Abstract: Second line antiretroviral therapy (ART) regimen is
used when patients fail their first line regimen. There are many
factors such as non-adherence, drug resistance as well as virological
and immunological failure that lead to second line highly active
antiretroviral therapy (HAART) regimen treatment failure. This study
was aimed at determining predictor factors to treatment failure with
second line HAART and analyzing median survival time.
An observational, retrospective study was conducted in Sungai
Buloh Hospital (HSB) to assess current status of HIV patients treated
with second line HAART regimen. Convenience sampling was used
and 104 patients were included based on the study’s inclusion and
exclusion criteria. Data was collected for six months i.e. from July
until December 2013. Data was then analysed using SPSS version 18.
Kaplan-Meier and Cox regression analyses were used to measure
median survival times and predictor factors for treatment failure.
The study population consisted mainly of male subjects, aged 30-
45 years, who were heterosexual, and had HIV infection for less than
6 years. The most common second line HAART regimen given was
lopinavir/ritonavir (LPV/r)-based combination. Kaplan-Meier
analysis showed that patients on LPV/r demonstrated longer median
survival times than patients on indinavir/ritonavir (IDV/r) based
combination (p
Abstract: Recently GPS data is used in a lot of studies to
automatically reconstruct travel patterns for trip survey. The aim is to
minimize the use of questionnaire surveys and travel diaries so as to
reduce their negative effects. In this paper data acquired from GPS and
accelerometer embedded in smart phones is utilized to predict the
mode of transportation used by the phone carrier. For prediction,
Support Vector Machine (SVM) and Adaptive boosting (AdaBoost)
are employed. Moreover a unique method to improve the prediction
results from these algorithms is also proposed. Results suggest that the
prediction accuracy of AdaBoost after improvement is relatively better
than the rest.
Abstract: We have studied a method to widen the spectrum
of optical pulses that pass through an InGaAsP waveguide for
application to broadband optical communication. In particular, we
have investigated the competitive effect between spectral broadening
arising from nonlinear refraction (optical Kerr effect) and shrinking
due to two photon absorption in the InGaAsP waveguide with
χ(3) nonlinearity. The shrunk spectrum recovers broadening by
the enhancement effect of the nonlinear refractive index near the
bandgap of InGaAsP with a bandgap wavelength of 1490 nm. The
broadened spectral width at around 1525 nm (196.7 THz) becomes
10.7 times wider than that at around 1560 nm (192.3 THz) without
the enhancement effect, where amplified optical pulses with a pulse
width of ∼ 2 ps and a peak power of 10 W propagate through a
1-cm-long InGaAsP waveguide with a cross-section of 4 (μm)2.
Abstract: In remote sensing, shadow causes problems in many
applications such as change detection and classification. It is caused
by objects which are elevated, thus can directly affect the accuracy of
information. For these reasons, it is very important to detect shadows
particularly in urban high spatial resolution imagery which created a
significant problem. This paper focuses on automatic shadow
detection based on a new spectral index for multispectral imagery
known as Shadow Detection Index (SDI). The new spectral index
was tested on different areas of WorldView-2 images and the results
demonstrated that the new spectral index has a massive potential to
extract shadows with accuracy of 94% effectively and automatically.
Furthermore, the new shadow detection index improved road
extraction from 82% to 93%.
Abstract: Artificial Neural Networks (ANN) trained using backpropagation
(BP) algorithm are commonly used for modeling
material behavior associated with non-linear, complex or unknown
interactions among the material constituents. Despite multidisciplinary
applications of back-propagation neural networks
(BPNN), the BP algorithm possesses the inherent drawback of
getting trapped in local minima and slowly converging to a global
optimum. The paper present a hybrid artificial neural networks and
genetic algorithm approach for modeling slump of ready mix
concrete based on its design mix constituents. Genetic algorithms
(GA) global search is employed for evolving the initial weights and
biases for training of neural networks, which are further fine tuned
using the BP algorithm. The study showed that, hybrid ANN-GA
model provided consistent predictions in comparison to commonly
used BPNN model. In comparison to BPNN model, the hybrid ANNGA
model was able to reach the desired performance goal quickly.
Apart from the modeling slump of ready mix concrete, the synaptic
weights of neural networks were harnessed for analyzing the relative
importance of concrete design mix constituents on the slump value.
The sand and water constituents of the concrete design mix were
found to exhibit maximum importance on the concrete slump value.
Abstract: Construction in Finland is focusing increasingly on
renovation instead of conventional new construction, and this trend
will continue to grow in the coming years and decades. Renovation of
the large number of suburban residential apartment buildings built in
the 1960s and 1970s poses a particular challenge. However,
renovation projects are demanding for the residents of these
buildings, since they usually are uninitiated in construction issues. On
the other hand, renovation projects generally apply the operating
models of new construction.
