Abstract: Bones are dynamic and responsive organs, they
regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/β-catenin pathway has profound
effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/β-catenin signaling, which results in the generation of new bone mass.
Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3β (Glycogen synthase kinase 3 beta) to cease the phosphorylation of β-catenin. β-catenin accumulation in the cytoplasm, followed by its
transport into the nucleus, binding to transcription factors (TCF/LEF)
that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter
β-galactosidase) mice in an experiment in which cyclic loads were
applied to the forearm. TOPGAL mice are reporters for cells effected
by the Wnt/β-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of β-
catenin, results in the production of an enzyme, β-galactosidase. The
presence of this enzyme allows us to localize transcriptional
activation of β-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/β-catenin pathway and new bone formation. The ulnae of loaded TOPGAL
mice were excised and transverse slices along different parts of the
ulnar shaft were assayed for the presence of β-galactosidase.
Our results indicate that loading increases β-catenin transcriptional
activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent
manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation.
Abstract: In this study, a longitudinal joint connection was
proposed for the short-span slab-type modular bridges with rapid
construction. The slab-type modular bridge consists of a number of
precast slab modules and has the joint connection between the
modules in the longitudinal direction of the bridge. A finite element
based parameter analysis was conducted to design the shape and the
dimensions of the longitudinal joint connection. Numbers of shear
keys within the joint, height and depth of the shear key, tooth angle,
and the spacing were considered as the design parameters. Using the
local cracking load at the corner of the shear key and the
cross-sectional area of the joint, an efficiency factor was proposed to
evaluate the effectiveness of the longitudinal joint connection. The
dimensions of shear key were determined by comparing the cracking
loads and the efficiency factors obtained from the finite element
analysis.
Abstract: Exclusive breastfeeding is the feeding of a baby on no other milk apart from breast milk. Exclusive breastfeeding during the first 6 months of life is of fundamental importance because it supports optimal growth and development during infancy and reduces the risk of obliterating diseases and problems. Moreover, in developed countries, exclusive breastfeeding has decreased the incidence and/or severity of diarrhea, lower respiratory infection and urinary tract infection. In this paper, we study the factors that influence exclusive breastfeeding and use the Generalized Poisson regression model to analyze the practices of exclusive breastfeeding in Mauritius. We develop two sets of quasi-likelihood equations (QLE)to estimate the parameters.
Abstract: This article presents the simulation, parameterization and optimization of an electromagnet with the C–shaped configuration, intended for the study of magnetic properties of materials. The electromagnet studied consists of a C-shaped yoke, which provides self–shielding for minimizing losses of magnetic flux density, two poles of high magnetic permeability and power coils wound on the poles. The main physical variable studied was the static magnetic flux density in a column within the gap between the poles, with 4cm2 of square cross section and a length of 5cm, seeking a suitable set of parameters that allow us to achieve a uniform magnetic flux density of 1x104 Gaussor values above this in the column, when the system operates at room temperature and with a current consumption not exceeding 5A. By means of a magnetostatic analysis by the finite element method, the magnetic flux density and the distribution of the magnetic field lines were visualized and quantified. From the results obtained by simulating an initial configuration of electromagnet, a structural optimization of the geometry of the adjustable caps for the ends of the poles was performed. The magnetic permeability effect of the soft magnetic materials used in the poles system, such as low– carbon steel (0.08% C), Permalloy (45% Ni, 54.7% Fe) and Mumetal (21.2% Fe, 78.5% Ni), was also evaluated. The intensity and uniformity of the magnetic field in the gap showed a high dependence with the factors described above. The magnetic field achieved in the column was uniform and its magnitude ranged between 1.5x104 Gauss and 1.9x104 Gauss according to the material of the pole used, with the possibility of increasing the magnetic field by choosing a suitable geometry of the cap, introducing a cooling system for the coils and adjusting the spacing between the poles. This makes the device a versatile and scalable tool to generate the magnetic field necessary to perform magnetic characterization of materials by techniques such as vibrating sample magnetometry (VSM), Hall-effect, Kerr-effect magnetometry, among others. Additionally, a CAD design of the modules of the electromagnet is presented in order to facilitate the construction and scaling of the physical device.
