Abstract: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the conversion of HMG-CoA to mevalonate using NADPH and the enzyme is involved in rate-controlling step of mevalonate. Inhibition of HMGR is considered as effective way to lower cholesterol levels so it is drug target to treat hypercholesterolemia, major risk factor of cardiovascular disease. To discover novel HMGR inhibitor, we performed structure-based pharmacophore modeling combined with molecular dynamics (MD) simulation. Four HMGR inhibitors were used for MD simulation and representative structure of each simulation were selected by clustering analysis. Four structure-based pharmacophore models were generated using the representative structure. The generated models were validated used in virtual screening to find novel scaffolds for inhibiting HMGR. The screened compounds were filtered by applying drug-like properties and used in molecular docking. Finally, four hit compounds were obtained and these complexes were refined using energy minimization. These compounds might be potential leads to design novel HMGR inhibitor.
Abstract: In Korea, the technology of a load fo nuclear power plant has been being developed.
automatic controller which is able to control temperature and axial power distribution was developed. identification algorithm and a model predictive contact former transforms the nuclear reactor status into
numerically. And the latter uses them and ge
manipulated values such as two kinds of control ro
this automatic controller, the performance of a coperation was evaluated. As a result, the automatic generated model parameters of a nuclear react to nuclear reactor average temperature and axial power the desired targets during a daily load follow.
Abstract: Recent years have seen a growing trend towards the
integration of multiple information sources to support large-scale
prediction of protein-protein interaction (PPI) networks in model
organisms. Despite advances in computational approaches, the
combination of multiple “omic" datasets representing the same type
of data, e.g. different gene expression datasets, has not been
rigorously studied. Furthermore, there is a need to further investigate
the inference capability of powerful approaches, such as fullyconnected
Bayesian networks, in the context of the prediction of PPI
networks. This paper addresses these limitations by proposing a
Bayesian approach to integrate multiple datasets, some of which
encode the same type of “omic" data to support the identification of
PPI networks. The case study reported involved the combination of
three gene expression datasets relevant to human heart failure (HF).
In comparison with two traditional methods, Naive Bayesian and
maximum likelihood ratio approaches, the proposed technique can
accurately identify known PPI and can be applied to infer potentially
novel interactions.
Abstract: Based on a non-linear single track model which
describes the dynamics of vehicle, an optimal path planning strategy
is developed. Real time optimization is used to generate reference
control values to allow leading the vehicle alongside a calculated lane
which is optimal for different objectives such as energy consumption,
run time, safety or comfort characteristics. Strict mathematic
formulation of the autonomous driving allows taking decision on
undefined situation such as lane change or obstacle avoidance. Based
on position of the vehicle, lane situation and obstacle position, the
optimization problem is reformulated in real-time to avoid the
obstacle and any car crash.
Abstract: This paper presents a several diagnostic methods designed to electrical machinesespecially for permanent magnets (PM) machines. Those machines are commonly used in small wind and water systems and vehicles drives.Thosemethodsare preferred by the author in periodic diagnostic of electrical machines. The special attentionshould be paid to diagnostic method of turn-to-turn insulation and vibrations. Both of those methodswere createdinInstitute of Electrical Drives and MachinesKomel. The vibration diagnostic method is the main thesis of author’s doctoral dissertation. This is method of determination the technical condition of PM electrical machine basing on its own signals is the subject of patent application No P.405669. Specific structural properties of machines excited by permanent magnets are used in this method - electromotive force (EMF) generated due to vibrations. There was analysed number of publications which describe vibration diagnostic methods and tests of electrical machines with permanent magnets and there was no method found to determine the technical condition of such machine basing on their own signals.
Abstract: Photovoltaic power generation forecasting is an
important task in renewable energy power system planning and
operating. This paper explores the application of neural networks
(NN) to study the design of photovoltaic power generation
forecasting systems for one week ahead using weather databases
include the global irradiance, and temperature of Ghardaia city
(south of Algeria) using a data acquisition system. Simulations were
run and the results are discussed showing that neural networks
Technique is capable to decrease the photovoltaic power generation
forecasting error.
