Abstract: Transcription factor p53 has a powerful tumor
suppressing function that is associated with many cancers. However,
p53 of the molecular weight was higher make the limitation across to
skin or cell membrane. Thymidine dinucleotide (pTT), an
oligonucleotide, can activate the p53 transcription factor. pTT is a
hydrophilic and negative charge oligonucleotide, which delivery in to
cell membrane need an appropriate carrier. The aim of this study was
to improve the bioavailability of the nucleotide fragment, thymidine
dinucleotide (pTT), using elasic liposome carriers to deliver the drug
into the skin. The study demonstrate that dioleoylphosphocholine
(DOPC) incorporated with sodium cholate at molar ratio 1:1 can
archived the particle size about 220 nm. This elastic liposome could
penetration through skin from stratum corneum to whole epidermis by
confocal laser scanning microscopy (CLSM). Moreover, we observed
the the slight increase in generation of p53 by western blot.
Abstract: The field research was carried out at the Látókép AGTC KIT research area of the University of Debrecen in Eastern-Hungary, on the area of the aeolain loess of the Hajdúság. We examined the effects of the sowing time on the phytopathogenic characteristics and yield production by applying various fertilizer treatments on two different sunflower genotypes (NK Ferti, PR64H42) in 2012 and 2013. We applied three different sowing times (early, optimal, late) and two different treatment levels of fungicides (control = no fungicides applied, double fungicide protection).
During our investigations, the studied cropyears were of different sowing time optimum in terms of yield amount (2012: early, 2013: average). By Pearson’s correlation analysis, we have found that delaying the sowing time pronouncedly decreased the extent of infection in both crop years (Diaporthe: r=0.663**, r=0.681**, Sclerotinia: r=0.465**, r=0.622**). The fungicide treatment not only decreased the extent of infection, but had yield increasing effect too (2012: r=0.498**, 2013: r=0.603**). In 2012, delaying of the sowing time increased (r=0.600**), but in 2013, it decreased (r= 0.356*) the yield amount.
Abstract: In this paper, we have focused on study of swelling kinetics and salt-sensitivity behavior of a superabsorbing hydrogel based on carboxymethylcellulose (CMC) and acrylic acid and 2- Buthyl methacrylate. The swelling kinetics of the hydrogels with various particle sizes was preliminary investigated as well. The swelling of the hydrogel showed a second order kinetics of swelling in water. In addition, swelling measurements of the synthesized hydrogels in various chloride salt solutions was measured. Results indicated that a swelling-loss with an increase in the ionic strength of the salt solutions.
Abstract: Vibration of thin cylindrical shells made of a
functionally gradient material composed of stainless steel and nickel
is presented. The effects of the FGM configuration are studied by
studying the frequencies of FG cylindrical shells. In this case FG
cylindrical shell has Nickel on its outer surface and stainless steel on
its inner surface. The study is carried out based on third order shear
deformation shell theory. The objective is to study the natural
frequencies, the influence of constituent volume fractions and the
effects of configurations of the constituent materials on the
frequencies. The properties are graded in the thickness direction
according to the volume fraction power-law distribution. Results are
presented on the frequency characteristics, the influence of the
constituent various volume fractions on the frequencies.
Abstract: Explosive forming is one of the unconventional
techniques in which, most commonly, the water is used as the
pressure transmission medium. One of the newest methods in
explosive forming is gas detonation forming which uses a normal
shock wave derived of gas detonation, to form sheet metals. For this
purpose a detonation is developed from the reaction of H2+O2
mixture in a long cylindrical detonation tube. The detonation wave
goes through the detonation tube and acts as a blast load on the steel
blank and forms it. Experimental results are compared with a finite
element model; and the comparison of the experimental and
numerical results obtained from strain, thickness variation and
deformed geometry is carried out. Numerical and experimental
results showed approximately 75 – 90 % similarity in formability of
desired shape. Also optimum percent of gas mixture obtained when
we mix 68% H2 with 32% O2.
