Abstract: Targeted drug delivery is a method of delivering
medication to a patient in a manner that increases the concentration
of the medication in some parts of the body relative to others.
Targeted drug delivery seeks to concentrate the medication in the
tissues of interest while reducing the relative concentration of the
medication in the remaining tissues. This improves efficacy of the
while reducing side effects. In the present work, we investigate the
effect of magnetic field, flow rate and particle concentration on the
capturing of magnetic particles transported in a stent implanted
fluidic channel. Iron oxide magnetic nanoparticles (Fe3O4)
nanoparticles were synthesized via co-precipitation method. The
synthesized Fe3O4 nanoparticles were added in the de-ionized (DI)
water to prepare the Fe3O4 magnetic particle suspended fluid. This
fluid is transported in a cylindrical tube of diameter 8 mm with help
of a peristaltic pump at different flow rate (25-40 ml/min). A
ferromagnetic coil of SS 430 has been implanted inside the
cylindrical tube to enhance the capturing of magnetic nanoparticles
under magnetic field. The capturing of magnetic nanoparticles was
observed at different magnetic magnetic field, flow rate and particle
concentration. It is observed that capture efficiency increases from
47-67% at magnetic field 2-5kG, respectively at particle
concentration 0.6mg/ml and at flow rate 30 ml/min. However, the
capture efficiency decreases from 65 to 44% by increasing the flow
rate from 25 to 40 ml/min, respectively. Furthermore, it is observed
that capture efficiency increases from 51 to 67% by increasing the
particle concentration from 0.3 to 0.6 mg/ml, respectively.
Abstract: In this glasshouse study, we developed a new imagebased
non-destructive technique for detecting leaf P status of
different crops such as cotton, tomato and lettuce. The plants were
grown on a nutrient solution containing different P concentrations,
e.g. 0%, 50% and 100% of recommended P concentration (P0 = no P,
L; P1 = 2.5 mL 10 L-1 of P and P2 = 5 mL 10 L-1 of P). After 7 weeks
of treatment, the plants were harvested and data on leaf P contents
were collected using the standard destructive laboratory method and
at the same time leaf images were collected by a handheld crop image
sensor. We calculated leaf area, leaf perimeter and RGB (red, green
and blue) values of these images. These data were further used in
linear discriminant analysis (LDA) to estimate leaf P contents, which
successfully classified these plants on the basis of leaf P contents.
The data indicated that P deficiency in crop plants can be predicted
using leaf image and morphological data. Our proposed nondestructive
imaging method is precise in estimating P requirements of
different crop species.
Abstract: The aim of the study is to improve the understanding
of latent and sensible thermal energy storage within a paraffin wax
media by an array of cylindrical tubes arranged both in in-line and
staggered layouts. An analytical and experimental study is carried out
in a horizontal shell-and-tube type system during melting process.
Pertamina paraffin-wax was used as a phase change material (PCM),
while the tubes are embedded in the PCM. From analytical study we
can obtain the useful information in designing a thermal energy
storage such as: the motion of interface, amount of material melted at
any time in the process, and the heat storage characteristic during
melting. The use of staggered tubes is proposed compared to in-line
layout in a heat exchanger as thermal storage. The experimental study
is used to verify the validity of the analytical predictions. From the
comparisons, the analytical and experimental data are in a good
agreement.
Abstract: In this study, we investigated numerically heat
transfer by mixed convection coupled to radiation in a square cavity;
the upper horizontal wall is movable. The purpose of this study is to
see the influence of the emissivity ε and the varying of the
Richardson number Ri on the variation of average Nusselt number
Nu. The vertical walls of the cavity are differentially heated, the left
wall is maintained at a uniform temperature higher than the right
wall, and the two horizontal walls are adiabatic. The finite volume
method is used for solving the dimensionless Governing Equations.
Emissivity values used in this study are ranged between 0 and 1, the
Richardson number in the range 0.1 to 10. The Rayleigh number is
fixed to Ra=104 and the Prandtl number is maintained constant
Pr=0.71. Streamlines, isothermal lines and the average Nusselt
number are presented according to the surface emissivity. The results
of this study show that the Richardson number Ri and emissivity ε
affect the average Nusselt number.
