Abstract: This paper presents the results and findings from a
parametric study on the water surface elevation at upstream of bridge
constriction for subcritical flow. In this study, the influence of
Manning's Roughness Coefficient of main channel (nmc) and
floodplain (nfp), and bridge opening (b) flow rate (Q), contraction
(kcon) and expansion coefficients (kexp) were investigated on
backwater level. The DECK bridge models with different span widths
and without any pier were investigated within the two stage channel
having various roughness conditions. One of the most commonly
used commercial one-dimensional HEC-RAS model was used in this
parametric study. This study showed that the effects of main channel
roughness (nmc) and flow rate (Q) on the backwater level are much
higher than those of the floodplain roughness (nfp). Bridge opening
(b) with contraction (kcon) and expansion coefficients (kexp) have very
little effect on the backwater level within this range of parameters.
Abstract: Ocimum americanum L (Lamiaceae) is an annual herb
that is native to tropical Africa. The in vitro and in vivo antioxidant
activity of its aqueous extract was carefully investigated by assessing
the DPPH radical scavenging activity, ABTS radical scavenging
activity and hydrogen peroxide radical scavenging activity. The
reducing power, total phenol, total flavonoids and flavonols content
of the extract were also evaluated. The data obtained revealed that the
extract is rich in polyphenolic compounds and scavenged the radicals
in a concentration dependent manner. This was done in comparison
with the standard antioxidants such as BHT and Vitamin C. Also, the
induction of oxidative damage with paracetamol (2000 mg/kg)
resulted in the elevation of lipid peroxides and significant (P < 0.05)
decrease in activities of superoxide dismutase, glutathione
peroxidase, glutathione reductase and catalase in the liver and kidney
of rats. However, the pretreatment of rats with aqueous extract of O.
americanum leaves (200 and 400 mg/kg) and silymarin (100 mg/kg)
caused a significant (P < 0.05) reduction in the values of lipid
peroxides and restored the levels of antioxidant parameters in these
organs. These findings suggest that the leaves of O. americanum have
potent antioxidant properties which may be responsible for its
acclaimed folkloric uses.
Abstract: The exact theoretical expression describing the
probability distribution of nonlinear sea-surface elevations derived
from the second-order narrowband model has a cumbersome form
that requires numerical computations, not well-disposed to theoretical
or practical applications. Here, the same narrowband model is reexamined
to develop a simpler closed-form approximation suitable
for theoretical and practical applications. The salient features of the
approximate form are explored, and its relative validity is verified
with comparisons to other readily available approximations, and
oceanic data.
Abstract: India holds 17.5% of the world’s population but has
only 2% of the total geographical area of the world where 27.35% of
the area is categorized as wasteland due to lack of or less
groundwater. So there is a demand for excessive groundwater for
agricultural and non agricultural activities to balance its growth rate.
With this in mind, an attempt is made to find the groundwater
potential zone in Gomukhi Nadhi sub basin of Vellar River basin,
TamilNadu, India covering an area of 1146.6 Sq.Km consists of 9
blocks from Peddanaickanpalayam to Virudhachalam in the sub
basin. The thematic maps such as Geology, Geomorphology,
Lineament, Landuse and Landcover and Drainage are prepared for
the study area using IRS P6 data. The collateral data includes rainfall,
water level, soil map are collected for analysis and inference. The
digital elevation model (DEM) is generated using Shuttle Radar
Topographic Mission (SRTM) and the slope of the study area is
obtained. ArcGIS 10.1 acts as a powerful spatial analysis tool to find
out the ground water potential zones in the study area by means of
weighted overlay analysis. Each individual parameter of the thematic
maps are ranked and weighted in accordance with their influence to
increase the water level in the ground. The potential zones in the
study area are classified viz., Very Good, Good, Moderate, Poor with
its aerial extent of 15.67, 381.06, 575.38, 174.49 Sq.Km respectively.
Abstract: Persea declinata (Bl.) Kosterm is a member of the
Lauraceae family, widely distributed in Southeast Asia. It is from the
same genus with avocado (Persea americana Mill), which is widely
consumed as food and for medicinal purposes. In the present study,
we examined the anticancer properties of Persea declinata (Bl.)
Kosterm bark methanolic crude extract (PDM). PDM exhibited a
potent antiproliferative effect in MCF-7 human breast cancer cells,
with an IC50 value of 16.68 .g/mL after 48h of treatment. We
observed that PDM caused cell cycle arrest and subsequent apoptosis
in MCF-7 cells, as exhibited by increased population at G0/G1 phase,
higher lactate dehydrogenase (LDH) release, and DNA
fragmentation. Mechanistic studies showed that PDM caused
significant elevation in ROS production, leading to perturbation of
mitochondrial membrane potential, cell permeability, and activation
of caspases-3/7. On the other hand, real-time PCR and Western blot
analysis showed that PDM treatment increased the expression of the
proapoptotic molecule, Bax, but decreased the expression of
prosurvival proteins, Bcl-2 and Bcl-xL, in a dose-dependent manner.
