Abstract: Snoring is prevalent and is the most significant feature
of sleep-disordered breathing (SDB). Ignore the therapies of SDB will
lead to serious problems in health. Based on the research of
mechanisms, diagnosis, and treatments of snoring, oral appliances are
ensured in therapeutic effect and compliance, especially the
mandibular advancement devices (MADs). Market survey includes
commercial product reviews and patent analyses. Due to pay more
attention to the sleep medicine, the oral appliances are considered as a
standard treatment of snoring that promoted by American Academy of
Sleep Medicine (AASM). There are more and more adjustable MADs
developed since 1995. According to the patent analyses, there are
many drawbacks existed in the present design, such as uncomfortable,
high cost, bulky volume, and complex adjustment. In this study,
several new designs of the MAD are proposed.
Abstract: Acute kidney injury (AKI) is a new worldwide public
health problem. A diagnosis of this disease using creatinine is still a
problem in clinical practice. Therefore, a measurement of biomarkers
responsible for AKI has received much attention in the past couple
years. Cytokine interleukin-18 (IL-18) was reported as one of the
early biomarkers for AKI. The most commonly used method to
detect this biomarker is an immunoassay. This study used a planar
platform to perform an immunoassay using fluorescence for
detection. In this study, anti-IL-18 antibody was immobilized onto a
microscope slide using a covalent binding method. Make-up samples
were diluted at the concentration between 10 to 1000 pg/ml to create
a calibration curve. The precision of the system was determined
using a coefficient of variability (CV), which was found to be less
than 10%. The performance of this immunoassay system was
compared with the measurement from ELISA.
Abstract: Hepatitis C is an infectious disease transmitted by
blood and due to hepatitis C virus (HCV), which attacks the liver.
The infection is characterized by liver inflammation (hepatitis) that is
often asymptomatic but can progress to chronic hepatitis and later
cirrhosis and liver cancer. Our problem tends to highlight on the one
hand the prevalence of infectious disease in the population of the
region of Batna and on other hand the biological characteristics of
this disease by a screening and a specific diagnosis based on
serological tests, liver checkup (measurement of haematological and
biochemical parameters).
The results showed:
The serology of hepatitis C establishes the diagnosis of infection
with hepatitis C. In this study and with the serological test, 24 cases
of the disease of hepatitis C were found in 1000 suspected cases (7
cases with normal transaminases and 17 cases with elevated
transaminases). The prevalence of this disease in this study
population was 2.4%.
The presence of hepatitis C disrupts liver function including the
onset of cytolysis, cholestasis, jaundice, thrombocytopenia, and
coagulation disorders.
Abstract: Gene expression profiling is rapidly evolving into a
powerful technique for investigating tumor malignancies. The
researchers are overwhelmed with the microarray-based platforms
and methods that confer them the freedom to conduct large-scale
gene expression profiling measurements. Simultaneously,
investigations into cross-platform integration methods have started
gaining momentum due to their underlying potential to help
comprehend a myriad of broad biological issues in tumor diagnosis,
prognosis, and therapy. However, comparing results from different
platforms remains to be a challenging task as various inherent
technical differences exist between the microarray platforms. In this
paper, we explain a simple ratio-transformation method, which can
provide some common ground for cDNA and Affymetrix platform
towards cross-platform integration. The method is based on the
characteristic data attributes of Affymetrix- and cDNA- platform. In
the work, we considered seven childhood leukemia patients and their
gene expression levels in either platform. With a dataset of 822
differentially expressed genes from both these platforms, we carried
out a specific ratio-treatment to Affymetrix data, which subsequently
showed an improvement in the relationship with the cDNA data.
Abstract: Microcirculation is essential for the proper supply of
oxygen and nutritive substances to the biological tissue and the
removal of waste products of metabolism. The determination of
blood flow in the capillaries is therefore of great interest to clinicians.
A comparison has been carried out using the developed non-invasive,
non-contact and whole field laser speckle contrast imaging (LSCI)
based technique and as well as a commercially available laser
Doppler blood flowmeter (LDF) to evaluate blood flow at the finger
tip and elbow and is presented here. The LSCI technique gives more
quantitative information on the velocity of blood when compared to
the perfusion values obtained using the LDF. Measurement of blood
flow in capillaries can be of great interest to clinicians in the
diagnosis of vascular diseases of the upper extremities.