Abstract: This paper focuses on the orbit avoidance strategy of
the optical remote sensing satellite. The optical remote sensing
satellite, moving along the Sun-synchronous orbit, is equipped with
laser warning equipment to alert CCD camera from laser attacks. This
paper explores the strategy of satellite avoidance to protect the CCD
camera and also the satellite. The satellite could evasive to several
target points in the orbital coordinates of virtual satellite. The so-called
virtual satellite is a passive vehicle which superposes the satellite at the
initial stage of avoidance. The target points share the consistent cycle
time and the same semi-major axis with the virtual satellite, which
ensures the properties of the satellite’s Sun-synchronous orbit remain
unchanged. Moreover, to further strengthen the avoidance capability
of satellite, it can perform multi-target-points avoid maneuvers. On
occasions of fulfilling the satellite orbit tasks, the orbit can be restored
back to virtual satellite through orbit maneuvers. There into, the avoid
maneuvers adopts pulse guidance. In addition, the fuel consumption is
optimized. The avoidance strategy discussed in this article is
applicable to optical remote sensing satellite when it is encountered
with hostile attack of space-based laser anti-satellite.
Abstract: In present study, a large deposit of oolitic iron ore of
Late Carboniferous-Permotriassic-Lower Jurassic age was discovered
in Wadi Halfa and Argein areas, North Sudan. It seems that the iron
ore mineralization exists in the west and east bank of the River Nile
of the study area that are found on the Egyptian-Sudanese border.
The Carboniferous-Lower Jurassic age strata were covered by 67
sections and each section has been examined and carefully described.
The iron-ore in Wadi Halfa occurs as oolitic ironstone and contained
two horizons: (A) horizon and (B) horizon. Only horizon (A) was
observed in southern Argein area. The texture of the ore is variable
depending on the volume of the component. In thin sections, the
average of the ooids was ranged between 90%-80%. The matrix
varies between 10%-20% by volume and detritus quartz in other
component my reach up to 30% by volume in sandy massive ore.
Ooids size ranges from 0.2mm-1.00 mm on average in very coarse
ooids may attend up to 1 mm in size. The matrix around the ooids is
dominated by iron hydroxide, carbonate, fine, and amorphous silica.
The probable ore reserve estimate of 1.234 billion at a head grade of
41.29% Fe for the Wadi Halfa Oolitic Ironstone Formation. The iron
ore shows higher content of phosphorus ranges from 6.15% to 0.16%,
with mean 1.45%. The new technology Hatch–Ironstone Chloride
Segregation (HICS) can be used to produce commercial-quality of
iron and reduce phosphorus and silica to acceptable levels for steel
industry. The presence of infrastructures in addition to the presence
of massive quantities of iron ore would make exploitation
economically.
Abstract: In this paper, a novel Linear Feedback Shift Register
(LFSR) with Look Ahead Clock Gating (LACG) technique is
presented to reduce the power consumption in modern processors
and System-on-Chip. Clock gating is a predominant technique used
to reduce unwanted switching of clock signals. Several clock gating
techniques to reduce the dynamic power have been developed, of
which LACG is predominant. LACG computes the clock enabling
signals of each flip-flop (FF) one cycle ahead of time, based on the
present cycle data of the flip-flops on which it depends. It overcomes
the timing problems in the existing clock gating methods like datadriven
clock gating and Auto-Gated flip-flops (AGFF) by allotting a
full clock cycle for the determination of the clock enabling signals.
Further to reduce the power consumption in LACG technique, FFs
can be grouped so that they share a common clock enabling signal.
Simulation results show that the novel grouped LFSR with LACG
achieves 15.03% power savings than conventional LFSR with LACG
and 44.87% than data-driven clock gating.
