Abstract: In this paper, we consider a two-neuron system with time-delayed connections between neurons. By analyzing the associated characteristic transcendental equation, its linear stability is investigated and Hopf bifurcation is demonstrated. Some explicit formulae for determining the stability and the direction of the Hopf bifurcation periodic solutions bifurcating from Hopf bifurcations are obtained by using the normal form theory and center manifold theory. Some numerical simulation results are given to support the theoretical predictions. Finally, main conclusions are given.
Abstract: Chinese Idioms are a type of traditional Chinese idiomatic
expressions with specific meanings and stereotypes structure
which are widely used in classical Chinese and are still common in
vernacular written and spoken Chinese today. Currently, Chinese
Idioms are retrieved in glossary with key character or key word in
morphology or pronunciation index that can not meet the need of
searching semantically. OCIRS is proposed to search the desired
idiom in the case of users only knowing its meaning without any key
character or key word. The user-s request in a sentence or phrase will
be grammatically analyzed in advance by word segmentation, key
word extraction and semantic similarity computation, thus can be
mapped to the idiom domain ontology which is constructed to provide
ample semantic relations and to facilitate description logics-based
reasoning for idiom retrieval. The experimental evaluation shows that
OCIRS realizes the function of searching idioms via semantics, obtaining
preliminary achievement as requested by the users.
Abstract: Based on the sources- smoothed rank profile (SRP) and modified minimum description length (MMDL) principle, a method for estimation of the source coherency structure (SCS) and the number of wideband sources is proposed in this paper. Instead of focusing, we first use a spatial smoothing technique to pre-process the array covariance matrix of each frequency for de-correlating the sources and then use smoothed rank profile to determine the SCS and the number of wideband sources. We demonstrate the availability of the method by numerical simulations.
Abstract: Severe acute respiratory syndrome (SARS) is a respiratory disease in humans which is caused by the SARS coronavirus. The treatment of coronavirus-associated SARS has been evolving and so far there is no consensus on an optimal regimen. The mainstream therapeutic interventions for SARS involve broad-spectrum antibiotics and supportive care, as well as antiviral agents and immunomodulatory therapy. The Protein- Ligand interaction plays a significant role in structural based drug designing. In the present work we have taken the receptor Angiotensin converting enzyme 2 and identified the drugs that are commonly used against SARS. They are Lopinavir, Ritonavir, Ribavirin, and Oseltamivir. The receptor Angiotensin converting enzyme 2 (ACE-2) was docked with above said drugs and the energy value obtained are as follows, Lopinavir (-292.3), Ritonavir (-325.6), Oseltamivir (- 229.1), Ribavirin (-208.8). Depending on the least energy value we have chosen the best two drugs out of the four conventional drugs. We tried to improve the binding efficiency and steric compatibility of the two drugs namely Ritonavir and Lopinavir. Several modifications were made to the probable functional groups (phenylic, ketonic groups in case of Ritonavir and carboxylic groups in case of Lopinavir respectively) which were interacting with the receptor molecule. Analogs were prepared by Marvin Sketch software and were docked using HEX docking software. Lopinavir analog 8 and Ritonavir analog 11 were detected with significant energy values and are probable lead molecule. It infers that some of the modified drugs are better than the original drugs. Further work can be carried out to improve the steric compatibility of the drug based upon the work done above for a more energy efficient binding of the drugs to the receptor.
Abstract: This paper deals with stability analysis for synchronous reluctance motors drive. Special attention is paid to the transient performance with variations in motor's parameters such as Ld and Rs. A study of the dynamic control using d-q model is presented first in order to clarify the stability of the motor drive system. Based on the experimental parameters of the synchronous reluctance motor, this paper gives some simulation results using MATLAB/SIMULINK software packages. It is concluded that the motor parameters, especially Ld, affect the estimator stability and hence the whole drive system.
