Abstract: The multiindex Mittag-Leffler (M-L) function and the multiindex Dzrbashjan-Gelfond-Leontiev (D-G-L) differentiation and integration play a very pivotal role in the theory and applications of generalized fractional calculus. The object of this paper is to investigate the relations that exist between the Riemann-Liouville fractional calculus and multiindex Dzrbashjan-Gelfond-Leontiev differentiation and integration with multiindex Mittag-Leffler function.
Abstract: The study of cytokine expression in mice under the
influence of inactivated poliovirus and Imovaks polio vaccine in
combination with derivatives of chitosan shows various kinds of
processes. There is a significant increase in IL-12 in the serum of
immunized animals, which should stimulate the production of IFN-γ
NK-cells and T-cells and polarize the immune response to Th1 type.
Thus, the derivatives of chitosan can promote cell component of the
immune response, providing a full antiviral immunity.
Abstract: Silver-exchanged zeolites and clays are used in
polymer composites to confer broad-spectrum antimicrobial
properties on a range of functional materials. Tobermorite is a layer
lattice mineral whose potential as a carrier for Ag+ ions in
antibacterial composites has not yet been investigated. Accordingly,
in this study, synthetic tobermorite was ion-exchanged with 10 wt%
silver ions and the resulting material was incorporated into a
composite film with chitosan. Chitosan is a biocompatible,
biodegradable derivative of chitin, a polysaccharide obtained from
the shells of crustaceans. The solvent-cast Ag+-exchanged
tobermorite-chitosan films were found to exhibit antimicrobial action
against Staphylococcus aureus, Escherichia coli and Pseudomonas
aeruginosa.
Abstract: Camptothecin (CPT) is a cytotoxic quinoline alkaloid,
which inhibits the DNA enzyme topoisomerase I (topo I). It was
discovered in 1966 by M. E. Wall and M. C. Wani in systematic
screening of natural products for anticancer drugs. It was isolated
from the bark and stem of Camptotheca acuminata (Camptotheca,
Happy tree), a tree native in China. CPT showed remarkable
anticancer activity in preliminary clinical trials but also low
solubility and (high) adverse drug reaction. Because of these
disadvantages synthetic and medicinal chemists have developed
numerous syntheses of Camptothecine [1][2][3] and various
derivatives to increase the benefits of the chemical, with good results.
In our method CPT analogues has be six steps starting from available
material DL Malic acid.
Abstract: In the present paper, we consider the generalized form of Baskakov Durrmeyer operators to study the rate of convergence, in simultaneous approximation for functions having derivatives of bounded variation.
Abstract: The motion planning procedure described in this paper has been developed in order to eliminate or reduce the residual vibrations of electromechanical positioning systems, without augmenting the motion time (usually imposed by production requirements), nor introducing overtime for vibration damping. The proposed technique is based on a suitable choice of the motion law assigned to the servomotor that drives the mechanism. The reference profile is defined by a Bezier curve, whose shape can be easily changed by modifying some numerical parameters. By means of an optimization technique these parameters can be modified without altering the continuity conditions imposed on the displacement and on its time derivatives at the initial and final time instants.
Abstract: Discretization of spatial derivatives is an important
issue in meshfree methods especially when the derivative terms
contain non-linear coefficients. In this paper, various methods used
for discretization of second-order spatial derivatives are investigated
in the context of Smoothed Particle Hydrodynamics. Three popular
forms (i.e. "double summation", "second-order kernel derivation",
and "difference scheme") are studied using one-dimensional unsteady
heat conduction equation. To assess these schemes, transient response
to a step function initial condition is considered. Due to parabolic
nature of the heat equation, one can expect smooth and monotone
solutions. It is shown, however in this paper, that regardless of
the type of kernel function used and the size of smoothing radius,
the double summation discretization form leads to non-physical
oscillations which persist in the solution. Also, results show that when
a second-order kernel derivative is used, a high-order kernel function
shall be employed in such a way that the distance of inflection
point from origin in the kernel function be less than the nearest
particle distance. Otherwise, solutions may exhibit oscillations near
discontinuities unlike the "difference scheme" which unconditionally
produces monotone results.
Abstract: In this paper, the problem of stability criteria of neural networks (NNs) with two-additive time-varying delay compenents is investigated. The relationship between the time-varying delay and its lower and upper bounds is taken into account when estimating the upper bound of the derivative of Lyapunov functional. As a result, some improved delay stability criteria for NNs with two-additive time-varying delay components are proposed. Finally, a numerical example is given to illustrate the effectiveness of the proposed method.
