Abstract: Transdermal delivery of ondansetron hydrochloride (OdHCl) can prevent the problems encountered with oral ondansetron. In previously conducted studies, effect of amount of polyvinyl pyrrolidone, permeation enhancer and casting solvent on the physicochemical properties on OdHCl were investigated. It is feasible to develop ondansetron transdermal patch by using ethyl cellulose and polyvinyl pyrrolidone with dibutyl pthalate as plasticizer, however, the desired flux is not achieved. The primary aim of this study is to use dimethyl succinate (DMS) and propylene glycol that are not incorporated in previous studies to determine their effect on the physicochemical properties of an OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone. This study also investigates the effect of permeation enhancer (eugenol and phosphatidylcholine) on the release of OdHCl. The results showed that propylene glycol is a more suitable plasticizer compared to DMS in the fabrication of OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone as polymers. Propylene glycol containing patch has optimum drug content, thickness, moisture content and water absorption, tensile strength, and a better release profile than DMS. Eugenol and phosphatidylcholine can increase release of OdHCl from the patches. From the physicochemical result and permeation profile, a combination of 350mg of ethyl cellulose, 150mg polyvinyl pyrrolidone, 3% of total polymer weight of eugenol, and 40% of total polymer weight of propylene glycol is the most suitable formulation to develop an OdHCl patch. OdHCl release did not increase with increasing the percentage of plasticiser. DMS 4, PG 4, DMS 9, PG 9, DMS 14, and PG 14 gave better release profiles where using 300mg: 0mg, 300mg: 100mg, and 350mg: 150mg of EC: PVP. Thus, 40% of PG or DMS appeared to be the optimum amount of plasticiser when the above combination where EC: PVP was used. It was concluded from the study that a patch formulation containing 350mg EC, 150mg PVP, 40% PG and 3% eugenol is the best transdermal matrix patch compositions for the uniform and continuous release/permeation of OdHCl over an extended period. This patch design can be used for further pharmacokinetic and pharmacodynamic studies in suitable animal models.
Abstract: This research studied the hypoglycemic effect of
water soluble polysaccharide (WSP) extracted from yam (Dioscorea
hispida) tuber by three different methods: aqueous extraction, papain
assisted extraction, and tempeh inoculums assisted extraction. The
two later extraction methods were aimed to remove WSP binding
protein to have more pure WSP. The hypoglycemic activities were
evaluated by means in vivo test on alloxan induced hyperglycemic
rats, glucose response test (GRT), in situ glucose absorption test
using everted sac, and short chain fatty acids (SCFAs) analysis. All
yam WSP extracts exhibited ability to decrease blood glucose level in
hyperglycemia condition as well as inhibited glucose absorption and
SCFA formation. The order of hypoglycemic activity was tempeh
inoculums assisted- >papain assisted- >aqueous WSP extracts. GRT
and in situ glucose absorption test showed that order of inhibition
was papain assisted- >tempeh inoculums assisted- >aqueous WSP
extracts. Digesta of caecum of yam WSP extracts oral fed rats had
more SCFA than control. Tempeh inoculums assisted WSP extract
exhibited the most significant hypoglycemic activity.
Abstract: An accurate procedure to determine free vibrations of
beams and plates is presented.
The natural frequencies are exact solutions of governing vibration
equations witch load to a nonlinear homogeny system.
The bilinear and linear structures considered simulate a bridge.
The dynamic behavior of this one is analyzed by using the theory of
the orthotropic plate simply supported on two sides and free on the
two others. The plate can be excited by a convoy of constant or
harmonic loads. The determination of the dynamic response of the
structures considered requires knowledge of the free frequencies and
the shape modes of vibrations. Our work is in this context. Indeed,
we are interested to develop a self-consistent calculation of the Eigen
frequencies.
The formulation is based on the determination of the solution of
the differential equations of vibrations. The boundary conditions
corresponding to the shape modes permit to lead to a homogeneous
system. Determination of the noncommonplace solutions of this
system led to a nonlinear problem in Eigen frequencies.
We thus, develop a computer code for the determination of the
eigenvalues. It is based on a method of bisection with interpolation
whose precision reaches 10 -12. Moreover, to determine the
corresponding modes, the calculation algorithm that we develop uses
the method of Gauss with a partial optimization of the "pivots"
combined with an inverse power procedure. The Eigen frequencies
of a plate simply supported along two opposite sides while
considering the two other free sides are thus analyzed. The results
could be generalized with the case of a beam by regarding it as a
plate with low width.
