Abstract: The technological concepts such as wireless hospital
and portable cardiac telemetry system require the development of
physiological signal acquisition devices to be easily integrated into
the hospital database. In this paper we present the low cost, portable
wireless ECG acquisition hardware that transmits ECG signals to a
dedicated computer.The front end of the system obtains and
processes incoming signals, which are then transmitted via a
microcontroller and wireless Bluetooth module. A monitoring
purpose Bluetooth based end user application integrated with patient
database management module is developed for the computers. The
system will act as a continuous event recorder, which can be used to
follow up patients who have been resuscitatedfrom cardiac arrest,
ventricular tachycardia but also for diagnostic purposes for patients
with arrhythmia symptoms. In addition, cardiac information can be
saved into the patient-s database of the hospital.
Abstract: Chronic hepatitis B can evolve to cirrhosis and liver
cancer. Interferon is the only effective treatment, for carefully selected
patients, but it is very expensive. Some of the selection criteria are
based on liver biopsy, an invasive, costly and painful medical procedure.
Therefore, developing efficient non-invasive selection systems,
could be in the patients benefit and also save money. We investigated
the possibility to create intelligent systems to assist the Interferon
therapeutical decision, mainly by predicting with acceptable accuracy
the results of the biopsy. We used a knowledge discovery in integrated
medical data - imaging, clinical, and laboratory data. The resulted
intelligent systems, tested on 500 patients with chronic hepatitis
B, based on C5.0 decision trees and boosting, predict with 100%
accuracy the results of the liver biopsy. Also, by integrating the other
patients selection criteria, they offer a non-invasive support for the
correct Interferon therapeutic decision. To our best knowledge, these
decision systems outperformed all similar systems published in the
literature, and offer a realistic opportunity to replace liver biopsy in
this medical context.
Abstract: The incidences of dengue hemorrhagic disease (DHF)
over the long term exhibit a seasonal behavior. It has been
hypothesized that these behaviors are due to the seasonal climate
changes which in turn induce a seasonal variation in the incubation
period of the virus while it is developing the mosquito. The standard
dynamic analysis is applied for analysis the Susceptible-Exposed-
Infectious-Recovered (SEIR) model which includes an annual
variation in the length of the extrinsic incubation period (EIP). The
presence of both asymptomatic and symptomatic infections is
allowed in the present model. We found that dynamic behavior of the
endemic state changes as the influence of the seasonal variation of
the EIP becomes stronger. As the influence is further increased, the
trajectory exhibits sustained oscillations when it leaves the chaotic
region.
Abstract: Hepatitis C is an infectious disease transmitted by
blood and due to hepatitis C virus (HCV), which attacks the liver.
The infection is characterized by liver inflammation (hepatitis) that is
often asymptomatic but can progress to chronic hepatitis and later
cirrhosis and liver cancer. Our problem tends to highlight on the one
hand the prevalence of infectious disease in the population of the
region of Batna and on other hand the biological characteristics of
this disease by a screening and a specific diagnosis based on
serological tests, liver checkup (measurement of haematological and
biochemical parameters).
The results showed:
The serology of hepatitis C establishes the diagnosis of infection
with hepatitis C. In this study and with the serological test, 24 cases
of the disease of hepatitis C were found in 1000 suspected cases (7
cases with normal transaminases and 17 cases with elevated
transaminases). The prevalence of this disease in this study
population was 2.4%.
The presence of hepatitis C disrupts liver function including the
onset of cytolysis, cholestasis, jaundice, thrombocytopenia, and
coagulation disorders.
Abstract: Bovine viral diarrhea virus (BVDV) can cause lifelong
persistent infection. One reason for the phenomena is attributed to
BVDV infection to placenta tissue. However the mechanisms that
BVDV invades into placenta tissue remain unclear. To clarify the
molecular mechanisms, we investigated the possible means that
BVDV entered into bovine trophoblast cells (TPC). Yeast two-hybrid
system was used to identify proteins extracted from TPC, which
interact with BVDV envelope glycoprotein E2. A PGbkt7-E2 yeast
expression vector and TPC cDNA library were constructed. Through
two rounds of screening, three positive clones were identified.
Sequencing analysis indicated that all the three positive clones
encoded the same protein clathrin. Physical interaction between
clathrin and BVDV E2 protein was further confirmed by
coimmunoprecipitation experiments. This result suggested that the
clathrin might play a critical role in the process of BVDV entry into
placenta tissue and might be a novel antiviral target for preventing
BVDV infection.
Abstract: Dengue fever has become a major concern for health
authorities all over the world particularly in the tropical countries.
