Abstract: The mechanics of rip currents are complex, involving
interactions between waves, currents, water levels and the bathymetry,
that present particular challenges for numerical models. Here,
the effects of a grid-spacing dependent horizontal mixing on the
wave-current interactions are studied. Near the shore, wave rays
diverge from channels towards bar crests because of refraction by
topography and currents, in a way that depends on the rip current
intensity which is itself modulated by the horizontal mixing. At
low resolution with the grid-spacing dependent horizontal mixing,
the wave motion is the same for both coupling modes because the
wave deviation by the currents is weak. In high resolution case,
however, classical results are found with the stabilizing effect of
the flow by feedback of waves on currents. Lastly, wave-current
interactions and the horizontal mixing strongly affect the intensity
of the three-dimensional rip velocity.
Abstract: Physics Education Research (PER) results have shown
that students do not achieve the expected level of competency in
understanding the concepts of different domains of Physics learning
when taught by the traditional teaching methods, the concepts of
Electricity and Magnetism (E&M) being one among them.
Simulation being one of the valuable instructional tools renders an
opportunity to visualize varied experiences with such concepts.
Considering the electric force concept which requires extensive use
of vector representations, we report here the outcome of the research
results pertaining to the student understanding of this concept and the
role of simulation in using vector representation. The simulation
platform provides a positive impact on the use of vector
representation.
The first stage of this study involves eliciting and analyzing
student responses to questions that probe their understanding of the
concept of electrostatic force and this is followed by four stages of
student interviews as they use the interactive simulations of electric
force in one dimension. Student responses to the questions are
recorded in real time using electronic pad. A validation test interview
is conducted to evaluate students' understanding of the electric force
concept after using interactive simulation. Results indicate lack of
procedural knowledge of the vector representation. The study
emphasizes the need for the choice of appropriate simulation and
mode of induction for learning.
Abstract: Building loss estimation methodologies which have
been advanced considerably in recent decades are usually used to
estimate socio and economic impacts resulting from seismic structural
damage. In accordance with these methods, this paper presents the
evaluation of an annual loss probability of a reinforced concrete
moment resisting frame designed according to Korean Building Code.
The annual loss probability is defined by (1) a fragility curve obtained
from a capacity spectrum method which is similar to a method adopted
from HAZUS, and (2) a seismic hazard curve derived from annual
frequencies of exceedance per peak ground acceleration. Seismic
fragilities are computed to calculate the annual loss probability of a
certain structure using functions depending on structural capacity,
seismic demand, structural response and the probability of exceeding
damage state thresholds. This study carried out a nonlinear static
analysis to obtain the capacity of a RC moment resisting frame
selected as a prototype building. The analysis results show that the
probability of being extensive structural damage in the prototype
building is expected to 0.01% in a year.
Abstract: This paper presents an evolutionary algorithm for
solving multi-objective optimization problems-based artificial neural
network (ANN). The multi-objective evolutionary algorithm used in
this study is genetic algorithm while ANN used is radial basis
function network (RBFN). The proposed algorithm named memetic
elitist Pareto non-dominated sorting genetic algorithm-based RBFN
(MEPGAN). The proposed algorithm is implemented on medical
diseases problems. The experimental results indicate that the
proposed algorithm is viable, and provides an effective means to
design multi-objective RBFNs with good generalization capability
and compact network structure. This study shows that MEPGAN
generates RBFNs coming with an appropriate balance between
accuracy and simplicity, comparing to the other algorithms found in
literature.
Abstract: At certain depths during large diameter displacement
pile driving, rebound well over 0.25 inches was experienced,
followed by a small permanent-set during each hammer blow. High
pile rebound (HPR) soils may stop the pile driving and results in a
limited pile capacity. In some cases, rebound leads to pile damage,
delaying the construction project, and the requiring foundations
redesign. HPR was evaluated at seven Florida sites, during driving of
square precast, prestressed concrete piles driven into saturated, fine
silty to clayey sands and sandy clays. Pile Driving Analyzer (PDA)
deflection versus time data recorded during installation, was used to
develop correlations between cone penetrometer (CPT) pore-water
pressures, pile displacements and rebound. At five sites where piles
experienced excessive HPR with minimal set, the pore pressure
yielded very high positive values of greater than 20 tsf. However, at
the site where the pile rebounded, followed by an acceptable
permanent-set, the measured pore pressure ranged between 5 and 20
tsf. The pore pressure exhibited values of less than 5 tsf at the site
where no rebound was noticed. In summary, direct correlations
between CPTu pore pressure and rebound were produced, allowing
identification of soils that produce HPR.