These findings imply that PDM could inhibit proliferation in MCF-7
cells via cell cycle arrest and apoptosis induction, indicating its
potential as a therapeutic agent worthy of further development.
Abstract: The aim of this work is to present a theoretical analysis of a 2D ultrasound transducer comprised of crossed arrays of metal strips placed on both sides of thin piezoelectric layer (a). Such a structure is capable of electronic beam-steering of generated wavebeam both in elevation and azimuth. In this paper a semi-analytical model of the considered transducer is developed. It is based on generalization of the well-known BIS-expansion method. Specifically, applying the electrostatic approximation, the electric field components on the surface of the layer are expanded into fast converging series of double periodic spatial harmonics with corresponding amplitudes represented by the properly chosen Legendre polynomials. The problem is reduced to numerical solving of certain system of linear equations for unknown expansion coefficients.
Abstract: The protective effect of hesperidin was investigated in
rats exposed to liver injury induced by a single intraperitoneal
injection of cyclophosphamide (CYP) at a dose of 150 mg kg-1.
Hesperidin treatment (100 mg kg-1/day, orally) was applied for seven
days, starting five days before CYP administration. Hesperidin
significantly decreased the CYP-induced elevations of serum alanine
aminotransferase, and hepatic malondialdehyde and myeloperoxidase
activity, significantly prevented the depletion of hepatic glutathione
peroxidase activity resulted from CYP administration. Also,
hesperidin ameliorated the CYP-induced liver tissue injury observed
by histopathological examination. In addition, hesperidin decreased
the CYP-induced expression of inducible nitric oxide synthase, tumor
necrosis factor-α, cyclooxygenase-2, Fas ligand, and caspase-9 in
liver tissue. It was concluded that hesperidin may represent a
potential candidate to protect against CYP-induced hepatotoxicity.
Abstract: Performance based design (PBD) is an iterative exercise in which a preliminary trial design of the building structure is selected and if the selected trial design of the building structure does not conform to the desired performance objective, the trial design is revised. In this context, development of a fundamental approach for performance based seismic design of masonry infilled frames with minimum number of trials is an important objective. The paper presents a plastic design procedure based on the energy balance concept for PBD of multi-story multi-bay masonry infilled reinforced concrete (R/C) frames subjected to near-field earthquakes. The proposed energy based plastic design procedure was implemented for trial performance based seismic design of representative masonry infilled reinforced concrete frames with various practically relevant distributions of masonry infill panels over the frame elevation. Non-linear dynamic analyses of the trial PBD of masonry infilled R/C frames was performed under the action of near-field earthquake ground motions. The results of non-linear dynamic analyses demonstrate that the proposed energy method is effective for performance based design of masonry infilled R/C frames under near-field as well as far-field earthquakes.
Abstract: The protective effect of thymoquinone (TQ) was investigated in rats exposed to testicular injury induced by sodium arsenite (10mg/kg/day, orally, for two days). TQ treatment (10mg/kg/day, intraperitoneal injection) was applied for five days, starting three day before arsenic administration. TQ significantly attenuated the arsenic-induced decreases of serum testosterone, and testicular reduced glutathione level, and significantly decreased the elevations of testicular malondialdehyde and nitric oxide levels resulted from arsenic administration. Also, TQ ameliorated the arsenic-induced testicular tissue injury observed by histopathological examination. In addition, TQ decreased the arsenic-induced expression of inducible nitric oxide synthase and caspase-3 in testicular tissue. It was concluded that TQ may represent a potential candidate to protect against arsenic-induced testicular injury.
