Abstract: Segmentation of left ventricle (LV) from cardiac
ultrasound images provides a quantitative functional analysis of the
heart to diagnose disease. Active Shape Model (ASM) is widely used
for LV segmentation, but it suffers from the drawback that
initialization of the shape model is not sufficiently close to the target,
especially when dealing with abnormal shapes in disease. In this work,
a two-step framework is improved to achieve a fast and efficient LV
segmentation. First, a robust and efficient detection based on Hough
forest localizes cardiac feature points. Such feature points are used to
predict the initial fitting of the LV shape model. Second, ASM is
applied to further fit the LV shape model to the cardiac ultrasound
image. With the robust initialization, ASM is able to achieve more
accurate segmentation. The performance of the proposed method is
evaluated on a dataset of 810 cardiac ultrasound images that are mostly
abnormal shapes. This proposed method is compared with several
combinations of ASM and existing initialization methods. Our
experiment results demonstrate that accuracy of the proposed method
for feature point detection for initialization was 40% higher than the
existing methods. Moreover, the proposed method significantly
reduces the number of necessary ASM fitting loops and thus speeds up
the whole segmentation process. Therefore, the proposed method is
able to achieve more accurate and efficient segmentation results and is
applicable to unusual shapes of heart with cardiac diseases, such as left
atrial enlargement.
Abstract: Quantification of cardiac function is performed by
calculating blood volume and ejection fraction in routine clinical
practice. However, these works have been performed by manual
contouring, which requires computational costs and varies on the
observer. In this paper, an automatic left ventricle segmentation
algorithm on cardiac magnetic resonance images (MRI) is presented.
Using knowledge on cardiac MRI, a K-mean clustering technique is
applied to segment blood region on a coil-sensitivity corrected image.
Then, a graph searching technique is used to correct segmentation
errors from coil distortion and noises. Finally, blood volume and
ejection fraction are calculated. Using cardiac MRI from 15 subjects,
the presented algorithm is tested and compared with manual
contouring by experts to show outstanding performance.
Abstract: A three-dimensional and pulsatile blood flow in the left ventricle of heart model has been studied numerically. The geometry was derived from a simple approximation of the left ventricle model and the numerical simulations were obtained using a formulation of the Navier-Stokes equations. In this study, simulation was used to investigate the pattern of flow velocity in 3D model of heart with consider the left ventricle based on critical parameter of blood under steady condition. Our results demonstrate that flow velocity focused from mitral valve channel and continuous linearly to left ventricle wall but this skewness progresses into outside wall in atrium through aortic valve with random distribution that is irregular due to force subtract from ventricle wall during cardiac cycle. The findings are the prediction of the behavior of the blood flow velocity pattern in steady flow condition which can assist the medical practitioners in their decision on the patients- treatments.
Abstract: The aim of this study was to develop a dynamic cardiac phantom for quality control in myocardial scintigraphy. The dynamic heart phantom constructed only contained the left ventricle, made of elastic material (latex), comprising two cavities: one internal and one external. The data showed a non-significant variation in the values of left ventricular ejection fraction (LVEF) obtained by varying the heart rate. It was also possible to evaluate the ejection fraction (LVEF) through different arrays of image acquisition and to perform an intercomparison of LVEF by two different scintillation cameras. The results of the quality control tests were satisfactory, showing that they can be used as parameters in future assessments. The new dynamic heart phantom was demonstrated to be effective for use in LVEF measurements. Therefore, the new heart simulator is useful for the quality control of scintigraphic cameras.
Abstract: This paper describes an automatic algorithm to restore
the shape of three-dimensional (3D) left ventricle (LV) models created
from magnetic resonance imaging (MRI) data using a geometry-driven
optimization approach. Our basic premise is to restore the LV shape
such that the LV epicardial surface is smooth after the restoration. A
geometrical measure known as the Minimum Principle Curvature (κ2)
is used to assess the smoothness of the LV. This measure is used to
construct the objective function of a two-step optimization process.