Abstract: A new reverse phase-high performance liquid chromatography (RP-HPLC) method with fluorescent detector (FLD) was developed and optimized for Norfloxacin determination in human plasma. Mobile phase specifications, extraction method and excitation and emission wavelengths were varied for optimization. HPLC system contained a reverse phase C18 (5 μm, 4.6 mm×150 mm) column with FLD operated at excitation 330 nm and emission 440 nm. The optimized mobile phase consisted of 14% acetonitrile in buffer solution. The aqueous phase was prepared by mixing 2g of citric acid, 2g sodium acetate and 1 ml of triethylamine in 1 L of Milli-Q water was run at a flow rate of 1.2 mL/min. The standard curve was linear for the range tested (0.156–20 μg/mL) and the coefficient of determination was 0.9978. Aceclofenac sodium was used as internal standard. A detection limit of 0.078 μg/mL was achieved. Run time was set at 10 minutes because retention time of norfloxacin was 0.99 min. which shows the rapidness of this method of analysis. The present assay showed good accuracy, precision and sensitivity for Norfloxacin determination in human plasma with a new internal standard and can be applied pharmacokinetic evaluation of Norfloxacin tablets after oral administration in human.
Abstract: The Time-Domain Boundary Element Method (TDBEM)
is a well known numerical technique that handles quite
properly dynamic analyses considering infinite dimension media.
However, when these analyses are also related to nonlinear behavior,
very complex numerical procedures arise considering the TD-BEM,
which may turn its application prohibitive. In order to avoid this
drawback and model nonlinear infinite media, the present work
couples two BEM formulations, aiming to achieve the best of two
worlds. In this context, the regions expected to behave nonlinearly
are discretized by the Domain Boundary Element Method (D-BEM),
which has a simpler mathematical formulation but is unable to deal
with infinite domain analyses; the TD-BEM is employed as in the
sense of an effective non-reflexive boundary. An iterative procedure
is considered for the coupling of the TD-BEM and D-BEM, which is
based on a relaxed renew of the variables at the common interfaces.
Elastoplastic models are focused and different time-steps are allowed
to be considered by each BEM formulation in the coupled analysis.
Abstract: In this paper, we introduce an mobile agent framework
with proactive load balancing for ambient intelligence (AmI) environments.
One of the main obstacles of AmI is the scalability in
which the openness of AmI environment introduces dynamic resource
requirements on agencies. To mediate this scalability problem, our
framework proposes a load balancing module to proactively analyze
the resource consumption of network bandwidth and preferred agencies
to suggest the optimal communication method to its user. The
framework generally formulates an AmI environment that consists
of three main components: (1) mobile devices, (2) hosts or agencies,
and (3) directory service center (DSC). A preliminary implementation
was conducted with NetLogo and the experimental results show that
the proposed approach provides enhanced system performance by
minimizing the network utilization to provide users with responsive
services.
Abstract: This paper presents a cold flow simulation study of a small gas turbine combustor performed using laboratory scale test rig. The main objective of this investigation is to obtain physical insight of the main vortex, responsible for the efficient mixing of fuel and air. Such models are necessary for predictions and optimization of real gas turbine combustors. Air swirler can control the combustor performance by assisting in the fuel-air mixing process and by producing recirculation region which can act as flame holders and influences residence time. Thus, proper selection of a swirler is needed to enhance combustor performance and to reduce NOx emissions. Three different axial air swirlers were used based on their vane angles i.e., 30°, 45°, and 60°. Three-dimensional, viscous, turbulent, isothermal flow characteristics of the combustor model operating at room temperature were simulated via Reynolds- Averaged Navier-Stokes (RANS) code. The model geometry has been created using solid model, and the meshing has been done using GAMBIT preprocessing package. Finally, the solution and analysis were carried out in a FLUENT solver. This serves to demonstrate the capability of the code for design and analysis of real combustor. The effects of swirlers and mass flow rate were examined. Details of the complex flow structure such as vortices and recirculation zones were obtained by the simulation model. The computational model predicts a major recirculation zone in the central region immediately downstream of the fuel nozzle and a second recirculation zone in the upstream corner of the combustion chamber. It is also shown that swirler angles changes have significant effects on the combustor flowfield as well as pressure losses.
Abstract: A bond graph model of an electrical transformer
including the nonlinear saturation is presented. A nonlinear observer for the transformer based on multivariable circle
criterion in the physical domain is proposed. In order to show the saturation and hysteresis effects on the electrical transformer,
simulation results are obtained. Finally, the paper describes that convergence of the estimates to the true states is achieved.