Abstract: This paper presents preliminary results on modeling
and control of a quadrotor UAV. With aerodynamic concepts, a
mathematical model is firstly proposed to describe the dynamics
of the quadrotor UAV. Parameters of this model are identified by
experiments with Matlab Identify Toolbox. A group of PID controllers
are then designed based on the developed model. To verify
the developed model and controllers, simulations and experiments for
altitude control, position control and trajectory tracking are carried
out. The results show that the quadrotor UAV well follows the
referenced commands, which clearly demonstrates the effectiveness
of the proposed approach.
Abstract: This paper describes an automatic algorithm to restore
the shape of three-dimensional (3D) left ventricle (LV) models created
from magnetic resonance imaging (MRI) data using a geometry-driven
optimization approach. Our basic premise is to restore the LV shape
such that the LV epicardial surface is smooth after the restoration. A
geometrical measure known as the Minimum Principle Curvature (κ2)
is used to assess the smoothness of the LV. This measure is used to
construct the objective function of a two-step optimization process.
The objective of the optimization is to achieve a smooth epicardial
shape by iterative in-plane translation of the MRI slices.
Quantitatively, this yields a minimum sum in terms of the magnitude
of κ
2, when κ2 is negative. A limited memory quasi-Newton algorithm,
L-BFGS-B, is used to solve the optimization problem. We tested our
algorithm on an in vitro theoretical LV model and 10 in vivo
patient-specific models which contain significant motion artifacts. The
results show that our method is able to automatically restore the shape
of LV models back to smoothness without altering the general shape of
the model. The magnitudes of in-plane translations are also consistent
with existing registration techniques and experimental findings.
Abstract: Construction projects generally take place in
uncontrolled and dynamic environments where construction waste is
a serious environmental problem in many large cities. The total
amount of waste and carbon dioxide emissions from transportation
vehicles are still out of control due to increasing construction
projects, massive urban development projects and the lack of
effective tools for minimizing adverse environmental impacts in
construction. This research is about utilization of the integrated
applications of automated advanced tracking and data storage
technologies in the area of environmental management to monitor
and control adverse environmental impacts such as construction
waste and carbon dioxide emissions. Radio Frequency Identification
(RFID) integrated with the Global Position System (GPS) provides
an opportunity to uniquely identify materials, components, and
equipments and to locate and track them using minimal or no worker
input. The transmission of data to the central database will be carried
out with the help of Global System for Mobile Communications
(GSM).
Abstract: The statistical distributions are modeled in explaining
nature of various types of data sets. Although these distributions are
mostly uni-modal, it is quite common to see multiple modes in the
observed distribution of the underlying variables, which make the
precise modeling unrealistic. The observed data do not exhibit
smoothness not necessarily due to randomness, but could also be due
to non-randomness resulting in zigzag curves, oscillations, humps
etc. The present paper argues that trigonometric functions, which
have not been used in probability functions of distributions so far,
have the potential to take care of this, if incorporated in the
distribution appropriately. A simple distribution (named as, Sinoform
Distribution), involving trigonometric functions, is illustrated in the
paper with a data set. The importance of trigonometric functions is
demonstrated in the paper, which have the characteristics to make
statistical distributions exotic. It is possible to have multiple modes,
oscillations and zigzag curves in the density, which could be suitable
to explain the underlying nature of select data set.
Abstract: To decompose organochlorides by bioremediation, co-culture biohydrogen producer and dehalogenation microorganisms is a useful method. In this study, we combined these two characteristics from a biohydrogen producer, Rhodopseudomonas palustris, and a dehalogenation microorganism, Pseudomonas putida, to enchance halorespiration in R. palustris. The genes encoding cytochrome P450cam system (camC, camA, and camB) from P. putida were expressed in R. palustris with designated expression plasmid. All tested strains were cultured to log phase then presented pentachloroethane (PCA) in media. The vector control strain could degrade PCA about 78% after 16 hours, however, the cytochrome P450cam system expressed strain, CGA-camCAB, could completely degrade PCA in 12 hours. While taking chlorinated aromatic, 3-chlorobenzoate, as sole carbon source or present benzoate as co-substrate, CGA-camCAB presented faster growth rate than vector control strain.