Abstract: Since 1984 many schemes have been proposed for
digital signature protocol, among them those that based on discrete
log and factorizations. However a new identification scheme based
on iterated function (IFS) systems are proposed and proved to be
more efficient. In this study the proposed identification scheme is
transformed into a digital signature scheme by using a one way hash
function. It is a generalization of the GQ signature schemes. The
attractor of the IFS is used to obtain public key from a private one,
and in the encryption and decryption of a hash function. Our aim is
to provide techniques and tools which may be useful towards
developing cryptographic protocols. Comparisons between the
proposed scheme and fractal digital signature scheme based on RSA
setting, as well as, with the conventional Guillou-Quisquater
signature, and RSA signature schemes is performed to prove that, the
proposed scheme is efficient and with high performance.
Abstract: Most Decision Support Systems (DSS) for waste
management (WM) constructed are not widely marketed and lack
practical applications. This is due to the number of variables and
complexity of the mathematical models which include the
assumptions and constraints required in decision making. The
approach made by many researchers in DSS modelling is to isolate a
few key factors that have a significant influence to the DSS. This
segmented approach does not provide a thorough understanding of
the complex relationships of the many elements involved. The
various elements in constructing the DSS must be integrated and
optimized in order to produce a viable model that is marketable and
has practical application. The DSS model used in assisting decision
makers should be integrated with GIS, able to give robust prediction
despite the inherent uncertainties of waste generation and the plethora
of waste characteristics, and gives optimal allocation of waste stream
for recycling, incineration, landfill and composting.
Abstract: In this paper we propose a computational model for the representation and processing of morpho-phonological phenomena in a natural language, like Modern Greek. We aim at a unified treatment of inflection, compounding, and word-internal phonological changes, in a model that is used for both analysis and generation. After discussing certain difficulties cuase by well-known finitestate approaches, such as Koskenniemi-s two-level model [7] when applied to a computational treatment of compounding, we argue that a morphology-based model provides a more adequate account of word-internal phenomena. Contrary to the finite state approaches that cannot handle hierarchical word constituency in a satisfactory way, we propose a unification-based word grammar, as the nucleus of our strategy, which takes into consideration word representations that are based on affixation and [stem stem] or [stem word] compounds. In our formalism, feature-passing operations are formulated with the use of the unification device, and phonological rules modeling the correspondence between lexical and surface forms apply at morpheme boundaries. In the paper, examples from Modern Greek illustrate our approach. Morpheme structures, stress, and morphologically conditioned phoneme changes are analyzed and generated in a principled way.
Abstract: In a nuclear reactor Loss of Coolant accident (LOCA)
considers wide range of postulated damage or rupture of pipe in the
heat transport piping system. In the case of LOCA with/without
failure of emergency core cooling system in a Pressurised Heavy
water Reactor, the Pressure Tube (PT) temperature could rise
significantly due to fuel heat up and gross mismatch of the heat
generation and heat removal in the affected channel. The extent and
nature of deformation is important from reactor safety point of view.
Experimental set-ups have been designed and fabricated to simulate
ballooning (radial deformation) of PT for 220 MWe IPHWRs.
Experiments have been conducted by covering the CT by ceramic
fibers and then by submerging CT in water of voided PTs. In both
the experiments, it is observed that ballooning initiates at a
temperature around 665´┐¢C and complete contact between PT and
Caldaria Tube (CT) occurs at around 700´┐¢C approximately. The
strain rate is found to be 0.116% per second. The structural integrity
of PT is retained (no breach) for all the experiments. The PT heatup
is found to be arrested after the contact between PT and CT, thus
establishing moderator acting as an efficient heat sink for IPHWRs.