Abstract: In Brazil, neonatal mortality rate is considered
incompatible with the country development conditions, and has been
a Public Health concern. Reduction in infant mortality rates has also
been part of the Millennium Development Goals, a commitment
made by countries, members of the Organization of United Nations
(OUN), including Brazil. Fetal mortality rate is considered a highly
sensitive indicator of health care quality. Suitable actions, such as
good quality and access to health services may contribute positively
towards reduction in these fetal and neonatal rates. With appropriate
antenatal follow-up and health care during gestation and delivery,
some death causes could be reduced or even prevented by means of
early diagnosis and intervention, as well as changes in risk factors
and interventions. Objectives: To study the quality of maternal and
infant health care based on fetal and neonatal mortality, as well as the
possible actions to prevent those deaths in Botucatu (Brazil).
Methods: Classification of prevention according to the International
Classification of Diseases and the modified Wigglesworth´s
classification. In order to evaluate adequacy, indicators of quality of
antenatal and delivery care were established by the authors. Results:
Considering fetal deaths, 56.7% of them occurred before delivery,
which reveals possible shortcomings in antenatal care, and 38.2% of
them were a result of intra- labor changes, which could be prevented
or reduced by adequate obstetric management. These findings were
different from those in the group of early neonatal deaths which were
also studied. Adequacy of health services showed that antenatal and
childbirth care was appropriate for 24% and 33.3% of pregnant
women, respectively, which corroborates the results of prevention.
These results revealed that shortcomings in obstetric and antenatal
care could be the causes of deaths in the study. Early and late
neonatal deaths have similar characteristics: 76% could be prevented
or reduced mainly by adequate newborn care (52.9%) and adequate
health care for gestational women (11.7%). When adequacy of care
was evaluated, childbirth and newborn care was adequate in 25.8%
and antenatal care was adequate in 16.1%. In conclusion, direct
relationship was found between adequacy and quality of care
rendered to pregnant women and newborns, and fetal and infant
mortality. Moreover, our findings highlight that deaths could be
prevented by an adequate obstetric and neonatal management.
Abstract: Chemotherapy and radiotherapy are one of the major
treatment modalities that play important role in the management of a
number of different cancers. This study for the first time evaluates the
toxicity of these treatment modalities and its impact on quality of life
of cancer patients in Pakistan. The study also for the first time
determines what cancer patients of different ages and cancer stages
believe would be an effective intervention to manage their
psychosocial needs and treatment induced toxicity. The article also
provides evidence based approach for the use of variety of
interventions to mange cancer treatment induced morbidity and
toxicity. In light of the present study and reviewed research data,
evidence based recommendations are also made for selection of
appropriate interventions to manage Pain, Nausea and Vomiting,
Anxiety and Depression, Fatigue and Overall QOL of cancer
survivors.
Abstract: In and around Erode District, it is estimated that more
than 1250 chemical and allied textile processing fabric industries are
affected, partially closed and shut off for various reasons such as poor
management, poor supplier performance, lack of planning for
productivity, fluctuation of output, poor investment, waste analysis,
labor problems, capital/labor ratio, accumulation of stocks, poor
maintenance of resources, deficiencies in the quality of fabric, low
capacity utilization, age of plant and equipment, high investment and
input but low throughput, poor research and development, lack of
energy, workers’ fear of loss of jobs, work force mix and work ethic.
The main objective of this work is to analyze the existing conditions
in textile fabric sector, validate the break even of Total Productivity
(TP), analyze, design and implement fuzzy sets and mathematical
programming for improvement of productivity and quality
dimensions in the fabric processing industry. It needs to be
compatible with the reality of textile and fabric processing industries.
The highly risk events from productivity and quality dimension were
found by fuzzy systems and results are wrapped up among the textile
fabric processing industry.