Abstract: The concept of myocardial injury, although first recognized from animal studies, is now recognized as a clinical phenomenon that may result in microvascular damage, no-reflow phenomenon, myocardial stunning, myocardial hibernation and ischemic preconditioning. The final consequence of this event is left ventricular (LV) systolic dysfunction leading to increased morbidity and mortality. The typical clinical case of reperfusion injury occurs in acute myocardial infarction (MI) with ST segment elevation in which an occlusion of a major epicardial coronary artery is followed by recanalization of the artery. This may occur spontaneously or by means of thrombolysis and/or by primary percutaneous coronary intervention (PCI) with efficient platelet inhibition by aspirin (acetylsalicylic acid), clopidogrel and glycoprotein IIb/IIIa inhibitors. In recent years, percutaneous coronary intervention (PCI) has become a well-established technique for the treatment of coronary artery disease. PCI improves symptoms in patients with coronary artery disease and it has been increasing safety of procedures. However, peri- and post-procedural myocardial injury, including angiographical slow coronary flow, microvascular embolization, and elevated levels of cardiac enzyme, such as creatine kinase and troponin-T and -I, has also been reported even in elective cases. Furthermore, myocardial reperfusion injury at the beginning of myocardial reperfusion, which causes tissue damage and cardiac dysfunction, may occur in cases of acute coronary syndrome. Because patients with myocardial injury is related to larger myocardial infarction and have a worse long-term prognosis than those without myocardial injury, it is important to prevent myocardial injury during and/or after PCI in patients with coronary artery disease. To date, many studies have demonstrated that adjunctive pharmacological treatment suppresses myocardial injury and increases coronary blood flow during PCI procedures. In this review, we highlight the usefulness of pharmacological treatment in combination with PCI in attenuating myocardial injury in patients with coronary artery disease.
Abstract: Planar systems of electrodes arranged on both sides of dielectric piezoelectric layer are applied in numerous transducers. They are capable of electronic beam-steering of generated wave both in azimuth and elevation. The wave-beam control is achieved by addressable driving of two-dimensional transducer through proper voltage supply of electrodes on opposite surfaces of the layer. In this paper a semi-analytical method of analysis of the considered transducer is proposed, which is a generalization of the well-known BIS-expansion method. It was earlier exploited with great success in the theory of interdigital transducers of surface acoustic waves, theory of elastic wave scattering by cracks and certain advanced electrostatic problems. The corresponding nontrivial electrostatic problem is formulated and solved numerically.
Abstract: Remote sensing image processing, spatial data analysis through GIS approach, and analytical hierarchy process were introduced in this study for assessing the vulnerability area and inundation area due to tsunami hazard in the area of Rikuzentakata, Iwate Prefecture, Japan. Appropriate input parameters were derived from GSI DEM data, ALOS AVNIR-2, and field data. We used the parameters of elevation, slope, shoreline distance, and vegetation density. Five classes of vulnerability were defined and weighted via pairwise comparison matrix. The assessment results described that 14.35km2 of the study area was under tsunami vulnerability zone. Inundation areas are those of high and slightly high vulnerability. The farthest area reached by a tsunami was about 7.50km from the shoreline and shows that rivers act as flooding strips that transport tsunami waves into the hinterland. This study can be used for determining a priority for land-use planning in the scope of tsunami hazard risk management.
Abstract: Standalone micro-hydrokinetic river (MHR) system is
one of the promising technologies to be used for remote rural
electrification. It simply requires the flow of water instead of
elevation or head, leading to expensive civil works. This paper
demonstrates an economic benefit offered by a standalone MHR
system when compared to the commonly used standalone systems
such as solar, wind and diesel generator (DG) at the selected study
site in Kwazulu Natal. Wind speed and solar radiation data of the
selected rural site have been taken from national aeronautics and
space administration (NASA) surface meteorology database. The
hybrid optimization model for electric renewable (HOMER) software
was used to determine the most feasible solution when using MHR,
solar, wind or DG system to supply 5 rural houses. MHR system
proved to be the best cost-effective option to consider at the study site
due to its low cost of energy (COE) and low net present cost (NPC).
Abstract: The Maximum entropy principle in spectral analysis
was used as an estimator of Direction of Arrival (DoA) of
electromagnetic or acoustic sources impinging on an array of sensors,
indeed the maximum entropy operator is very efficient when the
signals of the radiating sources are ergodic and complex zero mean
random processes which is the case for cosmic sources. In this paper,
we present basic review of the maximum entropy method (MEM)
which consists of rank one operator but not a projector, and we
elaborate a new operator which is full rank and sum of all possible
projectors. Two dimensional Simulation results based on Monte
Carlo trials prove the resolution power of the new operator where the
MEM presents some erroneous fluctuations.
Abstract: We investigate sonic cues for binaural sound localization within classrooms and present a structural model for the same. Two of the primary cues for localization, interaural time difference (ITD) and interaural level difference (ILD) created between the two ears by sounds from a particular point in space, are used. Although these cues do not lend any information about the elevation of a sound source, the torso, head, and outer ear carry out elevation dependent spectral filtering of sounds before they reach the inner ear. This effect is commonly captured in head related transfer function (HRTF) which aids in resolving the ambiguity from the ITDs and ILDs alone and helps localize sounds in free space. The proposed structural model of HRTF produces well controlled horizontal as well as vertical effects. The implemented HRTF is a signal processing model which tries to mimic the physical effects of the sounds interacting with different parts of the body. The effectiveness of the method is tested by synthesizing spatial audio, in MATLAB, for use in listening tests with human subjects and is found to yield satisfactory results in comparison with existing models.
