Abstract: Mendelian Disease Genes represent a collection of single points of failure for the various systems they constitute. Such genes have been shown, on average, to encode longer proteins than 'non-disease' proteins. Existing models suggest that this results from the increased likeli-hood of longer genes undergoing mutations. Here, we show that in saturated mutagenesis experiments performed on model organisms, where the likelihood of each gene mutating is one, a similar relationship between length and the probability of a gene being lethal was observed. We thus suggest an extended model demonstrating that the likelihood of a mutated gene to produce a severe phenotype is length-dependent. Using the occurrence of conserved domains, we bring evidence that this dependency results from a correlation between protein length and the number of functions it performs. We propose that protein length thus serves as a proxy for protein cardinality in different networks required for the organism's survival and well-being. We use this example to argue that the collection of Mendelian Disease Genes can, and should, be used to study the rules governing systems vulnerability in living organisms.
Abstract: We depend upon explanation in order to “make sense"
out of our world. And, making sense is all the more important when
dealing with change. But, what happens if our explanations are
wrong? This question is examined with respect to two types of
explanatory model. Models based on labels and categories we shall
refer to as “representations." More complex models involving
stories, multiple algorithms, rules of thumb, questions, ambiguity we
shall refer to as “compressions." Both compressions and
representations are reductions. But representations are far more
reductive than compressions. Representations can be treated as a set
of defined meanings – coherence with regard to a representation is
the degree of fidelity between the item in question and the definition
of the representation, of the label. By contrast, compressions contain
enough degrees of freedom and ambiguity to allow us to make
internal predictions so that we may determine our potential actions in
the possibility space. Compressions are explanatory via mechanism.
Representations are explanatory via category. Managers are often
confusing their evocation of a representation (category inclusion) as
the creation of a context of compression (description of mechanism).
When this type of explanatory error occurs, more errors follow. In
the drive for efficiency such substitutions are all too often proclaimed
– at the manager-s peril..
Abstract: This paper proposes a fast tree join scheme to provide
seamless multicast handover in the mobile networks based on the Fast
Mobile IPv6 (FMIPv6). In the existing FMIPv6-based multicast
handover scheme, the bi-directional tunnelling or the remote
subscription is employed with the packet forwarding from the previous
access router (AR) to the new AR. In general, the remote subscription
approach is preferred to the bi-directional tunnelling one, since in the
remote subscription scheme we can exploit an optimized multicast
path from a multicast source to many mobile receivers. However, in
the remote subscription scheme, if the tree joining operation takes a
long time, the amount of data packets to be forwarded and buffered for
multicast handover will increase, and thus the corresponding buffer
may overflow, which results in severe packet losses. In order to reduce
these costs associated with packet forwarding and buffering, this paper
proposes the fast join to multicast tree, in which the new AR will join
the multicast tree as fast as possible, so that the new multicast data
packets can also arrive at the new AR, by which the packet forwarding
and buffering costs can be reduced. From numerical analysis, it is
shown that the proposed scheme can give better performance than the
existing FMIPv6-based multicast handover schemes in terms of the
multicast packet delivery costs.
Abstract: Compaction testing methods allow at-speed detecting
of errors while possessing low cost of implementation. Owing to this
distinctive feature, compaction methods have been widely used for
built-in testing, as well as external testing. In the latter case, the
bandwidth requirements to the automated test equipment employed
are relaxed which reduces the overall cost of testing. Concurrent
compaction testing methods use operational signals to detect
misbehavior of the device under test and do not require input test
stimuli. These methods have been employed for digital systems only.
In the present work, we extend the use of compaction methods for
concurrent testing of analog-to-digital converters. We estimate
tolerance bounds for the result of compaction and evaluate the
aliasing rate.
Abstract: When a small H/W IP is designed, we can develop an
appropriate verification environment by observing the simulated
signal waves, or using the serial test vectors for the fixed output. In the
case of design and verification of a massive parallel processor with
multiple IPs, it-s difficult to make a verification system with existing
common verification environment, and to verify each partial IP. A
TestDrive verification environment can build easy and reliable
verification system that can produce highly intuitive results by
applying Modelsim and SystemVerilog-s DPI. It shows many
advantages, for example a high-level design of a GPGPU processor
design can be migrate to FPGA board immediately.
Abstract: IPN and IPE sections, which are commonly used European I shapes, are widely used in steel structures as cantilever beams to support overhangs. A considerable number of studies exist on calculating lateral torsional buckling load of I sections. However, most of them provide series solutions or complex closed-form equations. In this paper, a simple equation is presented to calculate lateral torsional buckling load of IPN and IPE section cantilever beams. First, differential equation of lateral torsional buckling is solved numerically for various loading cases. Then a parametric study is conducted on results to present an equation for lateral torsional buckling load of European IPN and IPE beams. Finally, results obtained by presented equation are compared to differential equation solutions and finite element model results. ABAQUS software is utilized to generate finite element models of beams. It is seen that the results obtained from presented equation coincide with differential equation solutions and ABAQUS software results. It can be suggested that presented formula can be safely used to calculate critical lateral torsional buckling load of European IPN and IPE section cantilevers.
