Abstract: Methods of contemporary mathematical physics such
as chaos theory are useful for analyzing and understanding the
behavior of complex biological and physiological systems. The three
dimensional model of HIV/AIDS is the basis of active research since
it provides a complete characterization of disease dynamics and the
interaction of HIV-1 with the immune system. In this work, the
behavior of the HIV system is analyzed using the three dimensional
HIV model and a chaotic measure known as the Hurst exponent.
Results demonstrate that Hurst exponents of CD4, CD8 cells and
viral load vary nonlinearly with respect to variations in system
parameters. Further, it was observed that the three dimensional HIV
model can accommodate both persistent (H>0.5) and anti-persistent
(H
Abstract: Shot boundary detection is a fundamental step for the organization of large video data. In this paper, we propose a new method for video gradual shots detection and classification, using advantages of fractal analysis and AIS-based classifier. Proposed features are “vertical intercept" and “fractal dimension" of each frame of videos which are computed using Fourier transform coefficients. We also used a classifier based on Clonal Selection Algorithm. We have carried out our solution and assessed it according to the TRECVID2006 benchmark dataset.
Abstract: Writer identification is one of the areas in pattern
recognition that attract many researchers to work in, particularly in
forensic and biometric application, where the writing style can be
used as biometric features for authenticating an identity. The
challenging task in writer identification is the extraction of unique
features, in which the individualistic of such handwriting styles
can be adopted into bio-inspired generalized global shape for
writer identification. In this paper, the feasibility of generalized
global shape concept of complimentary binding in Artificial
Immune System (AIS) for writer identification is explored. An
experiment based on the proposed framework has been conducted
to proof the validity and feasibility of the proposed approach for
off-line writer identification.
Abstract: The job shop scheduling problem (JSSP) is a
notoriously difficult problem in combinatorial optimization. This
paper presents a hybrid artificial immune system for the JSSP with the
objective of minimizing makespan. The proposed approach combines
the artificial immune system, which has a powerful global exploration
capability, with the local search method, which can exploit the optimal
antibody. The antibody coding scheme is based on the operation based
representation. The decoding procedure limits the search space to the
set of full active schedules. In each generation, a local search heuristic
based on the neighborhood structure proposed by Nowicki and
Smutnicki is applied to improve the solutions. The approach is tested
on 43 benchmark problems taken from the literature and compared
with other approaches. The computation results validate the
effectiveness of the proposed algorithm.
Abstract: Artificial Immune System is applied as a Heuristic
Algorithm for decades. Nevertheless, many of these applications
took advantage of the benefit of this algorithm but seldom proposed
approaches for enhancing the efficiency. In this paper, a
Self-evolving Artificial Immune System is proposed via developing
the T and B cell in Immune System and built a self-evolving
mechanism for the complexities of different problems. In this
research, it focuses on enhancing the efficiency of Clonal selection
which is responsible for producing Affinities to resist the invading of
Antigens. T and B cell are the main mechanisms for Clonal
Selection to produce different combinations of Antibodies.
Therefore, the development of T and B cell will influence the
efficiency of Clonal Selection for searching better solution.
Furthermore, for better cooperation of the two cells, a co-evolutional
strategy is applied to coordinate for more effective productions of
Antibodies. This work finally adopts Flow-shop scheduling
instances in OR-library to validate the proposed algorithm.
Abstract: Locating the critical slip surface with the minimum factor of safety for a rock slope is a difficult problem. In recent years, some modern global optimization methods have been developed with success in treating various types of problems, but very few of such methods have been applied to rock mechanical problems. In this paper, use of hybrid model based on artificial immune system and cellular learning automata is proposed. The results show that the algorithm is an effective and efficient optimization method with a high level of confidence rate.
Abstract: In article the data of chronic toxicity for pre-clinical
researches of Ramon preparation is described. Ramon effects to
hormone system and gastrointestinal tract; local irritative effect,
allergic, pyrogenic properties and reaction to the immune system
were studied.
Abstract: This paper explores an application of an adaptive learning mechanism for robots based on the natural immune system. Most of the research carried out so far are based either on the innate or adaptive characteristics of the immune system, we present a combination of these to achieve behavior arbitration wherein a robot learns to detect vulnerable areas of a track and adapts to the required speed over such portions. The test bed comprises of two Lego robots deployed simultaneously on two predefined near concentric tracks with the outer robot capable of helping the inner one when it misaligns. The helper robot works in a damage-control mode by realigning itself to guide the other robot back onto its track. The panic-stricken robot records the conditions under which it was misaligned and learns to detect and adapt under similar conditions thereby making the overall system immune to such failures.