Abstract: Biological Ammonia removal (nitrification), the
oxidation of ammonia to nitrate catalyzed by bacteria, is a key part of
global nitrogen cycling. In the first step of nitrification,
chemolithoautotrophic ammonia oxidizer transform ammonia to
nitrite, this subsequently oxidized to nitrate by nitrite oxidizing
bacteria. This process can be affected by several factors. In this study
the effect of influent COD on biological ammonia removal in a
bench-scale biological reactor was investigated. Experiments were
carried out using synthetic wastewater. The initial ammonium
concentration was 25mgNH4
+-N L-1. The effect of COD between
247.55±1.8 and 601.08±3.24mgL-1 on biological ammonia removal
was investigated by varying the COD loading supplied to reactor.
From the results obtained in this study it could be concluded in the
range of 247.55±1.8 to 351.35±2.05mgL-1, there is a direct
relationship between amount of COD and ammonia removal.
However more than 351.35±2.05 up to 601.08±3.24mgL-1 were
found an indirect relationship between them.
Abstract: Property investment in the real estate industry has a
high risk due to the uncertainty factors that will affect the decisions
made and high cost. Analytic hierarchy process has existed for some
time in which referred to an expert-s opinion to measure the
uncertainty of the risk factors for the risk analysis. Therefore,
different level of experts- experiences will create different opinion
and lead to the conflict among the experts in the field. The objective
of this paper is to propose a new technique to measure the uncertainty
of the risk factors based on multidimensional data model and data
mining techniques as deterministic approach. The propose technique
consist of a basic framework which includes four modules: user,
technology, end-user access tools and applications. The property
investment risk analysis defines as a micro level analysis as the
features of the property will be considered in the analysis in this
paper.
Abstract: At the present, auto part industries have become higher challenge in strategy market. As this consequence, manufacturers need to have better response to customers in terms of quality, cost, and delivery time. Moreover, they need to have a good management in factory to comply with international standard maximum capacity and lower cost. This would lead companies to have to order standard part from aboard and become the major cost of inventory. The development of auto part research by recycling materials experiment is to compare the auto parts from recycle materials to international auto parts (CKD). Factors studied in this research were the recycle material ratios of PU-foam, felt, and fabric. Results of recycling materials were considered in terms of qualities and properties on the parameters such as weight, sound absorption, water absorption, tensile strength, elongation, and heat resistance with the CKD. The results were showed that recycling materials would be used to replace for the CKD.
Abstract: The study was conducted to investigate the profile of
hepatitis in Kingdom of Saudi Arabia, and to determine which age
group hepatitis viruses most commonly infect. The epidemiology of
viral hepatitis in Saudi Arabia has undergone major changes,
concurrent with major socioeconomic developments over the last two
to three decades. This disease represents a major public health
problem in Saudi Arabia resulting in the need for considerable
healthcare resources. A retrospective cross sectional analysis of the
reported cases of viral hepatitis was conducted based on the reports
of The Ministry of Health in Saudi Arabia about Hepatitis A, B and C
infections in all regions from the period of January 2006 to December
2010. The study demonstrated that incidence of viral Hepatitis is
decreasing, except for Hepatitis B that showed minimal increase. Of
hepatitis A, B, and C, Hepatitis B virus (HBV) was the most
predominant type, accounting for (53%) of the cases, followed by
Hepatitis C virus (HCV) (30%) and HAV (17%). HAV infection
predominates in children (5–14 years) with 60% of viral hepatitis
cases, HBV in young adults (15–44 years) with 69% of viral hepatitis
cases, and HCV in older adults (>45 years) with 59% of viral
hepatitis cases. Despite significant changes in the prevalence of viral
hepatitis A, B and C, it remains a major public health problem in
Saudi Arabia; however, it showed a significant decline in the last two
decades that could be attributed to the vaccination programs and the
improved health facilities. Further researches are needed to identify
the risk factors making a specific age group or a specific region in
Saudi Arabia targeted for a specific type of hepatitis viruses.
Abstract: Ramadan requires individuals to abstain from food and fluid intake between sunrise and sunset; physiological considerations predict that poorer mood, physical performance and mental performance will result. In addition, any difficulties will be worsened because preparations for fasting and recovery from it often mean that nocturnal sleep is decreased in length, and this independently affects mood and performance.
A difficulty of interpretation in many studies is that the observed changes could be due to fasting but also to the decreased length of sleep and altered food and fluid intakes before and after the daytime fasting. These factors were separated in this study, which took place over three separate days and compared the effects of different durations of fasting (4, 8 or 16h) upon a wide variety of measures (including subjective and objective assessments of performance, body composition, dehydration and responses to a short bout of exercise) - but with an unchanged amount of nocturnal sleep, controlled supper the previous evening, controlled intakes at breakfast and daytime naps not being allowed. Many of the negative effects of fasting observed in previous studies were present in this experiment also. These findings indicate that fasting was responsible for many of the changes previously observed, though some effect of sleep loss, particularly if occurring on successive days (as would occur in Ramadan) cannot be excluded.
