Abstract: In this paper we consider a nonlinear feedback
control called augmented automatic choosing control (AACC)
using the automatic choosing functions of gradient optimization
type for nonlinear systems. Constant terms which arise from sectionwise
linearization of a given nonlinear system are treated as
coefficients of a stable zero dynamics. Parameters included in the
control are suboptimally selected by minimizing the Hamiltonian
with the aid of the genetic algorithm. This approach is applied to
a field excitation control problem of power system to demonstrate
the splendidness of the AACC. Simulation results show that the
new controller can improve performance remarkably well.
Abstract: Chikungunya virus (CHICKV) is an arboviruses belonging to family Tagoviridae and is transmitted to human through by mosquito (Aedes aegypti and Aedes albopictus) bite. A large outbreak of chikungunya has been reported in India between 2006 and 2007, along with several other countries from South-East Asia and for the first time in Europe. It was for the first time that the CHICKV outbreak has been reported with mortality from Reunion Island and increased mortality from Asian countries. CHICKV affects all age groups, and currently there are no specific drugs or vaccine to cure the disease. The need of antiviral agents for the treatment of CHICKV infection and the success of virtual screening against many therapeutically valuable targets led us to carry out the structure based drug design against Chikungunya nSP2 protease (PDB: 3TRK). Highthroughput virtual screening of publicly available databases, ZINC12 and BindingDB, has been carried out using the Openeye tools and Schrodinger LLC software packages. Openeye Filter program has been used to filter the database and the filtered outputs were docked using HTVS protocol implemented in GLIDE package of Schrodinger LLC. The top HITS were further used for enriching the similar molecules from the database through vROCS; a shape based screening protocol implemented in Openeye. The approach adopted has provided different scaffolds as HITS against CHICKV protease. Three scaffolds: Indole, Pyrazole and Sulphone derivatives were selected based on the docking score and synthetic feasibility. Derivatives of Pyrazole were synthesized and submitted for antiviral screening against CHICKV.
Abstract: Scarcity of resources for biodiversity conservation gives rise to the need of strategic investment with priorities given to the cost of conservation. While the literature provides abundant methodological options for biodiversity conservation; estimating true cost of conservation remains abstract and simplistic, without recognising dynamic nature of the cost. Some recent works demonstrate the prominence of economic theory to inform biodiversity decisions, particularly on the costs and benefits of biodiversity however, the integration of the concept of true cost into biodiversity actions and planning are very slow to come by, and specially on a farm level. Conservation planning studies often use area as a proxy for costs neglecting different land values as well as protected areas. These literature consider only heterogeneous benefits while land costs are considered homogenous. Analysis with the assumption of cost homogeneity results in biased estimation; since not only it doesn’t address the true total cost of biodiversity actions and plans, but also it fails to screen out lands that are more (or less) expensive and/or difficult (or more suitable) for biodiversity conservation purposes, hindering validity and comparability of the results. Economies of scope” is one of the other most neglected aspects in conservation literature. The concept of economies of scope introduces the existence of cost complementarities within a multiple output production system and it suggests a lower cost during the concurrent production of multiple outputs by a given farm. If there are, indeed, economies of scope then simplistic representation of costs will tend to overestimate the true cost of conservation leading to suboptimal outcomes. The aim of this paper, therefore, is to provide first road review of the various theoretical ways in which economies of scope are likely to occur of how they might occur in conservation. Consequently, the paper addresses gaps that have to be filled in future analysis.
Abstract: Alcohol and water extracts of Cymbopogon citratus
was investigated for anti-bacterial properties and phytochemical
constituents. The extract was screened against four gram-negative
bacteria Escherichia coli, Klebsiella pneumoniae, Pseudomonas
aeruginosa, Proteus vulgaris) and two grampositive bacteria Bacillus
subtilis and Staphylococcus aureus at four different concentrations
(1:1, 1:5, 1:10 and 1:20) using disc diffusion method. The antibacterial
examination was by disc diffusion techniques, while the
photochemical constituents were investigated using standard
chemical methods. Results showed that the extracts inhibited the
growth of standard and local strains of the organisms used. The
treatments were significantly different (P = 0.05). The minimum
inhibitory concentration of the extracts against the tested
microorganisms ranged between 150mg/ml and 50mg/ml. The
alcohol extracts were found to be generally more effective than the
water extract. The photochemical analysis revealed the presence of
alkaloids and phenol but absence of cardiac and cyanogenic
glycosides. The presence of alkaloid and phenols were inferred as
being responsible for the anti-bacterial properties of the extracts.
Abstract: The objective of the research was to evaluate the
quality of milk pomade sweet – sherbet packed in different packaging
materials (Multibarrier 60, met.BOPET/PE, Aluthen), by several
packaging technologies – active and modified atmosphere (MAP)
(consisting of 100% CO2), and control – in air ambiance.