Abstract: In this cyber age, the job market has been rapidly transforming and being digitalized. Submitting a paper-based curriculum vitae (CV) nowadays does not grant a job seeker a high employability rate. This paper calls for attention on the creation of mobile Curriculum Vitae or m-CV (http://mcurriculumvitae. blogspot.com), a sample of an individual CV developed using weblog, which can enhance the job hunter especially fresh graduate-s higher marketability rate. This study is designed to identify the perceptions held by Malaysian university students regarding m-CV grounded on a modified Technology Acceptance Model (TAM). It measures the strength and the direction of relationships among three major variables – Perceived Ease of Use (PEOU), Perceived Usefulness (PU) and Behavioral Intention (BI) to use. The finding shows that university students generally accepted adopting m-CV since they perceived m-CV to be more useful rather than easy to use. Additionally, this study has confirmed TAM to be a useful theoretical model in helping to understand and explain the behavioral intention to use Web 2.0 application-weblog publishing their CV. The result of the study has underlined another significant positive value of using weblog to create personal CV. Further research of m-CV has been highlighted in this paper.
Abstract: Nowadays, Gene Ontology has been used widely by many researchers for biological data mining and information retrieval, integration of biological databases, finding genes, and incorporating knowledge in the Gene Ontology for gene clustering. However, the increase in size of the Gene Ontology has caused problems in maintaining and processing them. One way to obtain their accessibility is by clustering them into fragmented groups. Clustering the Gene Ontology is a difficult combinatorial problem and can be modeled as a graph partitioning problem. Additionally, deciding the number k of clusters to use is not easily perceived and is a hard algorithmic problem. Therefore, an approach for solving the automatic clustering of the Gene Ontology is proposed by incorporating cohesion-and-coupling metric into a hybrid algorithm consisting of a genetic algorithm and a split-and-merge algorithm. Experimental results and an example of modularized Gene Ontology in RDF/XML format are given to illustrate the effectiveness of the algorithm.
Abstract: In general architecture means the art of creating the
space. Comprehensive and complete body which is created by a
creative and purposeful thought to respond the human needs.
Professionally, architecture is the are of designing and
comprehensive planning of physical spaces that is created for
human-s productivity. The purpose of architectural design is to
respond the human needs which is appeared in physical frame.
Human in response to his needs is always looking to achieve comfort.
Throughout history of human civilization this relative comfort has
been inspired by nature and assimilating the facility and natural
achievement in the format of artifact patterns base on the nature, so
that it is achieved in this comfort level and invention of these factors.
All physical factors like regional, social and economical factors are
made available to human in order to achieve a specific goal and are
made to gain an ideal architecture to respond the functional needs and
consider the aesthetics and elemental principles and pay attention to
residents- comfort. In this study the Persian architecture with
exploiting and transforming the energies into the requisite energies of
architecture spaces and importing fuel products, utilities, etc, in order
to achieve a relative comfort level will be investigated. In this paper
the study of structural and physical specialties of traditional houses in
desert regions and Central Plateau of Iran gave us this opportunity to
being more familiar with important specialties of energy productivity
in architecture body of traditional houses in these regions specially
traditional houses of Kashan and in order to use these principles to
create modern architectures in these regions.
Abstract: General requirements for knowledge representation in
the form of logic rules, applicable to design and control of industrial
processes, are formulated. Characteristic behavior of decision trees
(DTs) and rough sets theory (RST) in rules extraction from recorded
data is discussed and illustrated with simple examples. The
significance of the models- drawbacks was evaluated, using
simulated and industrial data sets. It is concluded that performance of
DTs may be considerably poorer in several important aspects,
compared to RST, particularly when not only a characterization of a
problem is required, but also detailed and precise rules are needed,
according to actual, specific problems to be solved.
