Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.
Abstract: Turbulence modeling of large-scale flow over a vegetated surface is complex. Such problems involve large scale computational domains, while the characteristics of flow near the surface are also involved. In modeling large scale flow, surface roughness including vegetation is generally taken into account by mean of roughness parameters in the modified law of the wall. However, the turbulence structure within the canopy region cannot be captured with this method, another method which applies source/sink terms to model plant drag can be used. These models have been developed and tested intensively but with a simple surface geometry. This paper aims to compare the use of roughness parameter, and additional source/sink terms in modeling the effect of plant drag on wind flow over a complex vegetated surface. The RNG k-ε turbulence model with the non-equilibrium wall function was tested with both cases. In addition, the k-ω turbulence model, which is claimed to be computationally stable, was also investigated with the source/sink terms. All numerical results were compared to the experimental results obtained at the study site Mason Bay, Stewart Island, New Zealand. In the near-surface region, it is found that the results obtained by using the source/sink term are more accurate than those using roughness parameters. The k-ω turbulence model with source/sink term is more appropriate as it is more accurate and more computationally stable than the RNG k-ε turbulence model. At higher region, there is no significant difference amongst the results obtained from all simulations.
Abstract: This paper is a simple and systematic approaches to the design and analysis a pulse width modulation (PWM) based sliding mode controller for buck DC-DC Converters. Various aspects of the design, including the practical problems and the proposed solutions, are detailed. However, these control strategies can't compensate for large load current and input voltage variations. In this paper, a new control strategy by compromising both schemes advantages and avoiding their drawbacks is proposed, analyzed and simulated.
Abstract: In this paper, a method based on Non-Dominated
Sorting Genetic Algorithm (NSGA) has been presented for the Volt /
Var control in power distribution systems with dispersed generation
(DG). Genetic algorithm approach is used due to its broad
applicability, ease of use and high accuracy. The proposed method is
better suited for volt/var control problems. A multi-objective
optimization problem has been formulated for the volt/var control of
the distribution system. The non-dominated sorting genetic algorithm
based method proposed in this paper, alleviates the problem of tuning
the weighting factors required in solving the multi-objective volt/var
control optimization problems. Based on the simulation studies
carried out on the distribution system, the proposed scheme has been
found to be simple, accurate and easy to apply to solve the multiobjective
volt/var control optimization problem of the distribution
system with dispersed generation.
Abstract: The paper compares different channel models used for
modeling Broadband Power-Line Communication (BPLC) system.
The models compared are Zimmermann and Dostert, Philipps,
Anatory et al and Anatory et al generalized Transmission Line (TL)
model. The validity of each model was compared in time domain
with ATP-EMTP software which uses transmission line approach. It
is found that for a power-line network with minimum number of
branches all the models give similar signal/pulse time responses
compared with ATP-EMTP software; however, Zimmermann and
Dostert model indicates the same amplitude but different time delay.
It is observed that when the numbers of branches are increased only
generalized TL theory approach results are comparable with ATPEMTP
results. Also the Multi-Carrier Spread Spectrum (MC-SS)
system was applied to check the implication of such behavior on the
modulation schemes. It is observed that using Philipps on the
underground cable can predict the performance up to 25dB better
than other channel models which can misread the actual performance
of the system. Also modified Zimmermann and Dostert under
multipath can predict a better performance of about 5dB better than
the actual predicted by Generalized TL theory. It is therefore
suggested for a realistic BPLC system design and analyses the model
based on generalized TL theory be used.