Abstract: A cross sectional survey design was used to collect
data from 370 diabetic patients. Two instruments were used in
obtaining data; in-depth interview guide and researchers- developed
questionnaire. Fisher's exact test was used to investigate association
between the identified factors and nonadherence. Factors identified
were: socio-demographic factors such as: gender, age, marital status,
educational level and occupation; psychosocial obstacles such as:
non-affordability of prescribed diet, frustration due to the restriction,
limited spousal support, feelings of deprivation, feeling that
temptation is inevitable, difficulty in adhering in social gatherings
and difficulty in revealing to host that one is diabetic; health care
providers obstacles were: poor attitude of health workers, irregular
diabetes education in clinics , limited number of nutrition education
sessions/ inability of the patients to estimate the desired quantity of
food, no reminder post cards or phone calls about upcoming patient
appointments and delayed start of appointment / time wasting in
clinics.
Abstract: This research aims to analyze the regenerative burner and the recuperative burner for the different reheating furnaces in the steel industry. The warm air temperatures of the burners are determined to suit with the sizes of the reheating furnaces by considering the air temperature, the fuel cost and the investment cost. The calculations of the payback period and the net present value are studied to compare the burners for the different reheating furnaces. The energy balance is utilized to calculate and compare the energy used in the different sizes of reheating furnaces for each burner. It is found that the warm air temperature is different if the sizes of reheating furnaces are varied. Based on the considerations of the net present value and the payback period, the regenerative burner is suitable for all plants at the same life of the burner. Finally, the sensitivity analysis of all factors has been discussed in this research.
Abstract: The damage tolerance behavior of integrally and
conventional stiffened panel is investigated based on the fracture
mechanics and finite element analysis. The load bearing capability
and crack growth characteristic of both types of the stiffened panels
having same configuration subjected to distributed tensile load is
examined in this paper. A fourteen-stringer stiffened panel is
analyzed for a central skin crack propagating towards the adjacent
stringers. Stress intensity factors and fatigue crack propagation rates
of both types of the stiffened panels are then compared. The analysis
results show that integral stiffening causes higher stress intensity
factor than conventional stiffened panel as the crack tip passes
through the stringer and the integrally stiffened panel has less load
bearing capability than the riveted stiffened panel.
Abstract: Particle Swarm Optimization (PSO) with elite PSO
parameters has been developed for power flow analysis under
practical constrained situations. Multiple solutions of the power flow
problem are useful in voltage stability assessment of power system.
A method of determination of multiple power flow solutions is
presented using a hybrid of Particle Swarm Optimization (PSO) and
local search technique. The unique and innovative learning factors of
the PSO algorithm are formulated depending upon the node power
mismatch values to be highly adaptive with the power flow problems.
The local search is applied on the pbest solution obtained by the PSO
algorithm in each iteration. The proposed algorithm performs reliably
and provides multiple solutions when applied on standard and illconditioned
systems. The test results show that the performances of
the proposed algorithm under critical conditions are better than the
conventional methods.
Abstract: In this research it is aimed that the effect of some demographic factors on Turkish Adolescents' subjective well being is investigated. 432 adolescents who are 247 girls and 185 boys are participated in this study. They are ages 15-17, and also are high school students. The Positive and Negative Affect Scale and Life Satisfaction Scale are used for measuring adolescents' subjective well being. The ANOVA method is used in order to examine the effect of ages. For gender differences, independent t-test method is used, and finally the Pearson Correlation method is used so as to examine the effect of socio economic statues of adolescents' parents. According to results, there is no gender difference on adolescents' subjective well being. On the other hand, SES and age are effect significantly lover level on adolescents' subjective well being.
Abstract: e-Government structures permits the government to operate in a more transparent and accountable manner of which it increases the power of the individual in relation to that of the government. This paper identifies the factors that determine customer-s attitude towards e-Government services using a theoretical model based on the Technology Acceptance Model. Data relating to the constructs were collected from 200 respondents. The research model was tested using Structural Equation Modeling (SEM) techniques via the Analysis of Moment Structure (AMOS 16) computer software. SEM is a comprehensive approach to testing hypotheses about relations among observed and latent variables. The proposed model fits the data well. The results demonstrated that e- Government services acceptance can be explained in terms of compatibility and attitude towards e-Government services. The setup of the e-Government services will be compatible with the way users work and are more likely to adopt e-Government services owing to their familiarity with the Internet for various official, personal, and recreational uses. In addition, managerial implications for government policy makers, government agencies, and system developers are also discussed.