Abstract: In its attempt to offer new ways into autonomy for a
large population of disabled people, assistive technology has largely
been inspired by robotics engineering. Recent human-like robots
carry new hopes that it seems to us necessary to analyze by means of
a specific theory of anthropomorphism. We propose to distinguish a
functional anthropomorphism which is the one of actual wheelchairs
from a structural anthropomorphism based on a mimicking of human
physiological systems. If functional anthropomorphism offers the
main advantage of eliminating the physiological systems
interdependence issue, the highly link between the robot for disabled
people and their human-built environment would lead to privilege in
the future the anthropomorphic structural way. In this future
framework, we highlight a general interdependence principle : any
partial or local structural anthropomorphism generates new
anthropomorphic needs due to the physiological systems
interdependency, whose effects can be evaluated by means of
specific anthropomorphic criterions derived from a set theory-based
approach of physiological systems.
Abstract: Small cracks or chips of a product appear very
frequently in the course of continuous production of an automatic
press process system. These phenomena become the cause of not only
defective product but also damage of a press mold. In order to solve
this problem AE system was introduced. AE system was expected to
be very effective to real time detection of the defective product and to
prevention of the damage of the press molds.
In this study, for pick and analysis of AE signals generated from the
press process, AE sensors/pre-amplifier/analysis and processing board
were used as frequently found in the other similar cases. For analysis
and processing the AE signals picked in real time from the good or bad
products, specialized software called cdm8 was used. As a result of
this work it was conformed that intensity and shape of the various AE
signals differ depending on the weight and thickness of metal sheet
and process type.
Abstract: Concept maps can be generated manually or
automatically. It is important to recognize differences of the two
types of concept maps. The automatically generated concept maps
are dynamic, interactive, and full of associations between the terms
on the maps and the underlying documents. Through a specific
concept mapping system, Visual Concept Explorer (VCE), this paper
discusses how automatically generated concept maps are different
from manually generated concept maps and how different
applications and learning opportunities might be created with the
automatically generated concept maps. The paper presents several
examples of learning strategies that take advantages of the
automatically generated concept maps for concept learning and
exploration.
Abstract: Long term rainfall analysis and prediction is a
challenging task especially in the modern world where the impact of
global warming is creating complications in environmental issues.
These factors which are data intensive require high performance
computational modeling for accurate prediction. This research paper
describes a prototype which is designed and developed on grid
environment using a number of coupled software infrastructural
building blocks. This grid enabled system provides the demanding
computational power, efficiency, resources, user-friendly interface,
secured job submission and high throughput. The results obtained
using sequential execution and grid enabled execution shows that
computational performance has enhanced among 36% to 75%, for
decade of climate parameters. Large variation in performance can be
attributed to varying degree of computational resources available for
job execution.
Grid Computing enables the dynamic runtime selection, sharing
and aggregation of distributed and autonomous resources which plays
an important role not only in business, but also in scientific
implications and social surroundings. This research paper attempts to
explore the grid enabled computing capabilities on weather indices
from HOAPS data for climate impact modeling and change
detection.
Abstract: The Mobile Ad-hoc Network (MANET) is a collection of self-configuring and rapidly deployed mobile nodes (routers) without any central infrastructure. Routing is one of the potential issues. Many routing protocols are reported but it is difficult to decide which one is best in all scenarios. In this paper on demand routing protocols DSR and DYMO based on IEEE 802.11 DCF MAC protocol are examined and characteristic summary of these routing protocols is presented. Their performance is analyzed and compared on performance measuring metrics throughput, dropped packets due to non availability of routes, duplicate RREQ generated for route discovery and normalized routing load by varying CBR data traffic load using QualNet 5.0.2 network simulator.
Abstract: This paper studies the mean square exponential synchronization problem of a class of stochastic neutral type chaotic neural networks with mixed delay. On the Basis of Lyapunov stability theory, some sufficient conditions ensuring the mean square exponential synchronization of two identical chaotic neural networks are obtained by using stochastic analysis and inequality technique. These conditions are expressed in the form of linear matrix inequalities (LMIs), whose feasibility can be easily checked by using Matlab LMI Toolbox. The feedback controller used in this paper is more general than those used in previous literatures. One simulation example is presented to demonstrate the effectiveness of the derived results.