Abstract: Even it has been recognized that Shape Memory
Alloys (SMA) have a significant potential for deployment actuators,
the number of applications of SMA-based actuators to the present
day is still quite small, due to the need of deep understanding of the
thermo-mechanical behavior of SMA, causing an important need for
a mathematical model able to describe all thermo-mechanical
properties of SMA by relatively simple final set of constitutive
equations. SMAs offer attractive potentials such as: reversible strains
of several percent, generation of high recovery stresses and high
power / weight ratios. The paper tries to provide an overview of the
shape memory functions and a presentation of the designed and
developed temperature control system used for a gripper actuated by
two pairs of differential SMA active springs. An experimental setup
was established, using electrical energy for actuator-s springs heating
process. As for holding the temperature of the SMA springs at certain
level for a long time was developed a control system in order to
avoid the active elements overheating.
Abstract: This experiment was conducted in attempt of
improving hydrodynamic efficiency of the propulsion mechanism by
installing a spring to the wing so that the opening angle of the wing in
one stroke can be changed automatically, compared to the existing
method of fixed maximum opening angle in Weis-Fogh type ship
propulsion mechanism. Average thrust coefficient was almost fixed
with all velocity ratio with the prototype, but with the spring type,
thrust coefficient increased sharply as velocity ratio increased.
Average propulsive efficiency was larger with bigger opening angle in
the prototype, but in the spring type, the one with smaller spring
coefficient had larger value. In the range over 1.0 in velocity ratio
where big thrust can be generated, spring type had more than twice of
propulsive efficiency increase compared to the prototype.
Abstract: In this paper, we present a technical and an economic
assessment of several sources of renewable energy in Saudi Arabia;
mainly solar, wind, hydro and biomass. We analyze the
environmental and climatic conditions in relation to these sources
and give an overview of some of the existing clean energy
technologies. Using standardized cost and efficiency data, we carry
out a cost benefit analysis to understand the economic factors
influencing the sustainability of energy production from renewable
sources in light of the energy cost and demand in the Saudi market.
Finally, we take a look at the Saudi petroleum industry and the
existing sources of conventional energy and assess the potential of
building a successful market for renewable energy under the
constraints imposed by the flow of subsidized cheap oil. We show
that while some renewable energy resources are well suited for
distributed or grid connected generation in the kingdom, their
viability is greatly undercut by the well developed and well
capitalized oil industry.
Abstract: This study experimentally and numerically investigates
motor cooling performance. The motor consists of a centrifugal fan,
two axial fans, a shaft, a stator, a rotor and a heat exchanger with 637
cooling tubes. The pressure rise-flow rate (P-Q) performance curves of
the cooling fans at 1800 rpm are tested using a test apparatus
complying with the Chinese National Standard (CNS) 2726.
Compared with the experimental measurements, the numerical
analysis results show that the P-Q performance curves of the axial fan
and centrifugal fan can be estimated within about 2% and 6%,
respectively. By using the simplified model, setting up the heat
exchanger and stator as porous media, the flow field in the motor is
calculated. By using the results of the flow field near the rotor and
stator, and subjecting the heat generation rate as a boundary condition,
the temperature distributions of the stator and rotor are also calculated.
The simulation results show that the calculated temperature of the
stator winding near the axial fans is lower by about 5% than the
measured value, and the calculated temperature of the stator core
located at the center of the stator is about 1% higher than the measured
value. Besides, discussion is made to improve the motor cooling
performance.
Abstract: We report on the results of a pilot study in which a data-mining tool was developed for mining audiology records. The records were heterogeneous in that they contained numeric, category and textual data. The tools developed are designed to observe associations between any field in the records and any other field. The techniques employed were the statistical chi-squared test, and the use of self-organizing maps, an unsupervised neural learning approach.
Abstract: Warranty is a powerful marketing tool for the
manufacturer and a good protection for both the manufacturer and the
customer. However, warranty always involves additional costs to the
manufacturer, which depend on product reliability characteristics and
warranty parameters. This paper presents an approach to optimisation
of warranty parameters for known product failure distribution to
reduce the warranty costs to the manufacturer while retaining the
promotional function of the warranty. Combination free replacement
and pro-rata warranty policy is chosen as a model and the length of
free replacement period and pro-rata policy period are varied, as well
as the coefficients that define the pro-rata cost function. Multiparametric
warranty optimisation is done by using genetic algorithm.
