Abstract: Development of a method to estimate gene functions is
an important task in bioinformatics. One of the approaches for the
annotation is the identification of the metabolic pathway that genes are
involved in. Since gene expression data reflect various intracellular
phenomena, those data are considered to be related with genes’
functions. However, it has been difficult to estimate the gene function
with high accuracy. It is considered that the low accuracy of the
estimation is caused by the difficulty of accurately measuring a gene
expression. Even though they are measured under the same condition,
the gene expressions will vary usually. In this study, we proposed a
feature extraction method focusing on the variability of gene
expressions to estimate the genes' metabolic pathway accurately. First,
we estimated the distribution of each gene expression from replicate
data. Next, we calculated the similarity between all gene pairs by KL
divergence, which is a method for calculating the similarity between
distributions. Finally, we utilized the similarity vectors as feature
vectors and trained the multiclass SVM for identifying the genes'
metabolic pathway. To evaluate our developed method, we applied the
method to budding yeast and trained the multiclass SVM for
identifying the seven metabolic pathways. As a result, the accuracy
that calculated by our developed method was higher than the one that
calculated from the raw gene expression data. Thus, our developed
method combined with KL divergence is useful for identifying the
genes' metabolic pathway.
Abstract: A Disaster Management System (DMS) is very important for countries with multiple disasters, such as Chile. In the world (also in Chile)different disasters (earthquakes, tsunamis, volcanic eruption, fire or other natural or man-made disasters) happen and have an effect on the population. It is also possible that two or more disasters occur at the same time. This meansthata multi-risk situation must be mastered. To handle such a situation a Decision Support System (DSS) based on multiagents is a suitable architecture. The most known DMSs are concernedwith only a singledisaster (sometimes thecombination of earthquake and tsunami) and often with a particular disaster. Nevertheless, a DSS helps for a better real-time response. Analyze the existing systems in the literature and expand them for multi-risk disasters to construct a well-organized system is the proposal of our work. The here shown work is an approach of a multi-risk system, which needs an architecture and well defined aims. In this moment our study is a kind of case study to analyze the way we have to follow to create our proposed system in the future.
Abstract: The Cone Penetration Test (CPT) is a common in-situ
test which generally investigates a much greater volume of soil more
quickly than possible from sampling and laboratory tests. Therefore,
it has the potential to realize both cost savings and assessment of soil
properties rapidly and continuously. The principle objective of this
paper is to demonstrate the feasibility and efficiency of using
artificial neural networks (ANNs) to predict the soil angle of internal
friction (Φ) and the soil modulus of elasticity (E) from CPT results
considering the uncertainties and non-linearities of the soil. In
addition, ANNs are used to study the influence of different
parameters and recommend which parameters should be included as
input parameters to improve the prediction. Neural networks discover
relationships in the input data sets through the iterative presentation
of the data and intrinsic mapping characteristics of neural topologies.
General Regression Neural Network (GRNN) is one of the powerful
neural network architectures which is utilized in this study. A large
amount of field and experimental data including CPT results, plate
load tests, direct shear box, grain size distribution and calculated data
of overburden pressure was obtained from a large project in the
United Arab Emirates. This data was used for the training and the
validation of the neural network. A comparison was made between
the obtained results from the ANN's approach, and some common
traditional correlations that predict Φ and E from CPT results with
respect to the actual results of the collected data. The results show
that the ANN is a very powerful tool. Very good agreement was
obtained between estimated results from ANN and actual measured
results with comparison to other correlations available in the
literature. The study recommends some easily available parameters
that should be included in the estimation of the soil properties to
improve the prediction models. It is shown that the use of friction
ration in the estimation of Φ and the use of fines content in the
estimation of E considerable improve the prediction models.
Abstract: Concrete is found to undergo degradation when
subjected to elevated temperatures and loose substantial amount of its
strength. The loss of strength in concrete is mainly attributed to
decomposition of C-S-H and release of physically and chemically
bound water, which begins when the exposure temperature exceeds
100°C. When such a concrete comes in contact with moisture, the
cement paste is found rehydrate and considerable amount of strength
lost is found to recover. This paper presents results of an
experimental program carried out to investigate the effect of recuring
on strength gain of OPC concrete specimens subjected to elevated
temperatures from 200°C to 800°C, which were subjected to
retention time of two hours and four hours at the designated
temperature. Strength recoveries for concrete subjected to 7
designated elevated temperatures are compared. It is found that the
efficacy of recuring as a measure of strength recovery reduces with
increase in exposure temperature.
