Abstract: Bones are dynamic and responsive organs, they
regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/β-catenin pathway has profound
effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/β-catenin signaling, which results in the generation of new bone mass.
Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3β (Glycogen synthase kinase 3 beta) to cease the phosphorylation of β-catenin. β-catenin accumulation in the cytoplasm, followed by its
transport into the nucleus, binding to transcription factors (TCF/LEF)
that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter
β-galactosidase) mice in an experiment in which cyclic loads were
applied to the forearm. TOPGAL mice are reporters for cells effected
by the Wnt/β-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of β-
catenin, results in the production of an enzyme, β-galactosidase. The
presence of this enzyme allows us to localize transcriptional
activation of β-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/β-catenin pathway and new bone formation. The ulnae of loaded TOPGAL
mice were excised and transverse slices along different parts of the
ulnar shaft were assayed for the presence of β-galactosidase.
Our results indicate that loading increases β-catenin transcriptional
activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent
manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation.
Abstract: Fatigue cracking continues to be the main challenges in
improving the performance of bituminous mixture pavements. The
purpose of this paper is to look at some aspects of the effects of fine
aggregate properties on the fatigue behaviour of hot mixture asphalt.
Two types of sand (quarry and mining sand) with two conventional
bitumen (PEN 50/60 & PEN 80/100) and four polymers modified
bitumen PMB (PM1_82, PM1_76, PM2_82 and PM2_76) were used.
Physical, chemical and mechanical tests were performed on the sands
to determine their effect when incorporated with a bituminous
mixture. According to the beam fatigue results, quarry sand that has
more angularity, rougher, higher shear strength and a higher
percentage of Aluminium oxide presented higher resistance to
fatigue. Also a PMB mixture gives better fatigue results than
conventional mixtures, this is due to the PMB having better viscosity
property than that of the conventional bitumen.
Abstract: This paper argues that networks, such as the ECN and the American network, are affected by certain small events which are inherent to path dependence and preclude the full evolution towards efficiency. It is advocated that the American network is superior to the ECN in many respects due to its greater flexibility and longer history. This stems in particular from the creation of the American network, which was based on a small number of cases. Such a structure encourages further changes and modifications which are not necessarily radical. The ECN, by contrast, was established by legislative action, which explains its rigid structure and resistance to change. This paper is an attempt to transpose the superiority of the American network on to the ECN. It looks at concepts such as judicial cooperation, harmonisation of procedure, peer review and regulatory impact assessments (RIAs), and dispute resolution procedures.
Abstract: In this study, a longitudinal joint connection was
proposed for the short-span slab-type modular bridges with rapid
construction. The slab-type modular bridge consists of a number of
precast slab modules and has the joint connection between the
modules in the longitudinal direction of the bridge. A finite element
based parameter analysis was conducted to design the shape and the
dimensions of the longitudinal joint connection. Numbers of shear
keys within the joint, height and depth of the shear key, tooth angle,
and the spacing were considered as the design parameters. Using the
local cracking load at the corner of the shear key and the
cross-sectional area of the joint, an efficiency factor was proposed to
evaluate the effectiveness of the longitudinal joint connection. The
dimensions of shear key were determined by comparing the cracking
loads and the efficiency factors obtained from the finite element
analysis.
Abstract: In this paper, we investigate the strategic stochastic air traffic flow management problem which seeks to balance airspace capacity and demand under weather disruptions. The goal is to reduce the need for myopic tactical decisions that do not account for probabilistic knowledge about the NAS near-future states. We present and discuss a scenario-based modeling approach based on a time-space stochastic process to depict weather disruption occurrences in the NAS. A solution framework is also proposed along with a distributed implementation aimed at overcoming scalability problems. Issues related to this implementation are also discussed.
Abstract: The possibility of using cassava residue containing
49.66% starch, 21.47% cellulose, 12.97% hemicellulose, and 21.86%
lignin as a raw material to produce glucose using enzymatic
hydrolysis was investigated. In the experiment, each reactor
contained the cassava residue, bacteria cells, and production medium.
The effects of particles size (40 mesh and 60 mesh) and strains of
bacteria (A002 and M015) isolated from Thai higher termites,
Microcerotermes sp., on the glucose concentration at 37°C were
focused. High performance liquid chromatography (HPLC) with a
refractive index detector was used to determine the quantity of
glucose. The maximum glucose concentration obtained at 37°C using
strain A002 and 60 mesh of the cassava residue was 1.51 g/L at 10 h.
Abstract: PDMS (Polydimethylsiloxane) polymer is a suitable material for biological and MEMS (Microelectromechanical systems) designers, because of its biocompatibility, transparency and high resistance under plasma treatment. PDMS round channel is always been of great interest due to its ability to confine the liquid with membrane type micro valves. In this paper we are presenting a very simple way to form round shapemicrofluidic channel, which is based on reflow of positive photoresist AZ® 40 XT. With this method, it is possible to obtain channel of different height simply by varying the spin coating parameters of photoresist.