Abstract: Risperidone (RISP) is an antipsychotic agent and has
low water solubility and nontargeted delivery results in numerous
side effects. Hence, an attempt was made to develop SLNs hydrogel
for intranasal delivery of RISP to achieve maximum bioavailability
and reduction of side effects. RISP loaded SLNs composed of 1.65%
(w/v) lipid mass were produced by high shear homogenization (HSH)
coupled ultrasound (US) method using glycerylmonostearate (GMS)
or Imwitor 900K (solid lipid). The particles were loaded with 0.2%
(w/v) of the RISP & surface-tailored with a 2.02% (w/v) non-ionic
surfactant Tween® 80. Optimization was done using 32 factorial
design using Design Expert® software. The prepared SLNs
dispersion incorporated into Polycarbophil AA1 hydrogel (0.5%
w/v). The final gel formulation was evaluated for entrapment
efficiency, particle size, rheological properties, X ray diffraction, in
vitro diffusion, ex vivo permeation using sheep nasal mucosa and
histopathological studies for nasocilliary toxicity. The entrapment
efficiency of optimized SLNs was found to be 76 ± 2%,
polydispersity index
Abstract: Shortfall of electrical energy in Pakistan is a challenge
adversely affecting its industrial output and social growth. As
elsewhere, Pakistan derives its electrical energy from a number of
conventional sources. The exhaustion of petroleum and conventional
resources, the rising costs coupled with extremely adverse climatic
effects are taking its toll especially on the under-developed countries
like Pakistan. As alternate, renewable energy sources like hydropower,
solar, wind, even bio-energy and a mix of some or all of them
could provide a credible alternative to the conventional energy
resources that would not only be cleaner but sustainable as well. As a
model, solar energy-based power grid for the near future has been
attempted to offset the energy shortfalls as a mix with our existing
sustainable natural energy resources. An assessment of solar energy
potential for electricity generation is being presented for fulfilling the
energy demands with higher level of reliability and sustainability.
This model is based on the premise that solar energy potential of
Pakistan is not only reliable but also sustainable. This research
estimates the present & future approaching renewable energy
resource specially the impact of solar energy based power grid for
mitigating energy shortage in Pakistan.
Abstract: The thyroid gland is the largest classic endocrine
organ that effects many organs of the body and plays a significant
role in the process of Metabolism in animals. The aim of this study
was to investigate the prevalence of thyroid disorders diagnosed by
ultrasound and microscopic Lesions of the thyroid during the
slaughter of apparently healthy One Humped Camels (Camelus
dromedarius) in Iran. Randomly, 520 male camels (With an age
range of 4 to 8 years), were studied in 2012 to 2013. The Camels’
thyroid glands were evaluated by sonographic examination. In both
longitudinal and transverse view and then tissue sections were
provide and stained with H & E and finally examined by light
microscopy. The results obtained indicated the following:
hyperplastic goiter (21%), degenerative changes (12%), follicular
cysts (8%), follicular atrophy (4%), nodular hyperplasia (3%),
adenoma (1%), carcinoma (1%) and simple goiter colloid (1%).
Ultrasound evaluation of thyroid gland in adenoma and carcinoma
showed enlargement and irregular of the gland, decreased
echogenicity, and the heterogeneous thyroid parenchyma. Also, in
follicular cysts were observed in the enlarged gland with no echo
structures of different sizes and decreased echogenicity as a local or
general. In nodular hyperplasia, increase echogenicity and
heterogeneous parenchymal were seen. These findings suggest the
use of sonography and pathology as a screening test in the diagnosis
of complications of thyroid disorders.
Abstract: As the current status and growth of Indian automobile
industry is remarkable, transportation sectors are the main concern in
terms of energy security and climate change. Due to rising demand of
fuel and its dependency on foreign countries that affects the GDP of
nation, suggests that penetration of electrical vehicle will increase in
near future. So in this context analysis is done if the 10 percent of
conventional vehicles including cars, three wheelers and two
wheelers becomes electrical vehicles in near future which is also a
part of Nations Electric Mobility Mission Plan then the saving which
improves the nation’s economy is analyzed in detail. Whether the
Indian electricity grid is capable of taking this load with current
generation and demand all over the country is also analyzed in detail.
Current situation of Indian grid is analyzed and how the gap between
generation and demand can be reduced is discussed in terms of
increasing generation capacity and energy conservation measures.
Electrical energy conservation measures in Industry and especially in
rural areas have been analyzed to improve performance of Indian
electricity grid in context of electrical vehicle penetration in near
future. Author was a part of Vishvakarma yojna in which energy
losses were measured in 255 villages of Gujarat and solutions were
suggested to mitigate them and corresponding reports was submitted
to the authorities of Gujarat government.
