Abstract: Heat-inducible gene expression vectors are useful for hyperthermia-induced cancer gene therapy, because the combination
of hyperthermia and gene therapy can considerably improve the therapeutic effects. In the present study, we developed an enhanced
heat-inducible transgene expression system in which a heat-shock
protein (HSP) promoter and tetracycline-responsive transactivator
were combined. When the transactivator plasmid containing the
tetracycline-responsive transactivator gene was co-transfected with
the reporter gene expression plasmid, a high level of heat-induced gene expression was observed compared with that using the HSP
promoter without the transactivator. In vitro evaluation of the
therapeutic effect using HeLa cells showed that heat-induced therapeutic gene expression caused cell death in a high percentage of
these cells, indicating that this strategy is promising for cancer gene therapy.
Abstract: This study examines the possibility to apply the theory of multidimensional accounting (momentum accounting) in a Brazilian Navy-s Services Provider Military Organization (Organização Militar Prestadora de Serviços - OMPS). In general, the core of the said theory is the fact that Accounting does not recognize the inertia of transactions occurring in an entity, and that occur repeatedly in some cases, regardless of the implementation of new actions by its managers. The study evaluates the possibility of greater use of information recorded in the financial statements of the unit of analysis, within the strategic decisions of the organization. As a research strategy, we adopted the case study. The results infer that it is possible to use the theory in the context of a multidimensional OMPS, promoting useful information for decision-making and thereby contributing to the strengthening of the necessary alignment of its administration with the current desires of the Brazilian society.
Abstract: In this paper, the modified optimal sliding mode control with a proposed method to design a sliding surface is presented. Because of the inability of the previous approach of the sliding mode method to design a bounded and suitable input, the new variation is proposed in the sliding manifold to obviate problems in a structural system. Although the sliding mode control is a powerful method to reject disturbances and noises, the chattering problem is not good for actuators. To decrease the chattering phenomena, the optimal control is added to the sliding mode control. Not only the proposed method can decline the intense variations in the inputs of the system but also it can produce the efficient responses respect to the sliding mode control and optimal control that are shown by performing some numerical simulations.
Abstract: This study was carried out in Ankara, the capital city of Turkey, in order to determine how people living in the slums of Ankara benefit from educational equality. Within the scope of the research, interviews were made with 64 families whose children have been getting education from the primary schools of these parts and the data of the study was collected by the researcher. The results of the research demonstrate that the children getting education in the slums of Ankara can not experience educational equality and justice. The results of this study show that the opportunities of the schools in the slums of Ankara are very limited, so the individuals in these districts can not equally benefit from the education. The families are aware of the problem they are faced with. KeywordsDiscrimination, inequality, primary education, slums of Turkey.
Abstract: High quality requirements analysis is one of the most
crucial activities to ensure the success of a software project, so that
requirements verification for software system becomes more and more
important in Requirements Engineering (RE) and it is one of the most
helpful strategies for improving the quality of software system.
Related works show that requirement elicitation and analysis can be
facilitated by ontological approaches and semantic web technologies.
In this paper, we proposed a hybrid method which aims to verify
requirements with structural and formal semantics to detect
interactions. The proposed method is twofold: one is for modeling
requirements with the semantic web language OWL, to construct a
semantic context; the other is a set of interaction detection rules which
are derived from scenario-based analysis and represented with
semantic web rule language (SWRL). SWRL based rules are working
with rule engines like Jess to reason in semantic context for
requirements thus to detect interactions. The benefits of the proposed
method lie in three aspects: the method (i) provides systematic steps
for modeling requirements with an ontological approach, (ii) offers
synergy of requirements elicitation and domain engineering for
knowledge sharing, and (3)the proposed rules can systematically assist
in requirements interaction detection.
Abstract: We study dynamic instability in high-rise steel moment
resisting frames (SMRFs) subjected to synthetic long-period ground
motions caused by hypothetical huge subduction earthquakes. Since
long duration as well as long dominant periods is a characteristic of
long-period ground motions, interstory drifts may enter the negative
postyield stiffness range many times when high-rise buildings are
subjected to long-period ground motions. Through the case studies of
9 high-rise SMRFs designed in accordance with the Japanese design
practice in 1980s, we demonstrate that drifting, or accumulation of
interstory drifts in one direction, occurs at the lower stories of the
SMRFs, if their natural periods are close to the dominant periods of the
long-period ground motions. The drifting led to residual interstory
drift ratio over 0.01, or to collapse if the design base shear was small.