Abstract: The objective of this study was to synthesize and
characterize the poly(alkenoic acid)s with different molecular
structures, use these polymers to formulate a dental cement
restorative, and study the effect of molecular structures on reaction
kinetics, viscosity, and mechanical strengths of the formed polymers
and cement restoratives. In this study, poly(alkenoic acid)s with
different molecular structures were synthesized. The purified
polymers were formulated with commercial Fuji II LC glass fillers to
form the experimental cement restoratives. The reaction kinetics was
studied via 1HNMR spectroscopy. The formed restoratives were
evaluated using compressive strength, diametral tensile strength,
flexural strength, hardness and wear-resistance tests. Specimens were
conditioned in distilled water at 37oC for 24 h prior to testing. Fuji II
LC restorative was used as control. The results show that the higher
the arm number and initiator concentration, the faster the reaction
was. It was also found that the higher the arm number and branching
that the polymer had, the lower the viscosity of the polymer in water
and the lower the mechanical strengths of the formed restorative. The
experimental restoratives were 31-53% in compressive strength, 37-
55% in compressive modulus, 80-126% in diametral tensile strength,
76-94% in flexural strength, 4-21% in fracture toughness and 53-96%
in hardness higher than Fuji II LC. For wear test, the experimental
restoratives were only 5.4-13% of abrasive and 6.4-12% of attritional
wear depths of Fuji II LC in each wear cycle. The aging study also
showed that all the experimental restoratives increased their strength
continuously during 30 days, unlike Fuji II LC. It is concluded that
polymer molecular structures have significant and positive impact on
mechanical properties of dental cement restoratives.
Abstract: Introduction: The process to build a better safety
culture, methods of error analysis, and preventive measures, starts
with an understanding of the effects when human factors engineering
refer to remote microscopic diagnosis in surgery and specially in
organ transplantation for the remote evaluation of the grafts. It has
been estimated that even in well-organized transplant systems an
average of 8% to 14% of the grafts (G) that arrive at the recipient
hospitals may be considered as diseased, injured, damaged or
improper for transplantation. Digital microscopy adds information on
a microscopic level about the grafts in Organ Transplant (OT), and
may lead to a change in their management. Such a method will
reduce the possibility that a diseased G, will arrive at the recipient
hospital for implantation. Aim: Ergonomics of Digital Microscopy
(DM) based on virtual slides, on Telemedicine Systems (TS) for
Tele-Pathological (TPE) evaluation of the grafts (G) in organ
transplantation (OT). Material and Methods: By experimental
simulation, the ergonomics of DM for microscopic TPE of Renal
Graft (RG), Liver Graft (LG) and Pancreatic Graft (PG) tissues is
analyzed. In fact, this corresponded to the ergonomics of digital
microscopy for TPE in OT by applying Virtual Slide (VS) system for
graft tissue image capture, for remote diagnoses of possible
microscopic inflammatory and/or neoplastic lesions. Experimentation
included: a. Development of an OTE-TS similar Experimental
Telemedicine System (Exp.-TS), b. Simulation of the integration of
TS with the VS based microscopic TPE of RG, LG and PG applying
DM. Simulation of the DM based TPE was performed by 2
specialists on a total of 238 human Renal Graft (RG), 172 Liver Graft
(LG) and 108 Pancreatic Graft (PG) tissues digital microscopic
images for inflammatory and neoplastic lesions on four electronic
spaces of the four used TS. Results: Statistical analysis of specialist‘s
answers about the ability to diagnose accurately the diseased RG, LG
and PG tissues on the electronic space among four TS (A,B,C,D)
showed that DM on TS for TPE in OT is elaborated perfectly on the
ES of a Desktop, followed by the ES of the applied Exp.-TS. Tablet
and Mobile-Phone ES seem significantly risky for the application of
DM in OT (p
Abstract: Background: To improve the delivery of paediatric
healthcare in low resource settings, Community Health Workers
(CHW) have been provided with a paper-based set of protocols
known as Community Case Management (CCM). Yet research has
shown that CHW adherence to CCM guidelines is poor, ultimately
impacting health service delivery. Digitising the CCM guidelines via
mobile technology is argued in extant literature to improve CHW
adherence. However, little research exist which outlines how (a) this