Obtained results are guideline for the manufacturer to choose the
warranty policy that minimises the costs and maximises the profit.
Abstract: The third generation (3G) of cellular system adopted
the spread spectrum as solution for the transmission of the data in the
physical layer. Contrary to systems IS-95 or CDMAOne (systems
with spread spectrum of the preceding generation), the new standard,
called Universal Mobil Telecommunications System (UMTS), uses
long codes in the down link. The system is conceived for the vocal
communication and the transmission of the data. In particular, the
down link is very important, because of the asymmetrical request of
the data, i.e., more remote loading towards the mobiles than towards
the basic station. Moreover, the UMTS uses for the down link an
orthogonal spreading out with a variable factor of spreading out
(OVSF for Orthogonal Variable Spreading Factor). This
characteristic makes it possible to increase the flow of data of one or
more users by reducing their factor of spreading out without
changing the factor of spreading out of other users. In the current
standard of the UMTS, two techniques to increase the performances
of the down link were proposed, the diversity of sending antenna and
the codes space-time. These two techniques fight only fainding. The
receiver proposed for the mobil station is the RAKE, but one can
imagine a receiver more sophisticated, able to reduce the interference
between users and the impact of the coloured noise and interferences
to narrow band. In this context, where the users have long codes
synchronized with variable factor of spreading out and ignorance by
the mobile of the other active codes/users, the use of the sequences of
code pseudo-noises different lengths is presented in the form of one
of the most appropriate solutions.
Abstract: This paper describes text mining technique for automatically extracting association rules from collections of textual documents. The technique called, Extracting Association Rules from Text (EART). It depends on keyword features for discover association rules amongst keywords labeling the documents. In this work, the EART system ignores the order in which the words occur, but instead focusing on the words and their statistical distributions in documents. The main contributions of the technique are that it integrates XML technology with Information Retrieval scheme (TFIDF) (for keyword/feature selection that automatically selects the most discriminative keywords for use in association rules generation) and use Data Mining technique for association rules discovery. It consists of three phases: Text Preprocessing phase (transformation, filtration, stemming and indexing of the documents), Association Rule Mining (ARM) phase (applying our designed algorithm for Generating Association Rules based on Weighting scheme GARW) and Visualization phase (visualization of results). Experiments applied on WebPages news documents related to the outbreak of the bird flu disease. The extracted association rules contain important features and describe the informative news included in the documents collection. The performance of the EART system compared with another system that uses the Apriori algorithm throughout the execution time and evaluating extracted association rules.
Abstract: In this paper an algorithm is used to detect the color defects of ceramic tiles. First the image of a normal tile is clustered using GCMA; Genetic C-means Clustering Algorithm; those results in best cluster centers. C-means is a common clustering algorithm which optimizes an objective function, based on a measure between data points and the cluster centers in the data space. Here the objective function describes the mean square error. After finding the best centers, each pixel of the image is assigned to the cluster with closest cluster center. Then, the maximum errors of clusters are computed. For each cluster, max error is the maximum distance between its center and all the pixels which belong to it. After computing errors all the pixels of defected tile image are clustered based on the centers obtained from normal tile image in previous stage. Pixels which their distance from their cluster center is more than the maximum error of that cluster are considered as defected pixels.
Abstract: The role of entrepreneurs in generating the economy is
very important. Thus, nurturing entrepreneurship skills among
society is very crucial and should start from the early age. One of the
methods is to teach through game such as board game. Game
provides a fun and interactive platform for players to learn and play.
Besides that as today-s world is moving towards Islamic approach in
terms of finance, banking and entertainment but Islamic based game
is still hard to find in the market especially games on
entrepreneurship. Therefore, there is a gap in this segment that can be
filled by learning entrepreneurship through game. The objective of
this paper is to develop an entrepreneurship digital-based game
entitled “Catur Bistari" that is based on Islamic business approach.