Abstract: Studies on Simultaneous Saccharification and Fermentation (SSF) of corn flour, a major agricultural product as the substrate using starch digesting glucoamylase enzyme derived from Aspergillus niger and non starch digesting and sugar fermenting Saccharomyces cerevisiae in a batch fermentation. Experiments based on Central Composite Design (CCD) were conducted to study the effect of substrate concentration, pH, temperature, enzyme concentration on Ethanol Concentration and the above parameters were optimized using Response Surface Methodology (RSM). The optimum values of substrate concentration, pH, temperature and enzyme concentration were found to be 160 g/l, 5.5, 30°C and 50 IU respectively. The effect of inoculums age on ethanol concentration was also investigated. The corn flour solution equivalent to 16% initial starch concentration gave the highest ethanol concentration of 63.04 g/l after 48 h of fermentation at optimum conditions of pH and temperature. Monod model and Logistic model were used for growth kinetics and Leudeking – Piret model was used for product formation kinetics.
Abstract: Tool Tracker is a client-server based application. It is essentially a catalogue of various network monitoring and management tools that are available online. There is a database maintained on the server side that contains the information about various tools. Several clients can access this information simultaneously and utilize this information. The various categories of tools considered are packet sniffers, port mappers, port scanners, encryption tools, and vulnerability scanners etc for the development of this application. This application provides a front end through which the user can invoke any tool from a central repository for the purpose of packet sniffing, port scanning, network analysis etc. Apart from the tool, its description and the help files associated with it would also be stored in the central repository. This facility will enable the user to view the documentation pertaining to the tool without having to download and install the tool. The application would update the central repository with the latest versions of the tools. The application would inform the user about the availability of a newer version of the tool currently being used and give the choice of installing the newer version to the user. Thus ToolTracker provides any network administrator that much needed abstraction and ease-ofuse with respect to the tools that he can use to efficiently monitor a network.
Abstract: Role of acoustic driving pressure on the
translational-radial dynamics of a moving single bubble
sonoluminescence (m-SBSL) has been numerically
investigated. The results indicate that increase in the
amplitude of the driving pressure leads to increase in the
bubble peak temperature. The length and the shape of the
trajectory of the bubble depends on the acoustic pressure and
because of the spatially dependence of the radial dynamics of
the moving bubble, its peak temperature varies during the
acoustical pulses. The results are in good agreement with the
experimental reports on m-SBSL.
Abstract: In this paper, a one-dimensional numerical approach is
used to study the effect of applying electrohydrodynamics on the
temperature and species mass fraction profiles along the microcombustor.
Premixed mixture is H2-Air with a multi-step chemistry
(9 species and 19 reactions). In the micro-scale combustion because
of the increasing ratio of area-to-volume, thermal and radical
quenching mechanisms are important. Also, there is a significant heat
loss from the combustor walls. By inserting a number of electrodes
into micro-combustor and applying high voltage to them corona
discharge occurs. This leads in moving of induced ions toward
natural molecules and colliding with them. So this phenomenon
causes the movement of the molecules and reattaches the flow to the
walls. It increases the velocity near the walls that reduces the wall
boundary layer. Consequently, applying electrohydrodynamics
mechanism can enhance the temperature profile in the microcombustor.
Ultimately, it prevents the flame quenching in microcombustor.
Abstract: With the rapid development in the field of life
sciences and the flooding of genomic information, the need for faster
and scalable searching methods has become urgent. One of the
approaches that were investigated is indexing. The indexing methods
have been categorized into three categories which are the lengthbased
index algorithms, transformation-based algorithms and mixed
techniques-based algorithms. In this research, we focused on the
transformation based methods. We embedded the N-gram method
into the transformation-based method to build an inverted index
table. We then applied the parallel methods to speed up the index
building time and to reduce the overall retrieval time when querying
the genomic database. Our experiments show that the use of N-Gram
transformation algorithm is an economical solution; it saves time and
space too. The result shows that the size of the index is smaller than
the size of the dataset when the size of N-Gram is 5 and 6. The
parallel N-Gram transformation algorithm-s results indicate that the
uses of parallel programming with large dataset are promising which
can be improved further.
Abstract: Recurrent event data is a special type of multivariate
survival data. Dynamic and frailty models are one of the approaches
that dealt with this kind of data. A comparison between these two
models is studied using the empirical standard deviation of the
standardized martingale residual processes as a way of assessing the
fit of the two models based on the Aalen additive regression model.
Here we found both approaches took heterogeneity into account and
produce residual standard deviations close to each other both in the
simulation study and in the real data set.
Abstract: The study of tourist activities and the mapping of their routes in space and time has become an important issue in tourism management. Here we represent space-time paths for the tourism industry by visualizing individual tourist activities and the paths followed using a 3D Geographic Information System (GIS). Considerable attention has been devoted to the measurement of accessibility to shopping, eating, walking and other services at the tourist destination. I turns out that GIS is a useful tool for studying the spatial behaviors of tourists in the area. The value of GIS is especially advantageous for space-time potential path area measures, especially for the accurate visualization of possible paths through existing city road networks. This study seeks to apply space-time concepts with a detailed street network map obtained from Google Maps to measure tourist paths both spatially and temporally. These paths are further determined based on data obtained from map questionnaires regarding the trip activities of 40 individuals. The analysis of the data makes it possible to determining the locations of the more popular paths. The results can be visualized using 3D GIS to show the areas and potential activity opportunities accessible to tourists during their travel time.
