Abstract: Advanced head and neck cancers are aggressive
tumours, which require aggressive treatment. Treatment efficiency is
often hindered by cancer cell repopulation during radiotherapy,
which is due to various mechanisms triggered by the loss of tumour
cells and involves both stem and differentiated cells. The aim of the
current paper is to present in silico simulations of radiotherapy
schedules on a virtual head and neck tumour grown with biologically
realistic kinetic parameters. Using the linear quadratic formalism of
cell survival after radiotherapy, altered fractionation schedules
employing various treatment breaks for normal tissue recovery are
simulated and repopulation mechanism implemented in order to
evaluate the impact of various cancer cell contribution on tumour
behaviour during irradiation. The model has shown that the timing of
treatment breaks is an important factor influencing tumour control in
rapidly proliferating tissues such as squamous cell carcinomas of the
head and neck. Furthermore, not only stem cells but also
differentiated cells, via the mechanism of abortive division, can
contribute to malignant cell repopulation during treatment.
Abstract: Exact solution of an unsteady flow of elastico-viscous
fluid through a porous media in a tube of spherical cross section
under the influence of constant pressure gradient has been obtained in
this paper. Initially, the flow is generated by a constant pressure
gradient. After attaining the steady state, the pressure gradient is
suddenly withdrawn and the resulting fluid motion in a tube of
spherical cross section by taking into account of the porosity factor of
the bounding surface is investigated. The problem is solved in twostages
the first stage is a steady motion in tube under the influence of
a constant pressure gradient, the second stage concern with an
unsteady motion. The problem is solved employing separation of
variables technique. The results are expressed in terms of a nondimensional
porosity parameter (K) and elastico-viscosity parameter
(β), which depends on the Non-Newtonian coefficient. The flow
parameters are found to be identical with that of Newtonian case as
elastic-viscosity parameter tends to zero and porosity tends to
infinity. It is seen that the effect of elastico-viscosity parameter,
porosity parameter of the bounding surface has significant effect on
the velocity parameter.
Abstract: The California Bearing Ratio (CBR) has been
acknowledged as an important parameter to characterize the bearing
capacity of earth structures, such as earth dams, road embankments,
airport runways, bridge abutments and pavements. Technically, the
CBR test can be carried out in the laboratory or in the field. The CBR
test is time-consuming and is infrequently performed due to the
equipment needed and the fact that the field moisture content keeps
changing over time. Over the years, many correlations have been
developed for the prediction of CBR by various researchers,
including the dynamic cone penetrometer, undrained shear strength
and Clegg impact hammer. This paper reports and discusses some of
the results from a study on the prediction of CBR. In the current
study, the CBR test was performed in the laboratory on some finegrained
subgrade soils collected from various locations in Victoria.
Based on the test results, a satisfactory empirical correlation was
found between the CBR and the physical properties of the
experimental soils.
Abstract: This paper presents the details of a numerical study of
buckling and post buckling behaviour of laminated carbon fiber
reinforced plastic (CFRP) thin-walled cylindrical shell under axial
compression using asymmetric meshing technique (AMT) by
ABAQUS. AMT is considered to be a new perturbation method to
introduce disturbance without changing geometry, boundary
conditions or loading conditions. Asymmetric meshing affects both
predicted buckling load and buckling mode shapes. Cylindrical shell
having lay-up orientation [0^o/+45^o/-45^o/0^o] with radius to thickness
ratio (R/t) equal to 265 and length to radius ratio (L/R) equal to 1.5 is
analysed numerically. A series of numerical simulations
(experiments) are carried out with symmetric and asymmetric
meshing to study the effect of asymmetric meshing on predicted
buckling behaviour. Asymmetric meshing technique is employed in
both axial direction and circumferential direction separately using
two different methods, first by changing the shell element size and
varying the total number elements, and second by varying the shell
element size and keeping total number of elements constant. The
results of linear analysis (Eigenvalue analysis) and non-linear
analysis (Riks analysis) using symmetric meshing agree well with
analytical results. The results of numerical analysis are presented in
form of non-dimensional load factor, which is the ratio of buckling
load using asymmetric meshing technique to buckling load using
symmetric meshing technique. Using AMT, load factor has about 2%
variation for linear eigenvalue analysis and about 2% variation for
non-linear Riks analysis. The behaviour of load end-shortening curve
for pre-buckling is same for both symmetric and asymmetric meshing
but for asymmetric meshing curve behaviour in post-buckling
becomes extraordinarily complex. The major conclusions are:
different methods of AMT have small influence on predicted
buckling load and significant influence on load displacement curve
behaviour in post buckling; AMT in axial direction and AMT in
circumferential direction have different influence on buckling load
and load displacement curve in post-buckling.