We give, in this paper, some examples of treated cases. The
comparison with results presented in the literature is completely
satisfactory.
Abstract: We propose photo-BJMOSFET (Bipolar Junction Metal-Oxide-Semiconductor Field Effect Transistor) fabricated on SOI film. ITO film is adopted in the device as gate electrode to reduce light absorption. I-V characteristics of photo-BJMOSFET obtained in dark (dark current) and under 570nm illumination (photo current) are studied furthermore to achieve high photo-to-dark-current contrast ratio. Two variables in the calculation were the channel length and the thickness of the film which were set equal to six different values, i.e., L=2, 4, 6, 8, 10, and 12μm and three different values, i.e., dsi =100, 200 and 300nm, respectively. The results indicate that the greatest photo-to-dark-current contrast ratio is achieved with L=10μm and dsi=200 nm at VGK=0.6V.
Abstract: The improvement of irrigation systems in the Nile
Delta is one of the most important attempts in Egypt to implement
more effective irrigation technology by improving the existing
irrigation networks. Demand delivery system in the existing irrigation
network is using of mechanical gates structures to automatically
divert water from one portion of an agricultural field to another in the
desired amount and sequence. This paper discusses evaluating main
irrigation networks system under the government managed before
and after improvement systems in the Nile Delta. The overall results
indicate that policy of using the demand delivery concept through
irrigation networks is successful by improving water delivery
performance among them than the rotation delivery concept that used
before. It is provided fair share of water delivery among irrigation
districts and available water in the end of irrigation network,
although this system located in an end of irrigation networks in the
Nile Delta.
Abstract: A major goal of any enterprise is to create a ratings
system of customer satisfaction, goods and services. It is obvious that
the company cannot change what is not measured. In order to get a
clearer picture of the preferences of the major consumer groups, this
stage should be based on extensive research, including a variety of
interviews and surveys. It is necessary to know the key benefits,
which determine customer satisfaction in the market segment, of the
properties of certain goods and services. It is important to estimate
the terms of these preferences from the viewpoint of the client. This
article discusses the importance of customer satisfaction, and ways of
assessing it.
Abstract: The aim of the present study was to investigate the
chemical and biological properties of local cowpea seed protein
cultivated in Gizan region. The results showed that the cowpea and
its products contain high level of protein (22.9-77.6%), high
carbohydrates (9.4-64.3%) and low fats (0.1-0.3%). The trypsin and
chymotrypsin activities were found to be 32.2 and 15.2 units,
respectively. These activities were not affected in both defatted and
protein concentrate whereas they were significantly reduced in
isolated protein and cooked samples. The phytate content of cooked
and concentrated cowpea samples varied from 0.25% -0.32%,
respectively. Tannin content was found to be 0.4% and 0.23% for
cooked and raw samples, respectively. The in vitro protein
digestibility was very high in cowpea seeds (75.04-78.76%). The
biological evaluation using rats showed that the group fed with
animal feed containing casein gain more weight than those fed with
that containing cowpea. However, the group fed with cooked cowpea
gain more weight than those fed with uncooked cowpea. On the
other hand, in vivo digestion showed high value (98.33%) among the
group consumed casein compared to other groups those consumed
cowpea contains feed. This could be attributed to low antinutritional
factors in casein contains feed compared to those of cowpea contains
feed because cooking significantly increased the digestion rate
(80.8% to 83.5%) of cowpea contains feed. Furthermore, the
biological evaluation was high (91.67%) of casein containing feed
compared to that of cowpea containing feed (80.83%-87.5%). The
net protein utilization (NPU) was higher (89.67%) in the group fed
with casein containing feed than that of cowpea containing feed
(56.33%-69.67%).
Abstract: All climate models agree that the temperature in
Greece will increase in the range of 1° to 2°C by the year 2030 and
mean sea level in Mediterranean is expected to rise at the rate of 5
cm/decade. The aim of the present paper is the estimation of the
coastline displacement driven by the climate change and sea level
rise. In order to achieve that, all known statistical and non-statistical
computational methods are employed on some Greek coastal areas.
Furthermore, Kalman filtering techniques are for the first time
introduced, formulated and tested. Based on all the above, shoreline
change signals and noises are computed and an inter-comparison
between the different methods can be deduced to help evaluating
which method is most promising as far as the retrieve of shoreline
change rate is concerned.