Abstract: Psoriasis is a chronic inflammatory skin condition
which affects 2-3% of population around the world. Psoriasis Area
and Severity Index (PASI) is a gold standard to assess psoriasis
severity as well as the treatment efficacy. Although a gold standard,
PASI is rarely used because it is tedious and complex. In practice,
PASI score is determined subjectively by dermatologists, therefore
inter and intra variations of assessment are possible to happen even
among expert dermatologists. This research develops an algorithm to
assess psoriasis lesion for PASI scoring objectively. Focus of this
research is thickness assessment as one of PASI four parameters
beside area, erythema and scaliness. Psoriasis lesion thickness is
measured by averaging the total elevation from lesion base to lesion
surface. Thickness values of 122 3D images taken from 39 patients
are grouped into 4 PASI thickness score using K-means clustering.
Validation on lesion base construction is performed using twelve
body curvature models and show good result with coefficient of
determinant (R2) is equal to 1.
Abstract: The morphological short-term evolution of Ponta do Tubarão Island (PTI) was investigated through high accurate surveys based on post-processed kinematic (PPK) relative positioning on Global Navigation Satellite Systems (GNSS). PTI is part of a barrier island system on a high energy northeast Brazilian coastal environment and also an area of high environmental sensitivity. Surveys were carried out quarterly over a two years period from May 2010 to May 2012. This paper assesses statically the performance of digital elevation models (DEM) derived from different interpolation methods to represent morphologic features and to quantify volumetric changes and TIN models shown the best results to that purposes. The MDE allowed quantifying surfaces and volumes in detail as well as identifying the most vulnerable segments of the PTI to erosion and/or accumulation of sediments and relate the alterations to climate conditions. The coastal setting and geometry of PTI protects a significant mangrove ecosystem and some oil and gas facilities installed in the vicinities from damaging effects of strong oceanwaves and currents. Thus, the maintenance of PTI is extremely required but the prediction of its longevity is uncertain because results indicate an irregularity of sedimentary balance and a substantial decline in sediment supply to this coastal area.
Abstract: Bio-electrical responses obtained from freshwater
sediments by employing microbial fuel cell (MFC) technology were
investigated in this experimental study. During the electricity
generation, organic matter in the sediment was microbially oxidized
under anaerobic conditions with an electrode serving as a terminal
electron acceptor. It was found that the sediment organic matter
(SOM) associated with electrochemically-active electrodes became
more humified, aromatic, and polydispersed, and had a higher average
molecular weight, together with the decrease in the quantity of SOM.
The alteration of characteristics of the SOM was analogous to that
commonly observed in the early stage of SOM diagenetic process (i.e.,
humification). These findings including an elevation of the sediment
redox potential present a possibility of the MFC technology as a new
soil/sediment remediation technique based on its potential benefits:
non-destructive electricity generation and bioremediation.
Abstract: A better understanding of cloud forest characteristic in a tropical montane cloud forest at Khao Nan, Nakhon Si Thammarat on climatic, vegetation, soil and hydrology were studied during 18-21 April 2007. The results showed that as air temperature at Sanyen cloud forest increased, the percent relative humidity decreased. The amount of solar radiation at Sanyen cloud forest had a positive association with the amount of solar radiation at Parah forest. The amount of solar radiation at Sanyen cloud forest was very low with a range of 0-19 W/m2. On the other hand, the amount of solar radiation at Parah forest was high with a range of 0-1000 W/m2. There was no difference between leaf width, leaf length, leaf thickness and leaf area with increasing in elevations. As the elevations increased, bush height and tree height decreased. There was no association between bush width and bush ratio with elevation. As the elevations increased, the percent epiphyte cover and the percent soil moisture increased but water temperature, conductivity, and dissolved oxygen decreased. The percent soil moistures and organic contents were higher at elevations above 900 m than elevations below.
Abstract: This paper presents the system identification by
physical-s law method and designs the controller for the Azimuth
Angle Control of the Platform of the Multi-Launcher Rocket System
(MLRS) by Root Locus technique. The plant mathematical model
was approximated using MATLAB for simulation and analyze the
system. The controller proposes the implementation of PID
Controller using Programmable Logic Control (PLC) for control the
plant. PID Controllers are widely applicable in industrial sectors and
can be set up easily and operate optimally for enhanced productivity,
improved quality and reduce maintenance requirement. The results
from simulation and experiments show that the proposed a PID
Controller to control the elevation angle that has superior control
performance by the setting time less than 12 sec, the rise time less
than 1.6 sec., and zero steady state. Furthermore, the system has a
high over shoot that will be continue development.