Abstract: The small interfering RNA (siRNA) alters the
regulatory role of mRNA during gene expression by translational
inhibition. Recent studies show that upregulation of mRNA because
serious diseases like cancer. So designing effective siRNA with good
knockdown effects plays an important role in gene silencing. Various
siRNA design tools had been developed earlier. In this work, we are
trying to analyze the existing good scoring second generation siRNA
predicting tools and to optimize the efficiency of siRNA prediction
by designing a computational model using Artificial Neural Network
and whole stacking energy (%G), which may help in gene silencing
and drug design in cancer therapy. Our model is trained and tested
against a large data set of siRNA sequences. Validation of our results
is done by finding correlation coefficient of experimental versus
observed inhibition efficacy of siRNA. We achieved a correlation
coefficient of 0.727 in our previous computational model and we
could improve the correlation coefficient up to 0.753 when the
threshold of whole tacking energy is greater than or equal to -32.5
kcal/mol.
Abstract: Unsteady natural convection and heat transfer in a square cavity partially filled with porous media using a thermal
non-equilibrium model is studied in this paper. The left vertical wall is
maintained at a constant hot temperature Th and the right vertical wall
is maintained at a constant cold temperature Tc, while the horizontal
walls are adiabatic. The governing equations are obtained by applying
the Darcy model and Boussinesq approximation. COMSOL’s finite
element method is used to solve the non-dimensional governing
equations together with specified boundary conditions. The governing
parameters of this study are the Rayleigh number (Ra = 10^5, and Ra = 10^6 ), Darcy namber (Da = 10^−2, and Da = 10^−3),
the modified thermal conductivity ratio (10^−1 ≤ γ ≤ 10^4), the inter-phase heat transfer coefficien (10^−1 ≤ H ≤ 10^3) and the
time dependent (0.001 ≤ τ ≤ 0.2). The results presented for
values of the governing parameters in terms of streamlines in both
fluid/porous-layer, isotherms of fluid in fluid/porous-layer, isotherms
of solid in porous layer, and average Nusselt number.
Abstract: A new approach to determine the machine layout in flexible manufacturing cell, and to find the feasible robot configuration of the robot to achieve minimum cycle time is presented in this paper. The location of the input/output location and the optimal robot configuration is obtained for all sequences of work tasks of the robot within a specified period of time. A more realistic approach has been presented to model the problem using the robot joint space. The problem is formulated as a nonlinear optimization problem and solved using Sequential Quadratic Programming algorithm.
Abstract: Equations on curved manifolds display interesting properties in a number of ways. In particular, the symmetries and, therefore, the conservation laws reduce depending on how curved the manifold is. Of particular interest are the wave and Gordon-type equations; we study the symmetry properties and conservation laws of these equations on the Milne and Bianchi type III metrics. Properties of reduction procedures via symmetries, variational structures and conservation laws are more involved than on the well known flat (Minkowski) manifold.
Abstract: The world wide web coupled with the ever-increasing
sophistication of online technologies and software applications puts
greater emphasis on the need of even more sophisticated and
consistent quality requirements modeling than traditional software
applications. Web sites and Web applications (WebApps) are
becoming more information driven and content-oriented raising the
concern about their information quality (InQ). The consistent and
consolidated modeling of InQ requirements for WebApps at different
stages of the life cycle still poses a challenge. This paper proposes an
approach to specify InQ requirements for WebApps by reusing and
extending the ISO 25012:2008(E) data quality model. We also
discuss learnability aspect of information quality for the WebApps.
The proposed ISO 25012 based InQ framework is a step towards a
standardized approach to evaluate WebApps InQ.
Abstract: Environmental investments, including ecological
projects, relating to the protection of atmosphere are today a need.
However, investing in the environment should be based on rational
management rules. This comes across a problem of selecting a
method to assess substances reduced during projects. Therefore, a
method allowing for the assessment of decision rationality has to be
found.
The purpose of this article is to present and systematise pollution
reduction assessment methods and illustrate theoretical analyses with
empirical data.
Empirical results confirm theoretical considerations, which proved
that the only method for judging pollution reduction, free of apparent
disadvantages, is the Eco 99-ratio method. To make decisions on
environmental projects, financing institutions should take into
account a rationality rule. Therefore the Eco 99-ratio method could
be applied to make decisions relating to environmental investments in
the area of air protection.
Abstract: One of the common problems encountered in software
engineering is addressing and responding to the changing nature of
requirements. While several approaches have been devised to address
this issue, ranging from instilling resistance to changing requirements
in order to mitigate impact to project schedules, to developing an
agile mindset towards requirements, the approach discussed in this
paper is one of conceptualizing the delta in requirement and
modeling it, in order to plan a response to it. To provide some
context here, change is first formally identified and categorized as
either formal change or informal change. While agile methodology
facilitates informal change, the approach discussed in this paper
seeks to develop the idea of facilitating formal change. To collect,
document meta-requirements that represent the phenomena of change
would be a pro-active measure towards building a realistic cognition
of the requirements entity that can further be harnessed in the
software engineering process.