The objective of the optimization is to achieve a smooth epicardial
shape by iterative in-plane translation of the MRI slices.
Quantitatively, this yields a minimum sum in terms of the magnitude
of κ
2, when κ2 is negative. A limited memory quasi-Newton algorithm,
L-BFGS-B, is used to solve the optimization problem. We tested our
algorithm on an in vitro theoretical LV model and 10 in vivo
patient-specific models which contain significant motion artifacts. The
results show that our method is able to automatically restore the shape
of LV models back to smoothness without altering the general shape of
the model. The magnitudes of in-plane translations are also consistent
with existing registration techniques and experimental findings.
Abstract: It is known that the heart interacts with and adapts to
its venous and arterial loading conditions. Various experimental
studies and modeling approaches have been developed to investigate
the underlying mechanisms. This paper presents a model of the left
ventricle derived based on nonlinear stress-length myocardial
characteristics integrated over truncated ellipsoidal geometry, and
second-order dynamic mechanism for the excitation-contraction
coupling system. The results of the model presented here describe the
effects of the viscoelastic damping element of the electromechanical
coupling system on the hemodynamic response. Different heart rates
are considered to study the pacing effects on the performance of the
left-ventricle against constant preload and afterload conditions under
various damping conditions. The results indicate that the pacing
process of the left ventricle has to take into account, among other
things, the viscoelastic damping conditions of the myofilament
excitation-contraction process.
Abstract: The myocardial sintigraphy is an imaging modality which provides functional informations. Whereas, coronarography modality gives useful informations about coronary arteries anatomy. In case of coronary artery disease (CAD), the coronarography can not determine precisely which moderate lesions (artery reduction between 50% and 70%), known as the “gray zone", are haemodynamicaly significant. In this paper, we aim to define the relationship between the location and the degree of the stenosis in coronary arteries and the observed perfusion on the myocardial scintigraphy. This allows us to model the impact evolution of these stenoses in order to justify a coronarography or to avoid it for patients suspected being in the gray zone. Our approach is decomposed in two steps. The first step consists in modelling a coronary artery bed and stenoses of different location and degree. The second step consists in modelling the left ventricle at stress and at rest using the sphercical harmonics model and myocardial scintigraphic data. We use the spherical harmonics descriptors to analyse left ventricle model deformation between stress and rest which permits us to conclude if ever an ischemia exists and to quantify it.
Abstract: Physiological control of a left ventricle assist device (LVAD) is generally a complicated task due to diverse operating environments and patient variability. In this work, a tracking control algorithm based on sliding mode and feed forward control for a class of discrete-time single input single output (SISO) nonlinear uncertain systems is presented. The controller was developed to track the reference trajectory to a set operating point without inducing suction in the ventricle. The controller regulates the estimated mean pulsatile flow Qp and mean pulsatility index of pump rotational speed PIω that was generated from a model of the assist device. We recall the principle of the sliding mode control theory then we combine the feed-forward control design with the sliding mode control technique to follow the reference trajectory. The uncertainty is replaced by its upper and lower boundary. The controller was tested in a computer simulation covering two scenarios (preload and ventricular contractility). The simulation results prove the effectiveness and the robustness of the proposed controller
Abstract: It is known that the heart interacts with and adapts to its venous and arterial loading conditions. Various experimental studies and modeling approaches have been developed to investigate the underlying mechanisms. This paper presents a model of the left ventricle derived based on nonlinear stress-length myocardial characteristics integrated over truncated ellipsoidal geometry, and second-order dynamic mechanism for the excitation-contraction coupling system. The results of the model presented here describe the effects of the viscoelastic damping element of the electromechanical coupling system on the hemodynamic response. Different heart rates are considered to study the pacing effects on the performance of the left-ventricle against constant preload and afterload conditions under various damping conditions. The results indicate that the pacing process of the left ventricle has to take into account, among other things, the viscoelastic damping conditions of the myofilament excitation-contraction process. The effects of left ventricular dimensions on the hemdynamic response have been examined. These effects are found to be different at different viscoelastic and pacing conditions.