Abstract: The aim of the present work was to test in vitro inhibition of food pathogens and spoilage bacteria by crude bacteriocins from autochthonous lactic acid bacteria. Thirty autochthonous lactic acid bacteria isolated previously, belonging to the genera: Lactobacillus, Carnobacterium, Lactococcus, Vagococcus, Streptococcus, and Pediococcus, have been screened by an agar spot test and a well diffusion assay against Gram-positive and Gram-negative harmful bacteria: Bacillus cereus, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 8739, Salmonella typhimurium ATCC 14028, Staphylococcus aureus ATCC 6538, and Pseudomonas aeruginosa under conditions means to reduce lactic acid and hydrogen peroxide effect to select bacteria with high bacteriocinogenic potential. Furthermore, crude bacteriocins semiquantification and heat sensitivity to different temperatures (80, 95, 110°C, and 121°C) were performed. Another exploratory test concerning the response of St. aureus ATCC 6538 to the presence of crude bacteriocins was realized. It has been observed by the agar spot test that fifteen candidates were active toward Gram-positive targets strains. The secondary screening demonstrated an antagonistic activity oriented only against St. aureus ATCC 6538, leading to the selection of five isolates: Lm14, Lm21, Lm23, Lm24, and Lm25 with a larger inhibition zone compared to the others. The ANOVA statistical analysis reveals a small variation of repeatability: Lm21: 0.56%, Lm23: 0%, Lm25: 1.67%, Lm14: 1.88%, Lm24: 2.14%. Conversely, slight variation was reported in terms of inhibition diameters: 9.58± 0.40, 9.83± 0.46 and 10.16± 0.24 8.5 ± 0.40 10 mm for, Lm21, Lm23, Lm25, Lm14and Lm24, indicating that the observed potential showed a heterogeneous distribution (BMS = 0.383, WMS = 0.117). The repeatability coefficient calculated displayed 7.35%. As for the bacteriocins semiquantification, the five samples exhibited production amounts about 4.16 for Lm21, Lm23, Lm25 and 2.08 AU/ml for Lm14, Lm24. Concerning the sensitivity the crude bacteriocins were fully insensitive to heat inactivation, until 121°C, they preserved the same inhibition diameter. As to, kinetic of growth , the µmax showed reductions in pathogens load for Lm21, Lm23, Lm25, Lm14, Lm24 of about 42.92%, 84.12%, 88.55%, 54.95%, 29.97% in the second trails. Inversely, this pathogen growth after five hours displayed differences of 79.45%, 12.64%, 11.82%, 87.88%, 85.66% in the second trails, compared to the control. This study showed potential inhibition to the growth of this food pathogen, suggesting the possibility to improve the hygienic food quality.
Abstract: Displacement ventilation of a room with an occupant is modeled using CFD. The geometry of manikin is accurately represented in CFD model to minimize potential. Indoor zero equation turbulence model is used to simulate all cases and the effect of the thermal radiation from manikin is taken into account. After validation of the code, predicted mean vote, mean age of air, and ventilation effectiveness are used to predict the thermal comfort zones and indoor air quality. The effect of the inlet velocity and temperature on the thermal comfort and indoor air quality is investigated. The results show that the inlet velocity has great effect on the thermal comfort and indoor air quality and low inlet velocity is sufficient to establish comfortable conditions inside the room. In addition, the displacement ventilation system achieves not only thermal comfort in ventilated rooms, but also energy saving of fan power.
Abstract: The newest semiconductor devices on the market are MOSFET transistors based on the silicon carbide – SiC. This material has exclusive features thanks to which it becomes a better switch than Si – silicon semiconductor switch. There are some special features that need to be understood to enable the device’s use to its full potential. The advantages and differences of SiC MOSFETs in comparison with Si IGBT transistors have been described in first part of this article. Second part describes driver for SiC MOSFET transistor and last part of article represents SiC MOSFET in the application of buck converter (step-down) and design of simple RC snubber.