Abstract: The aim of this study was to develop a storm water quality improvement strategy plan (WQISP) which assists managers and decision makers of local city councils in enhancing their activities to improve regional water quality. City of Gosnells in Western Australia has been considered as a case study. The procedure on developing the WQISP consists of reviewing existing water quality data, identifying water quality issues in the study areas and developing a decision making tool for the officers, managers and decision makers. It was found that land use type is the main factor affecting the water quality. Therefore, activities, sources and pollutants related to different land use types including residential, industrial, agricultural and commercial are given high importance during the study. Semi-structured interviews were carried out with coordinators of different management sections of the regional councils in order to understand the associated management framework and issues. The issues identified from these interviews were used in preparing the decision making tool. Variables associated with the defined “value versus threat" decision making tool are obtained from the intensive literature review. The main recommendations provided for improvement of water quality in local city councils, include non-structural, structural and management controls and potential impacts of climate change.
Abstract: Location-aware computing is a type of pervasive
computing that utilizes user-s location as a dominant factor for
providing urban services and application-related usages. One of the
important urban services is navigation instruction for wayfinders in a
city especially when the user is a tourist. The services which are
presented to the tourists should provide adapted location aware
instructions. In order to achieve this goal, the main challenge is to
find spatial relevant objects and location-dependent information. The
aim of this paper is the development of a reusable location-aware
model to handle spatial relevancy parameters in urban location-aware
systems. In this way we utilized ontology as an approach which could
manage spatial relevancy by defining a generic model. Our
contribution is the introduction of an ontological model based on the
directed interval algebra principles. Indeed, it is assumed that the
basic elements of our ontology are the spatial intervals for the user
and his/her related contexts. The relationships between them would
model the spatial relevancy parameters. The implementation language
for the model is OWLs, a web ontology language. The achieved
results show that our proposed location-aware model and the
application adaptation strategies provide appropriate services for the
user.
Abstract: A new and cost effective robotic device was designed
for remote tele surgery using dual tone multi frequency technology
(DTMF). Tele system with Dual Tone Multiple Frequency has a large
capability in sending and receiving of data in hardware and software.
The robot consists of DC motors for arm movements and it is
controlled manually through a mobile phone through DTMF
Technology. The system enables the surgeon from base station to
send commands through mobile phone to the patient’s robotic system
which includes two robotic arms that translate the input into actual
instrument manipulation. A mobile phone attached to the
microcontroller 8051 which can activate robot through relays. The
Remote robot-assisted tele surgery eliminates geographic constraints
for getting surgical expertise where it is needed and allows an expert
surgeon to teach or proctor the performance of surgical technique by
real-time intervention.
Abstract: In order to accelerate the similarity search in highdimensional database, we propose a new hierarchical indexing method. It is composed of offline and online phases. Our contribution concerns both phases. In the offline phase, after gathering the whole of the data in clusters and constructing a hierarchical index, the main originality of our contribution consists to develop a method to construct bounding forms of clusters to avoid overlapping. For the online phase, our idea improves considerably performances of similarity search. However, for this second phase, we have also developed an adapted search algorithm. Our method baptized NOHIS (Non-Overlapping Hierarchical Index Structure) use the Principal Direction Divisive Partitioning (PDDP) as algorithm of clustering. The principle of the PDDP is to divide data recursively into two sub-clusters; division is done by using the hyper-plane orthogonal to the principal direction derived from the covariance matrix and passing through the centroid of the cluster to divide. Data of each two sub-clusters obtained are including by a minimum bounding rectangle (MBR). The two MBRs are directed according to the principal direction. Consequently, the nonoverlapping between the two forms is assured. Experiments use databases containing image descriptors. Results show that the proposed method outperforms sequential scan and SRtree in processing k-nearest neighbors.
Abstract: Land surface temperature (LST) is an important
parameter to study in urban climate. The understanding of the
influence of biophysical factors could improve the establishment of
modeling urban thermal landscape. It is well established that climate
hold a great influence on the urban landscape. However, it has been
recognize that climate has a low priority in urban planning process,
due to the complex nature of its influence. This study will focus on
the relatively cloud free Landsat Thematic Mapper image of the study
area, acquired on the 2nd March 2006. Correlation analyses were
conducted to identify the relationship of LST to the biophysical
factors; vegetation indices, impervious surface, and albedo to
investigate the variation of LST. We suggest that the results can be
considered by the stackholders during decision-making process to
create a cooler and comfortable environment in the urban landscape
for city dwellers.
Abstract: Government spending is categorized into consumption spending and capital spending. Three categories of private consumption are used: food consumption, nonfood consumption, and services consumption. The estimated model indicates substitution effects of government consumption spending on budget shares of private nonfood consumption and of government capital spending on budget share of private food consumption. However, the results do not indicate whether the negative effects of changes in the budget shares of the nonfood and the food consumption equates to reduce total private consumption. The concept of aggregate demand comprising consumption, investment, government spending (consumption spending and capital spending), export, and import are used to estimate their relationship by using the Vector Error Correction Mechanism. The study found no effect of government capital spending on either the private consumption or the growth of GDP while the government consumption spending has negative effect on the growth of GDP.