Abstract: In this report we have discussed the theoretical aspects
of the flow transformation, occurring through a series of bifurcations.
The parameters and their continuous diversion, the intermittent bursts
in the transition zone, variation of velocity and pressure with time,
effect of roughness in turbulent zone, and changes in friction factor
and head loss coefficient as a function of Reynolds number for a
transverse flow across a cylinder have been discussed. An analysis of
the variation in the wake length with Reynolds number was done in
FORTRAN.
Abstract: Universal modeling method well proven for industrial
compressors was applied for design of the high flow rate supersonic
stage. Results were checked by ANSYS CFX and NUMECA Fine
Turbo calculations. The impeller appeared to be very effective at
transonic flow velocities. Stator elements efficiency is acceptable at
design Mach numbers too. Their loss coefficient versus inlet flow
angle performances correlates well with Universal modeling
prediction. The impeller demonstrates ability of satisfactory operation
at design flow rate. Supersonic flow behavior in the impeller inducer
at the shroud blade to blade surface Φ des deserves additional study.
Abstract: Many organizations bring e-Learning to use as a tool
in their training and human development department. It is getting
more popular because it is easy to access to get knowledge all the
time and also it provides a rich content, which can develop the
employees’ skill efficiently. This study is focused on the factors that
affect using e-Learning efficiently, so it will make job satisfaction
increasing. The questionnaires were sent to employees in large
commercial banks, which use e-Learning located in Bangkok, the
results from multiple linear regression analysis showed that
employee’s characteristics, characteristics of e-Learning, learning and
growth have influence on job satisfaction.
Abstract: The development, operation and maintenance of
Integrated Waste Management Systems (IWMS) affects essentially
the sustainable concern of every region. The features of such systems
have great influence on all of the components of sustainability. In
order to reach the optimal way of processes, a comprehensive
mapping of the variables affecting the future efficiency of the system
is needed such as analysis of the interconnections among the
components and modeling of their interactions. The planning of a
IWMS is based fundamentally on technical and economical
opportunities and the legal framework. Modeling the sustainability
and operation effectiveness of a certain IWMS is not in the scope of
the present research. The complexity of the systems and the large
number of the variables require the utilization of a complex approach
to model the outcomes and future risks. This complex method should
be able to evaluate the logical framework of the factors composing
the system and the interconnections between them. The authors of
this paper studied the usability of the Fuzzy Cognitive Map (FCM)
approach modeling the future operation of IWMS’s. The approach
requires two input data set. One is the connection matrix containing
all the factors affecting the system in focus with all the
interconnections. The other input data set is the time series, a
retrospective reconstruction of the weights and roles of the factors.
This paper introduces a novel method to develop time series by
content analysis.
Abstract: This study examines several critical dimensions of eservice
quality overlooked in the existing literature and proposes a
model and instrument framework for measuring customer perceived
e-service quality in the banking sector. The initial design was derived
from a pool of instrument dimensions and their items from the
existing literature review by content analysis. Based on focused
group discussion, nine dimensions were extracted. An exploratory
factor analysis approach was applied to data from a survey of 323
respondents. The instrument has been designed specifically for the
banking sector. Research data was collected from bank customers
who use electronic banking in a developing economy. A nine-factor
instrument has been proposed to measure the e-service quality. The
instrument has been checked for reliability. The validity and sample
place limited the applicability of the instrument across economies and
service categories. Future research must be conducted to check the
validity. This instrument can help bankers in developing economies
like India to measure the e-service quality and make improvements.