Abstract: Much attention is paid to the development of space
branch in Kazakhstan at present. Two Earth remote sensing satellites
of Kazakhstan have been launched successfully. Many projects
related to the development of components for satellite are carried in
Kazakhstan, in particular the project related to the development of
star tracker experimental model. It is planned to use the results of this
project for development of star tracker prototype in the future. This
article describes the main stages of development of star tracker
experimental model.
Abstract: In this paper, an effective non-destructive, noninvasive
approach for leak detection was proposed. The process relies
on analyzing thermal images collected by an IR viewer device that
captures thermo-grams. In this study a statistical analysis of the
collected thermal images of the ground surface along the expected
leak location followed by a visual inspection of the thermo-grams
was performed in order to locate the leak. In order to verify the
applicability of the proposed approach the predicted leak location
from the developed approach was compared with the real leak
location. The results showed that the expected leak location was
successfully identified with an accuracy of more than 95%.
Abstract: Human leukocyte antigen (HLA) typing from next
generation sequencing (NGS) data has the potential for applications in
clinical laboratories and population genetic studies. Here we introduce
a novel technique for HLA typing from NGS data based on
read-mapping using a comprehensive reference panel containing all
known HLA alleles and de novo assembly of the gene-specific short
reads. An accurate HLA typing at high-digit resolution was achieved
when it was tested on publicly available NGS data, outperforming
other newly-developed tools such as HLAminer and PHLAT.
Abstract: Experimental & numeral study of temperature
distribution during milling process, is important in milling quality
and tools life aspects. In the present study the milling cross-section
temperature is determined by using Artificial Neural Networks
(ANN) according to the temperature of certain points of the work
piece and the point specifications and the milling rotational speed of
the blade. In the present work, at first three-dimensional model of the
work piece is provided and then by using the Computational Heat
Transfer (CHT) simulations, temperature in different nods of the
work piece are specified in steady-state conditions. Results obtained
from CHT are used for training and testing the ANN approach. Using
reverse engineering and setting the desired x, y, z and the milling
rotational speed of the blade as input data to the network, the milling
surface temperature determined by neural network is presented as
output data. The desired points temperature for different milling
blade rotational speed are obtained experimentally and by
extrapolation method for the milling surface temperature is obtained
and a comparison is performed among the soft programming ANN,
CHT results and experimental data and it is observed that ANN soft
programming code can be used more efficiently to determine the
temperature in a milling process.
Abstract: Micro-alloyed steel components are used in
automotive industry for the necessity to make the manufacturing
process cycles shorter when compared to conventional steel by
eliminating heat treatment cycles, so an important saving of costs and
energy can be reached by reducing the number of operations. Microalloying
elements like vanadium, niobium or titanium have been
added to medium carbon steels to achieve grain refinement with or
without precipitation strengthening along with uniform
microstructure throughout the matrix. Present study reports the
applicability of medium carbon vanadium micro-alloyed steel in hot
forging. Forgeability has been determined with respect to different
cooling rates, after forging in a hydraulic press at 50% diameter
reduction in temperature range of 900-11000C. Final microstructures,
hardness, tensile strength, and impact strength have been evaluated.
The friction coefficients of different lubricating conditions, viz.,
graphite in hydraulic oil, graphite in furnace oil, DF 150 (Graphite,
Water-Based) die lubricant and dry or without any lubrication were
obtained from the ring compression test for the above micro-alloyed
steel. Results of ring compression tests indicate that graphite in
hydraulic oil lubricant is preferred for free forging and dry lubricant
is preferred for die forging operation. Exceptionally good forgeability
and high resistance to fracture, especially for faster cooling rate has
been observed for fine equiaxed ferrite-pearlite grains, some amount
of bainite and fine precipitates of vanadium carbides and
carbonitrides. The results indicated that the cooling rate has a
remarkable effect on the microstructure and mechanical properties at
room temperature.
Abstract: The aim of this study was to build ‘Ubi-Net’, a
decision-making support system for systematic establishment in
U-City planning. We have experienced various urban problems caused
by high-density development and population concentrations in
established urban areas. To address these problems, a U-Service
contributes to the alleviation of urban problems by providing real-time
information to citizens through network connections and related
information. However, technology, devices, and information for
consumers are required for systematic U-Service planning in towns
and cities where there are many difficulties in this regard, and a lack of
reference systems.
