Abstract: Candida spp. are common and aggressive pathogens. Because of the growing resistance of Candida spp. to current antifungals, novel targets, found in Candida spp. but not in humans or other flora, have to be identified. The alternative oxidase (AOX) is one such possibility. This enzyme is insensitive to cyanide, but is sensitive to compounds such as salicylhydroxamic acid (SHAM), disulfiram and n-alkyl gallates. The growth each of six Candida spp. was inhibited significantly by ~13 mM SHAM or 2 mM cyanide, albeit to differing extents. In C. dubliniensis, C. krusei and C. tropicalis the rate of O2 uptake was inhibited by 18-36% by 25 mM SHAM, but this had little or no effect on C. glabrata, C. guilliermondii or C. parapsilosis. Although SHAM substantially inhibited the growth of Candida spp., it is unlikely that the inhibition of AOX was the cause. Salicylhydroxamic acid is used therapeutically in the treatment of urinary tract infections and urolithiasis, but it also has some potential in the treatment of Candida spp. infection.
Abstract: Numerous facts evidence the increasing religiosity of
the population and the intensification of religious movements in
various countries in the last decade of the 20th century. The number
of international religious institutions and foundations; religious
movements; parties and sects operating worldwide is increasing as
well. Some ethnic and inter-state conflicts are obviously of a
religious origin. All of this make a number of analysts to conclude
that the religious factor is becoming an important part of international
life, including the formation and activities of terrorist organizations.
Most of all is said and written about Islam, the second, after
Christianity, world religions professed according to various estimates
by 1.5 bln. individuals in 127 countries.
Abstract: In this paper we consider a nonlinear control design for
nonlinear systems by using two-stage formal linearization and twotype
LQ controls. The ordinary LQ control is designed on almost
linear region around the steady state point. On the other region,
another control is derived as follows. This derivation is based on
coordinate transformation twice with respect to linearization functions
which are defined by polynomials. The linearized systems can be
made up by using Taylor expansion considered up to the higher order.
To the resulting formal linear system, the LQ control theory is applied
to obtain another LQ control. Finally these two-type LQ controls
are smoothly united to form a single nonlinear control. Numerical
experiments indicate that this control show remarkable performances
for a nonlinear system.
Abstract: Searching similar documents and document
management subjects have important place in text mining. One of the
most important parts of similar document research studies is the
process of classifying or clustering the documents. In this study, a
similar document search approach that includes discussion of out the
case of belonging to multiple categories (multiple categories
problem) has been carried. The proposed method that based on Fuzzy
Similarity Classification (FSC) has been compared with Rocchio
algorithm and naive Bayes method which are widely used in text
mining. Empirical results show that the proposed method is quite
successful and can be applied effectively. For the second stage,
multiple categories vector method based on information of categories
regarding to frequency of being seen together has been used.
Empirical results show that achievement is increased almost two
times, when proposed method is compared with classical approach.
Abstract: Nowadays, fluidized bed plays an important part in industry. The design of this kind of reactor requires knowing the interfacial area between two phases and this interfacial area leads to calculate the solid holdup in the bed. Consequently achieving interfacial area between gas and solid in the bed experimentally is so significant. On interfacial area measurement in fluidized bed with gas has been worked, but light transmission technique has been used less. Therefore, in the current research the possibility of using of this technique and its accuracy are investigated. Measuring, a fluidized bed was designed and the problems were averted as far as possible. By using fine solid with equal shape and diameter and installing an optical system, the absorption of light during the time of fluidization has been measured. Results indicate that this method that its validity has been proved in the gas-liquid system, by different reasons have less application in gas-solid system. One important reason could be non-uniformity in such systems.
Abstract: Traditional optical networks are gradually evolving towards intelligent optical networks due to the need for faster bandwidth provisioning, protection and restoration of the network that can be accomplished with devices like optical switch, add drop multiplexer and cross connects. Since dense wavelength multiplexing forms the physical layer for intelligent optical networking, the roll of high speed all optical switch is important. This paper analyzes such an ultra-high speed polymer electro-optic switch. The performances of the 2x2 optical waveguide switch with rectangular, triangular and trapezoidal grating profiles on various device parameters are analyzed. The simulation result shows that trapezoidal grating is the optimized structure which has the coupling length of 81μm and switching voltage of 11V for the operating wavelength of 1550nm. The switching time for this proposed switch is 0.47 picosecond. This makes the proposed switch to be an important element in the intelligent optical network.
Abstract: One of the major problems in liberalized power
markets is loss allocation. In this paper, a different method for
allocating transmission losses to pool market participants is
proposed. The proposed method is fundamentally based on
decomposition of loss function and current projection concept. The
method has been implemented and tested on several networks and
one sample summarized in the paper. The results show that the
method is comprehensive and fair to allocating the energy losses of a
power market to its participants.
