Abstract: Sensitive and predictive DILI (Drug Induced Liver
Injury) biomarkers are needed in drug R&D to improve early
detection of hepatotoxicity. The discovery of DILI biomarkers that
demonstrate the predictive power to identify individuals at risk to
DILI would represent a major advance in the development of
personalized healthcare approaches. In this healthy volunteer
acetaminophen study (4g/day for 7 days, with 3 monitored nontreatment
days before and 4 after), 450 serum samples from 32
subjects were analyzed using protein profiling by antibody
suspension bead arrays. Multiparallel protein profiles were generated
using a DILI target protein array with 300 antibodies, where the
antibodies were selected based on previous literature findings of
putative DILI biomarkers and a screening process using pre dose
samples from the same cohort. Of the 32 subjects, 16 were found to
develop an elevated ALT value (2Xbaseline, responders). Using the
plasma profiling approach together with multivariate statistical
analysis some novel findings linked to lipid metabolism were found
and more important, endogenous protein profiles in baseline samples
(prior to treatment) with predictive power for ALT elevations were
identified.
Abstract: A 3.5-bit stage of the CMOS pipelined ADC is proposed. In this report, the main part of 3.5-bit stage ADC is introduced. How the MDAC, comparator and encoder worked and designed are shown in details. Besides, an OTA which is used in fully differential pipelined ADC was described. Using gain-boost architecture with differential amplifier, this OTA achieve high-gain and high-speed. This design was using CMOS 0.18um process and simulation in Cadence. The result of the simulation shows that the OTA has a gain up to 80dB, the unity gain bandwidth of about 1.138GHz with 2pF load.
Abstract: A new approach for protection of power transformer is
presented using a time-frequency transform known as Wavelet transform.
Different operating conditions such as inrush, Normal, load,
External fault and internal fault current are sampled and processed
to obtain wavelet coefficients. Different Operating conditions provide
variation in wavelet coefficients. Features like energy and Standard
deviation are calculated using Parsevals theorem. These features
are used as inputs to PNN (Probabilistic neural network) for fault
classification. The proposed algorithm provides more accurate results
even in the presence of noise inputs and accurately identifies inrush
and fault currents. Overall classification accuracy of the proposed
method is found to be 96.45%. Simulation of the fault (with and
without noise) was done using MATLAB AND SIMULINK software
taking 2 cycles of data window (40 m sec) containing 800 samples.
The algorithm was evaluated by using 10 % Gaussian white noise.
Abstract: In this paper a novel approach for generalized image
retrieval based on semantic contents is presented. A combination of
three feature extraction methods namely color, texture, and edge
histogram descriptor. There is a provision to add new features in
future for better retrieval efficiency. Any combination of these
methods, which is more appropriate for the application, can be used
for retrieval. This is provided through User Interface (UI) in the
form of relevance feedback. The image properties analyzed in this
work are by using computer vision and image processing algorithms.
For color the histogram of images are computed, for texture cooccurrence
matrix based entropy, energy, etc, are calculated and for
edge density it is Edge Histogram Descriptor (EHD) that is found.
For retrieval of images, a novel idea is developed based on greedy
strategy to reduce the computational complexity. The entire system
was developed using AForge.Imaging (an open source product),
MATLAB .NET Builder, C#, and Oracle 10g. The system was tested
with Coral Image database containing 1000 natural images and
achieved better results.
Abstract: A low bit rate still image compression scheme by
compressing the indices of Vector Quantization (VQ) and generating
residual codebook is proposed. The indices of VQ are compressed by
exploiting correlation among image blocks, which reduces the bit per
index. A residual codebook similar to VQ codebook is generated that
represents the distortion produced in VQ. Using this residual
codebook the distortion in the reconstructed image is removed,
thereby increasing the image quality. Our scheme combines these two
methods. Experimental results on standard image Lena show that our
scheme can give a reconstructed image with a PSNR value of 31.6 db
at 0.396 bits per pixel. Our scheme is also faster than the existing VQ
variants.