Abstract: Pakistani doctors (MBBS) are emigrating towards developed countries for professional adjustments. This study aims to highlight causes and consequences of doctors- brain drain from Pakistan. Primary data was collected from Mayo Hospital, Lahore by interviewing doctors (n=100) through systematic random sampling technique. It found that various socio-economic and political conditions are working as push and pull factors for brain drain of doctors in Pakistan. Majority of doctors (83%) declared poor remunerations and professional infrastructure of health department as push factor of doctors- brain drain. 81% claimed that continuous instability in political situation and threats of terrorism are responsible for emigration of doctors. 84% respondents considered fewer opportunities of further studies responsible for their emigration. Brain drain of doctors is affecting health sector-s policies / programs, standard doctor-patient ratios and quality of health services badly.
Abstract: Gold passbook is an investing tool that is especially
suitable for investors to do small investment in the solid gold. The gold
passbook has the lower risk than other ways investing in gold, but its
price is still affected by gold price. However, there are many factors
can cause influences on gold price. Therefore, building a model to
predict the price of gold passbook can both reduce the risk of
investment and increase the benefits. This study investigates the
important factors that influence the gold passbook price, and utilize
the Group Method of Data Handling (GMDH) to build the predictive
model. This method can not only obtain the significant variables but
also perform well in prediction. Finally, the significant variables of
gold passbook price, which can be predicted by GMDH, are US dollar
exchange rate, international petroleum price, unemployment rate,
whole sale price index, rediscount rate, foreign exchange reserves,
misery index, prosperity coincident index and industrial index.
Abstract: The purpose of this study is i) to investigate the driving factors and barriers of the adoption of Information and Communication Technology (ICT) in Halal logistic and ii) to develop an ICT adoption framework for Halal logistic service provider. The Halal LSPs selected for the study currently used ICT service platforms, such as accounting and management system for Halal logistic business. The study categorizes the factors influencing the adoption decision and process by LSPs into four groups: technology related factors, organizational and environmental factors, Halal assurance related factors, and government related factors. The major contribution in this study is the discovery that technology related factors (ICT compatibility with Halal requirement) and Halal assurance related factors are the most crucial factors among the Halal LSPs applying ICT for Halal control in transportation-s operation. Among the government related factors, ICT requirement for monitoring Halal included in Halal Logistic Standard on Transportation (MS2400:2010) are the most influencing factors in the adoption of ICT with the support of the government. In addition, the government related factors are very important in the reducing the main barriers and the creation of the atmosphere of ICT adoption in Halal LSP sector.
Abstract: Environmental factors affect agriculture production
productivity and efficiency resulted in changing of profit efficiency.
This paper attempts to estimate the impacts of environmental factors
to profitability of rice farmers in the Red River Delta of Vietnam. The
dataset was extracted from 349 rice farmers using personal
interviews. Both OLS and MLE trans-log profit functions were used
in this study. Five production inputs and four environmental factors
were included in these functions. The estimation of the stochastic
profit frontier with a two-stage approach was used to measure
profitability. The results showed that the profit efficiency was about
75% on the average and environmental factors change profit
efficiency significantly beside farm specific characteristics. Plant
disease, soil fertility, irrigation apply and water pollution were the
four environmental factors cause profit loss in rice production. The
result indicated that farmers should reduce household size, farm
plots, apply row seeding technique and improve environmental
factors to obtain high profit efficiency with special consideration is
given for irrigation water quality improvement.
Abstract: We present a new method to reconstruct a temporally
coherent 3D animation from single or multi-view RGB-D video data
using unbiased feature point sampling. Given RGB-D video data, in
form of a 3D point cloud sequence, our method first extracts feature
points using both color and depth information. In the subsequent
steps, these feature points are used to match two 3D point clouds in
consecutive frames independent of their resolution. Our new motion
vectors based dynamic alignement method then fully reconstruct
a spatio-temporally coherent 3D animation. We perform extensive
quantitative validation using novel error functions to analyze the
results. We show that despite the limiting factors of temporal and
spatial noise associated to RGB-D data, it is possible to extract
temporal coherence to faithfully reconstruct a temporally coherent
3D animation from RGB-D video data.