Abstract: In this article, we discuss project-based learning in the context of a wheel garden as an instructional tool in science and mathematics education. A wheel garden provides multiple opportunities to teach across the curriculum, to integrate disciplines, and to promote community involvement. Grounded in the theoretical framework of constructivism, the wheel garden provides a multidisciplined educational tool that provides a hands-on, non-traditional arena for learning. We will examine some of the cultural, art, science, and mathematics connections made with this project.
Abstract: The image segmentation method described in this
paper has been developed as a pre-processing stage to be used in
methodologies and tools for video/image indexing and retrieval by
content. This method solves the problem of whole objects extraction
from background and it produces images of single complete objects
from videos or photos. The extracted images are used for calculating
the object visual features necessary for both indexing and retrieval
processes.
The segmentation algorithm is based on the cooperation among an
optical flow evaluation method, edge detection and region growing
procedures. The optical flow estimator belongs to the class of
differential methods. It permits to detect motions ranging from a
fraction of a pixel to a few pixels per frame, achieving good results in
presence of noise without the need of a filtering pre-processing stage
and includes a specialised model for moving object detection.
The first task of the presented method exploits the cues from
motion analysis for moving areas detection. Objects and background
are then refined using respectively edge detection and seeded region
growing procedures. All the tasks are iteratively performed until
objects and background are completely resolved.
The method has been applied to a variety of indoor and outdoor
scenes where objects of different type and shape are represented on
variously textured background.
Abstract: The occurrence and removal of trace organic
contaminants in the aquatic environment has become a focus of
environmental concern. For the selective removal of carbamazepine
from loaded waters molecularly imprinted polymers (MIPs) were
synthesized with carbamazepine as template. Parameters varied were
the type of monomer, crosslinker, and porogen, the ratio of starting
materials, and the synthesis temperature. Best results were obtained
with a template to crosslinker ratio of 1:20, toluene as porogen, and
methacrylic acid (MAA) as monomer. MIPs were then capable to
recover carbamazepine by 93% from a 10-5 M landfill leachate
solution containing also caffeine and salicylic acid. By comparison,
carbamazepine recoveries of 75% were achieved using a nonimprinted
polymer (NIP) synthesized under the same conditions, but
without template. In landfill leachate containing solutions
carbamazepine was adsorbed by 93-96% compared with an uptake of
73% by activated carbon. The best solvent for desorption was
acetonitrile, with which the amount of solvent necessary and dilution
with water was tested. Selected MIPs were tested for their reusability
and showed good results for at least five cycles. Adsorption
isotherms were prepared with carbamazepine solutions in the
concentration range of 0.01 M to 5*10-6 M. The heterogeneity index
showed a more homogenous binding site distribution.
Abstract: Ever since industrial revolution began, our ecosystem
has changed. And indeed, the negatives outweigh the positives.
Industrial waste usually released into all kinds of body of water, such
as river or sea. Tempeh waste is one example of waste that carries
many hazardous and unwanted substances that will affect the
surrounding environment. Tempeh is a popular fermented food in
Asia which is rich in nutrients and active substances. Tempeh liquid
waste- in particular- can cause an air pollution, and if penetrates
through the soil, it will contaminates ground-water, making it
unavailable for the water to be consumed. Moreover, bacteria will
thrive within the polluted water, which often responsible for causing
many kinds of diseases. The treatment used for this chemical waste is
biological treatment such as constructed wetland and activated
sludge. These kinds of treatment are able to reduce both physical and
chemical parameters altogether such as temperature, TSS, pH, BOD,
COD, NH3-N, NO3-N, and PO4-P. These treatments are implemented
before the waste is released into the water. The result is a
comparation between constructed wetland and activated sludge,
along with determining which method is better suited to reduce the
physical and chemical subtances of the waste.
Abstract: Fine alignment of main ship power plants mechanisms
and shaft lines provides long-term and failure-free performance of
propulsion system while fast and high-quality installation of
mechanisms and shaft lines decreases common labor intensity. For
checking shaft line allowed stress and setting its alignment it is
required to perform calculations considering various stages of life
cycle. In 2012 JSC SSTC developed special software complex
“Shaftline” for calculation of alignment of having its own I/O
interface and display of shaft line 3D model. Alignment of shaft line
as per bearing loads is rather labor-intensive procedure. In order to
decrease its duration, JSC SSTC developed automated alignment
system from ship power plants mechanisms. System operation
principle is based on automatic simulation of design load on bearings.