Abstract: This paper describes a practical approach to design
and develop a hybrid learning with acceleration feedback control
(HLC) scheme for input tracking and end-point vibration suppression
of flexible manipulator systems. Initially, a collocated proportionalderivative
(PD) control scheme using hub-angle and hub-velocity
feedback is developed for control of rigid-body motion of the system.
This is then extended to incorporate a further hybrid control scheme
of the collocated PD control and iterative learning control with
acceleration feedback using genetic algorithms (GAs) to optimize the
learning parameters. Experimental results of the response of the
manipulator with the control schemes are presented in the time and
frequency domains. The performance of the HLC is assessed in terms
of input tracking, level of vibration reduction at resonance modes and
robustness with various payloads.
Abstract: The present paper deals with the analysis and development of noise-reduction transformer that has a filter function for conductive noise transmission. Two types of prototype noise-reduction transformers with two different output voltages are proposed. To determine an optimum design for the noise-reduction transformer, noise attenuation characteristics are discussed based on the experiments and the equivalent circuit analysis. The analysis gives a relation between the circuit parameters and the noise attenuation. High performance step-down noise-reduction transformer for direct power supply to electronics equipment is developed. The input voltage of the transformer is 100 V and the output voltage is 5 V. Frequency characteristics of noise attenuation are discussed, and prevention of pulse noise transmission is demonstrated. Normal mode noise attenuation of this transformer is –80 dB, and common mode exceeds –90 dB. The step-down noise-reduction transformer eliminates pulse noise efficiently.
Abstract: The class of geometric deformable models, so-called
level sets, has brought tremendous impact to medical imagery. In
this paper we present yet another application of level sets to medical
imaging. The method we give here will in a way modify the speed
term in the standard level sets equation of motion. To do so we
build a potential based on the distance and the gradient of the
image we study. In turn the potential gives rise to the force field:
F~F(x, y) = P
∀(p,q)∈I
((x, y) - (p, q)) |ÔêçI(p,q)|
|(x,y)-(p,q)|
2 . The direction
and intensity of the force field at each point will determine the
direction of the contour-s evolution. The images we used to test
our method were produced by the Univesit'e de Sherbrooke-s PET
scanners.
Abstract: This paper describes the NEAR (Navigating Exhibitions, Annotations and Resources) panel, a novel interactive visualization technique designed to help people navigate and interpret groups of resources, exhibitions and annotations by revealing hidden relations such as similarities and references. NEAR is implemented on A•VI•RE, an extended online information repository. A•VI•RE supports a semi-structured collection of exhibitions containing various resources and annotations. Users are encouraged to contribute, share, annotate and interpret resources in the system by building their own exhibitions and annotations. However, it is hard to navigate smoothly and efficiently in A•VI•RE because of its high capacity and complexity. We present a visual panel that implements new navigation and communication approaches that support discovery of implied relations. By quickly scanning and interacting with NEAR, users can see not only implied relations but also potential connections among different data elements. NEAR was tested by several users in the A•VI•RE system and shown to be a supportive navigation tool. In the paper, we further analyze the design, report the evaluation and consider its usage in other applications.
Abstract: Wall-surface jet induced by the dielectric barrier
discharge (DBD) has been proposed as an actuator for active flow
control in aerodynamic applications. Discharge plasma evolution of
the DBD plasma actuator was simulated based on a simple fluid model,
in which the electron, one type of positive ion and negative ion were
taken into account. Two-dimensional simulation was conducted, and
the results are in agreement with the insights obtained from
experimental studies. The simulation results indicate that the discharge
mode changes depending on applied voltage slope; when the applied
voltage is positive-going with high applied voltage slope, the
corona-type discharge mode turns into the streamer-type discharge
mode and the threshold voltage slope is around 300 kV/ms in this
simulation. The characteristics of the electrohydrodynamic (EHD)
force, which is the source of the wall-surface jet, also change
depending on the discharge mode; the tentative peak value of the EHD
force during the positive-going voltage phase is saturated by the
periodical formation of the streamer-type discharge.
