Abstract: Cytogenetic analysis still remains the gold standard method for prenatal diagnosis of trisomy 21 (Down syndrome, DS). Nevertheless, the conventional cytogenetic analysis needs live cultured cells and is too time-consuming for clinical application. In contrast, molecular methods such as FISH, QF-PCR, MLPA and quantitative Real-time PCR are rapid assays with results available in 24h. In the present study, we have successfully used a novel MGB TaqMan probe-based real time PCR assay for rapid diagnosis of trisomy 21 status in Down syndrome samples. We have also compared the results of this molecular method with corresponding results obtained by the cytogenetic analysis. Blood samples obtained from DS patients (n=25) and normal controls (n=20) were tested by quantitative Real-time PCR in parallel to standard G-banding analysis. Genomic DNA was extracted from peripheral blood lymphocytes. A high precision TaqMan probe quantitative Real-time PCR assay was developed to determine the gene dosage of DSCAM (target gene on 21q22.2) relative to PMP22 (reference gene on 17p11.2). The DSCAM/PMP22 ratio was calculated according to the formula; ratio=2 -ΔΔCT. The quantitative Real-time PCR was able to distinguish between trisomy 21 samples and normal controls with the gene ratios of 1.49±0.13 and 1.03±0.04 respectively (p value
Abstract: In this paper a new fast simplification method is
presented. Such method realizes Karnough map with large
number of variables. In order to accelerate the operation of the
proposed method, a new approach for fast detection of group
of ones is presented. Such approach implemented in the
frequency domain. The search operation relies on performing
cross correlation in the frequency domain rather than time one.
It is proved mathematically and practically that the number of
computation steps required for the presented method is less
than that needed by conventional cross correlation. Simulation
results using MATLAB confirm the theoretical computations.
Furthermore, a powerful solution for realization of complex
functions is given. The simplified functions are implemented
by using a new desigen for neural networks. Neural networks
are used because they are fault tolerance and as a result they
can recognize signals even with noise or distortion. This is
very useful for logic functions used in data and computer
communications. Moreover, the implemented functions are
realized with minimum amount of components. This is done
by using modular neural nets (MNNs) that divide the input
space into several homogenous regions. Such approach is
applied to implement XOR function, 16 logic functions on one
bit level, and 2-bit digital multiplier. Compared to previous
non- modular designs, a clear reduction in the order of
computations and hardware requirements is achieved.
Abstract: Rounding of coefficients is a common practice in
hardware implementation of digital filters. Where some coefficients
are very close to zero or one, as assumed in this paper, this rounding
action also leads to some computation reduction. Furthermore, if the
discarded coefficient is of high order, a reduced order filter is
obtained, otherwise the order does not change but computation is
reduced. In this paper, the Least Squares approximation to rounded
(or discarded) coefficient FIR filter is investigated. The result also
succinctly extended to general type of FIR filters.
Abstract: In this study, any possible differences between mathematics beliefs and anxiety of prospective elementary mathematics teachers have been investigated according to their gender. In this purpose, 1st, 2nd, 3rd and 4th grade students from a Government University in Turkey were selected as a sample. Mathematics Teaching Anxiety Scale (MATAS) and Beliefs About Mathematics Survey (BAMS) has been used as data collection tools. As a result of the study, it has been observed that prospective male teachers have more instrumentalist approach in learning mathematics than females according to their mathematical beliefs. On the other hand, females have more mathematics teaching anxiety than males especially, for subject knowledge in mathematics and selfconfidence.
Abstract: In this paper, a new learning algorithm based on a
hybrid metaheuristic integrating Differential Evolution (DE) and
Reduced Variable Neighborhood Search (RVNS) is introduced to train
the classification method PROAFTN. To apply PROAFTN, values of
several parameters need to be determined prior to classification. These
parameters include boundaries of intervals and relative weights for
each attribute. Based on these requirements, the hybrid approach,
named DEPRO-RVNS, is presented in this study. In some cases, the
major problem when applying DE to some classification problems
was the premature convergence of some individuals to local optima.
To eliminate this shortcoming and to improve the exploration and
exploitation capabilities of DE, such individuals were set to iteratively
re-explored using RVNS. Based on the generated results on
both training and testing data, it is shown that the performance of
PROAFTN is significantly improved. Furthermore, the experimental
study shows that DEPRO-RVNS outperforms well-known machine
learning classifiers in a variety of problems.
Abstract: Morphogenesis is the process that underpins the selforganised development and regeneration of biological systems. The ability to mimick morphogenesis in artificial systems has great potential for many engineering applications, including production of biological tissue, design of robust electronic systems and the co-ordination of parallel computing. Previous attempts to mimick these complex dynamics within artificial systems have relied upon the use of evolutionary algorithms that have limited their size and complexity. This paper will present some insight into the underlying dynamics of morphogenesis, then show how to, without the assistance of evolutionary algorithms, design cellular architectures that converge to complex patterns.