Abstract: The main aim of the present research was to encapsulate mefenamic acid in niosomes andincorporate the prepared niosomes in the carbopol gel base for sustained therapeutic action. Mefenamic acid loaded niosomes were prepared by thin film hydration technique and evaluated for entrapment efficiency, vesicular size and zeta potential. The entrapment efficiency of the prepared niosomes was found to increase with decreasing the HLB values of surfactants and vesicle size was found to increase with increasing the cholesterol concentration. Niosomal vesicles with good entrapment efficiencies were incorporated in carbopol gel base to form the niosomal gel. The prepared niosomal gel was evaluated for pH, viscosity, spreadability, extrudability and skin permeation study across the rat skin. The results of permeation study revealed that the gel formulated with span 60 niosomes sustained the drug release for 12h. Further the in vivo study showed the good inhibition of inflammation by the gel prepared with span 60 niosomes.
Abstract: In times of global warming and the increasing
shortage of resources, sustainable production is becoming more and
more inevitable. Companies cannot only heighten their
competitiveness but also contribute positively to environmental
protection through efficient energy and resource consumption.
Regarding this, technical solutions are often preferred during
production, although organizational and process-related approaches
also offer great potential. This project focuses on reducing resource
usage, with a special emphasis on the human factor. It is the
aspiration to develop a methodology that systematically implements
and embeds suitable and individual measures and methods regarding
resource efficiency throughout the entire production. The measures
and methods established help employees handle resources and energy
more sensitively. With this in mind, this paper also deals with the
difficulties that can occur during the sensitization of employees and
the implementation of these measures and methods. In addition,
recommendations are given on how to avoid such difficulties.
Abstract: This study was conducted to formulate diclofenac sodium-loaded chitosan nanoparticles and to study the effect of formulation compositions on particle size and zeta potential of chitosan nanoparticles (CSN) containing diclofenac sodium (DC) prepared by ionotropic gelation method. It was found that the formulations containing chitosan, DC and tripolyphosphate (TPP) at a weight ratio of 4:1:1, respectively, with various pH provided various systems. At pH 5.0 and 6.0, the obtained systems were turbid because of precipitation of DC and chitosan, respectively. However, the dispersed system of CSN possessing diameter of 108±1 nm and zeta potential of 19±1 mV could be obtained at pH 5.5. These CSN also showed spherical morphology observed via a transmission scanning electron microscope. Change in weight ratio of chitosan:DC:TPP i.e. 1:1:1, 2:1:1, 3:1:1 and 4:1:1 showed that these ratios led to precipitation of particles except for the ratio of 4:1:1 providing CSN properly. The effect of Tween 80 as a stabilizer was also determined. It suggested that increment of Tween 80 concentration to 0.02% w/v could stabilize CSN at least 48 hours. However, increment of Tween 80 to 0.03% w/v led to quick precipitation of particles. The study of effect of TPP suggested that increment of TPP concentration increased particle size but decreased zeta potential. The excess TPP caused precipitation of CSN. Therefore, the optimized CSN was the CSN containing chitosan, DC and TPP at the ratio of 4:1:1and 0.02% w/v Tween 80 prepared at pH 5.5. Their particle size, zeta potential and entrapment efficiency were 128±1 nm, 15±1 mV and 45.8±2.6%, respectively.
Abstract: Hydrogen diffusion is the main problem for corrosion fatigue in corrosive environment. In order to analyze the phenomenon, it is needed to understand their behaviors specially the hydrogen behavior during the diffusion. So, Hydrogen embrittlement and prediction its behavior as a main corrosive part of the fractions, needed to solve combinations of different equations mathematically. The main point to obtain the equation, having knowledge about the source of causing diffusion and running the atoms into materials, called driving force. This is produced by either gradient of electrical or chemical potential. In this work, we consider the gradient of chemical potential to obtain the property equation. In diffusion of atoms, some of them may be trapped but, it could be ignorable in some conditions. According to the phenomenon of hydrogen embrittlement, the thermodynamic and chemical properties of hydrogen are considered to justify and relate them to fracture mechanics. It is very important to get a stress intensity factor by using fugacity as a property of hydrogen or other gases. Although, the diffusive behavior and embrittlement event are common and the same for other gases but, for making it more clear, we describe it for hydrogen. This considering on the definite gas and describing it helps us to understand better the importance of this relation.