Abstract: This work investigated the phenology of Parah tree
(Elateriospermum tapos) using the General Purpose Atmosphere
Plant Soil Simulator (GAPS model) to determine the amount of Plant
Available Water (PAW) in the soil. We found the correlation
between PAW and the timing of budburst and flower burst at Khao
Nan National Park, Nakhon Si Thammarat, Thailand. PAW from the
GAPS model can be used as an indicator of soil water stress. The low
amount of PAW may lead to leaf shedding in Parah trees.
Abstract: In this paper we report a study aimed at determining
the effects of animation on usability and appeal of educational
software user interfaces. Specifically, the study compares 3
interfaces developed for the Mathsigner™ program: a static
interface, an interface with highlighting/sound feedback, and an
interface that incorporates five Disney animation principles. The
main objectives of the comparative study were to: (1) determine
which interface is the most effective for the target users of
Mathsigner™ (e.g., children ages 5-11), and (2) identify any Gender
and Age differences in using the three interfaces. To accomplish
these goals we have designed an experiment consisting of a
cognitive walkthrough and a survey with rating questions. Sixteen
children ages 7-11 participated in the study, ten males and six
females. Results showed no significant interface effect on user task
performance (e.g., task completion time and number of errors);
however, interface differences were seen in rating of appeal, with
the animated interface rated more 'likeable' than the other two.
Task performance and rating of appeal were not affected
significantly by Gender or Age of the subjects.
Abstract: Integrated fiber-wireless (FiWi) access networks are a viable solution that can deliver the high profile quadruple play services. Passive optical networks (PON) networks integrated with wireless access networks provide ubiquitous characteristics for high bandwidth applications. Operation of PON improves by employing a variety of multiplexing techniques. One of it is time division/wavelength division multiplexed (TDM/WDM) architecture that improves the performance of optical-wireless access networks. This paper proposes a novel feedback-based TDM/WDM-PON architecture and introduces a model of integrated PON-FiWi networks. Feedback-based link architecture is an efficient solution to improves the performance of optical-line-terminal (OLT) and interlink optical-network-units (ONUs) communication. Furthermore, the feedback-based WDM/TDM-PON architecture is compared with existing architectures in terms of capacity of network throughput.
Abstract: Hearing impairment is the number one chronic
disability affecting many people in the world. Background noise is
particularly damaging to speech intelligibility for people with
hearing loss especially for sensorineural loss patients. Several
investigations on speech intelligibility have demonstrated
sensorineural loss patients need 5-15 dB higher SNR than the normal
hearing subjects. This paper describes Discrete Hartley Transform
Power Normalized Least Mean Square algorithm (DHT-LMS) to
improve the SNR and to reduce the convergence rate of the Least
Means Square (LMS) for sensorineural loss patients. The DHT
transforms n real numbers to n real numbers, and has the convenient
property of being its own inverse. It can be effectively used for noise
cancellation with less convergence time. The simulated result shows
the superior characteristics by improving the SNR at least 9 dB for
input SNR with zero dB and faster convergence rate (eigenvalue ratio
12) compare to time domain method and DFT-LMS.
Abstract: Automated operations based on voice commands will become more and more important in many applications, including robotics, maintenance operations, etc. However, voice command recognition rates drop quite a lot under non-stationary and chaotic noise environments. In this paper, we tried to significantly improve the speech recognition rates under non-stationary noise environments. First, 298 Navy acronyms have been selected for automatic speech recognition. Data sets were collected under 4 types of noisy environments: factory, buccaneer jet, babble noise in a canteen, and destroyer. Within each noisy environment, 4 levels (5 dB, 15 dB, 25 dB, and clean) of Signal-to-Noise Ratio (SNR) were introduced to corrupt the speech. Second, a new algorithm to estimate speech or no speech regions has been developed, implemented, and evaluated. Third, extensive simulations were carried out. It was found that the combination of the new algorithm, the proper selection of language model and a customized training of the speech recognizer based on clean speech yielded very high recognition rates, which are between 80% and 90% for the four different noisy conditions. Fourth, extensive comparative studies have also been carried out.
