes.
Abstract: The crystalline quality of the AlGaN/GaN high electron mobility transistor (HEMT) structure grown on a 200 mm silicon substrate has been investigated using UV-visible micro- Raman scattering and photoluminescence (PL). The visible Raman scattering probes the whole nitride stack with the Si substrate and shows the presence of a small component of residual in-plane stress in the thick GaN buffer resulting from a wafer bowing, while the UV micro-Raman indicates a tensile interfacial stress induced at the top GaN/AlGaN/AlN layers. PL shows a good crystal quality GaN channel where the yellow band intensity is very low compared to that of the near-band-edge transition. The uniformity of this sample is shown by measurements from several points across the epiwafer.
Abstract: Skin color based tracking techniques often assume a
static skin color model obtained either from an offline set of library
images or the first few frames of a video stream. These models
can show a weak performance in presence of changing lighting or
imaging conditions. We propose an adaptive skin color model based
on the Gaussian mixture model to handle the changing conditions.
Initial estimation of the number and weights of skin color clusters
are obtained using a modified form of the general Expectation
maximization algorithm, The model adapts to changes in imaging
conditions and refines the model parameters dynamically using spatial
and temporal constraints. Experimental results show that the method
can be used in effectively tracking of hand and face regions.
Abstract: The present paper reports the removal of Cd(II) and
Zn(II) ions using synthetic Zeolit NaA. The adsorption capacity of
the sorbent (Zeolite NaA) strongly depends on simultaneous or not
simultaneous (concurrent) presence of Cd(II) and Zn(II) in the
sorbate. When Cd(II) and Zn(II) are present simultaneously
(concurrently) in the sorbate, Zn(II) ions were sorbed at higher rate.
Equilibrium data fitted Langmuir, Freundlich and Tempkin isotherms
well. The applicability of the isotherm equation to describe the
adsorption process was judged by the correlation coefficients R2. The
Langmuir model yielded the best fit with R2 values equal to or higher
than 0.970, as compared to the Freundlich and Tempkin models. The
fact that 1/n values range from 0.322 to 0.755 indicates that the
adsorption of Cd(II) and Zn(II) ions from aqueous solutions also
favored by the Freundlich model.
Abstract: Wireless Sensor Networks (WSNs) are used to monitor/observe vast inaccessible regions through deployment of large number of sensor nodes in the sensing area. For majority of WSN applications, the collected data needs to be combined with geographic information of its origin to make it useful for the user; information received from remote Sensor Nodes (SNs) that are several hops away from base station/sink is meaningless without knowledge of its source. In addition to this, location information of SNs can also be used to propose/develop new network protocols for WSNs to improve their energy efficiency and lifetime. In this paper, range free localization protocols for WSNs have been proposed. The proposed protocols are based on weighted centroid localization technique, where the edge weights of SNs are decided by utilizing fuzzy logic inference for received signal strength and link quality between the nodes. The fuzzification is carried out using (i) Mamdani, (ii) Sugeno, and (iii) Combined Mamdani Sugeno fuzzy logic inference. Simulation results demonstrate that proposed protocols provide better accuracy in node localization compared to conventional centroid based localization protocols despite presence of unintentional radio frequency interference from radio frequency (RF) sources operating in same frequency band.
Abstract: In this paper, we explore the applicability of the Sinc-
Collocation method to a three-dimensional (3D) oceanography model.
The model describes a wind-driven current with depth-dependent
eddy viscosity in the complex-velocity system. In general, the
Sinc-based methods excel over other traditional numerical methods
due to their exponentially decaying errors, rapid convergence and
handling problems in the presence of singularities in end-points.
Together with these advantages, the Sinc-Collocation approach that
we utilize exploits first derivative interpolation, whose integration
is much less sensitive to numerical errors. We bring up several
model problems to prove the accuracy, stability, and computational
efficiency of the method. The approximate solutions determined by
the Sinc-Collocation technique are compared to exact solutions and
those obtained by the Sinc-Galerkin approach in earlier studies. Our
findings indicate that the Sinc-Collocation method outperforms other
Sinc-based methods in past studies.
Abstract: In this research, we propose a weighted class based
queuing (WCBQ) mechanism to provide class differentiation and to
reduce the load for the IMS (IP Multimedia Subsystem) presence
server (PS). The tasks of admission controller for the PS are
demonstrated. Analysis and simulation models are developed to
quantify the performance of WCBQ scheme. An optimized dropping
time frame has been developed based on which some of the preexisting
messages are dropped from the PS-buffer. Cost functions are
developed and simulation comparison has been performed with FCFS
(First Come First Served) scheme. The results show that the PS
benefits significantly from the proposed queuing and dropping
algorithm (WCBQ) during heavy traffic.
