Effect of Retinoic Acid on Fetus Reproductive Organ Mice (Mus musculus) Swiss Webster
Retinoic acid is like a steroid hormone that plays a
role in embryo formation, proliferation of spermatogonia cells,
ephitelial cells differentiation and organogenesis. Retinoic acid can
influences seminiferous tubule formation during embryonic testis
development and also play a role in the regulation of ovarian function
and female reproductive tract by suppressing the hormones FSH
receptor expression. The excessive use of retinoic acid caused
abnormalities in the fetus. The result showed that there is the
influence of retinoic acid on the developmet of mice fetal testes, for
examples disruption of the formation of seminiferous tubules and
tubules seemed to be hollow, spermatogonia cells are relatively few
in number and caused Leydig cells count relatively more. While in
the female fetus does not caused the formation of primordial follicles
and disrupted the development of germinal ephitelial cells of fetal
ovaries of female mice (mus musculus) Swiss Webster.
[1] Munir, Warrety M. S. 1990. Perkembangan Embrio Ayam (Gallus
gallus) yang diperlakukan dengan Vitamin A, MSG, dan Kombinasinya.
Laporan penelitian.Universitas Andalas, Padang.
[2] Liss, Allan R. 1987. Recommendations for Vitamin A Use during
Pregnancy. Teratology. 35:269-275.
[3] Yasuda, Yoshiko et al., 1986. Development Anomalies Induced by Alltrans
Retinoic Acid in Fetal Mice Macroscopic Findings.
Teratology.34:37-49.
[4] Livera, G., Fabre, V., Rouiller and R. Habert. 2001. Retinoid Receptors
involved in The Effect of Retinoid Acid on Rat Testis Development.
Biology of Reproduction. 64:1307-1314.
[5] Koshimizu, Uichi, Miho Watanabe, Norio Nakatsuji. 1995. Retinoic
Acid is a Potent Growth Activator of Mouse Primordial Germ Cells In
Vitro. Developmental Biology: 168:2:683-685
[6] Xing, Weirong and M. Ram Sairam. 2002. Retinoic Acid Mediates
Transcriptional Repression of Ovine Follicle stimulating
Hormone Receptor Gene via a Pleiotropic Nuclear Receptor Response
Element. Biology of Reproduction: 67:204-211
[7] Rugh, R. 1971. A Guide To Vetebrate Development 6 th. Burgess
Publishing Co. USA.
[8] Conn, H.J. dan M.A. Darrow. 1960. Staining Procedures. The William
and Wilkins Co. Baltimore.P.146-147
[9] Sarmanu. 1988. "Histologis dan Ultras-truktur Testis Tikus Putih yang
Diberi Pakan Mengandung Biji Lamtoro Gung". Laporan Penelitian.
Surabaya: Universitas Airlangga.
[10] Granner and Daryl K. 2003. Kerja Hormon, dalam "Biokimia Harper",
E/25. Penulis, Robert K. Murray et al., Alih Bahasa: Anna P. Bani dan
Tiara M.N.S., Jakarta: Penerbit Buku Kedokteran - EGC.
[11] Purba, Dameriyani Nathalia. 2004. Pertumbuhan dan Perkembangan In
Vitro Folikel Primordial pada Ovarium Mencit Dengan atau Tanpa
Vitrifikasi (Skripsi). IPB. Bogor.
[1] Munir, Warrety M. S. 1990. Perkembangan Embrio Ayam (Gallus
gallus) yang diperlakukan dengan Vitamin A, MSG, dan Kombinasinya.
Laporan penelitian.Universitas Andalas, Padang.
[2] Liss, Allan R. 1987. Recommendations for Vitamin A Use during
Pregnancy. Teratology. 35:269-275.
[3] Yasuda, Yoshiko et al., 1986. Development Anomalies Induced by Alltrans
Retinoic Acid in Fetal Mice Macroscopic Findings.
Teratology.34:37-49.
[4] Livera, G., Fabre, V., Rouiller and R. Habert. 2001. Retinoid Receptors
involved in The Effect of Retinoid Acid on Rat Testis Development.
Biology of Reproduction. 64:1307-1314.
[5] Koshimizu, Uichi, Miho Watanabe, Norio Nakatsuji. 1995. Retinoic
Acid is a Potent Growth Activator of Mouse Primordial Germ Cells In
Vitro. Developmental Biology: 168:2:683-685
[6] Xing, Weirong and M. Ram Sairam. 2002. Retinoic Acid Mediates
Transcriptional Repression of Ovine Follicle stimulating
Hormone Receptor Gene via a Pleiotropic Nuclear Receptor Response
Element. Biology of Reproduction: 67:204-211
[7] Rugh, R. 1971. A Guide To Vetebrate Development 6 th. Burgess
Publishing Co. USA.
[8] Conn, H.J. dan M.A. Darrow. 1960. Staining Procedures. The William
and Wilkins Co. Baltimore.P.146-147
[9] Sarmanu. 1988. "Histologis dan Ultras-truktur Testis Tikus Putih yang
Diberi Pakan Mengandung Biji Lamtoro Gung". Laporan Penelitian.
Surabaya: Universitas Airlangga.
[10] Granner and Daryl K. 2003. Kerja Hormon, dalam "Biokimia Harper",
E/25. Penulis, Robert K. Murray et al., Alih Bahasa: Anna P. Bani dan
Tiara M.N.S., Jakarta: Penerbit Buku Kedokteran - EGC.
[11] Purba, Dameriyani Nathalia. 2004. Pertumbuhan dan Perkembangan In
Vitro Folikel Primordial pada Ovarium Mencit Dengan atau Tanpa
Vitrifikasi (Skripsi). IPB. Bogor.
@article{"International Journal of Biological, Life and Agricultural Sciences:61704", author = "Yulia Irnidayanti", title = "Effect of Retinoic Acid on Fetus Reproductive Organ Mice (Mus musculus) Swiss Webster", abstract = "Retinoic acid is like a steroid hormone that plays a
role in embryo formation, proliferation of spermatogonia cells,
ephitelial cells differentiation and organogenesis. Retinoic acid can
influences seminiferous tubule formation during embryonic testis
development and also play a role in the regulation of ovarian function
and female reproductive tract by suppressing the hormones FSH
receptor expression. The excessive use of retinoic acid caused
abnormalities in the fetus. The result showed that there is the
influence of retinoic acid on the developmet of mice fetal testes, for
examples disruption of the formation of seminiferous tubules and
tubules seemed to be hollow, spermatogonia cells are relatively few
in number and caused Leydig cells count relatively more. While in
the female fetus does not caused the formation of primordial follicles
and disrupted the development of germinal ephitelial cells of fetal
ovaries of female mice (mus musculus) Swiss Webster.", keywords = "Retinoic acid, Leydig cell, Spermatogonia cells,
Semin- ferous tubules,Primordial follicles", volume = "6", number = "4", pages = "201-3", }