Experiments were carried out at the Faculty of Food Technology of
Latvia University of Agriculture. Samples were stored at the room
temperature +21±1 °C. The physiochemical properties – weight
losses, moisture, hardening, colour and changes in headspace
atmosphere concentration (CO2 and O2) of packs were analysed
before packaging and after 2, 4, 6, 8, 10 and 12 storage weeks.
Abstract: In this paper we consider a nonlinear feedback control
called augmented automatic choosing control (AACC) for nonlinear
systems with constrained input using weighted gradient optimization
automatic choosing functions. Constant term which arises from
linearization of a given nonlinear system is treated as a coefficient of
a stable zero dynamics. Parameters of the control are suboptimally
selected by maximizing the stable region in the sense of Lyapunov
with the aid of a genetic algorithm. This approach is applied to a
field excitation control problem of power system to demonstrate the
splendidness of the AACC. Simulation results show that the new
controller can improve performance remarkably well.
Abstract: Asynchronous Transfer Mode (ATM) is widely used
in telecommunications systems to send data, video and voice at a
very high speed. In ATM network optimizing the bandwidth through
dynamic routing is an important consideration. Previous research
work shows that traditional optimization heuristics result in suboptimal
solution. In this paper we have explored non-traditional
optimization technique. We propose comparison of two such
algorithms - Genetic Algorithm (GA) and Tabu search (TS), based on
non-traditional Optimization approach, for solving the dynamic
routing problem in ATM networks which in return will optimize the
bandwidth. The optimized bandwidth could mean that some
attractive business applications would become feasible such as high
speed LAN interconnection, teleconferencing etc. We have also
performed a comparative study of the selection mechanisms in GA
and listed the best selection mechanism and a new initialization
technique which improves the efficiency of the GA.
Abstract: In the context of spectrum surveillance, a new method
to recover the code of spread spectrum signal is presented, while the
receiver has no knowledge of the transmitter-s spreading sequence. In
our previous paper, we used Genetic algorithm (GA), to recover
spreading code. Although genetic algorithms (GAs) are well known
for their robustness in solving complex optimization problems, but
nonetheless, by increasing the length of the code, we will often lead
to an unacceptable slow convergence speed. To solve this problem we
introduce Particle Swarm Optimization (PSO) into code estimation in
spread spectrum communication system. In searching process for
code estimation, the PSO algorithm has the merits of rapid
convergence to the global optimum, without being trapped in local
suboptimum, and good robustness to noise. In this paper we describe
how to implement PSO as a component of a searching algorithm in
code estimation. Swarm intelligence boasts a number of advantages
due to the use of mobile agents. Some of them are: Scalability, Fault
tolerance, Adaptation, Speed, Modularity, Autonomy, and
Parallelism. These properties make swarm intelligence very attractive
for spread spectrum code estimation. They also make swarm
intelligence suitable for a variety of other kinds of channels. Our
results compare between swarm-based algorithms and Genetic
algorithms, and also show PSO algorithm performance in code
estimation process.
Abstract: The equivalence class subset algorithm is a powerful
tool for solving a wide variety of constraint satisfaction problems and
is based on the use of a decision function which has a very high but
not perfect accuracy. Perfect accuracy is not required in the decision
function as even a suboptimal solution contains valuable information
that can be used to help find an optimal solution. In the hardest
problems, the decision function can break down leading to a
suboptimal solution where there are more equivalence classes than
are necessary and which can be viewed as a mixture of good decision
and bad decisions. By choosing a subset of the decisions made in
reaching a suboptimal solution an iterative technique can lead to an
optimal solution, using series of steadily improved suboptimal
solutions. The goal is to reach an optimal solution as quickly as
possible. Various techniques for choosing the decision subset are
evaluated.
Abstract: The aim of the present study was to evaluate the
mucoadhesion and the release of nicotinamide gel formulations using
in vitro methods. An agar plate technique was used to investigate the
adhesiveness of the gels whereas a diffusion apparatus was employed
to determine the release of nicotinamide from the gels. In this
respect, 10% w/w nicotinamide gels containing bioadhesive
polymers: Carbopol 934P (0.5-2% w/w), hydroxypropylmethyl
cellulose (HPMC) (4-10% w/w), sodium carboxymethyl cellulose
(SCMC) (4-6% w/w) and methylcellulose 4000 (MC) (3-5% w/w)
were prepared. The gel formulations had pH values in the range of
7.14 - 8.17, which were considered appropriate to oral mucosa
application. In general, the rank order of pH values appeared to be
SCMC > MC4000 > HPMC > Carbopol 934P. Types and
concentrations of polymers used somewhat affected the
adhesiveness. It was found that anionic polymers (Carbopol 934 and
SCMC) adhered more firmly to the agar plate than the neutral
polymers (HPMC and MC 4000). The formulation containing 0.5%
Carbopol 934P (F1) showed the highest release rate. With the
exception of the formulation F1, the neutral polymers tended to give
higher relate rates than the anionic polymers. For oral tissue
treatment, the optimum has to be balanced between the residence
time (adhesiveness) of the formulations and the release rate of the
drug. The formulations containing the anionic polymers: Carbopol
934P or SCMC possessed suitable physical properties (appearance,
pH and viscosity). In addition, for anionic polymer formulations,
justifiable mucoadhesive properties and reasonable release rates of
nicotinamide were achieved. Accordingly, these gel formulations
may be applied for the treatment of oral mucosal lesions.