Abstract: Active vibration isolation systems are less commonly
used than passive systems due to their associated cost and power
requirements. In principle, semi-active isolation systems can deliver
the versatility, adaptability and higher performance of fully active
systems for a fraction of the power consumption. Various semi-active
control algorithms have been suggested in the past. This paper
studies the 4DOF model of semi-active suspension performance
controlled by on–off and continuous skyhook damping control
strategy. The frequency and transient responses of model are
evaluated in terms of body acceleration, roll angle and tire deflection
and are compared with that of a passive damper. The results show
that the semi-active system controlled by skyhook strategy always
provides better isolation than a conventional passively damped
system except at tire natural frequencies.
Abstract: The study examined the influence of pay differentials on employee retention in the State Colleges of Education in the South-South Region of Nigeria. 275 subjects drawn from members of the wage negotiating teams in the Colleges were administered questionnaires constructed for study. Analysis of Variance revealed that the observed pay differentials significantly influenced retainership, f(5,269 = 6.223, P< 0.05). However, the Multiple Classification Analysis and Post-Hoc test indicated that employees in two of the Colleges with slightly lower and higher pay levels may probably remain with their employers while employees in other Colleges with the least and highest pay levels suggested quitting. Based on these observations, the influence of pay on employee retention seems inconclusive. Generally, employees in the colleges studied are dissatisfied with current pay levels. Management should confront these challenges by improving pay packages to encourage employees to remain and be dedicated to duty.
Abstract: The chemistry of sulphone hydrazide has gained increase interest in both synthetic organic chemistry and biological fields and has considerable value. The therapeutic importance of these compounds is the attractive force to continue research in such a point. The present review covers the literature up to date for the synthesis, reactions and applications of such compounds.
Abstract: The Minimum Vertex Cover (MVC) problem is a classic
graph optimization NP - complete problem. In this paper a competent
algorithm, called Vertex Support Algorithm (VSA), is designed to
find the smallest vertex cover of a graph. The VSA is tested on a
large number of random graphs and DIMACS benchmark graphs.
Comparative study of this algorithm with the other existing methods
has been carried out. Extensive simulation results show that the VSA
can yield better solutions than other existing algorithms found in the
literature for solving the minimum vertex cover problem.
Abstract: Monitored 3-Dimensional (3D) video experience can be utilized as “feedback information” to fine tune the service parameters for providing a better service to the demanding 3D service customers. The 3D video experience which includes both video quality and depth perception is influenced by several contextual and content related factors (e.g., ambient illumination condition, content characteristics, etc) due to the complex nature of the 3D video. Therefore, effective factors on this experience should be utilized while assessing it. In this paper, structural information of the depth map sequences of the 3D video is considered as content related factor effective on the depth perception assessment. Cartoon-like filter is utilized to abstract the significant depth levels in the depth map sequences to determine the structural information. Moreover, subjective experiments are conducted using 3D videos associated with cartoon-like depth map sequences to investigate the effectiveness of ambient illumination condition, which is a contextual factor, on depth perception. Using the knowledge gained through this study, 3D video experience metrics can be developed to deliver better service to the 3D video service users.
Abstract: Learning programming is difficult for many learners. Some researches have found that the main difficulty relates to cognitive load. Cognitive overload happens in programming due to the nature of the subject which is intrinisicly over-bearing on the working memory. It happens due to the complexity of the subject itself. The problem is made worse by the poor instructional design methodology used in the teaching and learning process. Various efforts have been proposed to reduce the cognitive load, e.g. visualization softwares, part-program method etc. Use of many computer based systems have also been tried to tackle the problem. However, little success has been made to alleviate the problem. More has to be done to overcome this hurdle. This research attempts at understanding how cognitive load can be managed so as to reduce the problem of overloading. We propose a mechanism to measure the cognitive load during pre instruction, post instruction and in instructional stages of learning. This mechanism is used to help the instruction. As the load changes the instruction is made to adapt itself to ensure cognitive viability. This mechanism could be incorporated as a sub domain in the student model of various computer based instructional systems to facilitate the learning of programming.
Abstract: A synchronous network-on-chip using wormhole packet switching
and supporting guaranteed-completion best-effort with low-priority (LP)
and high-priority (HP) wormhole packet delivery service is presented in
this paper. Both our proposed LP and HP message services deliver a good
quality of service in term of lossless packet completion and in-order message
data delivery. However, the LP message service does not guarantee minimal
completion bound. The HP packets will absolutely use 100% bandwidth of
their reserved links if the HP packets are injected from the source node with
maximum injection. Hence, the service are suitable for small size messages
(less than hundred bytes). Otherwise the other HP and LP messages, which
require also the links, will experience relatively high latency depending on the
size of the HP message. The LP packets are routed using a minimal adaptive
routing, while the HP packets are routed using a non-minimal adaptive routing
algorithm. Therefore, an additional 3-bit field, identifying the packet type,
is introduced in their packet headers to classify and to determine the type
of service committed to the packet. Our NoC prototypes have been also
synthesized using a 180-nm CMOS standard-cell technology to evaluate the
cost of implementing the combination of both services.