Abstract: Enzymatic hydrolysis of starch from natural sources
finds potential application in commercial production of alcoholic
beverage and bioethanol. In this study the effect of starch
concentration, temperature, time and enzyme concentration were
studied and optimized for hydrolysis of Potato starch powder (of
mesh 80/120) into glucose syrup by immobilized (using Sodium
arginate) α-amylase using central composite design. The
experimental result on enzymatic hydrolysis of Potato starch was
subjected to multiple linear regression analysis using MINITAB 14
software. Positive linear effect of starch concentration, enzyme
concentration and time was observed on hydrolysis of Potato starch
by α-amylase. The statistical significance of the model was validated
by F-test for analysis of variance (p ≤ 0.01). The optimum value of
starch concentration, enzyme concentration, temperature, time and
were found to be 6% (w/v), 2% (w/v), 40°C and 80min respectively.
The maximum glucose yield at optimum condition was 2.34 mg/mL.
Abstract: A multi-rate discrete-time model, whose response
agrees exactly with that of a continuous-time original at all sampling
instants for any sampling periods, is developed for a linear system,
which is assumed to have multiple real eigenvalues. The sampling
rates can be chosen arbitrarily and individually, so that their ratios
can even be irrational. The state space model is obtained as a
combination of a linear diagonal state equation and a nonlinear output
equation. Unlike the usual lifted model, the order of the proposed
model is the same as the number of sampling rates, which is less than
or equal to the order of the original continuous-time system. The
method is based on a nonlinear variable transformation, which can be
considered as a generalization of linear similarity transformation,
which cannot be applied to systems with multiple eigenvalues in
general. An example and its simulation result show that the proposed
multi-rate model gives exact responses at all sampling instants.
Abstract: This paper discusses the investigation of a wearable
textile monopole antenna on specific absorption rate (SAR) for bodycentric
wireless communication applications at 2.45 GHz. The
antenna is characterized on a realistic 8 x 8 x 8 mm3 resolution
truncated Hugo body model in CST Microwave Studio software. The
result exhibited that the simulated SAR values were reduced
significantly by 83.5% as the position of textile monopole was
varying between 0 mm and 15 mm away from the human upper arm.
A power absorption reduction of 52.2% was also noticed as the
distance of textile monopole increased.
Abstract: In this study four Holstein steers with rumen fistula
fed 7 kg of dry matter (DM) of diets differing in concentrate to
alfalfa hay ratios as 60:40, 70:30, 80:20, and 90:10 in a 4 × 4 latin
square design. The pH of the ruminal fluid was measured before
the morning feeding (0.0 h) to 8 h post feeding. In this study, a
two-layered feed-forward neural network trained by the
Levenberg-Marquardt algorithm was used for modelling of ruminal
pH. The input variables of the network were time, concentrate to
alfalfa hay ratios (C/F), non fiber carbohydrate (NFC) and neutral
detergent fiber (NDF). The output variable was the ruminal pH.
The modeling results showed that there was excellent agreement
between the experimental data and predicted values, with a high
determination coefficient (R2 >0.96). Therefore, we suggest using
these model-derived biological values to summarize continuously
recorded pH data.
Abstract: This study aimed to investigate the influence of selected antecedents, which were tourists’ satisfaction towards attractions in Bangkok, perceived value of the attractions, feelings of engagement with the attractions, acquaintance with the attractions, push factors, pull factors and motivation to seek novelty, on foreign tourist’s loyalty towards tourist attractions in Bangkok. By using multi stage sampling technique, 400 international tourists were sampled. After that, Semi Structural Equation Model was utilized in the analysis stage by LISREL. The Semi Structural Equation Model of the selected antecedents of tourist’s loyalty attractions had a correlation with the empirical data through the following statistical descriptions: Chi- square = 3.43, df = 4, P- value = 0.48893; RMSEA = 0.000; CFI = 1.00; CN = 1539.75; RMR = 0.0022; GFI = 1.00 and AGFI = 0.98. The findings indicated that all antecedents were able together to predict the loyalty of the foreign tourists who visited Bangkok at 73 percent.
Abstract: Although, all high school students in Japan are required to learn informatics, many of them do not learn this topic sufficiently. In response to this situation, we propose a support package for high school informatics classes. To examine what students learned and if they sufficiently understood the context of the lessons, a questionnaire survey was distributed to 186 students. We analyzed the results of the questionnaire and determined the weakest units, which were “basic computer configuration” and “memory and secondary storage”. We then developed a package for teaching these units. We propose that our package be applied in high school classrooms.