Abstract: Work stress causes the organizational work-life
imbalance of employees. Because of this imbalance, workers perform
with lower effort to finish assignments and thus an organization will
experience reduced productivity. In order to investigate the problem
of an organizational work-life imbalance, this qualitative case study
focuses on an organizational work-life imbalance among Thai
software developers in a German-owned company in Chiang Mai,
Thailand. In terms of knowledge management, fishbone diagram is
useful analysis tool to investigate the root causes of an organizational
work-life imbalance systematically in focus-group discussions.
Furthermore, fishbone diagram shows the relationship between
causes and effects clearly. It was found that an organizational worklife
imbalance among Thai software developers is influenced by
management team, work environment, and information tools used in
the company over time.
Abstract: This paper present an effective method to accurately reconstruct and measure the 3D curve edges of small industrial parts based on stereo vision. To effectively fit the curve of the measured parts using a series of line segments in the images, a strategy from coarse to fine is employed based on multi-scale curve fitting. After reconstructing the 3D curve of a hole through a curved surface, its axis is adjusted so that it is parallel to the Z axis with least squares error and the dimensions of the hole can be calculated on the XY plane easily. Experimental results show that the presented method can accurately measure the dimensions of round holes through a curved surface.
Abstract: Logistics is part of the supply chain processes that plans, implements, and controls the efficient and effective forward and reverse flow and storage of goods, services, and related information between the point of origin and the point of consumption in order to meet customer requirements. This research aims to investigate the current status and future direction of the use of Information Technology (IT) for logistics, focusing on Supply Chain Management (SCM) and E-Commerce adoption in Johor. Therefore, this research stresses on the type of technology being adopted, factors, benefits and barriers affecting the innovation in SCM and ECommerce technology adoption among Logistics Service Providers (LSP). A mailed questionnaire survey was conducted to collect data from 265 logistics companies in Johor. The research revealed that SCM technology adoption among LSP was higher as they had adopted SCM technology in various business processes while they perceived a high level of benefits from SCM adoption. Obviously, ECommerce technology adoption among LSP is relatively low.
Abstract: In this study, the effect of nanofluids on the pool film
boiling was experimentally investigated at saturated condition under
atmospheric pressure. For this purpose, four different water-based
nanofluids (Al2O3, SiO2, TiO2 and CuO) with 0.1% particle volume
fraction were prepared. To investigate the boiling heat transfer, a
cylindrical rod with high temperature was used. The rod heated up to
high temperatures was immersed into nanofluids. The center
temperature of rod during the cooling process was recorded by using
a K-type thermocouple. The quenching curves showed that the pool
boiling heat transfer was strongly dependent on the nanoparticle
materials. During the repetitive quenching tests, the cooling time
decreased and thus, the film boiling vanished. Consequently, the
primary reason of this was the change of the surface characteristics
due to the nanoparticles deposition on the rod-s surface.
Abstract: Groundwater has become the most dependable source
of fresh water for agriculture, domestic and industrial uses in the past
few decades. This wide use of groundwater if left uncontrolled and
unseen will lead to overexploitation causing sea water intrusion in the
coastal areas and illegal water marketing. Several Policies and Acts
have been enacted to regulate and manage the use of this valuable
resource. In spite of this the over extraction of groundwater beyond
the recharging capacity of aquifers and depletion in the quality of
groundwater is continuing. The current study aims at reviewing the
Acts and Policies existing in the State of Tamil Nadu and in the
National level regarding groundwater regulation and management.
Further an analysis is made on the rights associated with the usage of
groundwater resources and the gaps in these policies have been
analyzed. Some suggestions are made to reform the existing
groundwater policies for better management and regulation of the
resource.
Abstract: The object of this research is the design and
evaluation of an immersive Virtual Learning Environment (VLE) for
deaf children. Recently we have developed a prototype immersive
VR game to teach sign language mathematics to deaf students age K-
4 [1] [2]. In this paper we describe a significant extension of the
prototype application. The extension includes: (1) user-centered
design and implementation of two additional interactive
environments (a clock store and a bakery), and (2) user-centered
evaluation including development of user tasks, expert panel-based
evaluation, and formative evaluation. This paper is one of the few to
focus on the importance of user-centered, iterative design in VR
application development, and to describe a structured evaluation
method.
Abstract: Recently studies in area of supply chain network
(SCN) have focused on the disruption issues in distribution systems.
Also this paper extends the previous literature by providing a new biobjective
model for cost minimization of designing a three echelon
SCN across normal and failure scenarios with considering multi
capacity option for manufacturers and distribution centers. Moreover,
in order to solve the problem by means of LINGO software, novel
model will be reformulated through a branch of LP-Metric method
called Min-Max approach.