Nevertheless, the residents of an existing residential apartment
building are some of the best experts on the site. Thus, in this
research project we applied a relational model in developing and
testing at case sites a planning process that employs interactive
planning methods. Current residents, housing company managers, the
city zoning manager, the contractor’s and prefab element supplier’s
representatives, professional designers and researchers all took part in
the planning. The entire interactive planning process progressed
phase by phase as the participants’ and designers’ concerted
discussion and ideation process, so that the end result was a
renovation plan desired by the residents.
Abstract: Fibrin degradation is an important part in prevention
or treatment of intravascular thrombosis and cardiovascular diseases.
Plasmin like fibrinolytic enzymes has given new hope to patient with
cardiovascular diseases by treating fibrin aggregation related diseases
with traditional plasminogen activator which have many side effects.
Various researches involving wide range of sources for production of
fibrinolytic proteases, from bacteria, fungi, insects and fermented
foods. But few have looked into endophytic fungi as a potential
source. Sixteen (16) endophytic fungi were isolated from Hibiscus sp.
leaves from six different locations in Shah Alam, Selangor. Only two
endophytic fungi, FH3 and S13 showed positive fibrinolytic protease
activities. FH3 produced 5.78cm and S13 produced 4.48cm on Skim
Milk Agar after 4 days of incubation at 27°C. Fibrinolytic activity
was observed; 3.87cm and 1.82cm diameter clear zone on fibrin plate
of FH3 and S13 respectively. 18srRNA was done for identification of
the isolated fungi with positive fibrinolytic protease. S13 had the
highest similarity (100%) to that of Penicillium citrinum strain TG2
and FH3 had the highest similarity (99%) to that of Fusarium sp.
FW2PhC1, Fusarium sp. 13002, Fusarium sp. 08006, Fusarium
equiseti strain Salicorn 8 and Fungal sp. FCASAn-2. Media
composition variation showed the effects of carbon nitrogen on
protein concentration, where the decrement of 50% of media
composition caused drastic decrease in protease of FH3 from 1.081 to
0.056 and also S13 from 2.946 to 0.198.
Abstract: This paper presents circular polar coordinates
transformation of periodic fuzzy membership function. The purpose
is identification of domain of periodic membership functions in
consequent part of IF-THEN rules. Proposed methods in this paper
remove complicatedness concerning domain of periodic membership
function from defuzzification in fuzzy approximate reasoning.
Defuzzification on circular polar coordinates is also proposed.
Abstract: The need to extract R&D keywords from issues and use
them to retrieve R&D information is increasing rapidly. However, it is
difficult to identify related issues or distinguish them. Although the
similarity between issues cannot be identified, with an R&D lexicon,
issues that always share the same R&D keywords can be determined.
In detail, the R&D keywords that are associated with a particular issue
imply the key technology elements that are needed to solve a particular
issue.
Furthermore, the relationship among issues that share the same
R&D keywords can be shown in a more systematic way by clustering
them according to keywords. Thus, sharing R&D results and reusing
R&D technology can be facilitated. Indirectly, redundant investment
in R&D can be reduced as the relevant R&D information can be shared
among corresponding issues and the reusability of related R&D can be
improved. Therefore, a methodology to cluster issues from the
perspective of common R&D keywords is proposed to satisfy these
demands.
Abstract: An extensive amount of work has been done in data
clustering research under the unsupervised learning technique in Data
Mining during the past two decades. Moreover, several approaches
and methods have been emerged focusing on clustering diverse data
types, features of cluster models and similarity rates of clusters.
However, none of the single clustering algorithm exemplifies its best
nature in extracting efficient clusters. Consequently, in order to
rectify this issue, a new challenging technique called Cluster
Ensemble method was bloomed. This new approach tends to be the
alternative method for the cluster analysis problem. The main
objective of the Cluster Ensemble is to aggregate the diverse
clustering solutions in such a way to attain accuracy and also to
improve the eminence the individual clustering algorithms. Due to
the massive and rapid development of new methods in the globe of
data mining, it is highly mandatory to scrutinize a vital analysis of
existing techniques and the future novelty. This paper shows the
comparative analysis of different cluster ensemble methods along
with their methodologies and salient features. Henceforth this
unambiguous analysis will be very useful for the society of clustering
experts and also helps in deciding the most appropriate one to resolve
the problem in hand.
Abstract: This paper presents the electrical effect of two neighboring distribution substation during the construction phase. The size of auxiliary grounding grid have an effect on entire grounding system. The bigger the size of auxiliary grounding grid, the lower the GPR and maximum touch voltage, with the exception that when the two grids are unconnected, i.e. the bigger the size of auxiliary grounding grid, the higher the maximum step voltage. The results in this paper could be served as design guideline of grounding system, and perhaps remedy of some troublesome grounding grids in power distribution’s system. Modeling and simulation is carried out on the Current Distribution Electromagnetic interference Grounding and Soil structure (CDEGS) program. The simulation results exhibit the design and analysis of power system grounding and perhaps could be set as a standard in grounding system design and modification in distribution substations.