process can be digitised and (b) adherence could be improved as a
result. Aim: To explore how an electronic mobile version of CCM
(eCCM) can overcome issues associated with the paper-based CCM
protocol (inadequate adherence to guidelines) vis-à-vis service
blueprinting. This service blueprint will outline how (a) the CCM
process can be digitised using mobile Clinical Decision Support
Systems software to support clinical decision-making and (b)
adherence can be improved as a result. Method: Development of a
single service blueprint for a standalone application which visually
depicts the service processes (eCCM) when supporting the CHWs,
using an application known as Supporting LIFE (SL eCCM app) as
an exemplar. Results: A service blueprint is developed which
illustrates how the SL eCCM app can be utilised by CHWs to assist
with the delivery of healthcare services to children. Leveraging
smartphone technologies can (a) provide CHWs with just-in-time
data to assist with their decision making at the point-of-care and (b)
improve CHW adherence to CCM guidelines. Conclusions: The
development of the eCCM opens up opportunities for the CHWs to
leverage the inherent benefit of mobile devices to assist them with
health service delivery in rural settings. To ensure that benefits are
achieved, it is imperative to comprehend the functionality and form
of the eCCM service process. By creating such a service blueprint for
an eCCM approach, CHWs are provided with a clear picture
regarding the role of the eCCM solution, often resulting in buy-in
from the end-users.
Abstract: Lateral torsional buckling is a global buckling mode
which should be considered in design of slender structural members
under flexure about their strong axis. It is possible to compute the
load which causes lateral torsional buckling of a beam by finite
element analysis, however, closed form equations are needed in
engineering practice for calculation ease which can be obtained by
using energy method. In lateral torsional buckling applications of
energy method, a proper function for the critical lateral torsional
buckling mode should be chosen which can be thought as the
variation of twisting angle along the buckled beam. Accuracy of the
results depends on how close is the chosen function to the exact
mode. Since critical lateral torsional buckling mode of the cantilever
I-beams varies due to material properties, section properties and
loading case, the hardest step is to determine a proper mode function
in application of energy method. This paper presents an approximate function for critical lateral
torsional buckling mode of doubly symmetric cantilever I-beams.
Coefficient matrices are calculated for concentrated load at free end,
uniformly distributed load and constant moment along the beam
cases. Critical lateral torsional buckling modes obtained by presented
function and exact solutions are compared. It is found that the modes
obtained by presented function coincide with differential equation
solutions for considered loading cases.
Abstract: In this study, a general approach to the reliability
based limit analysis of laterally loaded piles is presented. In
engineering practice the uncertainties play a very important role. The
aim of this study is to evaluate the lateral load capacity of free-head
and fixed-head long pile when plastic limit analysis is considered. In
addition to the plastic limit analysis to control the plastic behaviour
of the structure, uncertain bound on the complementary strain energy
of the residual forces is also applied. This bound has significant effect
for the load parameter. The solution to reliability-based problems is
obtained by a computer program which is governed by the reliability
index calculation.
Abstract: Temperature regulating system by gaseous nitrogen is
of importance to the space environment simulator, which keeps the
shrouds in the temperature range from -150°C to +150°C. Liquid
nitrogen spray equipment is one of the most critical parts in the
temperature regulating system by gaseous nitrogen. Y type jet
atomizer and internal mixing atomizer of the liquid nitrogen spray
equipment are studied in this paper, 2D/3D atomizer model was
established and grid division was conducted respectively by the
software of Catia and ICEM. Based on the above preparation,
numerical simulation on the spraying process of the atomizer by
FLUENT is performed. Using air and water as the medium,
comparison between the tests and numerical simulation was conducted
and the results of two ways match well. Hence, it can be conclude that
this atomizer model can be applied in the numerical simulation of
liquid nitrogen spray equipment.