Abstract: In this paper, we are going to determine the threshold levels of adaptive modulation in a burst by burst CDMA system by a suboptimum method so that the above method attempts to increase the average bit per symbol (BPS) rate of transceiver system by switching between the different modulation modes in variable channel condition. In this method, we choose the minimum values of average bit error rate (BER) and maximum values of average BPS on different values of average channel signal to noise ratio (SNR) and then calculate the relative threshold levels of them, so that when the instantaneous SNR increases, a higher order modulation be employed for increasing throughput and vise-versa when the instantaneous SNR decreases, a lower order modulation be employed for improvement of BER. In transmission step, by this adaptive modulation method, in according to comparison between obtained estimation of pilot symbols and a set of above suboptimum threshold levels, above system chooses one of states no transmission, BPSK, 4QAM and square 16QAM for modulation of data. The expected channel in this paper is a slow Rayleigh fading.
Abstract: This paper presents the results related to the
interference reduction technique in multistage multiuser detector for
asynchronous DS-CDMA system. To meet the real-time
requirements for asynchronous multiuser detection, a bit streaming,
cascade architecture is used. An asynchronous multiuser detection
involves block-based computations and matrix inversions. The paper
covers iterative-based suboptimal schemes that have been studied to
decrease the computational complexity, eliminate the need for matrix
inversions, decreases the execution time, reduces the memory
requirements and uses joint estimation and detection process that
gives better performance than the independent parameter estimation
method. The stages of the iteration use cascaded and bits processed
in a streaming fashion. The simulation has been carried out for
asynchronous DS-CDMA system by varying one parameter, i.e.,
number of users. The simulation result exhibits that system gives
optimum bit error rate (BER) at 3rd stage for 15-users.
Abstract: Multiple-Input-Multiple-Output (MIMO) is one of the most important communication techniques that allow wireless systems to achieve higher data rate. To overcome the practical difficulties in implementing Dirty Paper Coding (DPC), various suboptimal MIMO Broadcast (MIMO-BC) scheduling algorithms are employed which choose the best set of users among all the users. In this paper we discuss such a sub-optimal MIMO-BC scheduling algorithm which employs antenna selection at the receiver side. The channels for the users considered here are not Identical and Independent Distributed (IID) so that users at the receiver side do not get equal opportunity for communication. So we introduce a method of applying weights to channels of the users which are not IID in such a way that each of the users gets equal opportunity for communication. The effect of weights on overall sum-rate achieved by the system has been investigated and presented.
Abstract: Renewed interest in propeller propulsion on aircraft
configurations combined with higher propeller loads lead to the question how the effects of the propulsion on model support disturbances
should be accounted for. In this paper, the determination of engine power effects on support interference of sting-mounted models is
demonstrated by a measurement on a four-engine turboprop aircraft.
CFD results on a more generic model are presented in order to clarify
the possible mechanism behind engine power effects on support
interference. The engine slipstream induces a local change in angle
of sideslip at the model sting thereby influencing the sting near-field and far-field effects. Whether or not the net result of these changes
in the disturbance pattern leads to a significant engine power effect depends on the configuration of the wind tunnel model and the test
setup.
Abstract: In this paper we consider a nonlinear feedback control
called augmented automatic choosing control (AACC) using the
gradient optimization automatic choosing functions for nonlinear
systems. Constant terms which arise from sectionwise linearization
of a given nonlinear system are treated as coefficients of a stable
zero dynamics. Parameters included in the control are suboptimally
selected by expanding a stable region in the sense of Lyapunov
with the aid of the genetic algorithm. This approach is applied to
a field excitation control problem of power system to demonstrate
the splendidness of the AACC. Simulation results show that the new
controller can improve performance remarkably well.