Abstract: Adsorption of CS2 vapors has been studied on
different types of activated carbons obtained from different source
raw materials. The activated carbons have different surface areas and
are associated with varying amounts of the carbon-oxygen surface
groups. The adsorption of CS2 vapors is not directly related to surface
area, but is considerably influenced by the presence of carbonoxygen
surface groups. The adsorption decreases on increasing the
amount of carbon-oxygen surface groups on oxidation and increases
when these surface groups are eliminated on degassing. The
adsorption is maximum in case of the 950°-degassed carbon sample
which is almost completely free of any associated oxygen. The
kinetic data as analysed by Empirical diffusion model and Linear
driving force mass transfer model indicate that the adsorption does
not involve Fickian diffusion but may be considered as a pseudo first
order mass transfer process. The activation energy of adsorption and
isosteric enthalpies of adsorption indicate that the adsorption does not
involve interaction between CS2 and carbon-oxygen surface groups,
but hydrophobic interactions between CS2 and C-C atoms in the
carbon lattice.
Abstract: A dynamic of Bertrand duopoly game is analyzed, where players use different production methods and choose their prices with bounded rationality. The equilibriums of the corresponding discrete dynamical systems are investigated. The stability conditions of Nash equilibrium under a local adjustment process are studied. The stability conditions of Nash equilibrium under a local adjustment process are studied. The stability of Nash equilibrium, as some parameters of the model are varied, gives rise to complex dynamics such as cycles of higher order and chaos. On this basis, we discover that an increase of adjustment speed of bounded rational player can make Bertrand market sink into the chaotic state. Finally, the complex dynamics, bifurcations and chaos are displayed by numerical simulation.
Abstract: Postgraduate education is generally aimed at providing in-depth knowledge and understanding that include general philosophy in the world sciences, management, technologies, applications and other elements closely related to specific areas. In most universities, besides core and non-core subjects, a thesis is one of the requirements for the postgraduate student to accomplish before graduating. This paper reports on the empirical investigation into attributes that are associated with the obstacles to thesis accomplishment among postgraduate students. Using the quantitative approach the experiences of postgraduate students were tapped. Findings clearly revealed that information seeking, writing skills and other factors which refer to supervisor and time management, in particular, are recognized as contributory factors which positively or negatively influence postgraduates’ thesis accomplishment. Among these, writing skills dimensions were found to be the most difficult process in thesis accomplishment compared to information seeking and other factors. This pessimistic indication has provided some implications not only for the students but supervisors and institutions as a whole.
Abstract: This paper investigates the problem of spreading
sequence and receiver code synchronization techniques for satellite
based CDMA communications systems. The performance of CDMA
system depends on the autocorrelation and cross-correlation
properties of the used spreading sequences. In this paper we propose
the uses of chaotic Lu system to generate binary sequences for
spreading codes in a direct sequence spread CDMA system. To
minimize multiple access interference (MAI) we propose the use of
genetic algorithm for optimum selection of chaotic spreading
sequences. To solve the problem of transmitter-receiver
synchronization, we use the passivity controls. The concept of
semipassivity is defined to find simple conditions which ensure
boundedness of the solutions of coupled Lu systems. Numerical
results are presented to show the effectiveness of the proposed
approach.
Abstract: AAM has been successfully applied to face alignment,
but its performance is very sensitive to initial values. In case the initial
values are a little far distant from the global optimum values, there
exists a pretty good possibility that AAM-based face alignment may
converge to a local minimum. In this paper, we propose a progressive
AAM-based face alignment algorithm which first finds the feature
parameter vector fitting the inner facial feature points of the face and
later localize the feature points of the whole face using the first
information. The proposed progressive AAM-based face alignment
algorithm utilizes the fact that the feature points of the inner part of the
face are less variant and less affected by the background surrounding
the face than those of the outer part (like the chin contour). The
proposed algorithm consists of two stages: modeling and relation
derivation stage and fitting stage. Modeling and relation derivation
stage first needs to construct two AAM models: the inner face AAM
model and the whole face AAM model and then derive relation matrix
between the inner face AAM parameter vector and the whole face
AAM model parameter vector. In the fitting stage, the proposed
algorithm aligns face progressively through two phases. In the first
phase, the proposed algorithm will find the feature parameter vector
fitting the inner facial AAM model into a new input face image, and
then in the second phase it localizes the whole facial feature points of
the new input face image based on the whole face AAM model using
the initial parameter vector estimated from using the inner feature
parameter vector obtained in the first phase and the relation matrix
obtained in the first stage. Through experiments, it is verified that the
proposed progressive AAM-based face alignment algorithm is more
robust with respect to pose, illumination, and face background than the
conventional basic AAM-based face alignment algorithm.
Abstract: In this work we present an efficient approach for face
recognition in the infrared spectrum. In the proposed approach
physiological features are extracted from thermal images in order to
build a unique thermal faceprint. Then, a distance transform is used
to get an invariant representation for face recognition. The obtained
physiological features are related to the distribution of blood vessels
under the face skin. This blood network is unique to each individual
and can be used in infrared face recognition. The obtained results are
promising and show the effectiveness of the proposed scheme.