Abstract: The ElectroEncephaloGram (EEG) is useful for
clinical diagnosis and biomedical research. EEG signals often
contain strong ElectroOculoGram (EOG) artifacts produced
by eye movements and eye blinks especially in EEG recorded
from frontal channels. These artifacts obscure the underlying
brain activity, making its visual or automated inspection
difficult. The goal of ocular artifact removal is to remove
ocular artifacts from the recorded EEG, leaving the underlying
background signals due to brain activity. In recent times,
Independent Component Analysis (ICA) algorithms have
demonstrated superior potential in obtaining the least
dependent source components. In this paper, the independent
components are obtained by using the JADE algorithm (best
separating algorithm) and are classified into either artifact
component or neural component. Neural Network is used for
the classification of the obtained independent components.
Neural Network requires input features that exactly represent
the true character of the input signals so that the neural
network could classify the signals based on those key
characters that differentiate between various signals. In this
work, Auto Regressive (AR) coefficients are used as the input
features for classification. Two neural network approaches
are used to learn classification rules from EEG data. First, a
Polynomial Neural Network (PNN) trained by GMDH (Group
Method of Data Handling) algorithm is used and secondly,
feed-forward neural network classifier trained by a standard
back-propagation algorithm is used for classification and the
results show that JADE-FNN performs better than JADEPNN.
Abstract: In this paper, we present user pattern learning
algorithm based MDSS (Medical Decision support system) under
ubiquitous. Most of researches are focus on hardware system, hospital
management and whole concept of ubiquitous environment even
though it is hard to implement. Our objective of this paper is to design
a MDSS framework. It helps to patient for medical treatment and
prevention of the high risk patient (COPD, heart disease, Diabetes).
This framework consist database, CAD (Computer Aided diagnosis
support system) and CAP (computer aided user vital sign prediction
system). It can be applied to develop user pattern learning algorithm
based MDSS for homecare and silver town service. Especially this
CAD has wise decision making competency. It compares current vital
sign with user-s normal condition pattern data. In addition, the CAP
computes user vital sign prediction using past data of the patient. The
novel approach is using neural network method, wireless vital sign
acquisition devices and personal computer DB system. An intelligent
agent based MDSS will help elder people and high risk patients to
prevent sudden death and disease, the physician to get the online
access to patients- data, the plan of medication service priority (e.g.
emergency case).
Abstract: In Knowledge Structure Graph, each course unit
represents a phase of learning activities. Both learning portfolios and
Knowledge Structure Graphs contain learning information of students
and let teachers know which content are difficulties and fails. The
study purposes "Dual Mode On-line Learning Diagnosis System" that
integrates two search methods: learning portfolio and knowledge
structure. Teachers can operate the proposed system and obtain the
information of specific students without any computer science
background. The teachers can find out failed students in advance and
provide remedial learning resources.
Abstract: In this paper we describe a computer-aided diagnosis (CAD) system for automated detection of pulmonary nodules in computed-tomography (CT) images. After extracting the pulmonary parenchyma using a combination of image processing techniques, a region growing method is applied to detect nodules based on 3D geometric features. We applied the CAD system to CT scans collected in a screening program for lung cancer detection. Each scan consists of a sequence of about 300 slices stored in DICOM (Digital Imaging and Communications in Medicine) format. All malignant nodules were detected and a low false-positive detection rate was achieved.