Thus, this study suggests methods to support the establishment of
sustainable planning by providing comprehensive information
including IT technology, devices, news, and social networking
services (SNS) to U-City planners through intelligent searches. In this
study, we targeted Smart U-Parking Planning to solve parking
problems in an ‘old’ city. Through this study, we sought to contribute
to supporting advances in U-Space and the alleviation of urban
problems.
Abstract: Unmanned Aircraft Systems (UAS) become
indispensable parts of modern airpower as force multiplier. One of
the main advantages of UAS is long endurance. UAS have to take
extra payloads to accomplish different missions but these payloads
decrease endurance of aircraft because of increasing drag. There are
continuing researches to increase the capability of UAS. There are
some vertical thermal air currents, which can cause climb and
increase endurance, in nature. Birds and gliders use thermals to gain
altitude with no effort. UAS have wide wings which can use
thermals like birds and gliders. Thermal regions, which is area of
2000-3000 meter (1 NM), exist all around the world. It is natural and
infinite source. This study analyses if thermal regions can be adopted
and implemented as an assistant tool for UAS route planning. First
and second part of study will contain information about the thermal
regions and current applications about UAS in aviation and climbing
performance with a real example. Continuing parts will analyze the
contribution of thermal regions to UAS endurance. Contribution is
important because planning declaration of UAS navigation rules will
be in 2015.
Abstract: The ultrasound imaging is very popular to diagnosis
the disease because of its non-invasive nature. The ultrasound
imaging slowly produces low quality images due to the presence of
spackle noise and wave interferences. There are several algorithms to
be proposed for the segmentation of ultrasound carotid artery images
but it requires a certain limit of user interaction. The pixel in an
image is highly correlated so the spatial information of surrounding
pixels may be considered in the process of image segmentation which
improves the results further. When data is highly correlated, one pixel
may belong to more than one cluster with different degree of
membership. There is an important step to computerize the evaluation
of arterial disease severity using segmentation of carotid artery lumen
in 2D and 3D ultrasonography and in finding vulnerable
atherosclerotic plaques susceptible to rupture which can cause stroke.
Abstract: The Ombudsman is a procedural mechanism that
provides a different approach of dispute resolution. The ombudsman
primarily deals with specific grievances from the public against
governmental injustice and misconduct. The ombudsman theory is
considered an important instrument to any democratic government.
This is true since it improves the transparency of the governmental
activities in a world in which executive power are rising. Many
countries have adopted the concept of Ombudsman but under
different terminologies. This paper will provide the different types of
Ombudsman and the common activities/processes of fulfilling their
mandates.
Abstract: The goal of image segmentation is to cluster pixels
into salient image regions. Segmentation could be used for object
recognition, occlusion boundary estimation within motion or stereo
systems, image compression, image editing, or image database lookup.
In this paper, we present a color image segmentation using
support vector machine (SVM) pixel classification. Firstly, the pixel
level color and texture features of the image are extracted and they
are used as input to the SVM classifier. These features are extracted
using the homogeneity model and Gabor Filter. With the extracted
pixel level features, the SVM Classifier is trained by using FCM
(Fuzzy C-Means).The image segmentation takes the advantage of
both the pixel level information of the image and also the ability of
the SVM Classifier. The Experiments show that the proposed method
has a very good segmentation result and a better efficiency, increases
the quality of the image segmentation compared with the other
segmentation methods proposed in the literature.
Abstract: Although there had been a many studies that shows
the impact of air pollution on physical health, comparatively less was
known of human behavioral responses and annoyance impacts.
Annoyance caused by air pollution is a public health problem because
it can be an ambient stressor causing stress and disease and can affect
quality of life. The objective of this work is to evaluate the
annoyance caused by air pollution in two different industrialized
urban areas, Dunkirk (France) and Vitoria (Brazil). The populations
of these cities often report feeling annoyed by dust. Surveys were
conducted, and the collected data were analyzed using statistical
analyses. The results show that sociodemographic variables,
importance of air quality, perceived industrial risk, perceived air
pollution and occurrence of health problems play important roles in
the perceived annoyance. These results show the existence of a
common problem in geographically distant areas and allow
stakeholders to develop prevention strategies.
Abstract: In this research (using induction furnace process)
nodular iron with three different percentages of copper (residual,
0.5% and 1,2%) was obtained. Chemical analysis was performed by
mass spectrometry and microstructures were characterized by Optical
Microscopy (ASTM E3) and Scanning Electron Microscopy (SEM).
The study of mechanical behavior was carried out in a mechanical
test machine (ASTM E8) and a Pin on disk tribometer (ASTM G99)
was used to assess wear resistance. It is observed that the dissolution
of copper in crystal lattice increases the pearlite structure improving
the wear and hardness behavior, but producing a contrary effect on
the energy absorption.