Abstract: The influence of viscosity on droplet diameter for
water-in-crude oil (w/o) emulsion with two different ratios; 20-80 %
and 50-50 % w/o emulsion was examined in the Brookfield
Rotational Digital Rheometer. The emulsion was prepared with
sorbitan sesquiolate (Span 83) act as emulsifier at varied temperature
and stirring speed in rotation per minute (rpm). Results showed that
the viscosity of w/o emulsion was strongly augmented by increasing
volume of water and decreased the temperature. The changing of
viscosity also altered the droplet size distribution. Changing of
droplet diameter was depends on the viscosity and the behavior of
emulsion either Newtonian or non-Newtonian.
Abstract: Although many studies on the assembly technology of
the bridge construction have dealt mostly with on the pier, girder or the
deck of the bridge, studies on the prefabricated barrier have rarely been
performed. For understanding structural characteristics and
application of the concrete barrier in the modular bridge, which is an
assembly of structure members, static loading test was performed.
Structural performances as a road barrier of the three methods,
conventional cast-in-place(ST), vertical bolt connection(BVC) and
horizontal bolt connection(BHC) were evaluated and compared
through the analyses of load-displacement curves, strain curves of the
steel, concrete strain curves and the visual appearances of crack
patterns. The vertical bolt connection(BVC) method demonstrated
comparable performance as an alternative to conventional
cast-in-place(ST) while providing all the advantages of prefabricated
technology. Necessities for the future improvement in nuts
enforcement as well as legal standard and regulation are also
addressed.
Abstract: This paper discuss the separation of the miscible
liquids by means of fractional distillation. For complete separation of
liquids, the process of heating, condensation, separation and storage
is done automatically to achieve the objective. PIC micro-controller
has been used to control each and every process of the work. The
controller also controls the storage process by activating and deactivating
the conveyors. The liquids are heated which on reaching
their respective boiling points evaporate and enter the condensation
chamber where they convert into liquid. The liquids are then directed
to their respective tanks by means of stepper motor which moves in
three directions, each movement into different tank. The tank on
filling sends the signal to controller which then opens the solenoid
valves. The tank is emptied into the beakers below the nozzle. As the
beaker filled, the nozzle closes and the conveyors come into
operation. The filled beaker is replaced by an empty beaker from
behind. The work can be used in oil industries, chemical industries
and paint industries.
Abstract: Dengue disease is an infectious vector-borne viral
disease that is commonly found in tropical and sub-tropical regions,
especially in urban and semi-urban areas, around the world and
including Malaysia. There is no currently available vaccine or
chemotherapy for the prevention or treatment of dengue disease.
Therefore prevention and treatment of the disease depend on vector
surveillance and control measures. Disease risk mapping has been
recognized as an important tool in the prevention and control
strategies for diseases. The choice of statistical model used for
relative risk estimation is important as a good model will
subsequently produce a good disease risk map. Therefore, the aim of
this study is to estimate the relative risk for dengue disease based
initially on the most common statistic used in disease mapping called
Standardized Morbidity Ratio (SMR) and one of the earliest
applications of Bayesian methodology called Poisson-gamma model.
This paper begins by providing a review of the SMR method, which
we then apply to dengue data of Perak, Malaysia. We then fit an
extension of the SMR method, which is the Poisson-gamma model.
Both results are displayed and compared using graph, tables and
maps. Results of the analysis shows that the latter method gives a
better relative risk estimates compared with using the SMR. The
Poisson-gamma model has been demonstrated can overcome the
problem of SMR when there is no observed dengue cases in certain
regions. However, covariate adjustment in this model is difficult and
there is no possibility for allowing spatial correlation between risks in
adjacent areas. The drawbacks of this model have motivated many
researchers to propose other alternative methods for estimating the
risk.
Abstract: The paper contains an investigation on basic problems
about the zeros of analytic theta functions. A brief introduction to
analytic representation of finite quantum systems is given. The zeros
of this function and there evolution time are discussed. Two open
problems are introduced. The first problem discusses the cases when
the zeros follow the same path. As the basis change the quantum state
|f transforms into different quantum state. The second problem is
to define a map between two toruses where the domain and the range
of this map are the analytic functions on toruses.
Abstract: In Multiple Sclerosis, pathological changes in the
brain results in deviations in signal intensity on Magnetic Resonance
Images (MRI). Quantitative analysis of these changes and their
correlation with clinical finding provides important information for
diagnosis. This constitutes the objective of our work. A new approach
is developed. After the enhancement of images contrast and the brain
extraction by mathematical morphology algorithm, we proceed to the
brain segmentation. Our approach is based on building statistical
model from data itself, for normal brain MRI and including clustering
tissue type. Then we detect signal abnormalities (MS lesions) as a
rejection class containing voxels that are not explained by the built
model. We validate the method on MR images of Multiple Sclerosis
patients by comparing its results with those of human expert
segmentation.