Knowledge and skill of entrepreneurship and Islamic business
approach will be learned through the tasks that are incorporated
inside the game.
Abstract: A complex valued neural network is a neural network
which consists of complex valued input and/or weights and/or thresholds
and/or activation functions. Complex-valued neural networks
have been widening the scope of applications not only in electronics
and informatics, but also in social systems. One of the most important
applications of the complex valued neural network is in signal
processing. In Neural networks, generalized mean neuron model
(GMN) is often discussed and studied. The GMN includes a new
aggregation function based on the concept of generalized mean of all
the inputs to the neuron. This paper aims to present exhaustive results
of using Generalized Mean Neuron model in a complex-valued neural
network model that uses the back-propagation algorithm (called
-Complex-BP-) for learning. Our experiments results demonstrate the
effectiveness of a Generalized Mean Neuron Model in a complex
plane for signal processing over a real valued neural network. We
have studied and stated various observations like effect of learning
rates, ranges of the initial weights randomly selected, error functions
used and number of iterations for the convergence of error required on
a Generalized Mean neural network model. Some inherent properties
of this complex back propagation algorithm are also studied and
discussed.
Abstract: Chua’s circuit is one of the most important electronic devices that are used for Chaos and Bifurcation studies. A central role of secure communication is devoted to it. Since the adaptive control is used vastly in the linear systems control, here we introduce a new trend of application of adaptive method in the chaos controlling field. In this paper, we try to derive a new adaptive control scheme for Chua’s circuit controlling because control of chaos is often very important in practical operations. The novelty of this approach is for sake of its robustness against the external perturbations which is simulated as an additive noise in all measured states and can be generalized to other chaotic systems. Our approach is based on Lyapunov analysis and the adaptation law is considered for the feedback gain. Because of this, we have named it NAFT (Nonlinear Adaptive Feedback Technique). At last, simulations show the capability of the presented technique for Chua’s circuit.
Abstract: Palladium-catalyzed hydrodechlorination is a
promising alternative for the treatment of environmentally relevant
water bodies, such as groundwater, contaminated with chlorinated
organic compounds (COCs). In the aqueous phase
hydrodechlorination of COCs, Pd-based catalysts were found to have
a very high catalytic activity. However, the full utilization of the
catalyst-s potential is impeded by the sensitivity of the catalyst to
poisoning and deactivation induced by reduced sulfur compounds
(e.g. sulfides). Several regenerants have been tested before to recover
the performance of sulfide-fouled Pd catalyst. But these only
delivered partial success with respect to re-establishment of the
catalyst activity. In this study, the deactivation behaviour of
Pd/Al2O3 in the presence of sulfide was investigated. Subsequent to
total deactivation the catalyst was regenerated in the aqueous phase
using potassium permanganate. Under neutral pH condition,
oxidative regeneration with permanganate delivered a slow recovery
of catalyst activity. However, changing the pH of the bulk solution to
acidic resulted in the complete recovery of catalyst activity within a
regeneration time of about half an hour. These findings suggest the
superiority of permanganate as regenerant in re-activating Pd/Al2O3
by oxidizing Pd-bound sulfide.
Abstract: Image convolution similar to the receptive fields
found in mammalian visual pathways has long been used in
conventional image processing in the form of Gabor masks.
However, no VLSI implementation of parallel, multi-layered pulsed
processing has been brought forward which would emulate this
property. We present a technical realization of such a pulsed image
processing scheme. The discussed IC also serves as a general testbed
for VLSI-based pulsed information processing, which is of interest
especially with regard to the robustness of representing an analog
signal in the phase or duration of a pulsed, quasi-digital signal, as
well as the possibility of direct digital manipulation of such an
analog signal. The network connectivity and processing properties
are reconfigurable so as to allow adaptation to various processing
tasks.