Abstract: Image mosaicing techniques are usually employed to offer researchers a wider field of view of microscopic image of biological samples. a mosaic is commonly achieved using automated microscopes and often with one “color" channel, whether it refers to natural or fluorescent analysis. In this work we present a method to achieve three subsequent mosaics of the same part of a stem cell culture analyzed in phase contrast and in fluorescence, with a common non-automated inverted microscope. The mosaics obtained are then merged together to mark, in the original contrast phase images, nuclei and cytoplasm of the cells referring to a mosaic of the culture, rather than to single images. The experiments carried out prove the effectiveness of our approach with cultures of cells stained with calcein (green/cytoplasm and nuclei) and hoechst (blue/nuclei) probes.
Abstract: This paper examines the role and the place of
transdisciplinarity in the urbanism of the 21st century, with the
emphasis on Montenegro urbanism. Global processes require a
systematic strategy and systemic synergistic engagement in the
development of cities in 21st centuries. Urbanism as a profession and
a discipline should be developed parallel and in correlation, based on
the principles of integrality and communication skills, in order to
enable development of the sustainable urban system. The importance
of integrated urbanism and other disciplines are also emphasized as
well as their synergies activities. The paper also presents the positive
examples of urban theory and practice in the world, which influenced
the direction of development of the modern urbanism.
Transdisciplinarity is a priority methodology for sustainable urban
development, which is insufficiently developed in Montenegro, but
there is a basis for its development. It is necessary to unite different
social sensibilities, academic and non-academic knowledge, as well
as the public and private sectors in order to develop holistic,
inclusive and sustainable urban spaces of the 21st centuries.
Abstract: In this paper, an efficient wave concept iterative
process (WCIP) with auxiliary Sources is presented for full wave
investigation of an active microwave structure on micro strip
technology. Good agreement between the experimental and
simulation results is observed.
Abstract: A big organization may have multiple branches spread across different locations. Processing of data from these branches becomes a huge task when innumerable transactions take place. Also, branches may be reluctant to forward their data for centralized processing but are ready to pass their association rules. Local mining may also generate a large amount of rules. Further, it is not practically possible for all local data sources to be of the same size. A model is proposed for discovering valid rules from different sized data sources where the valid rules are high weighted rules. These rules can be obtained from the high frequency rules generated from each of the data sources. A data source selection procedure is considered in order to efficiently synthesize rules. Support Equalization is another method proposed which focuses on eliminating low frequency rules at the local sites itself thus reducing the rules by a significant amount.
Abstract: Ethnicity identification of face images is of interest in
many areas of application, but existing methods are few and limited.
This paper presents a fusion scheme that uses block-based uniform
local binary patterns and Haar wavelet transform to combine local
and global features. In particular, the LL subband coefficients of the
whole face are fused with the histograms of uniform local binary
patterns from block partitions of the face. We applied the principal
component analysis on the fused features and managed to reduce the
dimensionality of the feature space from 536 down to around 15
without sacrificing too much accuracy. We have conducted a number
of preliminary experiments using a collection of 746 subject face
images. The test results show good accuracy and demonstrate the
potential of fusing global and local features. The fusion approach is
robust, making it easy to further improve the identification at both
feature and score levels.
Abstract: This study analyzes characteristics determining
member’s willingness to invest in cooperatives using ordered logit
model. The data were collected in a field survey among 122
cooperative members in north-central China. The descriptive analysis
of survey evidence suggests that cooperatives in China generally
having poor ability to deliver the processing services related to
product package, grading, and storage, performing worse in
profitability, inability of providing returns to capital and obtaining
agricultural loan. The regression results demonstrate that members’
farm size, their satisfaction with cooperative price preferential
services, attitudes toward cooperative operational scale and
development potential have statistically significant impact on
willingness to invest.
Abstract: The current paper presents the findings of a research
study on learners- barriers and motivators engaged into blended
programs in a workplace context. In this study, the participants were
randomly assigned to one of four parallel e-learning courses, each of
which was delivered using a different learning strategy. Data were
collected through web-based and telephone surveys developed by the
researchers. The results showed that vague instruction, time
management, and insufficient feedback were the top-most barriers to
blended learning. The major motivators for blended learning included
content relevance, flexibility in time, and the ability to work at own
pace.