Abstract: Cancer is still one of the serious diseases threatening
the lives of human beings. How to have an early diagnosis and
effective treatment for tumors is a very important issue. The animal
carcinoma model can provide a simulation tool for the studies of
pathogenesis, biological characteristics, and therapeutic effects.
Recently, drug delivery systems have been rapidly developed to
effectively improve the therapeutic effects. Liposome plays an
increasingly important role in clinical diagnosis and therapy for
delivering a pharmaceutic or contrast agent to the targeted sites.
Liposome can be absorbed and excreted by the human body, and is
well known that no harm to the human body. This study aimed to
compare the therapeutic effects between encapsulated (doxorubicin
liposomal, Lipodox) and un-encapsulated (doxorubicin, Dox)
anti-tumor drugs using magnetic resonance imaging (MRI).
Twenty-four New Zealand rabbits implanted with VX2 carcinoma at
left thighs were classified into three groups: control group (untreated),
Dox-treated group, and LipoDox-treated group, 8 rabbits for each
group. MRI scans were performed three days after tumor implantation.
A 1.5T GE Signa HDxt whole body MRI scanner with a high
resolution knee coil was used in this study. After a 3-plane localizer
scan was performed, three-dimensional (3D) fast spin echo (FSE)
T2-weighted Images (T2WI) was used for tumor volumetric
quantification. Afterwards, two-dimensional (2D) spoiled gradient
recalled echo (SPGR) dynamic contrast-enhanced (DCE) MRI was
used for tumor perfusion evaluation. DCE-MRI was designed to
acquire four baseline images, followed by contrast agent Gd-DOTA
injection through the ear vein of rabbit. A series of 32 images were
acquired to observe the signals change over time in the tumor and
muscle. The MRI scanning was scheduled on a weekly basis for a
period of four weeks to observe the tumor progression longitudinally.
The Dox and LipoDox treatments were prescribed 3 times in the first
week immediately after the first MRI scan; i.e. 3 days after VX2 tumor
implantation. ImageJ was used to quantitate tumor volume and time
course signal enhancement on DCE images. The changes of tumor size
showed that the growth of VX2 tumors was effectively inhibited for
both LipoDox-treated and Dox-treated groups. Furthermore, the tumor
volume of LipoDox-treated group was significantly lower than that of
Dox-treated group, which implies that LipoDox has better therapeutic effect than Dox. The signal intensity of LipoDox-treated group is
significantly lower than that of the other two groups, which implies
that targeted therapeutic drug remained in the tumor tissue. This study
provides a radiation-free and non-invasive MRI method for
therapeutic monitoring of targeted liposome on an animal tumor
model.
Abstract: A growing demand is felt today for realistic 3D
models enabling the cognition and popularization of historical-artistic
heritage. Evaluation and preservation of Cultural Heritage is
inextricably connected with the innovative processes of gaining,
managing, and using knowledge. The development and perfecting of
techniques for acquiring and elaborating photorealistic 3D models,
made them pivotal elements for popularizing information of objects
on the scale of architectonic structures.
Abstract: This paper presents the design and implementation
details of a complete unmanned aerial system (UAS) based
on commercial-off-the-shelf (COTS) components, focusing on
safety, security, search and rescue scenarios in GPS-denied
environments. In particular, The aerial platform is capable
of semi-autonomously navigating through extremely low-light,
GPS-denied indoor environments based on onboard sensors only,
including a downward-facing optical flow camera. Besides, an
additional low-cost payload camera system is developed to stream
both infra-red video and visible light video to a ground station in
real-time, for the purpose of detecting sign of life and hidden humans.
The total cost of the complete system is estimated to be $1150,
and the effectiveness of the system has been tested and validated
in practical scenarios.
Abstract: In this paper a very simple and effective user
administration view of computing clusters systems is implemented in
order of friendly provide the configuration and monitoring of
distributed application executions. The user view, the administrator
view, and an internal control module create an illusionary
management environment for better system usability. The
architecture, properties, performance, and the comparison with others
software for cluster management are briefly commented.
Abstract: The garment manufacturing industry involves
sequential processes that are subjected to uncontrollable variations.