Abstract: Kwashiorkor is one of nutritional problem in
Indonesia, which lead to decrease immune system. This condition
causes susceptibility to infectious disease, especially tuberculosis.
Development of new tuberculosis vaccine will be an important
strategy to eliminate tuberculosis in kwashiorkor. Previous research
showed that 38-kDa Mycobacterium tuberculosis protein is one of the
potent immunogen. However, the role of oral immunization with 38-
kDa Mycobacterium tuberculosis protein to the number of
lymphocytes in the rat model of kwashiorkor is still unknown. We
used kwashiorkor rat model groups with 4% and 2% low protein diet.
Oral immunization with 38-kDa Mycobacterium tuberculosis protein
given with 2 booster every week. The lymphocytes number were
measured by flowcytometry. There was no significant difference
between the number of lymphocytes in the normal rat group and the
kwashiorkor rat groups. It may reveal the role of 38-kDa
Mycobacterium tuberculosis protein as a potent immunogen that can
increase the lymphocytes number from kwashiorkor rat model same
as normal rat.
Abstract: This research focus on the intrusion detection system (IDS) development which using artificial immune system (AIS) with population based incremental learning (PBIL). AIS have powerful distinguished capability to extirpate antigen when the antigen intrude into human body. The PBIL is based on past learning experience to adjust new learning. Therefore we propose an intrusion detection system call PBIL-AIS which combine two approaches of PBIL and AIS to evolution computing. In AIS part we design three mechanisms such as clonal selection, negative selection and antibody level to intensify AIS performance. In experimental result, our PBIL-AIS IDS can capture high accuracy when an intrusion connection attacks.
Abstract: This study presents a mathematical modeling approach to the planning of HIV therapies on an individual basis. The model replicates clinical data from typical-progressors to AIDS for all stages of the disease with good agreement. Clinical data from rapid-progressors and long-term non-progressors is also matched by estimation of immune system parameters only. The ability of the model to reproduce these phenomena validates the formulation, a fact which is exploited in the investigation of effective therapies. The therapy investigation suggests that, unlike continuous therapy, structured treatment interruptions (STIs) are able to control the increase in both the drug-sensitive and drug-resistant virus population and, hence, prevent the ultimate progression from HIV to AIDS. The optimization results further suggest that even patients characterised by the same progression type can respond very differently to the same treatment and that the latter should be designed on a case-by-case basis. Such a methodology is presented here.
Abstract: The Artificial immune systems algorithms are Meta
heuristic optimization method, which are used for clustering and
pattern recognition applications are abundantly. These algorithms in
multimodal optimization problems are more efficient than genetic
algorithms. A major drawback in these algorithms is their slow
convergence to global optimum and their weak stability can be
considered in various running of these algorithms. In this paper,
improved Artificial Immune System Algorithm is introduced for the
first time to overcome its problems of artificial immune system. That
use of the small size of a local search around the memory antibodies
is used for improving the algorithm efficiently. The credibility of the
proposed approach is evaluated by simulations, and it is shown that
the proposed approach achieves better results can be achieved
compared to the standard artificial immune system algorithms
Abstract: Artificial Immune System is adopted as a Heuristic
Algorithm to solve the combinatorial problems for decades.
Nevertheless, many of these applications took advantage of the benefit
for applications but seldom proposed approaches for enhancing the
efficiency. In this paper, we continue the previous research to develop
a Self-evolving Artificial Immune System II via coordinating the T
and B cell in Immune System and built a block-based artificial
chromosome for speeding up the computation time and better
performance for different complexities of problems. Through the
design of Plasma cell and clonal selection which are relative the
function of the Immune Response. The Immune Response will help
the AIS have the global and local searching ability and preventing
trapped in local optima. From the experimental result, the significant
performance validates the SEAIS II is effective when solving the
permutation flows-hop problems.
Abstract: The use of the oncologic index ISTER allows for a more effective planning of the radiotherapic facilities in the hospitals. Any change in the radiotherapy treatment, due to unexpected stops, may be adapted by recalculating the doses to the new treatment duration while keeping the optimal prognosis. The results obtained in a simulation model on millions of patients allow the definition of optimal success probability algorithms.