Abstract: Linear stability analysis of wake-shear layers in twophase
shallow flows is performed in the present paper. Twodimensional
shallow water equations are used in the analysis. It is
assumed that the fluid contains uniformly distributed solid particles.
No dynamic interaction between the carrier fluid and particles is
expected in the initial moment. The stability calculations are
performed for different values of the particle loading parameter and
two other parameters which characterize the velocity ratio and the
velocity deficit. The results show that the particle loading parameter
has a stabilizing effect on the flow while the increase in the velocity
ratio or in the velocity deficit destabilizes the flow.
Abstract: Retinoic acid is like a steroid hormone that plays a
role in embryo formation, proliferation of spermatogonia cells,
ephitelial cells differentiation and organogenesis. Retinoic acid can
influences seminiferous tubule formation during embryonic testis
development and also play a role in the regulation of ovarian function
and female reproductive tract by suppressing the hormones FSH
receptor expression. The excessive use of retinoic acid caused
abnormalities in the fetus. The result showed that there is the
influence of retinoic acid on the developmet of mice fetal testes, for
examples disruption of the formation of seminiferous tubules and
tubules seemed to be hollow, spermatogonia cells are relatively few
in number and caused Leydig cells count relatively more. While in
the female fetus does not caused the formation of primordial follicles
and disrupted the development of germinal ephitelial cells of fetal
ovaries of female mice (mus musculus) Swiss Webster.
Abstract: The spectral action balance equation is an equation that
used to simulate short-crested wind-generated waves in shallow water
areas such as coastal regions and inland waters. This equation consists
of two spatial dimensions, wave direction, and wave frequency which
can be solved by finite difference method. When this equation with
dominating convection term are discretized using central differences,
stability problems occur when the grid spacing is chosen too coarse.
In this paper, we introduce the splitting upwind schemes for avoiding
stability problems and prove that it is consistent to the upwind scheme
with same accuracy. The splitting upwind schemes was adopted
to split the wave spectral action balance equation into four onedimensional
problems, which for each small problem obtains the
independently tridiagonal linear systems. For each smaller system
can be solved by direct or iterative methods at the same time which
is very fast when performed by a multi-processor computer.
Abstract: In the last decade, energy based control theory has undergone a significant breakthrough in dealing with underactated mechanical systems with two successful and similar tools, controlled Lagrangians and controlled Hamiltanians (IDA-PBC). However, because of the complexity of these tools, successful case studies are lacking, in particular, MIMO cases. The seminal theoretical paper of controlled Lagrangians proposed by Bloch and his colleagues presented a benchmark example–a 4 d.o.f underactuated pendulum on a cart but a detailed and completed design is neglected. To compensate this ignorance, the note revisit their design idea by addressing explicit control functions for a similar device motivated by a vector thrust body hovering in the air. To the best of our knowledge, this system is the first MIMO, underactuated example that is stabilized by using energy based tools at the courtesy of the original design idea. Some observations are given based on computer simulation.
Abstract: Cloud Computing has recently emerged as a
compelling paradigm for managing and delivering services over the
internet. The rise of Cloud Computing is rapidly changing the
landscape of information technology, and ultimately turning the longheld
promise of utility computing into a reality. As the development
of Cloud Computing paradigm is speedily progressing, concepts, and
terminologies are becoming imprecise and ambiguous, as well as
different technologies are interfering. Thus, it becomes crucial to
clarify the key concepts and definitions. In this paper, we present the
anatomy of Cloud Computing, covering its essential concepts,
prominent characteristics, its affects, architectural design and key
technologies. We differentiate various service and deployment
models. Also, significant challenges and risks need are tackled in
order to guarantee the long-term success of Cloud Computing. The
aim of this paper is to provide a better understanding of the anatomy
of Cloud Computing and pave the way for further research in this
area.
Abstract: Software-as-a-Service (SaaS) is a form of cloud
computing that relieves the user of the burden of hardware and
software installation and management. SaaS can be used at the course
level to enhance curricula and student experience. When cloud
computing and SaaS are included in educational literature, the focus
is typically on implementing administrative functions. Yet, SaaS can
make more immediate and substantial contributions to the technical
course content in educational offerings. This paper explores cloud
computing and SaaS, provides examples, reports on experiences
using SaaS to offer specialized software in courses, and analyzes the
advantages and disadvantages of using SaaS at the course level. The
paper contributes to the literature in higher education by analyzing
the major technical concepts, potential, and constraints for using
SaaS to deliver specialized software at the course level. Further it
may enable more educators and students to benefit from this
emerging technology.