Abstract: The adverse effects of Clindamycin (Clind.) /
Ibuprofen (Ibu.) combination on liver, kidney, blood elements and the
significances of antioxidants (N-acetylcysteine and Zinc) against
these effects were evaluated. The study includes: Group I; control
n=30, Group II; patients on Clind.300mg/Ibu.400mg twice daily for a
week n=30, Group III; patients on Clind.300mg/Ibu.400mg+Nacetylcysteine
200mg twice daily for a week n=15 and Group IV;
patients on Clind.300mg/Ibu.400mg+Zinc50mg twice daily for a
week n=15. Serum malondialdehyde (MDA), alanine transferase
(ALT), aspartate transferase (AST), γ glutamyl transferase (GGT),
creatinine, blood urea nitrogen (BUN) were measured. Applying one
way ANOVA followed by Tuckey Kramer post test, Group II showed
significant increase in ALT, AST, GGT, BUN and decrease in Hb,
RBCs, platelets than Group I. Group III showed significant decrease
in ALT, AST, GGT, BUN than Group II. Moreover, Group IV
showed significant decrease in ALT, AST, GGT and increase in Hb,
RBCs, and platelets than Group II. Conclusively, Adding Zinc or Nacetylcysteine
buffer the oxidative stress and improve the therapeutic
outcome of Clindamycin/Ibuprofen combination.
Abstract: Developers need to evaluate software's performance to make software efficient. This paper suggests a performance evaluation system for embedded software. The suggested system consists of code analyzer, testing agents, data analyzer, and report viewer. The code analyzer inserts additional code dependent on target system into source code and compiles the source code. The testing agents execute performance test. The data analyzer translates raw-level results data to class-level APIs for reporting viewer. The report viewer offers users graphical report views by using the APIs. We hope that the suggested tool will be useful for embedded-related software development,because developers can easily and intuitively analyze software's performance and resource utilization.
Abstract: Non-stationary trend in R-R interval series is
considered as a main factor that could highly influence the evaluation
of spectral analysis. It is suggested to remove trends in order to obtain
reliable results. In this study, three detrending methods, the
smoothness prior approach, the wavelet and the empirical mode
decomposition, were compared on artificial R-R interval series with
four types of simulated trends. The Lomb-Scargle periodogram was
used for spectral analysis of R-R interval series. Results indicated that
the wavelet method showed a better overall performance than the other
two methods, and more time-saving, too. Therefore it was selected for
spectral analysis of real R-R interval series of thirty-seven healthy
subjects. Significant decreases (19.94±5.87% in the low frequency
band and 18.97±5.78% in the ratio (p
Abstract: The evaluation of the contribution of professional
baseball starting pitchers is a complex decision-making problem that
includes several quantitative attributes. It is considered a type of
multi-attribute or multi-criteria decision making (MADM/MCDM)
problem. This study proposes a model using the Grey Relational
Analysis (GRA) to evaluate the starting pitcher contribution for teams
of the Chinese Professional Baseball League. The GRA calculates the
individual grey relational degree of each alternative to the positive
ideal alternative. An empirical analysis was conducted to show the use
of the model for the starting pitcher contribution problem. The results
demonstrate the effectiveness and feasibility of the proposed model.
Abstract: This paper developed the c-Chart based on a Zero- Inflated Poisson (ZIP) processes that approximated by a geometric distribution with parameter p. The p estimated that fit for ZIP distribution used in calculated the mean, median, and variance of geometric distribution for constructed the c-Chart by three difference methods. For cg-Chart, developed c-Chart by used the mean and variance of the geometric distribution constructed control limits. For cmg-Chart, the mean used for constructed the control limits. The cme- Chart, developed control limits of c-Chart from median and variance values of geometric distribution. The performance of charts considered from the Average Run Length and Average Coverage Probability. We found that for an in-control process, the cg-Chart is superior for low level of mean at all level of proportion zero. For an out-of-control process, the cmg-Chart and cme-Chart are the best for mean = 2, 3 and 4 at all level of parameter.
Abstract: Ad hoc networks are characterized by multihop wireless connectivity, frequently changing network topology and the need for efficient dynamic routing protocols. We compare the performance of three routing protocols for mobile ad hoc networks: Dynamic Source Routing (DSR), Ad Hoc On-Demand Distance Vector Routing (AODV), location-aided routing (LAR1).Our evaluation is based on energy consumption in mobile ad hoc networks. The performance differentials are analyzed using varying network load, mobility, and network size. We simulate protocols with GLOMOSIM simulator. Based on the observations, we make recommendations about when the performance of either protocol can be best.