Abstract: Pressure vessels are usually operating at temperatures
where the conditions of linear elastic fracture mechanics are no
longer met because massive plasticity precedes crack propagation. In
this work the development of a surface crack in a pressure vessel
subject to bending and tension under elastic-plastic fracture
mechanics conditions was investigated. Finite element analysis was
used to evaluate the hydrostatic stress, the J-integral and crack
growth for semi-elliptical surface-breaking cracks. The results
showed non-uniform stress triaxiality and crack driving force around
the crack front at large deformation levels. Different ductile crack
extensions were observed which emphasis the dependent of ductile
tearing on crack geometry and type of loading. In bending the crack
grew only beneath the surface, and growth was suppressed at the
deepest segment. This contrasts to tension where the crack breaks
through the thickness with uniform growth along the entire crack
front except at the free surface. Current investigations showed that
the crack growth developed under linear elastic fracture mechanics
conditions will no longer be applicable under ductile tearing
scenarios.
Abstract: A potentially serious problem with current payment systems is that their underlying hard problems from number theory may be solved by either a quantum computer or unanticipated future advances in algorithms and hardware. A new quantum payment system is proposed in this paper. The suggested system makes use of fundamental principles of quantum mechanics to ensure the unconditional security without prior arrangements between customers and vendors. More specifically, the new system uses Greenberger-Home-Zeilinger (GHZ) states and Quantum Key Distribution to authenticate the vendors and guarantee the transaction integrity.
Abstract: In the study of chironomids in Armenia several
species of Orthocladiinae subfamily of Cricotopus genus,
Diamesinae subfamily of Diamesa genus, and Chironominae
subfamily of Chironomus genus, have been identified. In the
Cricotopus genus two sibling species were found, not distinguishable
by larval morphological features, but clearly distinct cytogenetically.
Abstract: A prototype of an anomaly detection system was
developed to automate process of recognizing an anomaly of
roentgen image by utilizing fuzzy histogram hyperbolization image
enhancement and back propagation artificial neural network.
The system consists of image acquisition, pre-processor, feature
extractor, response selector and output. Fuzzy Histogram
Hyperbolization is chosen to improve the quality of the roentgen
image. The fuzzy histogram hyperbolization steps consist of
fuzzyfication, modification of values of membership functions and
defuzzyfication. Image features are extracted after the the quality of
the image is improved. The extracted image features are input to the
artificial neural network for detecting anomaly. The number of nodes
in the proposed ANN layers was made small.
Experimental results indicate that the fuzzy histogram
hyperbolization method can be used to improve the quality of the
image. The system is capable to detect the anomaly in the roentgen
image.
Abstract: The IEEE802.16 standard which has emerged as
Broadband Wireless Access (BWA) technology, promises to deliver
high data rate over large areas to a large number of subscribers in the
near future. This paper analyze the effect of overheads over capacity
of downlink (DL) of orthogonal frequency division multiple access
(OFDMA)–based on the IEEE802.16e mobile WiMAX system with
and without overheads. The analysis focuses in particular on the
impact of Adaptive Modulation and Coding (AMC) as well as
deriving an algorithm to determine the maximum numbers of
subscribers that each specific WiMAX sector may support. An
analytical study of the WiMAX propagation channel by using Cost-
231 Hata Model is presented. Numerical results and discussion
estimated by using Matlab to simulate the algorithm for different
multi-users parameters.
Abstract: Most standard software development methodologies
are often not applied to software projects in many developing
countries of the world. The approach generally practice is close to
what eXtreme Programming (XP) is likely promoting, just keep
coding and testing as the requirement evolves. XP is an agile
software process development methodology that has inherent
capability for improving efficiency of Business Software
Development (BSD). XP can facilitate Business-to-Development
(B2D) relationship due to its customer-oriented advocate. From
practitioner point of view, we applied XP to BSD and result shows
that customer involvement has positive impact on productivity, but
can as well frustrate the success of the project. In an effort to
promote software engineering practice in developing countries of
Africa, we present the experiment performed, lessons learned,
problems encountered and solution adopted in applying XP
methodology to BSD.
Abstract: The implementation of the new software and hardware-s technologies for tritium processing nuclear plants, and especially those with an experimental character or of new technology developments shows a coefficient of complexity due to issues raised by the implementation of the performing instrumentation and equipment into a unitary monitoring system of the nuclear technological process of tritium removal. Keeping the system-s flexibility is a demand of the nuclear experimental plants for which the change of configuration, process and parameters is something usual. The big amount of data that needs to be processed stored and accessed for real time simulation and optimization demands the achievement of the virtual technologic platform where the data acquiring, control and analysis systems of the technological process can be integrated with a developed technological monitoring system. Thus, integrated computing and monitoring systems needed for the supervising of the technological process will be executed, to be continued with the execution of optimization system, by choosing new and performed methods corresponding to the technological processes within the tritium removal processing nuclear plants. The developing software applications is executed with the support of the program packages dedicated to industrial processes and they will include acquisition and monitoring sub-modules, named “virtually" as well as the storage sub-module of the process data later required for the software of optimization and simulation of the technological process for tritium removal. The system plays and important role in the environment protection and durable development through new technologies, that is – the reduction of and fight against industrial accidents in the case of tritium processing nuclear plants. Research for monitoring optimisation of nuclear processes is also a major driving force for economic and social development.