Abstract: The purpose of this work is to optimize a Switched Reluctance Motor (SRM) for an automotive application, specifically for a fully electric car. A new optimization approach is proposed. This unique approach transforms automotive customer requirements into an optimization problem, based on sound knowledge of a SRM theory. The approach combines an analytical and a finite element analysis of the motor to quantify static nonlinear and dynamic performance parameters, as phase currents and motor torque maps, an output power and power losses in order to find the optimal motor as close to the reality as possible, within reasonable time. The new approach yields the optimal motor which is competitive with other types of already proposed motors for automotive applications. This distinctive approach can also be used to optimize other types of electrical motors, when parts specifically related to the SRM are adjusted accordingly.
Abstract: A theoretical study has been presented to describe the boundary layer flow and heat transfer on an exponentially shrinking sheet with a variable wall temperature and suction, in the presence of magnetic field. The governing nonlinear partial differential equations are converted into ordinary differential equations by similarity transformation, which are then solved numerically using the shooting method. Results for the skin friction coefficient, local Nusselt number, velocity profiles as well as temperature profiles are presented through graphs and tables for several sets of values of the parameters. The effects of the governing parameters on the flow and heat transfer characteristics are thoroughly examined.
Abstract: This paper presents development of the light-weight manipulator with series elastic actuation for medical telediagnostics (USG examination). General structure of realized impedance control algorithm was shown. It was described how to perform force measurements based mainly on elasticity of manipulator links.
Abstract: In this paper, we present a new maintenance model
for a partially observable system subject to two failure modes,
namely a catastrophic failure and a failure due to the system
degradation. The system is subject to condition monitoring and the
degradation process is described by a hidden Markov model. A
cost-optimal Bayesian control policy is developed for maintaining
the system. The control problem is formulated in the semi-Markov
decision process framework. An effective computational algorithm is
developed, illustrated by a numerical example.
Abstract: In this paper the vibration of a synchronous belt drive
during start-up is analyzed and discussed. Besides considering the
belt elasticity, the model here proposed also takes into consideration
the electromagnetic response of the DC motor. The solution of the
motion equations is obtained by means of the modal analysis in
state space, which allows to obtain the decoupling of all equations,
without introducing the hypothesis of proportional damping. The
mathematical model of the transmission and the solution algorithms
have been implemented within a computing software that allows the
user to simulate the dynamics of the system and to evaluate the effects
due to the elasticity of the belt branches and to the electromagnetic
behavior of the DC motor. In order to show the details of the
calculation procedure, the paper presents a case study developed with
the aid of the above-mentioned software.
Abstract: The concept of corporate social responsibility (CSR) in the Czech Republic has evolved notably during the last few years and an issue that started as an interest- and motive-based activity for businesses is becoming more commonplace. Governments have a role to play in ensuring that corporations behave according to the rules and norms of society and can legislate, foster, collaborate with businesses and endorse good practice in order to facilitate the development of CSR. The purpose of this paper is to examine the opportunities and options of CSR in government policy and research its relevance to a business sector. An increasing number of companies is engaging in responsible activities, the public awareness of CSR is rising, and customers are giving higher importance to CSR of companies in their choice. By drawing on existing CSR approach in Czech and understanding of CSR are demonstrated. The paper provides an overview, more detailed government approach of CSR.
Abstract: The paper deals with the importance of information flow for providing of defined level of customer service in the firms. Setting of the criteria for the selection and implementation of logistics information system is a prerequisite for ensuring of the flow of information in firms. The decision on the selection and implementation of logistics information system is linked to the investment costs and operating costs, which are included in the total logistics costs. The article also deals with the conclusions of the research focused on the logistics information system selection in companies in the Czech Republic.
Abstract: This article deals with the perceived quality of regional products in the Moravian-Silesian region in the Czech Republic. Research was focused on finding out what do consumers perceive as a quality product and what characteristics make a quality product. The data were obtained by questionnaire survey andanalysed by IBM SPSS. From the thousands of respondents the representative sample of 719 for MS region was created based on demographic factors of gender, age, education and income. The research analysis disclosed that consumers in MS region are still price oriented and that the preference of quality over price does not depend on regional brand knowledge.
Abstract: Turbulent flow in complex geometries receives considerable attention due to its importance in many engineering applications. It has been the subject of interest for many researchers. Some of these interests include the design of storm water channels. The design of these channels requires testing through physical models. The main practical limitation of physical models is the so called “scale effect”, that is, the fact that in many cases only primary physical mechanisms can be correctly represented, while secondary mechanisms are often distorted. These observations form the basis of our study, which centered on problems associated with the design of storm water channels near the Dead Sea, in Israel. To help reach a final design decision we used different physical models. Our research showed good coincidence with the results of laboratory tests and theoretical calculations, and allowed us to study different effects of fluid flow in an open channel. We determined that problems of this nature cannot be solved only by means of theoretical calculation and computer simulation. This study demonstrates the use of physical models to help resolve very complicated problems of fluid flow through baffles and similar structures. The study applies these models and observations to different construction and multiphase water flows, among them, those that include sand and stone particles, a significant attempt to bring to the testing laboratory a closer association with reality.