Abstract: Heterogeneous repolarization causes dispersion of the T-wave and has been linked to arrhythmogenesis. Such heterogeneities appear due to differential expression of ionic currents in different regions of the heart, both in healthy and diseased animals and humans. Mice are important animals for the study of heart diseases because of the ability to create transgenic animals. We used our previously reported model of mouse ventricular myocytes to develop 2D mouse ventricular tissue model consisting of 14,000 cells (apical or septal ventricular myocytes) and to study the stability of action potential propagation and Ca2+ dynamics. The 2D tissue model was implemented as a FORTRAN program code for highperformance multiprocessor computers that runs on 36 processors. Our tissue model is able to simulate heterogeneities not only in action potential repolarization, but also heterogeneities in intracellular Ca2+ transients. The multicellular model reproduced experimentally observed velocities of action potential propagation and demonstrated the importance of incorporation of realistic Ca2+ dynamics for action potential propagation. The simulations show that relatively sharp gradients of repolarization are predicted to exist in 2D mouse tissue models, and they are primarily determined by the cellular properties of ventricular myocytes. Abrupt local gradients of channel expression can cause alternans at longer pacing basic cycle lengths than gradual changes, and development of alternans depends on the site of stimulation.
Abstract: The aim of this research was to calculate the
mechanical properties of Pd3Rh and PdRh3 ordered alloys. The
molecular dynamics (MD) simulation technique was used to obtain
temperature dependence of the energy, the Yong modulus, the shear
modulus, the bulk modulus, Poisson-s ratio and the elastic stiffness
constants at the isobaric-isothermal (NPT) ensemble in the range of
100-325 K. The interatomic potential energy and force on atoms were
calculated by Quantum Sutton-Chen (Q-SC) many body potential.
Our MD simulation results show the effect of temperature on the
cohesive energy and mechanical properties of Pd3Rh as well as
PdRh3 alloys. Our computed results show good agreement with the
experimental results where they have been available.
Abstract: In this paper, several improvements are proposed to
previous work of automated classification of alcoholics and nonalcoholics.
In the previous paper, multiplayer-perceptron neural
network classifying energy of gamma band Visual Evoked Potential
(VEP) signals gave the best classification performance using 800
VEP signals from 10 alcoholics and 10 non-alcoholics. Here, the
dataset is extended to include 3560 VEP signals from 102 subjects:
62 alcoholics and 40 non-alcoholics. Three modifications are
introduced to improve the classification performance: i) increasing
the gamma band spectral range by increasing the pass-band width of
the used filter ii) the use of Multiple Signal Classification algorithm
to obtain the power of the dominant frequency in gamma band VEP
signals as features and iii) the use of the simple but effective knearest
neighbour classifier. To validate that these two modifications
do give improved performance, a 10-fold cross validation
classification (CVC) scheme is used. Repeat experiments of the
previously used methodology for the extended dataset are performed
here and improvement from 94.49% to 98.71% in maximum
averaged CVC accuracy is obtained using the modifications. This
latest results show that VEP based classification of alcoholics is
worth exploring further for system development.