Abstract: According to the statistics, the prevalence of congenital hearing loss in Taiwan is approximately six thousandths; furthermore, one thousandths of infants have severe hearing impairment. Hearing ability during infancy has significant impact in the development of children-s oral expressions, language maturity, cognitive performance, education ability and social behaviors in the future. Although most children born with hearing impairment have sensorineural hearing loss, almost every child more or less still retains some residual hearing. If provided with a hearing aid or cochlear implant (a bionic ear) timely in addition to hearing speech training, even severely hearing-impaired children can still learn to talk. On the other hand, those who failed to be diagnosed and thus unable to begin hearing and speech rehabilitations on a timely manner might lose an important opportunity to live a complete and healthy life. Eventually, the lack of hearing and speaking ability will affect the development of both mental and physical functions, intelligence, and social adaptability. Not only will this problem result in an irreparable regret to the hearing-impaired child for the life time, but also create a heavy burden for the family and society. Therefore, it is necessary to establish a set of computer-assisted predictive model that can accurately detect and help diagnose newborn hearing loss so that early interventions can be provided timely to eliminate waste of medical resources. This study uses information from the neonatal database of the case hospital as the subjects, adopting two different analysis methods of using support vector machine (SVM) for model predictions and using logistic regression to conduct factor screening prior to model predictions in SVM to examine the results. The results indicate that prediction accuracy is as high as 96.43% when the factors are screened and selected through logistic regression. Hence, the model constructed in this study will have real help in clinical diagnosis for the physicians and actually beneficial to the early interventions of newborn hearing impairment.
Abstract: Research on damage of gears and gear pairs using
vibration signals remains very attractive, because vibration signals
from a gear pair are complex in nature and not easy to interpret.
Predicting gear pair defects by analyzing changes in vibration signal
of gears pairs in operation is a very reliable method. Therefore, a
suitable vibration signal processing technique is necessary to extract
defect information generally obscured by the noise from dynamic
factors of other gear pairs.This article presents the value of cepstrum
analysis in vehicle gearbox fault diagnosis. Cepstrum represents the
overall power content of a whole family of harmonics and sidebands
when more than one family of sidebands is present at the same time.
The concept for the measurement and analysis involved in using the
technique are briefly outlined. Cepstrum analysis is used for detection
of an artificial pitting defect in a vehicle gearbox loaded with
different speeds and torques. The test stand is equipped with three
dynamometers; the input dynamometer serves asthe internal
combustion engine, the output dynamometers introduce the load on
the flanges of the output joint shafts. The pitting defect is
manufactured on the tooth side of a gear of the fifth speed on the
secondary shaft. Also, a method for fault diagnosis of gear faults is
presented based on order Cepstrum. The procedure is illustrated with
the experimental vibration data of the vehicle gearbox. The results
show the effectiveness of Cepstrum analysis in detection and
diagnosis of the gear condition.
Abstract: In recent years, there has been an increasing interest
toward the use of bovine genotyped embryos for commercial embryo
transfer programs. Biopsy of a few cells in morulla stage is essential
for preimplantation genetic diagnosis (PGD). Low amount of DNA
have limited performing the several molecular analyses within PGD
analyses. Whole genome amplification (WGA) promises to eliminate
this problem. We evaluated the possibility and performance of an
improved primer extension preamplification (I-PEP) method with a
range of starting bovine genomic DNA from 1-8 cells into the WGA
reaction. We optimized a short and simple I-PEP (ssI-PEP) procedure
(~3h). This optimized WGA method was assessed by 6 loci specific
polymerase chain reactions (PCRs), included restriction fragments
length polymorphism (RFLP). Optimized WGA procedure possesses
enough sensitivity for molecular genetic analyses through the few
input cells. This is a new era for generating characterized bovine
embryos in preimplantation stage.
Abstract: The aim of this study is to show innovative techniques that describe the effectiveness of individuals diagnosed with antisocial personality disorders (ASPD). The author presents information about hate schemas regarding persons with ASPD and their understanding of the role of hate. The data of 60 prisoners with ASPD, 40 prisoners without ASPD, and 60 men without antisocial tendencies, has been analyzed. The participants were asked to describe their hate inspired by a photograph. The narrative discourse was analyzed, the three groups were compared. The results show the differences between the inmates with ASPD, those without ASPD, and the controls. The antisocial individuals describe hate as an ambivalent feeling with low emotional intensity, i.e., actors (in stories) are presented more as positives than as partners. They use different mechanisms to keep them from understanding the meaning of the emotional situation. The schema's characteristics were expressed in narratives attributed to high Psychopathy.