Abstract: In this study, production possibilities of hydrogen and/or methane via SCWG from black grape residues have been investigated. For this aim, grape residues which remain as a byproduct of the wine making process have been used. Since utilization from grape residues is limited due to the high moisture content, supercritical water gasification is the most convenient method. The effect of the gasification temperature and type of catalyst on supercritical water gasification have been investigated. Gasification experiments were performed in a batch autoclave at four different temperatures 300, 400, 500 and 600°C. K2CO3 and Trona (NaHCO3.Na2CO3·2H2O) were used as catalyst. Real biomass types of black grape residues have been successfully gasified and the product gas (hydrogen, methane, carbon dioxide, carbon monoxide and a small amount of ethane and ethylene) were identified by using gas chromatography. A TOC analyzer was used to determine total organic carbon (TOC) content of aqueous phase. The amounts of carboxylic acids, aldehydes, ketones, furfurals and phenols present in the aqueous solutions were analyzed by high performance liquid chromatography. When the temperature increased from 300°C to 600°C, mol% of H2 in gas products increased. The presence of catalysts improves the hydrogen yield. Trona showed gasification activity to be similar to that of K2CO3. It may be concluded that the use of Trona instead of commercially produced catalysts, can be preferably used in the gasification of biomass in supercritical water.
Abstract: Three-dimensional simulation of harmonic up
generation in free electron laser amplifier operating simultaneously
with a cold and relativistic electron beam is presented in steady-state
regime where the slippage of the electromagnetic wave with respect
to the electron beam is ignored. By using slowly varying envelope
approximation and applying the source-dependent expansion to wave
equations, electromagnetic fields are represented in terms of the
Hermit Gaussian modes which are well suited for the planar wiggler
configuration. The electron dynamics is described by the fully threedimensional
Lorentz force equation in presence of the realistic planar
magnetostatic wiggler and electromagnetic fields. A set of coupled
nonlinear first-order differential equations is derived and solved
numerically. The fundamental and third harmonic radiation of the
beam is considered. In addition to uniform beam, prebunched
electron beam has also been studied. For this effect of sinusoidal
distribution of entry times for the electron beam on the evolution of
radiation is compared with uniform distribution. It is shown that
prebunching reduces the saturation length substantially. For
efficiency enhancement the wiggler is set to decrease linearly when
the radiation of the third harmonic saturates. The optimum starting
point of tapering and the slope of radiation in the amplitude of
wiggler are found by successive run of the code.
Abstract: Ligula intestinalis is a three-host life-cycle
Pseudophyllidean Cestode which in its plerocercoid stage infests a
range of fresh water species. The objective of the present study was
the worm occurrence within planctonic copepods, fishes and
piscivorous birds and examine of parasite-hosts samples in the Lake
of Sattarkhan Dam (near the city of Ahar, East Azerbaijan, Iran).
Fish sample were collected with fyke and gill nets and the abdominal
cavity was examined for the presence of ligula. Zooplanktons were
captured using a planktonic net and occurrence of parasitic larval
form in the body cavity was determined. Piscivorous birds were
selected by telescope, they hunted and dissected for presence of
parasite eggs in their gut. Results indicated that prevalence of
infection was 16% for cyclopid copepoda and majority of infected
cyclopid were female Cyclops. Investigation of 310 fishes specimens
were indicated to infection of five species of cyprinid fishes. In
addition, results indicated to manipulation of six species of migratory
aquatic and semi aquatic birds by ligula. Obtained results are in
agreement by previous studies. Its definite in this study that all of
fishes in Sattarkhan Lake capable to infection, its important for
health because they capture by native people and it is documented
that ligula can be introduce as a zoonose. It's seemed that to prevent
from disperses of parasite and restricted of infection, biological
elimination can be effective and it's necessary to inform native
people about sanitation.
Abstract: Insufficient Quality of Service (QoS) of Voice over
Internet Protocol (VoIP) is a growing concern that has lead the need
for research and study. In this paper we investigate the performance
of VoIP and the impact of resource limitations on the performance of
Access Networks. The impact of VoIP performance in Access
Networks is particularly important in regions where Internet
resources are limited and the cost of improving these resources is
prohibitive. It is clear that perceived VoIP performance, as measured
by mean opinion score [2] in experiments, where subjects are asked
to rate communication quality, is determined by end-to-end delay on
the communication path, delay variation, packet loss, echo, the
coding algorithm in use and noise. These performance indicators can
be measured and the affect in the Access Network can be estimated.
This paper investigates the congestion in the Access Network to the
overall performance of VoIP services with the presence of other
substantial uses of internet and ways in which Access Networks can
be designed to improve VoIP performance. Methods for analyzing
the impact of the Access Network on VoIP performance will be
surveyed and reviewed. This paper also considers some approaches
for improving performance of VoIP by carrying out experiments
using Network Simulator version 2 (NS2) software with a view to
gaining a better understanding of the design of Access Networks.
Abstract: The present contribution deals with the
thermophoretic deposition of nanoparticles over a rapidly rotating
permeable disk in the presence of partial slip, magnetic field, thermal
radiation, thermal-diffusion, and diffusion-thermo effects. The
governing nonlinear partial differential equations such as continuity,
momentum, energy and concentration are transformed into nonlinear
ordinary differential equations using similarity analysis, and the
solutions are obtained through the very efficient computer algebra
software MATLAB. Graphical results for non-dimensional
concentration and temperature profiles including thermophoretic
deposition velocity and Stanton number (thermophoretic deposition
flux) in tabular forms are presented for a range of values of the
parameters characterizing the flow field. It is observed that slip
mechanism, thermal-diffusion, diffusion-thermo, magnetic field and
radiation significantly control the thermophoretic particles deposition
rate. The obtained results may be useful to many industrial and
engineering applications.