The industry depends on the skill of labour in handling the varieties
of fabrics and accessories, machines, as well as complicated sewing
operation. Due to these reasons, garment manufacturers have created
systems to monitor and to control the quality of the products on a
regular basis by conducting quality approaches to minimize variation.
With that, the aim of this research has been to ascertain the quality
approaches deployed by Malaysian garment manufacturers in three
key areas - quality systems and tools; quality control and types of
inspection; as well as sampling procedures chosen for garment
inspection. Besides, the focus of this research was to distinguish the
quality approaches adopted by companies that supplied finished
garments to both domestic and international markets. Feedback from
each company representative has been obtained via online survey,
which comprised of five sections and 44 questions on the
organizational profile and the quality approaches employed in the
garment industry. As a result, the response rate was 31%. The results
revealed that almost all companies have established their own
mechanism of process control by conducting a series of quality
inspections for daily production, either it was formally set up or
otherwise. In addition, quality inspection has been the predominant
quality control activity in the garment manufacturing, while the level
of complexity of these activities was substantially dictated by the
customers. Moreover, AQL-based sampling was utilized by
companies dealing with exports, whilst almost all the companies that
only concentrated on the domestic market were comfortable using
their own sampling procedures for garment inspection. Hence, this
research has provided insights into the implementation of a number
of quality approaches that were perceived as important and useful in
the garment manufacturing sector, which is truly labour-intensive.
Abstract: South Africa is in its post-industrial era moving from
the primary and secondary sector to the tertiary sector. The study
investigated the impact of the disaggregated energy consumption
(coal, oil, and electricity) on the primary, secondary and tertiary
sectors of the economy between 1980 and 2012 in South Africa.
Using vector error correction model, it was established that South
Africa is an energy dependent economy, and that energy (especially
electricity and oil) is a limiting factor of growth. This implies that
implementation of energy conservation policies may hamper
economic growth. Output growth is significantly outpacing energy
supply, which has necessitated load shedding. To meet up the excess
energy demand, there is a need to increase the generating capacity
which will necessitate increased investment in the electricity sector as
well as strategic steps to increase oil production. There is also need to
explore more renewable energy sources, in order to meet the growing
energy demand without compromising growth and environmental
sustainability. Policy makers should also pursue energy efficiency
policies especially at sectoral level of the economy.
Abstract: Hypertension is a common condition causing cardio
and cerebrovascular complications. Portugal has one of the highest
mortality rates from stroke and a high prevalence of hypertension.
Systolic Blood Pressure (SBP) is an important risk factor for
cardiovascular events (myocardial infarction and stroke) and
premature mortality, particularly in the elderly population. The
present study aims to estimate the prevalence of hypertension in a
Portuguese population living in a coastal city and to identify some of
its determinants (namely gender, age, the body mass index and
physical activity frequency). A total of 91 adults who attended three pharmacies of a coastal
city in the center of Portugal, between May and August of 2013 were
evaluated. Attendants who reported to have diabetes or taking
antihypertensive drugs in the 2 previous weeks were excluded from
the study. Sociodemographic factors, BMI, habits of exercise and BP
were assessed. Hypertension was defined as blood pressure ≥140/90
mmHg. The majority of the studied population was constituted by women
(75.8%), with a mean age of 54.2±1.6 years old, married or living in
civil union and that had completed secondary school or had higher
education (40%). They presented a mean BMI of 26.2±4.76 Kg/m2.,
and were sedentary. The mean BP was 127.0±17.77mmHg- 74.69 ±
9.53. In this population we found 4.3% of people with hypertension
and 16.1% with normal high blood pressure. Men exhibit a tendency to present higher systolic blood pressure
values than women. Of all the factors considered, SBP values also
tended to be higher with age and higher BMI values.
Despite the fact that the mean values of SBP did not present values
higher than 140 mmHg we must be concerned because the studied
population is undiagnosed for hypertension. Although this is a preliminary study, it might be a prelude to the
upcoming research about the underlying factors responsible for the
occurrence of SBP.