Abstract: This paper studies the dependability of componentbased
applications, especially embedded ones, from the diagnosis
point of view. The principle of the diagnosis technique is to
implement inter-component tests in order to detect and locate the
faulty components without redundancy. The proposed approach for
diagnosing faulty components consists of two main aspects. The first
one concerns the execution of the inter-component tests which
requires integrating test functionality within a component. This is the
subject of this paper. The second one is the diagnosis process itself
which consists of the analysis of inter-component test results to
determine the fault-state of the whole system. Advantage of this
diagnosis method when compared to classical redundancy faulttolerant
techniques are application autonomy, cost-effectiveness and
better usage of system resources. Such advantage is very important
for many systems and especially for embedded ones.
Abstract: Segmentation is an important step in medical image
analysis and classification for radiological evaluation or computer
aided diagnosis. This paper presents the problem of inaccurate lung
segmentation as observed in algorithms presented by researchers
working in the area of medical image analysis. The different lung
segmentation techniques have been tested using the dataset of 19
patients consisting of a total of 917 images. We obtained datasets of
11 patients from Ackron University, USA and of 8 patients from
AGA Khan Medical University, Pakistan. After testing the algorithms
against datasets, the deficiencies of each algorithm have been
highlighted.
Abstract: The numerous qualities of squirrel cage induction
machines enhance their use in industry. However, various faults can
occur, such as stator short-circuits and rotor failures.
In this paper, we use a technique based on the spectral analysis of
stator current in order to detect the fault in the machine: broken rotor
bars. Thus, the number effect of the breaks has been highlighted. The
effect is highlighted by considering the machine controlled by the
Direct Torque Control (DTC). The key to fault detection is the
development of a simplified dynamic model of a squirrel cage
induction motor taking account the broken bars fault and the stator
current spectrum analysis (FFT).
Abstract: A new approach based on the consideration that electroencephalogram (EEG) signals are chaotic signals was presented for automated diagnosis of electroencephalographic changes. This consideration was tested successfully using the nonlinear dynamics tools, like the computation of Lyapunov exponents. This paper presented the usage of statistics over the set of the Lyapunov exponents in order to reduce the dimensionality of the extracted feature vectors. Since classification is more accurate when the pattern is simplified through representation by important features, feature extraction and selection play an important role in classifying systems such as neural networks. Multilayer perceptron neural network (MLPNN) architectures were formulated and used as basis for detection of electroencephalographic changes. Three types of EEG signals (EEG signals recorded from healthy volunteers with eyes open, epilepsy patients in the epileptogenic zone during a seizure-free interval, and epilepsy patients during epileptic seizures) were classified. The selected Lyapunov exponents of the EEG signals were used as inputs of the MLPNN trained with Levenberg- Marquardt algorithm. The classification results confirmed that the proposed MLPNN has potential in detecting the electroencephalographic changes.
Abstract: The remote diagnosis and remote medical smoked to
part. In China, in accordance with the requirements of different
applications of remote diagnosis and Relates to the technical
difference, which can be divided into special purpose remote diagnosis
and treatment system, the remote will Referral system, remote medical
consultation system, remote rehabilitation technology and remote
operation technology. In this article, will introduce China for the
special purpose of service remote diagnosis and treatment system and
technology, including: China disabled status and virtual reality
technology; China 's domestic family medical care system and China 's
current situation of the development of telemedicine.
Abstract: In this study, fuzzy rule-based classifier is used for the
diagnosis of congenital heart disease. Congenital heart diseases are
defined as structural or functional heart disease. Medical data sets
were obtained from Pediatric Cardiology Department at Selcuk
University, from years 2000 to 2003. Firstly, fuzzy rules were
generated by using medical data. Then the weights of fuzzy rules
were calculated. Two different reasoning methods as “weighted vote
method" and “singles winner method" were used in this study. The
results of fuzzy classifiers were compared.
Abstract: This paper presents the application of Intelligent
Techniques to the various duties of Intelligent Condition Monitoring
Systems (ICMS) for Unmanned Aerial Vehicle (UAV) Robots. These
Systems are intended to support these Intelligent Robots in the event
of a Fault occurrence. Neural Networks are used for Diagnosis, whilst
Fuzzy Logic is intended for Prognosis and Remedy. The ultimate
goals of ICMS are to save large losses in financial cost, time and
data.