Abstract: An existing RC building in Madinah is seismically
evaluated with and without infill wall. Four model systems have been
considered i.e. model I (no infill), model IIA (strut infill-update from
field test), model IIB (strut infill- ASCE/SEI 41) and model IIC (strut
infill-Soft storey- ASCE/SEI 41). Three dimensional pushover
analyses have been carried out using SAP2000 software
incorporating inelastic material behavior for concrete, steel and infill
walls. Infill wall has been modeled as equivalent strut according to
suggested equation matching field test measurements and to the
ASCE/SEI 41 equation. The effect of building modeling on the
performance point as well as capacity and demand spectra due to EQ
design spectrum function in Madinah area has been investigated. The
response modification factor (R) for the 5 story RC building is
evaluated from capacity and demand spectra (ATC-40) for the
studied models. The results are summarized and discussed.
Abstract: Early pre-code reinforced concrete structures present
undetermined resistance to earthquakes. This situation is particularly
unacceptable in the case of essential structures, such as healthcare
structures and pilgrims' houses. Amongst these, an existing old RC
building in Madinah city (KSA) is seismically evaluated with and
without infill wall and their dynamic characteristics are compared
with measured values in the field using ambient vibration
measurements (AVM). After updating the mathematical models for
this building with the experimental results, three dimensional
pushover analysis (Nonlinear static analysis) was carried out using
commercial structural analysis software incorporating inelastic
material properties for concrete, infill and steel. The purpose of this
analysis is to evaluate the expected performance of structural systems
by estimating, strength and deformation demands in design, and
comparing these demands to available capacities at the performance
levels of interest. The results summarized and discussed.
Abstract: Complexation of anthocyanins to mimic natural
copigmentation process was investigated. Cyanidin-rich extracts from
Zea mays L. ceritina Kulesh. and delphinidin-rich extracts from
Clitoria ternatea L. were used to form 4 anthocyanin complexes,
AC1, AC2, AC3 and AC4, in the presence of several polyphenols and
a trace metal. Characterizations of the ACs were conducted by UV,
FTIR, DSC/TGA and morphological observations. Bathochromic
shifts of the UV spectra of 4 formulas of ACs were observed at peak
wavelengths of about 510-620 nm by 10 nm suggesting complex
formation. FTIR spectra of the ACs indicate shifts of peaks from
1,733 cm-1 to 1,696 cm-1 indicating interactions and a decrease in the
peak areas within the wavenumber of 3,400-3,500 cm-1 indicating
changes in hydrogen bonding. Thermal analysis of all of the ACs
suggests increases in melting temperature after complexation. AC
with the highest melting temperature was morphologically observed
by SEM and TEM to be crystal-like particles within a range of 50 to
200 nm. Particle size analysis of the AC by laser diffraction gave a
range of 50-600 nm, indicating aggregation. This AC was shown to
have no cytotoxic effect on cultured HGEPp0.5 and HGF (all p>
0.05) by MTT. Therefore, complexation of anthocyanins was simple
and self-assembly process, potentially resulting in nanosized particles
of anthocyanin complex.
Abstract: Anthocyanins are natural pigments with effective UV
protection but their topical use could be limited due to their
physicochemical characteristics. An attempt to overcome such
limitations by complexation of 2 major anthocyanin-rich sources, C.
ternatea and Z. mays, has potentiated its use as topical antiinflammatory.
Cell studies indicate no cytotoxicity of the
anthocyanin complex (AC) up to 1 mg/ml tested in HaCaT and
human fore head fibroblasts by MTT. Croton oil-induced ear edema
in Wistar rats suggests an effective dose of 5 mg/cm2 of AC as a
topical anti-inflammatory in comparison to 0.5 mg/cm2 of
fluocinolone acetonide. Niosomal encapsulation of the AC
significantly prolonged the anti-inflammatory activity particularly at
8 h after topical application (p = 0.0001). The AC was not cytotoxic
and its anti-inflammatory and activity was dose-dependent and
prolonged by niosomal encapsulation. It has also shown to promote
collagen type 1 production in cell culture. Thus, AC could be a
potential candidate for topical anti-inflammatory agent from natural
resources.