These countries, in particular are experiencing the most worrying
outbreak of dengue fever (DF) and dengue haemorrhagic fever
(DHF). The DF and DHF epidemics, thus, have become the main
causes of hospital admissions and deaths in Malaysia. This paper,
therefore, attempts to examine the environmental factors that may
influence the recent dengue outbreak. The aim of this study is twofold,
firstly is to establish a statistical model to describe the
relationship between the number of dengue cases and a range of
explanatory variables and secondly, to identify the lag operator for
explanatory variables which affect the dengue incidence the most.
The explanatory variables involved include the level of cloud cover,
percentage of relative humidity, amount of rainfall, maximum
temperature, minimum temperature and wind speed. The Poisson and
Negative Binomial regression analyses were used in this study. The
results of the analyses on the 915 observations (daily data taken from
July 2006 to Dec 2008), reveal that the climatic factors comprising of
daily temperature and wind speed were found to significantly
influence the incidence of dengue fever after 2 and 3 weeks of their
occurrences. The effect of humidity, on the other hand, appears to be
significant only after 2 weeks.
Abstract: Exclusive breastfeeding is the feeding of a baby on no other milk apart from breast milk. Exclusive breastfeeding during the first 6 months of life is very important as it supports optimal growth and development during infancy and reduces the risk of obliterating diseases and problems. Moreover, it helps to reduce the incidence and/or severity of diarrhea, lower respiratory infection and urinary tract infection. In this paper, we make a survey of the factors that influence exclusive breastfeeding and use two dispersed statistical models to analyze data. The models are the Generalized Poisson regression model and the Com-Poisson regression models.
Abstract: The adaptive power control of Code Division Multiple
Access (CDMA) communications using Remote Radio Head
(RRH) between multiple Unmanned Aerial Vehicles (UAVs) with
a link-budget based Signal-to-Interference Ratio (SIR) estimate is
applied to four inner loop power control algorithms. It is concluded
that Base Station (BS) can calculate not only UAV distance using
linearity between speed and Consecutive Transmit-Power-Control
Ratio (CTR) of Adaptive Step-size Closed Loop Power Control (ASCLPC),
Consecutive TPC Ratio Step-size Closed Loop Power Control
(CS-CLPC), Fixed Step-size Power Control (FSPC), but also UAV
position with Received Signal Strength Indicator (RSSI) ratio of
RRHs.
Abstract: Ionic liquids are well known as green solvents, reaction media and catalysis. Here, three different sulfonic acid functional ionic liquids prepared in the laboratory are used as catalysts in alkylation of p-cresol with tert-butyl alcohol. The kinetics on each of the catalysts was compared and a kinetic model was developed based on the product distribution over these catalysts. The kinetic parameters were estimated using Marquadt's algorithm to minimize the error function. The Arrhenius plots show a curvature which is best interpreted by the extended Arrhenius equation.
Abstract: An epidemiological cross sectional study was
undertaken in Yaoundé in 2002 and updated in 2005. Focused on
health within the city, the objectives were to measure diarrheal
prevalence and to identify the risk factors associated with them.
Results of microbiological examinations have revealed an urban
average prevalence rate of 14.5%. Access to basic services in the
living environment appears to be an important risk factor for
diarrheas. Statistical and spatial analyses conducted have revealed
that prevalence of diarrheal diseases vary among the two main types
of settlement (informal and planned). More importantly, this study
shows that, diarrhea prevalence rates (notably bacterial and parasitic
diarrheas) vary according to the sub- category of settlements. The
study draws a number of theoretical and policy implications for
researchers and policy decision makers.
Abstract: Clinically, chickens showed progressively developed
clinical signs represented by sever cyanosis of the comb and wattles
with hemorrhage at the shanks, depression, and ruffling feathers with
loss of appetite and high daily mortalities. The ducks showed severe
neurological signs as torticollus, seizures and inability to stand with
mild signs of diarrhea and depression. Grossly, chickens showed
hemorrhages and congestion in most of the organs particularly lung,
liver, spleen, trachea and kidney. The examined ducks showed
multiple petechial hemorrhages, multifocal hemorrhagic necrosis in
the pancreas, pulmonary edema, congestion and hemorrhage in
meninges and congestion in the skeletal muscles. Histopathology
revealed severe congestion and hemorrhages in most of the organs
particularly lung, liver and kidney. Microscopic erosive tracheitis,
sever pulmonary congestion and perivascular oedema and lymphogranulocytic
pneumonia were constant. The liver showed hepatocyts
necrosis and lympho-granulocytic infiltration. The kidney showed
renal tubular necrosis and diffuse congestion. Multifocal, neuronal
necrosis, hemorrhages, multifocal glial nodules, lympho- histiocytic
perivascular cuffing, and occasional neuronophagia were observed in
the cerebrum. Other organs showed moderate changes.