Abstract: Obfuscation is a low cost software protection
methodology to avoid reverse engineering and re engineering of
applications. Source code obfuscation aims in obscuring the source
code to hide the functionality of the codes. This paper proposes an
Array data transformation in order to obfuscate the source code
which uses arrays. The applications using the proposed data
structures force the programmer to obscure the logic manually. It
makes the developed obscured codes hard to reverse engineer and
also protects the functionality of the codes.
Abstract: There have been different approaches to compute the
analytic instantaneous frequency with a variety of background reasoning
and applicability in practice, as well as restrictions. This paper presents an adaptive Fourier decomposition and (α-counting) based
instantaneous frequency computation approach. The adaptive Fourier
decomposition is a recently proposed new signal decomposition
approach. The instantaneous frequency can be computed through the so called mono-components decomposed by it. Due to the fast energy
convergency, the highest frequency of the signal will be discarded by the adaptive Fourier decomposition, which represents the noise of
the signal in most of the situation. A new instantaneous frequency
definition for a large class of so-called simple waves is also proposed
in this paper. Simple wave contains a wide range of signals for which
the concept instantaneous frequency has a perfect physical sense.
The α-counting instantaneous frequency can be used to compute the highest frequency for a signal. Combination of these two approaches one can obtain the IFs of the whole signal. An experiment is demonstrated the computation procedure with promising results.
Abstract: The objective of this paper is to use the Pfaffian
technique to construct different classes of exact Pfaffian solutions and
N-soliton solutions to some of the generalized integrable nonlinear
partial differential equations in (3+1) dimensions. In this paper, I will
show that the Pfaffian solutions to the nonlinear PDEs are nothing but
Pfaffian identities. Solitons are among the most beneficial solutions
for science and technology, from ocean waves to transmission of
information through optical fibers or energy transport along protein
molecules. The existence of multi-solitons, especially three-soliton
solutions, is essential for information technology: it makes possible
undisturbed simultaneous propagation of many pulses in both directions.
Abstract: Creep stresses and strain rates have been obtained
for a thin rotating disc having variable density with inclusion by
using Seth-s transition theory. The density of the disc is assumed to
vary radially, i.e. ( ) 0 ¤ü ¤ü r/b m - = ; ¤ü 0 and m being real positive
constants. It has been observed that a disc, whose density increases
radially, rotates at higher angular speed, thus decreasing the
possibility of a fracture at the bore, whereas for a disc whose
density decreases radially, the possibility of a fracture at the bore
increases.
Abstract: The hypercube Qn is one of the most well-known
and popular interconnection networks and the k-ary n-cube Qk
n is
an enlarged family from Qn that keeps many pleasing properties
from hypercubes. In this article, we study the panpositionable
hamiltonicity of Qk
n for k ≥ 3 and n ≥ 2. Let x, y of V (Qk
n)
be two arbitrary vertices and C be a hamiltonian cycle of Qk
n.
We use dC(x, y) to denote the distance between x and y on the
hamiltonian cycle C. Define l as an integer satisfying d(x, y) ≤ l ≤ 1
2 |V (Qk
n)|. We prove the followings:
• When k = 3 and n ≥ 2, there exists a hamiltonian cycle C
of Qk
n such that dC(x, y) = l.
• When k ≥ 5 is odd and n ≥ 2, we request that l /∈ S
where S is a set of specific integers. Then there exists a
hamiltonian cycle C of Qk
n such that dC(x, y) = l.
• When k ≥ 4 is even and n ≥ 2, we request l-d(x, y) to be
even. Then there exists a hamiltonian cycle C of Qk
n such
that dC(x, y) = l.
The result is optimal since the restrictions on l is due to the
structure of Qk
n by definition.
Abstract: In this study we investigate silica nanoparticle (SiO2- NP) effects on the structure and phase properties of supported lipid monolayers and bilayers, coupling surface pressure measurements, fluorescence microscopy and atomic force microscopy. SiO2-NPs typically in size range of 10nm to 100 nm in diameter are tested. Our results suggest first that lipid molecules organization depends to their nature. Secondly, lipid molecules in the vinicity of big aggregates nanoparticles organize in liquid condensed phase whereas small aggregates are localized in both fluid liquid-expanded (LE) and liquid-condenced (LC). We demonstrated also by atomic force microscopy that by measuring friction forces it is possible to get information as if nanoparticle aggregates are recovered or not by lipid monolayers and bilayers.
Abstract: A zero-field ferromagnetic Ising model is utilized to
simulate the propagation of infection in a population that assumes a
square lattice structure. The rate of infection increases with
temperature. The disease spreads faster among individuals with low J
values. Such effect, however, diminishes at higher temperatures.