Abstract: In this work, we developed the concept of
supercompression, i.e., compression above the compression standard
used. In this context, both compression rates are multiplied. In fact,
supercompression is based on super-resolution. That is to say,
supercompression is a data compression technique that superpose
spatial image compression on top of bit-per-pixel compression to
achieve very high compression ratios. If the compression ratio is very
high, then we use a convolutive mask inside decoder that restores the
edges, eliminating the blur. Finally, both, the encoder and the
complete decoder are implemented on General-Purpose computation
on Graphics Processing Units (GPGPU) cards. Specifically, the
mentio-ned mask is coded inside texture memory of a GPGPU.
Abstract: In this paper a study on the vibration of thin
cylindrical shells with ring supports and made of functionally graded
materials (FGMs) composed of stainless steel and nickel is presented.
Material properties vary along the thickness direction of the shell
according to volume fraction power law. The cylindrical shells have
ring supports which are arbitrarily placed along the shell and impose
zero lateral deflections. The study is carried out based on third order
shear deformation shell theory (T.S.D.T). The analysis is carried out
using Hamilton-s principle. The governing equations of motion of
FGM cylindrical shells are derived based on shear deformation
theory. Results are presented on the frequency characteristics,
influence of ring support position and the influence of boundary
conditions. The present analysis is validated by comparing results
with those available in the literature.
Abstract: The paper deals with the perspectives and possibilities
of "smart solutions" to critical infrastructure protection. It means that
common computer aided technologies are used from the perspective
of new, better protection of selected infrastructure objects. The paper
is focused on the co-product of the Czech Defence Research Project -
ADAPTIV. This project is carrying out by the University of Defence,
Faculty of Economics and Management at the Department of Civil
Protection. The project creates system and technology for adaptive
cybernetic camouflage of armed forces objects, armaments, vehicles
and troops and of mobilization infrastructure. These adaptive
camouflage system and technology will be useful for army tactic
activities protection and for decoys generation also. The fourth
chapter of the paper concerns the possibilities of using the introduced
technology to the protection of selected civil (economically
important), critical infrastructure objects. The aim of this section
is to introduce the scientific capabilities and potential of the
University of Defence research results and solutions for the practice.
Abstract: We constructed a method of phase unwrapping for a typical wave-front by utilizing the maximizer of the posterior marginal (MPM) estimate corresponding to equilibrium statistical mechanics of the three-state Ising model on a square lattice on the basis of an analogy between statistical mechanics and Bayesian inference. We investigated the static properties of an MPM estimate from a phase diagram using Monte Carlo simulation for a typical wave-front with synthetic aperture radar (SAR) interferometry. The simulations clarified that the surface-consistency conditions were useful for extending the phase where the MPM estimate was successful in phase unwrapping with a high degree of accuracy and that introducing prior information into the MPM estimate also made it possible to extend the phase under the constraint of the surface-consistency conditions with a high degree of accuracy. We also found that the MPM estimate could be used to reconstruct the original wave-fronts more smoothly, if we appropriately tuned hyper-parameters corresponding to temperature to utilize fluctuations around the MAP solution. Also, from the viewpoint of statistical mechanics of the Q-Ising model, we found that the MPM estimate was regarded as a method for searching the ground state by utilizing thermal fluctuations under the constraint of the surface-consistency condition.
Abstract: In this work, bending fatigue life of notched
specimens with various notch geometries and dimensions is
investigated by experiment and Manson-Caffin theoretical method. In
this theoretical method, fatigue life of notched specimens is
calculated using the fatigue life obtained from the experiments for
plain specimens (without notch). Three notch geometries including
∪-shape, ∨-shape and C -shape notches are considered in this
investigation. The experiments are conducted on a rotary bending
Moore machine. The specimens are made of a low carbon steel alloy,
which has wide application in industry. The stress- life curves are
captured for all notched specimen by experiment. The results indicate
that Manson-Caffin analytical method cannot adequately predict
the fatigue life of notched specimen. However, it seems that the
difference between the experiments and Manson-Caffin predictions
can be compensated by a proportional factor.