The present study offers a systematic procedure that provides insights
on to the conceptual and empirical comprehension of customer
perceived e-service quality and its constituents.
Abstract: In medical imaging, segmentation of different areas of
human body like bones, organs, tissues, etc. is an important issue.
Image segmentation allows isolating the object of interest for further
processing that can lead for example to 3D model reconstruction of
whole organs. Difficulty of this procedure varies from trivial for
bones to quite difficult for organs like liver. The liver is being
considered as one of the most difficult human body organ to segment.
It is mainly for its complexity, shape versatility and proximity of
other organs and tissues. Due to this facts usually substantial user
effort has to be applied to obtain satisfactory results of the image
segmentation. Process of image segmentation then deteriorates from
automatic or semi-automatic to fairly manual one. In this paper,
overview of selected available software applications that can handle
semi-automatic image segmentation with further 3D volume
reconstruction of human liver is presented. The applications are being
evaluated based on the segmentation results of several consecutive
DICOM images covering the abdominal area of the human body.
Abstract: In this paper a real-time obstacle avoidance approach
for both autonomous and non-autonomous dynamical systems (DS) is
presented. In this approach the original dynamics of the controller
which allow us to determine safety margin can be modulated.
Different common types of DS increase the robot’s reactiveness in
the face of uncertainty in the localization of the obstacle especially
when robot moves very fast in changeable complex environments.
The method is validated by simulation and influence of different
autonomous and non-autonomous DS such as important
characteristics of limit cycles and unstable DS. Furthermore, the
position of different obstacles in complex environment is explained.
Finally, the verification of avoidance trajectories is described through
different parameters such as safety factor.
Abstract: In this paper, Bayesian online inference in models of
data series are constructed by change-points algorithm, which
separated the observed time series into independent series and study
the change and variation of the regime of the data with related
statistical characteristics. variation of statistical characteristics of time
series data often represent separated phenomena in the some
dynamical system, like a change in state of brain dynamical reflected
in EEG signal data measurement or a change in important regime of
data in many dynamical system. In this paper, prediction algorithm
for studying change point location in some time series data is
simulated. It is verified that pattern of proposed distribution of data
has important factor on simpler and smother fluctuation of hazard
rate parameter and also for better identification of change point
locations. Finally, the conditions of how the time series distribution
effect on factors in this approach are explained and validated with
different time series databases for some dynamical system.
Abstract: In Brazil, neonatal mortality rate is considered
incompatible with the country development conditions, and has been
a Public Health concern. Reduction in infant mortality rates has also
been part of the Millennium Development Goals, a commitment
made by countries, members of the Organization of United Nations
(OUN), including Brazil. Fetal mortality rate is considered a highly
sensitive indicator of health care quality. Suitable actions, such as
good quality and access to health services may contribute positively
towards reduction in these fetal and neonatal rates. With appropriate
antenatal follow-up and health care during gestation and delivery,
some death causes could be reduced or even prevented by means of
early diagnosis and intervention, as well as changes in risk factors
and interventions. Objectives: To study the quality of maternal and
infant health care based on fetal and neonatal mortality, as well as the
possible actions to prevent those deaths in Botucatu (Brazil).
Methods: Classification of prevention according to the International
Classification of Diseases and the modified Wigglesworth´s
classification. In order to evaluate adequacy, indicators of quality of
antenatal and delivery care were established by the authors. Results:
Considering fetal deaths, 56.7% of them occurred before delivery,
which reveals possible shortcomings in antenatal care, and 38.2% of
them were a result of intra- labor changes, which could be prevented
or reduced by adequate obstetric management. These findings were
different from those in the group of early neonatal deaths which were
also studied. Adequacy of health services showed that antenatal and
childbirth care was appropriate for 24% and 33.3% of pregnant
women, respectively, which corroborates the results of prevention.