Abstract: This study analyzed environmental health risks and
people-s perceptions of risks related to waste management in poor
settlements of Abidjan, to develop integrated solutions for health and
well-being improvement. The trans-disciplinary approach used relied
on remote sensing, a geographic information system (GIS),
qualitative and quantitative methods such as interviews and a
household survey (n=1800). Mitigating strategies were then
developed using an integrated participatory stakeholder workshop.
Waste management deficiencies resulting in lack of drainage and
uncontrolled solid and liquid waste disposal in the poor settlements
lead to severe environmental health risks. Health problems were
caused by direct handling of waste, as well as through broader
exposure of the population. People in poor settlements had little
awareness of health risks related to waste management in their
community and a general lack of knowledge pertaining to sanitation
systems. This unfortunate combination was the key determinant
affecting the health and vulnerability. For example, an increased
prevalence of malaria (47.1%) and diarrhoea (19.2%) was observed
in the rainy season when compared to the dry season (32.3% and
14.3%). Concerted and adapted solutions that suited all the
stakeholders concerned were developed in a participatory workshop
to allow for improvement of health and well-being.
Abstract: An electrocardiogram (ECG) feature extraction system
based on the calculation of the complex resonance frequency
employing Prony-s method is developed. Prony-s method is applied
on five different classes of ECG signals- arrhythmia as a finite sum
of exponentials depending on the signal-s poles and the resonant
complex frequencies. Those poles and resonance frequencies of the
ECG signals- arrhythmia are evaluated for a large number of each
arrhythmia. The ECG signals of lead II (ML II) were taken from
MIT-BIH database for five different types. These are the ventricular
couplet (VC), ventricular tachycardia (VT), ventricular bigeminy
(VB), and ventricular fibrillation (VF) and the normal (NR). This
novel method can be extended to any number of arrhythmias.
Different classification techniques were tried using neural networks
(NN), K nearest neighbor (KNN), linear discriminant analysis (LDA)
and multi-class support vector machine (MC-SVM).
Abstract: The present paper develops and validates a numerical procedure for the calculation of turbulent combustive flow in converging and diverging ducts and throuh simulation of the heat transfer processes, the amount of production and spread of Nox pollutant has been measured. A marching integration solution procedure employing the TDMA is used to solve the discretized equations. The turbulence model is the Prandtl Mixing Length method. Modeling the combustion process is done by the use of Arrhenius and Eddy Dissipation method. Thermal mechanism has been utilized for modeling the process of forming the nitrogen oxides. Finite difference method and Genmix numerical code are used for numerical solution of equations. Our results indicate the important influence of the limiting diverging angle of diffuser on the coefficient of recovering of pressure. Moreover, due to the intense dependence of Nox pollutant to the maximum temperature in the domain with this feature, the Nox pollutant amount is also in maximum level.
Abstract: In the present study, a procedure was developed to
determine the optimum reaction rate constants in generalized
Arrhenius form and optimized through the Nelder-Mead method. For
this purpose, a comprehensive mathematical model of a fixed bed
reactor for dehydrogenation of heavy paraffins over Pt–Sn/Al2O3
catalyst was developed. Utilizing appropriate kinetic rate expressions
for the main dehydrogenation reaction as well as side reactions and
catalyst deactivation, a detailed model for the radial flow reactor was
obtained. The reactor model composed of a set of partial differential
equations (PDE), ordinary differential equations (ODE) as well as
algebraic equations all of which were solved numerically to
determine variations in components- concentrations in term of mole
percents as a function of time and reactor radius. It was demonstrated
that most significant variations observed at the entrance of the bed
and the initial olefin production obtained was rather high. The
aforementioned method utilized a direct-search optimization
algorithm along with the numerical solution of the governing
differential equations. The usefulness and validity of the method was
demonstrated by comparing the predicted values of the kinetic
constants using the proposed method with a series of experimental
values reported in the literature for different systems.
Abstract: Breastfeeding is an important concept in the maternal life of a woman. In this paper, we focus on exclusive breastfeeding. Exclusive breastfeeding is the feeding of a baby on no other milk apart from breast milk. This type of breastfeeding is very important during the first six months because it supports optimal growth and development during infancy and reduces the risk of obliterating diseases and problems. Moreover, in Mauritius, exclusive breastfeeding has decreased the incidence and/or severity of diarrhea, lower respiratory infection and urinary tract infection. In this paper, we give an overview of exclusive breastfeeding in Mauritius and the factors influencing it. We further analyze the local practices of exclusive breastfeeding using the Generalized Poisson regression model and the negative-binomial model since the data are over-dispersed.