Abstract: The purpose of this research is to study the concepts
of multiple Cartesian product, variety of multiple algebras and to
present some examples. In the theory of multiple algebras, like other
theories, deriving new things and concepts from the things and
concepts available in the context is important. For example, the first
were obtained from the quotient of a group modulo the equivalence
relation defined by a subgroup of it. Gratzer showed that every
multiple algebra can be obtained from the quotient of a universal
algebra modulo a given equivalence relation.
The purpose of this study is examination of multiple algebras and
basic relations defined on them as well as introduction to some
algebraic structures derived from multiple algebras. Among the
structures obtained from multiple algebras, this article studies submultiple
algebras, quotients of multiple algebras and the Cartesian
product of multiple algebras.
Abstract: Through the course of this paper we define Locationbased
Intelligence (LBI) which is outgrowing from process of
amalgamation of geolocation and Business Intelligence.
Amalgamating geolocation with traditional Business Intelligence (BI)
results in a new dimension of BI named Location-based Intelligence.
LBI is defined as leveraging unified location information for business
intelligence. Collectively, enterprises can transform location data into
business intelligence applications that will benefit all aspects of the
enterprise. Expectations from this new dimension of business
intelligence are great and its future is obviously bright.
Abstract: The antimicrobial, antiplasmid and cytotoxic activities of marine algae Halimeda opuntia and Sarconema filiforme were investigated. Antimicrobial bioassay against some human pathogenic bacteria and yeast were conducted using disc diffusion method. Halimeda extract exhibited antibacterial activity against six species of microrganisms, with significant inhibition against Staphylococcus aureus. While Sarconema extract was better potent as antifungal against Candida albicans. Comparative antibacterial studies showed that Halimeda extract showed equivalent or better activity as compared with commercial antibiotic when tested against Staphylococcus aureus. Further tests conducted using dilution method showed both extracts as having bacteriostatic mode of action against the tested microorganisms. Methanol extract of two species showed significant cytotoxicity (LC50
Abstract: To determine the presence and location of faults in a transmission by the adaptation of protective distance relay based on the measurement of fixed settings as line impedance is achieved by several different techniques. Moreover, a fast, accurate and robust technique for real-time purposes is required for the modern power systems. The appliance of radial basis function neural network in transmission line protection is demonstrated in this paper. The method applies the power system via voltage and current signals to learn the hidden relationship presented in the input patterns. It is experiential that the proposed technique is competent to identify the particular fault direction more speedily. System simulations studied show that the proposed approach is able to distinguish the direction of a fault on a transmission line swiftly and correctly, therefore suitable for the real-time purposes.
Abstract: The identification and classification of weeds are of
major technical and economical importance in the agricultural
industry. To automate these activities, like in shape, color and
texture, weed control system is feasible. The goal of this paper is to
build a real-time, machine vision weed control system that can detect
weed locations. In order to accomplish this objective, a real-time
robotic system is developed to identify and locate outdoor plants
using machine vision technology and pattern recognition. The
algorithm is developed to classify images into broad and narrow class
for real-time selective herbicide application. The developed
algorithm has been tested on weeds at various locations, which have
shown that the algorithm to be very effectiveness in weed
identification. Further the results show a very reliable performance
on weeds under varying field conditions. The analysis of the results
shows over 90 percent classification accuracy over 140 sample
images (broad and narrow) with 70 samples from each category of
weeds.
Abstract: A facile vapour deposition method of synthesis of vertically aligned ZnO nanowires on carbon seed layer was developed. The received samples were investigated on electronic microscope JSM-6490 LA JEOL and x-ray diffractometer X, pert MPD PRO. The photoluminescence spectra (PL) of obtained ZnO samples at a room temperature were studied using He-Cd laser (325 nm line) as excitation source.
Abstract: Fatigue life prediction and evaluation are the key
technologies to assure the safety and reliability of automotive rubber
components. The objective of this study is to develop the fatigue
analysis process for vulcanized rubber components, which is
applicable to predict fatigue life at initial product design step. Fatigue
life prediction methodology of vulcanized natural rubber was
proposed by incorporating the finite element analysis and fatigue
damage parameter of maximum strain appearing at the critical location
determined from fatigue test. In order to develop an appropriate
fatigue damage parameter of the rubber material, a series of
displacement controlled fatigue test was conducted using threedimensional
dumbbell specimen with different levels of mean
displacement. It was shown that the maximum strain was a proper
damage parameter, taking the mean displacement effects into account.
Nonlinear finite element analyses of three-dimensional dumbbell
specimens were performed based on a hyper-elastic material model
determined from the uni-axial tension, equi-biaxial tension and planar
test. Fatigue analysis procedure employed in this study could be used
approximately for the fatigue design.