Abstract: The motion planning technique described in this paper has been developed to eliminate or reduce the residual vibrations of belt-driven rotary platforms, while maintaining unchanged the motion time and the total angular displacement of the platform. The proposed approach is based on a suitable choice of the motion command given to the servomotor that drives the mechanical device; this command is defined by some numerical coefficients which determine the shape of the displacement, velocity and acceleration profiles. Using a numerical optimization technique, these coefficients can be changed without altering the continuity conditions imposed on the displacement and its time derivatives at the initial and final time instants. The proposed technique can be easily and quickly implemented on an actual device, since it requires only a simple modification of the motion command profile mapped in the memory of the electronic motion controller.
Abstract: This paper focuses on systematic analysis and
controller design of the two-inertia STABILIZATION system,
considering the angular motion on a base body. This approach is
essential to the stabilization system to aim at a target under three or six
degrees of freedom base motion. Four controllers, such as
conventional PDF(Pseudo-Derivative Feedback) controller with
motor speed feedback, PDF controller with load speed feedback,
modified PDF controller with motor-load speed feedback and
feedforward controller added to modified PDF controller, are
suggested to improve reference tracking and disturbance rejection
performance. Characteristics and performance of each controller are
analyzed and validated by simulation in the case of the modified PDF
controller with and without a feedforward controller.
Abstract: The back-propagation algorithm calculates the weight
changes of an artificial neural network, and a two-term algorithm
with a dynamically optimal learning rate and a momentum factor
is commonly used. Recently the addition of an extra term, called a
proportional factor (PF), to the two-term BP algorithm was proposed.
The third term increases the speed of the BP algorithm. However,
the PF term also reduces the convergence of the BP algorithm, and
optimization approaches for evaluating the learning parameters are
required to facilitate the application of the three terms BP algorithm.
This paper considers the optimization of the new back-propagation
algorithm by using derivative information. A family of approaches
exploiting the derivatives with respect to the learning rate, momentum
factor and proportional factor is presented. These autonomously
compute the derivatives in the weight space, by using information
gathered from the forward and backward procedures. The three-term
BP algorithm and the optimization approaches are evaluated using
the benchmark XOR problem.
Abstract: In this paper, a worm-like micro robot designed for inpipe
application with intelligent active force control (AFC) capability
is modelled and simulated. The motion of the micro robot is based on
an impact drive mechanism (IDM) that is actuated using piezoelectric
device. The trajectory tracking performance of the modelled micro
robot is initially experimented via a conventional proportionalintegral-
derivative (PID) controller in which the dynamic response of
the robot system subjected to different input excitations is
investigated. Subsequently, a robust intelligent method known as
active force control with fuzzy logic (AFCFL) is later incorporated
into the PID scheme to enhance the system performance by
compensating the unwanted disturbances due to the interaction of the
robot with its environment. Results show that the proposed AFCFL
scheme is far superior than the PID control counterpart in terms of
the system-s tracking capability in the wake of the disturbances.
Abstract: Chikungunya virus (CHICKV) is an arboviruses belonging to family Tagoviridae and is transmitted to human through by mosquito (Aedes aegypti and Aedes albopictus) bite. A large outbreak of chikungunya has been reported in India between 2006 and 2007, along with several other countries from South-East Asia and for the first time in Europe. It was for the first time that the CHICKV outbreak has been reported with mortality from Reunion Island and increased mortality from Asian countries. CHICKV affects all age groups, and currently there are no specific drugs or vaccine to cure the disease. The need of antiviral agents for the treatment of CHICKV infection and the success of virtual screening against many therapeutically valuable targets led us to carry out the structure based drug design against Chikungunya nSP2 protease (PDB: 3TRK). Highthroughput virtual screening of publicly available databases, ZINC12 and BindingDB, has been carried out using the Openeye tools and Schrodinger LLC software packages. Openeye Filter program has been used to filter the database and the filtered outputs were docked using HTVS protocol implemented in GLIDE package of Schrodinger LLC. The top HITS were further used for enriching the similar molecules from the database through vROCS; a shape based screening protocol implemented in Openeye. The approach adopted has provided different scaffolds as HITS against CHICKV protease. Three scaffolds: Indole, Pyrazole and Sulphone derivatives were selected based on the docking score and synthetic feasibility. Derivatives of Pyrazole were synthesized and submitted for antiviral screening against CHICKV.
Abstract: Numerical parametric study is conducted to study the effects of ampoule rotation on the flows and the dopant segregation in vertical bridgman (vb) crystal growth. Calculations were performed in unsteady state. The extended darcy model, which includes the time derivative and coriolis terms, has been employed in the momentum equation. It’s found that the convection, and dopant segregation can be affected significantly by ampoule rotation, and the effect is similar to that by an axial magnetic field. Ampoule rotation decreases the intensity of convection and stretches the flow cell axially. When the convection is weak, the flow can be suppressed almost completely by moderate ampoule rotation and the dopant segregation becomes diffusion-controlled. For stronger convection, the elongated flow cell by ampoule rotation may bring dopant mixing into the bulk melt reducing axial segregation at the early stage of the growth. However, if the cellular flow cannot be suppressed completely, ampoule rotation may induce larger radial segregation due to poor mixing.