Abstract: Liver disorders are one of the major problems of the
world. Despite its frequent occurrence, high morbidity and high
mortality, its medical management is currently inadequate. This study
was designed to evaluate the hepatoprotective effect of saponin
extract of the root of Garcinia kola on the integrity of the liver of
paracetamol induced wistar albino rats. Twenty five (25) male adult
wistar albino rats were divided into five (5) groups. Group I was the
Control group that received distilled water only, group II was the
negative control that received 2 g/kg of paracetamol on the 13th day,
and group III, IV and V were pre-treated with 100, 200 and
400mg/kg of the saponin extract before inducing the liver damage on
the 13th day with 2 g/kg of paracetamol. Twenty four (24) h after
administration, the rats were sacrificed and blood samples were
collected. The serum Alanine Transaminase (ALT), Aspartate
Transaminase (AST), Alkaline Phosphatase (ALP) activities,
Bilirubin and conjugated bilirubin, glucose and protein
concentrations were evaluated. The liver was fixed immediately in
Formalin and was processed and stained in Haematoxylin and Eosin
(H&E). Administration of saponin extract from the root of Garcinia
kola significantly decreased paracetamol induced elevated enzymes
in the test group. Also histological observations showed that saponin
extract of the root of Garcinia kola exhibited a significant liver
protection against the toxicant as evident by the cells trying to return
to normal. Saponin extract from the root of Garcinia kola indicated a
protection of structural integrity of the hepatocytic cell membrane
and regeneration of the damaged liver.
Abstract: A capacity spectrum method (CSM), one of methodologies to evaluate seismic fragilities of building structures, has been long recognized as the most convenient method, even if it contains several limitations to predict the seismic response of structures of interest. This paper proposes the procedure to estimate seismic fragility curves using an incremental dynamic analysis (IDA) rather than the method adopting a CSM. To achieve the research purpose, this study compares the seismic fragility curves of a 5-story reinforced concrete (RC) moment frame obtained from both methods; an IDA method and aCSM. Both seismic fragility curves are similar in slight and moderate damage states whereas the fragility curve obtained from the IDA method presents less variation (or uncertainties) in extensive and complete damage states. This is due to the fact that the IDA method can properly capture the structural response beyond yielding rather than the CSM and can directly calculate higher mode effects. From these observations, the CSM could overestimate seismic vulnerabilities of the studied structure in extensive or complete damage states.
Abstract: The effect of the inclusion of thyme and rosemary
essential oils into chitosan films, as well as the microbiological and
physical properties when storing chitosan film with and without the
mentioned inclusion was studied. The film forming solution was
prepared by dissolving chitosan (2%, w/v), polysorbate 80 (4% w/w
CH) and glycerol (16% w/w CH) in aqueous lactic acid solutions
(control). The thyme (TEO) and rosemary (REO) essential oils (EOs)
were included 1:1 w/w (EOs:CH) on their combination 50/50
(TEO:REO). The films were stored at temperatures of 5, 20, 33°C
and a relative humidity of 75% during four weeks. The films with
essential oil inclusion did not show an antimicrobial activity against
strains. This behavior could be explained because the chitosan only
inhibits the growth of microorganisms in direct contact with the
active sites. However, the inhibition capacity of TEO was higher than
the REO and a synergic effect between TEO:REO was found for S.
enteritidis strains in the chitosan solution.
Some physical properties were modified by the inclusion of
essential oils. The addition of essential oils does not affect the
mechanical properties (tensile strength, elongation at break, puncture
deformation), the water solubility, the swelling index nor the DSC
behavior. However, the essential oil inclusion can significantly
decrease the thickness, the moisture content, and the L* value of
films whereas the b* value increased due to molecular interactions
between the polymeric matrix, the loosing of the structure, and the
chemical modifications. On the other hand, the temperature and time
of storage changed some physical properties on the chitosan films.
This could have occurred because of chemical changes, such as
swelling in the presence of high humidity air and the reacetylation of
amino groups. In the majority of cases, properties such as moisture
content, tensile strength, elongation at break, puncture deformation,
a*, b*, chrome, 7E increased whereas water resistance, swelling
index, L*, and hue angle decreased.
Abstract: The article deals with one of the most significant
issues concerning the functioning of the public sector in the European
Union. The objectives of good governance were formulated by the
EU itself and also the Scholars in reaction to the discussion that
started a decade ago and concerned the role of the government in 21st
century, the future of integration processes and globalization
challenges in Europe. Currently, the concept of good governance is
mainly associated with the improvement of management of public
policies in the European Union, concerning both domestic and EU
policies. However, it goes beyond the issues of state capacity and
effectiveness of management. Good governance relates also to
societal participation in the public administration and verification of
decisions made in public authorities’ (including public
administration). Indirectly, the concept and practice of good
governance are connected to societal legitimisation of public bodies
in the European Union.