Abstract: This paper describes the development of a 16-ports optical code division multiple access (OCDMA) encoder prototype based on Arrayed Waveguide Grating (AWG) and optical switches. It is potentially to provide a high security for data transmission due to all data will be transmitted in binary code form. The output signals from AWG are coded with a binary code that given to an optical switch before it signal modulate with the carrier and transmitted to the receiver. The 16-ports encoder used 16 double pole double throw (DPDT) toggle switches to control the polarization of voltage source from +5 V to -5 V for 16 optical switches. When +5 V is given, the optical switch will give code '1' and vice versa. The experimental results showed the insertion loss, crosstalk, uniformity, and optical signal-noise-ratio (OSNR) for the developed prototype are
Abstract: This paper presents an adaptive feedback linearization approach to derive helicopter. Ideal feedback linearization is defined for the cases when the system model is known. Adaptive feedback linearization is employed to get asymptotically exact cancellation for the inherent uncertainty in the knowledge of the given parameters of system. The control algorithm is implemented using the feedback linearization technique and adaptive method. The controller parameters are unknown where an adaptive control law aims to drive them towards their ideal values for providing perfect model matching between the reference model and the closed-loop plant model. The converged parameters of controller would then provide good estimates for the unknown plant parameters.
Abstract: This paper features the proposed modeling and design
of a Robust Decentralized Periodic Output Feedback (RDPOF)
control technique for the active vibration control of smart flexible
multimodel Euler-Bernoulli cantilever beams for a multivariable
(MIMO) case by retaining the first 6 vibratory modes. The beam
structure is modeled in state space form using the concept of
piezoelectric theory, the Euler-Bernoulli beam theory and the Finite
Element Method (FEM) technique by dividing the beam into 4 finite
elements and placing the piezoelectric sensor / actuator at two finite
element locations (positions 2 and 4) as collocated pairs, i.e., as
surface mounted sensor / actuator, thus giving rise to a multivariable
model of the smart structure plant with two inputs and two outputs.
Five such multivariable models are obtained by varying the
dimensions (aspect ratios) of the aluminum beam, thus giving rise to
a multimodel of the smart structure system. Using model order
reduction technique, the reduced order model of the higher order
system is obtained based on dominant eigen value retention and the
method of Davison. RDPOF controllers are designed for the above 5
multivariable-multimodel plant. The closed loop responses with the
RDPOF feedback gain and the magnitudes of the control input are
observed and the performance of the proposed multimodel smart
structure system with the controller is evaluated for vibration control.
Abstract: In this paper, a self starting two step continuous block
hybrid formulae (CBHF) with four Off-step points is developed using
collocation and interpolation procedures. The CBHF is then used to
produce multiple numerical integrators which are of uniform order
and are assembled into a single block matrix equation. These
equations are simultaneously applied to provide the approximate
solution for the stiff ordinary differential equations. The order of
accuracy and stability of the block method is discussed and its
accuracy is established numerically.
Abstract: This case study investigates the effects of reactive
focus on form through negotiation on the linguistic development of
an adult EFL learner in an exclusive private EFL classroom. The
findings revealed that in this classroom negotiated feedback occurred
significantly more often than non-negotiated feedback. However, it
was also found that in the long run the learner was significantly more
successful in correcting his own errors when he had received nonnegotiated
feedback than negotiated feedback. This study, therefore,
argues that although negotiated feedback seems to be effective for
some learners in the short run, it is non-negotiated feedback which
seems to be more effective in the long run. This long lasting effect
might be attributed to the impact of schooling system which is itself
indicative of the dominant culture, or to the absence of other
interlocutors in the course of interaction.