Abstract: The objectives of study are the following: To study
the way of life in terms of one hundred years co-existence of the
Muslim and local community in this area 2) To analyze factors affect
to this community with happy co-existence. The study requires
quantitative research to study a history together with the study of
humanity. The result of this study showed that the area of Petchburi
7 community is an ancient area which has owned by the Muslim for
almost 100 years. There is a sanctuary as & center of unity. Later
Bangkok becomes developed and provides more infrastructures like
motorway and other transportation: however, the owners of lands in
this community still keep their lands and build many buildings to run
business. With this purpose, there are many non-Muslim people come
to live here with co-existence. Not only are they convenient to work
but also easy to transport by sky train. There are factors that make
them live harmonious as following: 1) All Muslims in this area are
strict to follow their rules and allocate their community for business.
2) All people, who come and live here, are middle-aged and working
men and women. They, rent rooms closed to their work. 3) There are
Muslim food and desserts, especially Roti, the popular fried flour,
and local Chachak, tea originated from the south of Thailand. All
these food and desserts are famous for working men and women to
home and join after work 4) All Muslim in this area are independent
to lead their own lives although a society changes rapidly.
Abstract: Doxorubicin, also known as Adriamycin, is an
anthracycline class of drug used in cancer chemotherapy. It is used in
the treatment of non-Hodgkin’s lymphoma, multiple myeloma, acute
leukemia, breast cancer, lung cancer, endometrium cancer and ovary
cancers. It functions via intercalating DNA and ultimately killing
cancer cells. The major side effects of doxorubicin are hair loss,
myelosuppression, nausea & vomiting, oesophagitis, diarrhea, heart
damage and liver dysfunction. The minor modifications in the
structure of compound exhibit large variation in the biological
activity, has prompted us to carry out the synthesis of sulfonamide
derivatives. Sulfonamide is an important feature with broad spectrum
of biological activity such as antiviral, antifungal, diuretics, antiinflammatory,
antibacterial and anticancer activities. Structure of the
synthesized compound N-(1-methyl-2-oxo-2-N-methyl anilinoethyl)
benzene sulfonamide confirmed by proton nuclear magnetic
resonance (1H NMR),13C NMR, Mass and FTIR spectroscopic tools
to assure the position of all protons and hence stereochemistry of the
molecule. Further we have reported the binding potential of
synthesized sulfonamide analogues in comparison to doxorubicin
drug using Auto Dock 4.2 software. Computational binding energy
(B.E.) and inhibitory constant (Ki) has been evaluated for the
synthesized compound in comparison of doxorubicin against Poly
(dA-dT).Poly (dA-dT) and Poly (dG-dC).Poly (dG-dC) sequences.
The in vitro cytotoxic study against human breast cancer cell lines
confirms the better anticancer activity of the synthesized compound
over currently in use anticancer drug doxorubicin. The IC50 value of
the synthesized compound is 7.12 μM whereas for doxorubicin is 7.2
μM.
Abstract: Formal verification is proposed to ensure the
correctness of the design and make functional verification more
efficient. As cache plays a vital role in the design of System on Chip
(SoC), and cache with Memory Management Unit (MMU) and cache
memory unit makes the state space too large for simulation to verify,
then a formal verification is presented for such system design. In the
paper, a formal model checking verification flow is suggested and a
new cache memory model which is called “exhaustive search model”
is proposed. Instead of using large size ram to denote the whole cache
memory, exhaustive search model employs just two cache blocks. For
cache system contains data cache (Dcache) and instruction cache
(Icache), Dcache memory model and Icache memory model are
established separately using the same mechanism. At last, the novel
model is employed to the verification of a cache which is module of a
custom-built SoC system that has been applied in practical, and the
result shows that the cache system is verified correctly using the
exhaustive search model, and it makes the verification much more
manageable and flexible.
Abstract: As the economies of other countries in the
Mediterranean Basin, the tourism sector in our country has a high
denominator in economics. Tourism businesses, which are building
blocks of tourism, sector faces with a variety of problems during their
activities. These problems faced make business efficiency and
competition conditions of the businesses difficult. Most of the
problems faced by the tourism businesses and the information of
consumers about consumers’ rights were used in this study, which is
conducted to determine the problems of tourism businesses in the
Central Anatolia Region. It is aimed to contribute the awareness of
staff and executives working at tourism sector and to attract attention
of businesses active concurrently with tourism sector and legislators.