These results revealed that shortcomings in obstetric and antenatal
care could be the causes of deaths in the study. Early and late
neonatal deaths have similar characteristics: 76% could be prevented
or reduced mainly by adequate newborn care (52.9%) and adequate
health care for gestational women (11.7%). When adequacy of care
was evaluated, childbirth and newborn care was adequate in 25.8%
and antenatal care was adequate in 16.1%. In conclusion, direct
relationship was found between adequacy and quality of care
rendered to pregnant women and newborns, and fetal and infant
mortality. Moreover, our findings highlight that deaths could be
prevented by an adequate obstetric and neonatal management.
Abstract: Negative pressure phenomenon appears in many
thermodynamic, geophysical and biophysical processes in the Nature
and technological systems. For more than 100 years of the laboratory
researches beginning from F. M. Donny’s tests, the great values of
negative pressure have been achieved. But this phenomenon has not
been practically applied, being only a nice lab toy due to the special
demands for the purity and homogeneity of the liquids for its
appearance. The possibility of creation of direct wave of negative
pressure in real heterogeneous liquid systems was confirmed
experimentally under the certain kinetic and hydraulic conditions.
The negative pressure can be considered as the factor of both useful
and destroying energies. The new approach to generation of the
negative pressure waves in impure, unclean fluids has allowed the
creation of principally new energy saving technologies and
installations to increase the effectiveness and efficiency of different
production processes. It was proved that the negative pressure is one
of the main factors causing hard troubles in some technological and
natural processes. Received results emphasize the necessity to take
into account the role of the negative pressure as an energy factor in
evaluation of many transient thermohydrodynamic processes in the
Nature and production systems.
Abstract: Risperidone (RISP) is an antipsychotic agent and has
low water solubility and nontargeted delivery results in numerous
side effects. Hence, an attempt was made to develop SLNs hydrogel
for intranasal delivery of RISP to achieve maximum bioavailability
and reduction of side effects. RISP loaded SLNs composed of 1.65%
(w/v) lipid mass were produced by high shear homogenization (HSH)
coupled ultrasound (US) method using glycerylmonostearate (GMS)
or Imwitor 900K (solid lipid). The particles were loaded with 0.2%
(w/v) of the RISP & surface-tailored with a 2.02% (w/v) non-ionic
surfactant Tween® 80. Optimization was done using 32 factorial
design using Design Expert® software. The prepared SLNs
dispersion incorporated into Polycarbophil AA1 hydrogel (0.5%
w/v). The final gel formulation was evaluated for entrapment
efficiency, particle size, rheological properties, X ray diffraction, in
vitro diffusion, ex vivo permeation using sheep nasal mucosa and
histopathological studies for nasocilliary toxicity. The entrapment
efficiency of optimized SLNs was found to be 76 ± 2%,
polydispersity index
Abstract: The research was conducted to empirically validate
the proposed maturity model of e-Government implementation,
composed of four dimensions, further specified by 54 success factors
as attributes. To do so, there are two steps were performed. First,
expert’s judgment was conducted to test its content validity. The
second, reliability study was performed to evaluate inter-rater
agreement by using Fleiss Kappa approach. The kappa statistic
(kappa coefficient) is the most commonly used method for testing the
consistency among raters. Fleiss Kappa was a generalization of
Kappa in extensions to the case of more than two raters (multiple
raters) with multi-categorical ratings. Our findings show that most
attributes of the proposed model were related to their corresponding
dimensions. According to our results, The percentage of agree
answers given by the experts was 73.69% in dimension A, 89.76% in
B, 81.5% in C and 60.37% in D. This means that more than half of
the attributes of each dimensions were appropriate or relevant to the
dimensions they were supposed to measure, while 85% of attributes
were relevant enough to their corresponding dimensions. Inter-rater
reliability coefficient also showed satisfactory result and interpreted
as substantial agreement among raters. Therefore, the proposed
model in this paper was valid and reliable to measure the maturity of
e-Government implementation.