Abstract: The steady state response of bond graphs representing
passive and active suspension is presented. A bond graph with
preferred derivative causality assignment to get the steady state
is proposed. A general junction structure of this bond graph
is proposed. The proposed methodology to passive and active
suspensions is applied.
Abstract: This paper describes an efficient and practical method
for economic dispatch problem in one and two area electrical power
systems with considering the constraint of the tie transmission line
capacity constraint. Direct search method (DSM) is used with some
equality and inequality constraints of the production units with any
kind of fuel cost function. By this method, it is possible to use several
inequality constraints without having difficulty for complex cost
functions or in the case of unavailability of the cost function
derivative. To minimize the number of total iterations in searching,
process multi-level convergence is incorporated in the DSM.
Enhanced direct search method (EDSM) for two area power system
will be investigated. The initial calculation step size that causes less
iterations and then less calculation time is presented. Effect of the
transmission tie line capacity, between areas, on economic dispatch
problem and on total generation cost will be studied; line
compensation and active power with reactive power dispatch are
proposed to overcome the high generation costs for this multi-area
system.
Abstract: This paper presents a Neural Network (NN) identification of icing parameters in an A340 aircraft and a reconfiguration technique to keep the A/C performance close to the performance prior to icing. Five aircraft parameters are assumed to be considerably affected by icing. The off-line training for identifying the clear and iced dynamics is based on the Levenberg-Marquard Backpropagation algorithm. The icing parameters are located in the system matrix. The physical locations of the icing are assumed at the right and left wings. The reconfiguration is based on the technique known as the control mixer approach or pseudo inverse technique. This technique generates the new control input vector such that the A/C dynamics is not much affected by icing. In the simulations, the longitudinal and lateral dynamics of an Airbus A340 aircraft model are considered, and the stability derivatives affected by icing are identified. The simulation results show the successful NN identification of the icing parameters and the reconfigured flight dynamics having the similar performance before the icing. In other words, the destabilizing icing affect is compensated.
Abstract: Traditional wind tunnel models are meticulously machined from metal in a process that can take several months. While very precise, the manufacturing process is too slow to assess a new design's feasibility quickly. Rapid prototyping technology makes this concurrent study of air vehicle concepts via computer simulation and in the wind tunnel possible. This paper described the Affects layer thickness models product with rapid prototyping on Aerodynamic Coefficients for Constructed wind tunnel testing models. Three models were evaluated. The first model was a 0.05mm layer thickness and Horizontal plane 0.1μm (Ra) second model was a 0.125mm layer thickness and Horizontal plane 0.22μm (Ra) third model was a 0.15mm layer thickness and Horizontal plane 4.6μm (Ra). These models were fabricated from somos 18420 by a stereolithography (SLA). A wing-body-tail configuration was chosen for the actual study. Testing covered the Mach range of Mach 0.3 to Mach 0.9 at an angle-of-attack range of -2° to +12° at zero sideslip. Coefficients of normal force, axial force, pitching moment, and lift over drag are shown at each of these Mach numbers. Results from this study show that layer thickness does have an effect on the aerodynamic characteristics in general; the data differ between the three models by fewer than 5%. The layer thickness does have more effect on the aerodynamic characteristics when Mach number is decreased and had most effect on the aerodynamic characteristics of axial force and its derivative coefficients.
Abstract: The pigments covered by film-forming polymers have
opened a prospect to improve the quality of water-based printing
inks. In this study such pigments were prepared by the initiated
polymerization of styrene and methacrylate derivative monomers in
the aqueous pigment dispersions. The formation of polymer films
covering pigment cores depends on the polymerization time and the
ratio of pigment to monomers. At the time of 4 hours and the ratio of
1/10 almost pigment particles are coated by the polymer. The formed
polymer covers of pigments have the average thickness of 5.95 nm.
The size increasing percentage of the coated particles after a week is
4.5 %, about fourteen-fold lower than of the original ones. The
obtained results indicate that the coated pigments are improved
dispersion stability in water medium along with a guarantee for the
optical colour.
Abstract: Tailor-welded Blanks (TWBs) are tailor made for
different complex component designs by welding multiple metal
sheets with different thicknesses, shapes, coatings or strengths prior
to forming. In this study the Hemispherical Die Stretching (HDS) test
(out-of-plane stretching) of TWBs were simulated via
ABAQUS/Explicit to obtain the Forming Limit Diagrams (FLDs) of
Stainless steel (AISI 304) laser welded blanks with different
thicknesses. Two criteria were used to detect the start of necking to
determine the FLD for TWBs and parent sheet metals. These two
criteria are the second derivatives of the major and thickness strains
that are given from the strain history of simulation. In the other word,
in these criteria necking starts when the second derivative of
thickness or major strain reaches its maximum. With having the time
of onset necking, one can measure the major and minor strains at the
critical area and determine the forming limit curve.