Abstract: As days go by, we hear more and more about HIV,
Ebola, Bird Flu and other dreadful viruses which were unknown a
few decades ago. In both detecting and fighting viral diseases
ordinary methods have come across some basic and important
difficulties. Vaccination is by a sense introduction of the virus to the
immune system before the occurrence of the real case infection. It is
very successful against some viruses (e.g. Poliomyelitis), while
totally ineffective against some others (e.g. HIV or Hepatitis-C). On
the other hand, Anti-virus drugs are mostly some tools to control and
not to cure a viral disease. This could be a good motivation to try
alternative treatments. In this study, some key features of possible
physical-based alternative treatments for viral diseases are presented.
Electrification of body parts or fluids (especially blood) with micro
electric signals with adjusted current or frequency is also studied. The
main approach of this study is to find a suitable energy field, with
appropriate parameters that are able to kill or deactivate viruses. This
would be a lengthy, multi-disciplinary research which needs the
contribution of virology, physics, and signal processing experts. It
should be mentioned that all the claims made by alternative cures
researchers must be tested carefully and are not advisable at the time
being.
Abstract: Content-based music retrieval generally involves analyzing, searching and retrieving music based on low or high level features of a song which normally used to represent artists, songs or music genre. Identifying them would normally involve feature extraction and classification tasks. Theoretically the greater features analyzed, the better the classification accuracy can be achieved but with longer execution time. Technique to select significant features is important as it will reduce dimensions of feature used in classification and contributes to the accuracy. Artificial Immune System (AIS) approach will be investigated and applied in the classification task. Bio-inspired audio content-based retrieval framework (B-ACRF) is proposed at the end of this paper where it embraces issues that need further consideration in music retrieval performances.
Abstract: The temporal nature of negative selection is an under exploited area. In a negative selection system, newly generated antibodies go through a maturing phase, and the survivors of the phase then wait to be activated by the incoming antigens after certain number of matches. These without having enough matches will age and die, while these with enough matches (i.e., being activated) will become active detectors. A currently active detector may also age and die if it cannot find any match in a pre-defined (lengthy) period of time. Therefore, what matters in a negative selection system is the dynamics of the involved parties in the current time window, not the whole time duration, which may be up to eternity. This property has the potential to define the uniqueness of negative selection in comparison with the other approaches. On the other hand, a negative selection system is only trained with “normal" data samples. It has to learn and discover unknown “abnormal" data patterns on the fly by itself. Consequently, it is more appreciate to utilize negation selection as a system for pattern discovery and recognition rather than just pattern recognition. In this paper, we study the potential of using negative selection in discovering unknown temporal patterns.
Abstract: The human body has a complex system of innate and adaptive mechanisms for combating infection. This article discusses the role and relative effectiveness of these mechanisms in relation to small pox and AIDS.
Abstract: Spatial trends are one of the valuable patterns in geo
databases. They play an important role in data analysis and
knowledge discovery from spatial data. A spatial trend is a regular
change of one or more non spatial attributes when spatially moving
away from a start object. Spatial trend detection is a graph search
problem therefore heuristic methods can be good solution. Artificial
immune system (AIS) is a special method for searching and
optimizing. AIS is a novel evolutionary paradigm inspired by the
biological immune system. The models based on immune system
principles, such as the clonal selection theory, the immune network
model or the negative selection algorithm, have been finding
increasing applications in fields of science and engineering.
In this paper, we develop a novel immunological algorithm based
on clonal selection algorithm (CSA) for spatial trend detection. We
are created neighborhood graph and neighborhood path, then select
spatial trends that their affinity is high for antibody. In an
evolutionary process with artificial immune algorithm, affinity of
low trends is increased with mutation until stop condition is satisfied.
Abstract: Goat milk has an hypoallergenic effects, and allergic
diseases related to abnormal of intestinal flora. Probiotic microorganisms
do exert an activity on the immune system in the skin of
the individual.The purpose of this study are to determine the number
of leukocyte and lymphocyte proliferation in rat supplemented with
fermented goat milk (acidophilus milk and kefir) and sensitized with
dinitrochlorobenzene (DNCB). Female Wistar rats 6-8 weeks olds
were divided into 3 treatment groups. The first group supplemented
goat milk kefir, second group acidophilus goat milk, and third group
as control. During 28-day experiment, on day 15 rat sensitized with
allergen DNCB on the dorsal of the body, and on day 24 was
challenged with DNCB on the ear. Sampling of blood and tissue of
intestinal Peyer'patch (PP) were performed on day 14 (before DNCB
sensitized) and on day 28 (after DNCB sensitized). The results
showed the number of neutrophils in rats supplemented with
acidophilus milk was higher (P