Abstract: An existing RC building in Madinah is seismically
evaluated with and without infill wall. Four model systems have been
considered i.e. model I (no infill), model IIA (strut infill-update from
field test), model IIB (strut infill- ASCE/SEI 41) and model IIC (strut
infill-Soft storey- ASCE/SEI 41). Three dimensional pushover
analyses have been carried out using SAP2000 software
incorporating inelastic material behavior for concrete, steel and infill
walls. Infill wall has been modeled as equivalent strut according to
suggested equation matching field test measurements and to the
ASCE/SEI 41 equation. The effect of building modeling on the
performance point as well as capacity and demand spectra due to EQ
design spectrum function in Madinah area has been investigated. The
response modification factor (R) for the 5 story RC building is
evaluated from capacity and demand spectra (ATC-40) for the
studied models. The results are summarized and discussed.
Abstract: Rotary draw bending is a method which is being used
in tube forming. In the tube bending process, the neutral axis moves
towards the inner arc and the wall thickness distribution changes for
tube’s cross section. Thinning takes place in the outer arc of the tube
(extrados) due to the stretching of the material, whereas thickening
occurs in the inner arc of the tube (intrados) due to the comparison of
the material. The calculations of the wall thickness distribution,
neutral axis shifting, and strain distribution have not been accurate
enough, so far. The previous model (the geometrical model)
describes the neutral axis shifting and wall thickness distribution. The
geometrical of the tube, bending radius and bending angle are
considered in the geometrical model, while the influence of the
material properties of the tube forming are ignored. The advanced
model is a modification of the previous model using material
properties that depends on the correction factor. The correction factor
is a purely empirically determined factor. The advanced model was
compared with the Finite element simulation (FE simulation) using a
different bending factor (Bf =bending radius/ diameter of the tube),
wall thickness (Wf = diameter of the tube/ wall thickness), and
material properties (strain hardening exponent). Finite element model
of rotary draw bending has been performed in PAM-TUBE program
(version: 2012). Results from the advanced model resemble the FE
simulation and the experimental test.
Abstract: For cycling, the analysis of the pedal force is one of the
important factors in the study of exercise ability assessment and
overuse injuries. In past studies, a two-axis measurement sensor was
used at the sagittal plane to measure the force only in the anterior,
posterior, and vertical directions and to analyze the loss of force and
the injury on the frontal plane due to the forces in the right and left
directions. In this study, which is a basic study on diverse analyses of
the pedal force that consider the forces on the sagittal plane and the
frontal plane, a three-axis pedal force measurement sensor was
developed to measure the anterior-posterior (Fx), medio-lateral (Fz),
and vertical (Fy) forces. The sensor was fabricated with a size and
shape similar to those of the general flat pedal, and had a 550g weight
that allowed smooth pedaling. Its measurement range was ±1000 N for
Fx and Fz and ±2000 N for Fy, and its non-linearity, hysteresis, and
repeatability were approximately 0.5%. The data were sampled at
1000 Hz using a signal collector. To use the developed sensor, the
pedaling efficiency (index of efficiency, IE) and the range of left and
right (medio-lateral, ML) forces were measured with two seat heights
(low and high). The results of the measurement showed that the IE was
higher and the force range in the ML direction was lower with the high
position than with the low position. The developed measurement
sensor and its application results will be useful in understanding and
explaining the complicated pedaling technique, and will enable
diverse kinematic analyses of the pedal force on the sagittal plane and
the frontal plane.
Abstract: The design, manufacture, and operation of thin-walled
pressure vessels must be based on maximum safe operating pressure
and an adequate factor of safety (FoS). This research paper first
reports experimental evaluation of longitudinal and hoops stresses
based on working pressure as well as maximum pressure; and then
includes a critical study of factor of safety (FoS) in the design of a
glass fiber pressure vessel. Experimental work involved the use of
measuring instruments and the readings from pressure gauges.
Design calculations involved the computations of design stress and
FoS; the latter was based on breaking strength of 55 MPa for the
glass fiber (pressure-vessel material). The experimentally determined
FoS value has been critically compared with the general FoS allowed
in the design of glass fiber pressure vessels.