Abstract: Brain ArterioVenous Malformation (BAVM) is an abnormal tangle of brain blood vessels where arteries shunt directly into veins with no intervening capillary bed which causes high pressure and hemorrhage risk. The success of treatment by embolization in interventional neuroradiology is highly dependent on the accuracy of the vessels visualization. In this paper the performance of clustering techniques on vessel segmentation from 3- D rotational angiography (3DRA) images is investigated and a new technique of segmentation is proposed. This method consists in: preprocessing step of image enhancement, then K-Means (KM), Fuzzy C-Means (FCM) and Expectation Maximization (EM) clustering are used to separate vessel pixels from background and artery pixels from vein pixels when possible. A post processing step of removing false-alarm components is applied before constructing a three-dimensional volume of the vessels. The proposed method was tested on six datasets along with a medical assessment of an expert. Obtained results showed encouraging segmentations.
Abstract: This paper describes a new supervised fusion (hybrid)
electrocardiogram (ECG) classification solution consisting of a new
QRS complex geometrical feature extraction as well as a new version
of the learning vector quantization (LVQ) classification algorithm
aimed for overcoming the stability-plasticity dilemma. Toward this
objective, after detection and delineation of the major events of ECG
signal via an appropriate algorithm, each QRS region and also its
corresponding discrete wavelet transform (DWT) are supposed as
virtual images and each of them is divided into eight polar sectors.
Then, the curve length of each excerpted segment is calculated
and is used as the element of the feature space. To increase the
robustness of the proposed classification algorithm versus noise,
artifacts and arrhythmic outliers, a fusion structure consisting of
five different classifiers namely as Support Vector Machine (SVM),
Modified Learning Vector Quantization (MLVQ) and three Multi
Layer Perceptron-Back Propagation (MLP–BP) neural networks with
different topologies were designed and implemented. The new proposed
algorithm was applied to all 48 MIT–BIH Arrhythmia Database
records (within–record analysis) and the discrimination power of the
classifier in isolation of different beat types of each record was
assessed and as the result, the average accuracy value Acc=98.51%
was obtained. Also, the proposed method was applied to 6 number
of arrhythmias (Normal, LBBB, RBBB, PVC, APB, PB) belonging
to 20 different records of the aforementioned database (between–
record analysis) and the average value of Acc=95.6% was achieved.
To evaluate performance quality of the new proposed hybrid learning
machine, the obtained results were compared with similar peer–
reviewed studies in this area.
Abstract: Atrial Fibrillation is the most common sustained
arrhythmia encountered by clinicians. Because of the invisible
waveform of atrial fibrillation in atrial activation for human, it is
necessary to develop an automatic diagnosis system. 12-Lead ECG
now is available in hospital and is appropriate for using Independent
Component Analysis to estimate the AA period. In this research, we
also adopt a second-order blind identification approach to transform
the sources extracted by ICA to more precise signal and then we use
frequency domain algorithm to do the classification. In experiment,
we gather a significant result of clinical data.
Abstract: Ventricular fibrillation is a very important health
problem as is the cause of most of the sudden deaths in the world.
Waves of electrical activity are sent by the SA node, propagate
through the cardiac tissue and activate the mechanisms of cell
contraction, and therefore are responsible to pump blood to the body
harmonically. A spiral wave is an abnormal auto sustainable wave
that is responsible of certain types of arrhythmias. When these waves
break up, give rise to the fibrillation regime, in which there is a
complete loss in the coordination of the contraction of the heart
muscle. Interaction of spiral waves and obstacles is also of great
importance as it is believed that the attachment of a spiral wave to an
obstacle can provide with a transition of two different arrhythmias.
An obstacle can be partially excitable or non excitable. In this talk,
we present a numerical study of the interaction of meandering spiral
waves with partially and non excitable obstacles and focus on the
problem where the obstacle plays a fundamental role in the switch
between different spiral regimes, which represent different
arrhythmic regimes. Particularly, we study the phenomenon of
destabilization of spiral waves due to the presence of obstacles, a
phenomenon not completely understood (This work will appear as a
Chapter in a Book named Cardiac Arrhytmias by INTECH under the
name "Spiral Waves, Obstacles and Cardiac Arrhythmias", ISBN
979-953-307-050-5.).