Features of the Immune Response in Mice were Immunized with Polio Vaccine in Combination with Chitosan Preparations as Adjuvants

The study of cytokine expression in mice under the influence of inactivated poliovirus and Imovaks polio vaccine in combination with derivatives of chitosan shows various kinds of processes. There is a significant increase in IL-12 in the serum of immunized animals, which should stimulate the production of IFN-γ NK-cells and T-cells and polarize the immune response to Th1 type. Thus, the derivatives of chitosan can promote cell component of the immune response, providing a full antiviral immunity.

Authors:

• Nelly К. Akhmatova
• Оlga V. Lebedinskaya
• Stanislav G. Markushin
• Elvin А. Akhmatov
• Lidiya A. Geiderova
• Еlena А. Lebedinskaya
• Vera M. Axenova
• Аnatoliy P. Godovalov

Keywords:

• Poliovirus
• chitosan
• cytokine expression
• antiviral immunity.

References:

[1] L. Casettari, E. Castagnino, S. Stolnik, A. Lewis, S.M. Howdle, L. Illum
"Surface characterisation of bioadhesive PLGA/chitosan microparticles
produced by supercritical fluid technology", Pharm. Res., vol. 28(7),
2011, pp. 1668-1682.
[2] M.J. Heffernan, D.A. Zaharoff, J.K. Fallon, J. Schlom, J.W. Greiner "In
vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based
vaccines", Biomaterials, vol. 32(3), 2011, pp. 926-932.
[3] C. Prego, Paolicelly Pr Diaz B. "Chitosan-based nanoparticles for
improving imunization against hepatitis infection", Vaccine, vol. 28,
2010, pp. 2607-2614.
[4] Zheng-Shun Wen, Ying-Lei Xu, Xiao-Ting Zou, Zi-Rong Xu "Chitosan
Nanoparticles Act as an Adjuvant to Promote both Th1 and Th2 Immune
Responses Induced by Ovalbumin in Mice", Mar. Drugs., vol. 9(6),
2011, pp. 1038-1055.