Initial data for shaft line alignment can be exported to automated
alignment system from PC “Shaft line”.
Abstract: This paper addresses the fundamental requirements for
starting an online business. It covers the process of ideation,
conceptualization, formulation, and implementation of new venture
ideas on the Web. Using Facebook as an illustrative example, we learn
how to turn an idea into a successful electronic business and to execute
a business plan with IT skills, management expertise, a good
entrepreneurial attitude, and an understanding of Internet culture. The
personality traits and characteristics of a successful e-commerce
entrepreneur are discussed with reference to Facebook-s founder,
Mark Zuckerberg. Facebook is a social and e-commerce success. It
provides a trusted environment of which participants can conduct
business with social experience. People are able to discuss products
before, during the after the sale within the Facebook environment. The
paper also highlights the challenges and opportunities for e-commerce
entrepreneurial startups to go public and of entering the China market.
Abstract: This article demonstrated development of
controlled release system of an NSAID drug, Diclofenac
sodium employing different ratios of Ethyl cellulose.
Diclofenac sodium and ethyl cellulose in different proportions
were processed by microencapsulation based on phase
separation technique to formulate microcapsules. The
prepared microcapsules were then compressed into tablets to
obtain controlled release oral formulations. In-vitro evaluation
was performed by dissolution test of each preparation was
conducted in 900 ml of phosphate buffer solution of pH 7.2
maintained at 37 ± 0.5 °C and stirred at 50 rpm. At predetermined
time intervals (0, 0.5, 1.0, 1.5, 2, 3, 4, 6, 8, 10, 12,
16, 20 and 24 hrs). The drug concentration in the collected
samples was determined by UV spectrophotometer at 276 nm.
The physical characteristics of diclofenac sodium
microcapsules were according to accepted range. These were
off-white, free flowing and spherical in shape. The release
profile of diclofenac sodium from microcapsules was found to
be directly proportional to the proportion of ethylcellulose and
coat thickness. The in-vitro release pattern showed that with
ratio of 1:1 and 1:2 (drug: polymer), the percentage release of
drug at first hour was 16.91 and 11.52 %, respectively as
compared to 1:3 which is only 6.87 % with in this time. The
release mechanism followed higuchi model for its release
pattern. Tablet Formulation (F2) of present study was found
comparable in release profile the marketed brand Phlogin-SR,
microcapsules showed an extended release beyond 24 h.
Further, a good correlation was found between drug release
and proportion of ethylcellulose in the microcapsules.
Microencapsulation based on coacervation found as good
technique to control release of diclofenac sodium for making
the controlled release formulations.
Abstract: Two geometrically nonlinear plate theories, based either on first- or third-order transverse shear deformation theory are used for finite element modeling and simulation of the transient response of smart structures incorporating piezoelectric layers. In particular the time histories of nonlinear vibrations and sensor voltage output of a thin beam with a piezoelectric patch bonded to the surface due to an applied step force are studied.
Abstract: A homologous series of aromatic esters, 4-nalkanoyloxybenzylidene-
4--bromoanilines, nABBA,
consisting of two 1,4-disubstituted phenyl cores and a Schiff
base central linkage was synthesized. All the members can be
differed by the number of carbon atoms at terminal
alkanoyloxy chain (CnH2n-1COO-, n = 2, 6, 18). The molecular
structure of nABBA was confirmed with infrared
spectroscopy, nuclear magnetic resonance (NMR)
spectroscopy and electron-ionization mass (EI-MS)
spectrometry. Mesomorphic properties were studied using
differential scanning calorimetry and polarizing optical
microscopy.
Abstract: In this treatise we will study the capability of static
compensator for reactive power to stabilize sheen voltage with motor
loading on power networks system. We also explain the structure and main function of STATCOM and the method to control it using STATCOM transformer current to simultaneously predict after
telling about the necessity of FACTS tools to compensate in power networks. Then we study topology and controlling system to stabilize
voltage during start of inductive motor. The outcome of stimulat by MATLAB software supports presented controlling idea and
system in the treatise.