Abstract: IMCS is Integrated Monitoring and Control System for
thermal power plant. This system consists of mainly two parts; controllers and OIS (Operator Interface System). These two parts are
connected by Ethernet-based communication. The controller side of communication is managed by CNet module and OIS side is managed
by data server of OIS. CNet module sends the data of controller to data
server and receives commend data from data server. To minimizes or
balance the load of data server, this module buffers data created by controller at every cycle and send buffered data to data server on request of data server. For multiple data server, this module manages
the connection line with each data server and response for each request
from multiple data server. CNet module is included in each controller
of redundant system. When controller fail-over happens on redundant system, this module can provide data of controller to data sever
without loss. This paper presents three main features – separation of get task, usage of ring buffer and monitoring communication status –of CNet module to carry out these functions.
Abstract: Several trillion cigarettes produced worldwide annually lead to many thousands of kilograms of toxic waste. Cigarette butts (CBs) accumulate in the environment due to the poor biodegradability of the cellulose acetate filters. This paper presents some of the results from a continuing study on recycling CBs into fired clay bricks. Physico-mechanical properties of fired clay bricks manufactured with different percentages of CBs are reported and discussed. The results show that the density of fired bricks was reduced by up to 30 %, depending on the percentage of CBs incorporated into the raw materials. Similarly, the compressive strength of bricks tested decreased according to the percentage of CBs included in the mix. The thermal conductivity performance of bricks was improved by 51 and 58 % for 5 and 10 % CBs content respectively. Leaching tests were carried out to investigate the levels of possible leachates of heavy metals from the manufactured clay-CB bricks. The results revealed trace amounts of heavy metals.
Abstract: The present study based on removal of natural dyes of
Roselle petals, then used Roselle petals powder (RPP) as an
adsorbent for the removal of methylene blue dye (as a typical cationic
or basic dye) from aqueous solutions. The present study shows that
used Roselle petals powder exhibit adsorption trend for the dye. The
adsorption processes were carried out at various conditions of
temperatures ranging from 278 to 338 K ± 2 K , concentrations,
processing time and a wide range of pH between 2.5-11. Adsorption
isotherm equations such as Freundlich, and Langmuir were applied to
calculate the values of respective constants. Adsorption study was
found that the currently introduced adsorbent can be used to remove
cationic dyes such as methylene blue from aqueous solutions.
Abstract: Free convection effects and heat transfer due to a pulsating point heat source embedded in an infinite, fluid saturated, porous dusty medium are studied analytically. Both velocity and temperature fields are discussed in the form of series expansions in the Rayleigh number, for both the fluid and particle phases based on the mean heat generation rate from source and on the permeability of the porous dusty medium. This study is carried out by assuming the Rayleigh number small and the validity of Darcy-s law. Analytical expressions for both phases are obtained for second order mean in both velocity and temperature fields and evolution of different wave patterns are observed in the fluctuating part. It has been observed that, at the vicinity of the origin, the second order mean flow is influenced only by relaxation time of dust particles and not by dust concentration.
Abstract: A challenging problem in radar signal processing is to
achieve reliable target detection in the presence of interferences. In
this paper, we propose a novel algorithm for automatic censoring of
radar interfering targets in log-normal clutter. The proposed
algorithm, termed the forward automatic censored cell averaging
detector (F-ACCAD), consists of two steps: removing the corrupted
reference cells (censoring) and the actual detection. Both steps are
performed dynamically by using a suitable set of ranked cells to
estimate the unknown background level and set the adaptive
thresholds accordingly. The F-ACCAD algorithm does not require
any prior information about the clutter parameters nor does it require
the number of interfering targets. The effectiveness of the F-ACCAD
algorithm is assessed by computing, using Monte Carlo simulations,
the probability of censoring and the probability of detection in
different background environments.