Abstract: The objective of this study is to present the test
results of variable air volume (VAV) air conditioning system
optimized by two objective genetic algorithm (GA). The objective
functions are energy savings and thermal comfort. The optimal set
points for fuzzy logic controller (FLC) are the supply air temperature
(Ts), the supply duct static pressure (Ps), the chilled water
temperature (Tw), and zone temperature (Tz) that is taken as the
problem variables. Supply airflow rate and chilled water flow rate are
considered to be the constraints. The optimal set point values are
obtained from GA process and assigned into fuzzy logic controller
(FLC) in order to conserve energy and maintain thermal comfort in
real time VAV air conditioning system. A VAV air conditioning
system with FLC installed in a software laboratory has been taken for
the purpose of energy analysis. The total energy saving obtained in
VAV GA optimization system with FLC compared with constant air
volume (CAV) system is expected to achieve 31.5%. The optimal
duct static pressure obtained through Genetic fuzzy methodology
attributes to better air distribution by delivering the optimal quantity
of supply air to the conditioned space. This combination enhanced
the advantages of uniform air distribution, thermal comfort and
improved energy savings potential.
Abstract: Renewable energy systems are becoming a topic of
great interest and investment in the world. In recent years wind
power generation has experienced a very fast development in the
whole world. For planning and successful implementations of good
wind power plant projects, wind potential measurements are
required. In these projects, of great importance is the effective choice
of the micro location for wind potential measurements, installation of
the measurement station with the appropriate measuring equipment,
its maintenance and analysis of the gained data on wind potential
characteristics. In this paper, a wavelet transform has been applied to
analyze the wind speed data in the context of insight in the
characteristics of the wind and the selection of suitable locations that
could be the subject of a wind farm construction. This approach
shows that it can be a useful tool in investigation of wind potential.
Abstract: Confucius was a fifth-century BCE Chinese thinker whose influence upon East Asian intellectual and social history is immeasurable. Better known is in China as “Master Kong”. As a culturally symbolic figure, he has been alternately idealized, deified, dismissed, vilified, and rehabilitated over the millennia by both Asian and non-Asian thinkers and regimes. Given his extraordinary impact on Chinese, Korean, Japanese, and Vietnamese thought, it is ironic that so little can be known about Confucius. The tradition that bears his name – “Confucianizm” (Chinese: Rujia) – ultimately traces itself to the sayings and biographical fragments recorded in the text known as the Analects (Chinese: Lunyu). In the Analects, two types of persons are opposed to one another – not in terms of basic potential, but in terms of developed potential. These are the junzi (literally, “lord’s son” or “gentleman”) and the xiaoren (“small person”). The junzi is the person who always manifests the quality of ren in his
person and the displays the quality of lee in his actions. In this article examines the category of the ideal man and the spiritual and moral values of the philosophy of Confucius. According to Confucius high-morality Jun-zi is characterized by two things: a sense of humanity and duty. This article provides an analysis of the ethical category for the ideal man.
Abstract: Digital Video Terrestrial Broadcasting (DVB-T)
allows combining broadcasting, telephone and data services in one
network. It has facilitated mobile TV broadcasting. Mobile TV
broadcasting is dominated by fragmentation of standards in use in
different continents. In Asia T-DMB and ISDB-T are used while
Europe uses mainly DVB-H and in USA it is MediaFLO. Issues of
royalty for developers of these different incompatible technologies,
investments made and differing local conditions shall make it
difficult to agree on a unified standard in a very near future. Despite
this shortcoming, mobile TV has shown very good market potential.
There are a number of challenges that still exist for regulators,
investors and technology developers but the future looks bright.
There is need for mobile telephone operators to cooperate with
content providers and those operating terrestrial digital broadcasting
infrastructure for mutual benefit.
Abstract: Fossil fuels are the major source to meet the world
energy requirements but its rapidly diminishing rate and adverse
effects on our ecological system are of major concern. Renewable
energy utilization is the need of time to meet the future challenges.
Ocean energy is the one of these promising energy resources. Threefourths
of the earth-s surface is covered by the oceans. This enormous
energy resource is contained in the oceans- waters, the air above the
oceans, and the land beneath them. The renewable energy source of
ocean mainly is contained in waves, ocean current and offshore solar
energy. Very fewer efforts have been made to harness this reliable
and predictable resource. Harnessing of ocean energy needs detail
knowledge of underlying mathematical governing equation and their
analysis. With the advent of extra ordinary computational resources
it is now possible to predict the wave climatology in lab simulation.