Abstract: With the rapid popularization of internet services, it is apparent that the next generation terrestrial communication systems must be capable of supporting various applications like voice, video, and data. This paper presents the performance evaluation of turbo- coded mobile terrestrial communication systems, which are capable of providing high quality services for delay sensitive (voice or video) and delay tolerant (text transmission) multimedia applications in urban and suburban areas. Different types of multimedia information require different service qualities, which are generally expressed in terms of a maximum acceptable bit-error-rate (BER) and maximum tolerable latency. The breakthrough discovery of turbo codes allows us to significantly reduce the probability of bit errors with feasible latency. In a turbo-coded system, a trade-off between latency and BER results from the choice of convolutional component codes, interleaver type and size, decoding algorithm, and the number of decoding iterations. This trade-off can be exploited for multimedia applications by using optimal and suboptimal performance parameter amalgamations to achieve different service qualities. The results are therefore proposing an adaptive framework for turbo-coded wireless multimedia communications which incorporate a set of performance parameters that achieve an appropriate set of service qualities, depending on the application's requirements.
Abstract: Proteins levels produced by bacteria may be increased
in stressful surroundings, such as in the presence of antibiotics. It
appears that many antimicrobial agents or antibiotics, when used at
low concentrations, have in common the ability to activate or repress
gene transcription, which is distinct from their inhibitory effect.
There have been comparatively few studies on the potential of
antibiotics or natural compounds in nature as a specific chemical
signal that can trigger a variety of biological functions. Therefore,
this study was focusing on the effect of essential oils from
Cymbopogon flexuosus and C. nardus in regulating proteins
production by Bacillus subtilis ATCC 21332. The Minimum
Inhibition Concentrations (MICs) of both essential oils on B. subtilis
were determined by using microdilution assay, resulting 0.2% and
1.56% for each C. flexuosus and C. nardus subsequently. The
bacteria were further exposed to each essential oils at concentration
of 0.01XMIC for 2 days. The proteins were then isolated and
analyzed by sodium dodecyl sulfate polyacrylamide gel
electrophoresis (SDS-PAGE). Protein profile showed that a band
with approximate size of 250 kD was appeared for the treated
bacteria with essential oils. Thus, Bacillus subtilis ATCC 21332 in
stressful condition with the presence of essential oils at low
concentration could induce the protein production.
Abstract: Real options theory suggests that managerial flexibility embedded within irreversible investments can account for a significant value in project valuation. Although the argument has become the dominant focus of capital investment theory over decades, yet recent survey literature in capital budgeting indicates that corporate practitioners still do not explicitly apply real options in investment decisions. In this paper, we explore how real options decision criteria can be transformed into equivalent capital budgeting criteria under the consideration of uncertainty, assuming that underlying stochastic process follows a geometric Brownian motion (GBM), a mixed diffusion-jump (MX), or a mean-reverting process (MR). These equivalent valuation techniques can be readily decomposed into conventional investment rules and “option impacts", the latter of which describe the impacts on optimal investment rules with the option value considered. Based on numerical analysis and Monte Carlo simulation, three major findings are derived. First, it is shown that real options could be successfully integrated into the mindset of conventional capital budgeting. Second, the inclusion of option impacts tends to delay investment. It is indicated that the delay effect is the most significant under a GBM process and the least significant under a MR process. Third, it is optimal to adopt the new capital budgeting criteria in investment decision-making and adopting a suboptimal investment rule without considering real options could lead to a substantial loss in value.
Abstract: In this paper, a framework for the simplification and
standardization of metaheuristic related parameter-tuning by applying
a four phase methodology, utilizing Design of Experiments and
Artificial Neural Networks, is presented. Metaheuristics are multipurpose
problem solvers that are utilized on computational optimization
problems for which no efficient problem specific algorithm
exist. Their successful application to concrete problems requires the
finding of a good initial parameter setting, which is a tedious and
time consuming task. Recent research reveals the lack of approach
when it comes to this so called parameter-tuning process. In the
majority of publications, researchers do have a weak motivation for
their respective choices, if any. Because initial parameter settings
have a significant impact on the solutions quality, this course of
action could lead to suboptimal experimental results, and thereby
a fraudulent basis for the drawing of conclusions.
Abstract: This paper presents the application of an enhanced
Particle Swarm Optimization (EPSO) combined with Gaussian
Mutation (GM) for solving the Dynamic Economic Dispatch (DED)
problem considering the operating constraints of generators. The
EPSO consists of the standard PSO and a modified heuristic search
approaches. Namely, the ability of the traditional PSO is enhanced
by applying the modified heuristic search approach to prevent the
solutions from violating the constraints. In addition, Gaussian
Mutation is aimed at increasing the diversity of global search, whilst
it also prevents being trapped in suboptimal points during search. To
illustrate its efficiency and effectiveness, the developed EPSO-GM
approach is tested on the 3-unit and 10-unit 24-hour systems
considering valve-point effect. From the experimental results, it can
be concluded that the proposed EPSO-GM provides, the accurate
solution, the efficiency, and the feature of robust computation
compared with other algorithms under consideration.