Abstract: In this study, a fuzzy integrated logical forecasting method (FILF) is extended for multi-variate systems by using a vector autoregressive model. Fuzzy time series forecasting (FTSF) method was recently introduced by Song and Chissom [1]-[2] after that Chen improved the FTSF method. Rather than the existing literature, the proposed model is not only compared with the previous FTS models, but also with the conventional time series methods such as the classical vector autoregressive model. The cluster optimization is based on the C-means clustering method. An empirical study is performed for the prediction of the chartering rates of a group of dry bulk cargo ships. The root mean squared error (RMSE) metric is used for the comparing of results of methods and the proposed method has superiority than both traditional FTS methods and also the classical time series methods.
Abstract: This paper investigates the effects of knowledge-based acceleration feedback control integrated with Automatic Generation Control (AGC) to enhance the quality of frequency control of governing system. The Intelligent Acceleration Feedback Controller (IAFC) is proposed to counter the over and under frequency occurrences due to major load change in power system network. Therefore, generator tripping and load shedding operations can be reduced. Meanwhile, the integration of IAFC with AGC, a well known Load-Frequency Control (LFC) is essential to ensure the system frequency is restored to the nominal value. Computer simulations of frequency response of governing system are used to optimize the parameters of IAFC. As a result, there is substantial improvement on the LFC of governing system that employing the proposed control strategy.
Abstract: An experimental study is presented on the effect
of microstructural change on the Portevin-Le Chatelier effect
behaviour of Al-2.5%Mg alloy. Tensile tests are performed on
the as received and heat treated (at 400 ºC for 16 hours)
samples for a wide range of strain rates. The serrations
observed in the stress-time curve are investigated from
statistical analysis point of view. Microstructures of the
samples are characterized by optical metallography and X-ray
diffraction. It is found that the excess vacancy generated due
to heat treatment leads to decrease in the strain rate sensitivity
and the increase in the number of stress drop occurrences per
unit time during the PLC effect. The microstructural
parameters like domain size, dislocation density have no
appreciable effect on the PLC effect as far as the statistical
behavior of the serrations is considered.
Abstract: A triangular fin with variable fin base thickness is analyzed and optimized using a two-dimensional analytical method. The influence of fin base height and fin base thickness on the temperature in the fin is listed. For the fixed fin volumes, the maximum heat loss, the corresponding optimum fin effectiveness, fin base height and fin tip length as a function of the fin base thickness, convection characteristic number and dimensionless fin volume are represented. One of the results shows that the optimum heat loss increases whereas the corresponding optimum fin effectiveness decreases with the increase of fin volume.
Abstract: In this paper we have numerically analyzed terahertzrange
wavelength conversion using nondegenerate four wave mixing
(NDFWM) in a SOA integrated DFB laser (experiments reported
both in MIT electronics and Fujitsu research laboratories). For
analyzing semiconductor optical amplifier (SOA), we use finitedifference
beam propagation method (FDBPM) based on modified
nonlinear SchrÖdinger equation and for distributed feedback (DFB)
laser we use coupled wave approach. We investigated wavelength
conversion up to 4THz probe-pump detuning with conversion
efficiency -5dB in 1THz probe-pump detuning for a SOA integrated
quantum-well
Abstract: The model of neural networks on the small-world
topology, with metric (local and random connectivity) is investigated.
The synaptic weights are random, driving the network towards a
chaotic state for the neural activity. An ordered macroscopic neuron
state is induced by a bias in the network connections. When the
connections are mainly local, the network emulates a block-like
structure. It is found that the topology and the bias compete to
influence the network to evolve into a global or a block activity
ordering, according to the initial conditions.
Abstract: In this study, the theoretical relationship between pressure and density was investigated on cylindrical hollow fuel briquettes produced of a mixture of fibrous biomass material using a screw press without any chemical binder. The fuel briquettes were made of biomass and other waste material such as spent coffee beans, mielie husks, saw dust and coal fines under pressures of 0.878-2.2 Mega Pascals (MPa). The material was densified into briquettes of outer diameter of 100mm, inner diameter of 35mm and 50mm long. It was observed that manual screw compression action produces briquettes of relatively low density as compared to the ones made using hydraulic compression action. The pressure and density relationship was obtained in the form of power law and compare well with other cylindrical solid briquettes made using hydraulic compression action. The produced briquettes have a dry density of 989 kg/m3 and contain 26.30% fixed carbon, 39.34% volatile matter, 10.9% moisture and 10.46% ash as per dry proximate analysis. The bomb calorimeter tests have shown the briquettes yielding a gross calorific value of 18.9MJ/kg.
Abstract: To reveal the temperature field distribution of disc
brake in downward belt conveyor, mathematical models of heat
transfer for disc brake were established combined with heat transfer
theory. Then, the simulation process was stated in detail and the
temperature field of disc brake under conditions of dynamic speed and
dynamic braking torque was numerically simulated by using ANSYS
software. Finally the distribution and variation laws of temperature
field in the braking process were analyzed. Results indicate that the
maximum surface temperature occurs at a time before the brake end
and there exist large temperature gradients in both radial and axial
directions, while it is relatively small in the circumferential direction.