Several techniques have been developed mostly stem from numerical
analysis of Navier Stokes equations. This paper presents a brief over
view of such mathematical model and tools to understand and
analyze the wave climatology. Models of 1st, 2nd and 3rd generations
have been developed to estimate the wave characteristics to assess the
power potential. A brief overview of available wave energy
technologies is also given. A novel concept of on-shore wave energy
extraction method is also presented at the end. The concept is based
upon total energy conservation, where energy of wave is transferred
to the flexible converter to increase its kinetic energy. Squeezing
action by the external pressure on the converter body results in
increase velocities at discharge section. High velocity head then can
be used for energy storage or for direct utility of power generation.
This converter utilizes the both potential and kinetic energy of the
waves and designed for on-shore or near-shore application. Increased
wave height at the shore due to shoaling effects increases the
potential energy of the waves which is converted to renewable
energy. This approach will result in economic wave energy
converter due to near shore installation and more dense waves due to
shoaling. Method will be more efficient because of tapping both
potential and kinetic energy of the waves.
Abstract: In this paper, He-s amplitude frequency formulation is used to obtain a periodic solution for a nonlinear oscillator with fractional potential. By calculation and computer simulations, compared with the exact solution shows that the result obtained is of high accuracy.
Abstract: In this paper, applying He-s energy balance method to determine frequency formulation relations of nonlinear oscillators with discontinuous term or fractional potential. By calculation and computer simulations, compared with the exact solutions show that the results obtained are of high accuracy.
Abstract: This paper describes the architectural design
considerations for building a new class of application, a Personal
Knowledge Integrator and a particular example a Knowledge Theatre.
It then supports this description by describing a scenario of a child
acquiring knowledge and how this process could be augmented by
the proposed architecture and design of a Knowledge Theatre. David
Merrill-s first “principles of instruction" are kept in focus to provide
a background to view the learning potential.
Abstract: In this paper, a second order autoregressive (AR)
model is proposed to discriminate alcoholics using single trial
gamma band Visual Evoked Potential (VEP) signals using 3 different
classifiers: Simplified Fuzzy ARTMAP (SFA) neural network (NN),
Multilayer-perceptron-backpropagation (MLP-BP) NN and Linear
Discriminant (LD). Electroencephalogram (EEG) signals were
recorded from alcoholic and control subjects during the presentation
of visuals from Snodgrass and Vanderwart picture set. Single trial
VEP signals were extracted from EEG signals using Elliptic filtering
in the gamma band spectral range. A second order AR model was
used as gamma band VEP exhibits pseudo-periodic behaviour and
second order AR is optimal to represent this behaviour. This
circumvents the requirement of having to use some criteria to choose
the correct order. The averaged discrimination errors of 2.6%, 2.8%
and 11.9% were given by LD, MLP-BP and SFA classifiers. The
high LD discrimination results show the validity of the proposed
method to discriminate between alcoholic subjects.
Abstract: Today, any organization - regardless of the specific activity - must be prepared to face continuous radical changes, innovation thus becoming a condition of survival in a globalized market. Few managers have a wider vision that includes innovation, to enable better performance of the critical activities, namely the degree of novelty that it must submit an innovation to be considered as such. Companies need not only radical changes in the products or their services, but also to their business strategies. Not all managers have an overall view on the real size of necessary innovation potential. Unfortunately there is still no common understanding (and correct) of the term of innovation among managers. Moreover, not all managers are aware of the need for innovation. In these conditions, increasing the processes adaptability of firms (through innovation) to meet the needs and performance requirements is difficult without a systematic framework. To overcome this disadvantage, the authors propose a framework for designing an innovation management system,, to cover all the important aspects of a business system, to reach the actual performance of an organization.