Abstract: Information in the nervous system is coded as firing patterns of electrical signals called action potential or spike so an essential step in analysis of neural mechanism is detection of action potentials embedded in the neural data. There are several methods proposed in the literature for such a purpose. In this paper a novel method based on empirical mode decomposition (EMD) has been developed. EMD is a decomposition method that extracts oscillations with different frequency range in a waveform. The method is adaptive and no a-priori knowledge about data or parameter adjusting is needed in it. The results for simulated data indicate that proposed method is comparable with wavelet based methods for spike detection. For neural signals with signal-to-noise ratio near 3 proposed methods is capable to detect more than 95% of action potentials accurately.
Abstract: Emerging Bio-engineering fields such as Brain
Computer Interfaces, neuroprothesis devices and modeling and
simulation of neural networks have led to increased research activity
in algorithms for the detection, isolation and classification of Action
Potentials (AP) from noisy data trains. Current techniques in the field
of 'unsupervised no-prior knowledge' biosignal processing include
energy operators, wavelet detection and adaptive thresholding. These
tend to bias towards larger AP waveforms, AP may be missed due to
deviations in spike shape and frequency and correlated noise
spectrums can cause false detection. Also, such algorithms tend to
suffer from large computational expense.
A new signal detection technique based upon the ideas of phasespace
diagrams and trajectories is proposed based upon the use of a
delayed copy of the AP to highlight discontinuities relative to
background noise. This idea has been used to create algorithms that
are computationally inexpensive and address the above problems.
Distinct AP have been picked out and manually classified from
real physiological data recorded from a cockroach. To facilitate
testing of the new technique, an Auto Regressive Moving Average
(ARMA) noise model has been constructed bases upon background
noise of the recordings. Along with the AP classification means this
model enables generation of realistic neuronal data sets at arbitrary
signal to noise ratio (SNR).