Abstract: Evidence-based medicine is a new direction in modern healthcare. Its task is to prevent, diagnose and medicate diseases using medical evidence. Medical data about a large patient population is analyzed to perform healthcare management and medical research. In order to obtain the best evidence for a given disease, external clinical expertise as well as internal clinical experience must be available to the healthcare practitioners at right time and in the right manner. External evidence-based knowledge can not be applied directly to the patient without adjusting it to the patient-s health condition. We propose a data warehouse based approach as a suitable solution for the integration of external evidence-based data sources into the existing clinical information system and data mining techniques for finding appropriate therapy for a given patient and a given disease. Through integration of data warehousing, OLAP and data mining techniques in the healthcare area, an easy to use decision support platform, which supports decision making process of care givers and clinical managers, is built. We present three case studies, which show, that a clinical data warehouse that facilitates evidence-based medicine is a reliable, powerful and user-friendly platform for strategic decision making, which has a great relevance for the practice and acceptance of evidence-based medicine.
Abstract: For evaluating the severity of Chronic Obstructive Pulmonary Disease (COPD), one is interested in inspecting the airway wall thickening due to inflammation. Although airway segmentations have being well developed to reconstruct in high order, airway wall segmentation remains a challenge task. While tackling such problem as a multi-surface segmentation, the interrelation within surfaces needs to be considered. We propose a new method for three-dimensional airway wall segmentation using spring structural active contour model. The method incorporates the gravitational field of the image and repelling force field of the inner lumen as the soft constraint and the geometric spring structure of active contour as the hard constraint to approximate a three-dimensional coupled surface readily for thickness measurements. The results show the preservation of topology constraints of coupled surfaces. In conclusion, our springy, soft-tissue-like structure ensures the globally optimal solution and waives the shortness following by the inevitable improper inner surface constraint.
Abstract: Tuberculosis (TB) is a bacterial infectious disease caused by the obligate human pathogen, Mycobacterium tuberculosis. Multidrug-resistant tuberculosis (MDR-TB) is a global reality that threatens tuberculosis control. Resistance to antibiotic Rifampicin, occurs in 95% of cases through nucleotide substitutions in an 81-bp core region of the rpoB i.e; beta subunit of DNA dependant RNA polymerase. In this paper, we studied the Rifampicin-rpoB receptor interactions In silico. First, homology modeling was performed to obtain the three dimensional structure of Mycobacterium rpoB. Sixty analogs of Rifampicin were prepared using Marvin sketch software. Both original Rifampicin and the analogs were docked with rpoB and energy values were obtained. Out of sixty analogs, 43 analogs had lesser energy values than conventional Rifampicin and hence are predicted to have greater binding affinity to rpoB. Thus, this study offers a route for the development of Rifampicin analogs against multi drug resistant Mycobacterium rpoB.
Abstract: Microarrays have become the effective, broadly used tools in biological and medical research to address a wide range of problems, including classification of disease subtypes and tumors. Many statistical methods are available for analyzing and systematizing these complex data into meaningful information, and one of the main goals in analyzing gene expression data is the detection of samples or genes with similar expression patterns. In this paper, we express and compare the performance of several clustering methods based on data preprocessing including strategies of normalization or noise clearness. We also evaluate each of these clustering methods with validation measures for both simulated data and real gene expression data. Consequently, clustering methods which are common used in microarray data analysis are affected by normalization and degree of noise and clearness for datasets.
Abstract: Medical applications are among the most impactful
areas of microrobotics. The ultimate goal of medical microrobots is
to reach currently inaccessible areas of the human body and carry out
a host of complex operations such as minimally invasive surgery
(MIS), highly localized drug delivery, and screening for diseases at
their very early stages. Miniature, safe and efficient propulsion
systems hold the key to maturing this technology but they pose
significant challenges. A new type of propulsion developed recently,
uses multi-flagella architecture inspired by the motility mechanism of
prokaryotic microorganisms. There is a lack of efficient methods for
designing this type of propulsion system. The goal of this paper is to
overcome the lack and this way, a numerical strategy is proposed to
design multi-flagella propulsion systems. The strategy is based on the
implementation of the regularized stokeslet and rotlet theory, RFT
theory and new approach of “local corrected velocity". The effects of
shape parameters and angular velocities of each flagellum on overall
flow field and on the robot net forces and moments are considered.
Then a multi-layer perceptron artificial neural network is designed
and employed to adjust the angular velocities of the motors for
propulsion control. The proposed method applied successfully on a
sample configuration and useful demonstrative results is obtained.
Abstract: The performances of small and medium enterprises
have stagnated in the last two decades. This has mainly been due to
the emergence of HIV / Aids. The disease has had a detrimental
effect on the general economy of the country leading to morbidity
and mortality of the Kenyan workforce in their primary age. The
present study sought to establish the economic impact of HIV / Aids
on the micro-enterprise development in Obunga slum – Kisumu, in
terms of production loss, increasing labor related cost and to establish
possible strategies to address the impact of HIV / Aids on microenterprises.
The study was necessitated by the observation that most
micro-enterprises in the slum are facing severe economic and social
crisis due to the impact of HIV / Aids, they get depleted and close
down within a short time due to death of skilled and experience
workforce. The study was carried out between June 2008 and June
2009 in Obunga slum. Data was subjected to computer aided
statistical analysis that included descriptive statistic, chi-squared and
ANOVA techniques. Chi-squared analysis on the micro-enterprise
owners opinion on the impact of HIV / Aids on depletion of microenterprise
compared to other diseases indicated high levels of the
negative effects of the disease at significance levels of P
Abstract: Mathematical models can be used to describe the
dynamics of the spread of infectious disease between susceptibles
and infectious populations. Dengue fever is a re-emerging disease in
the tropical and subtropical regions of the world. Its incidence has
increased fourfold since 1970 and outbreaks are now reported quite
frequently from many parts of the world. In dengue endemic regions,
more cases of dengue infection in pregnancy and infancy are being
found due to the increasing incidence. It has been reported that
dengue infection was vertically transmitted to the infants. Primary
dengue infection is associated with mild to high fever, headache,
muscle pain and skin rash. Immune response includes IgM antibodies
produced by the 5th day of symptoms and persist for 30-60 days. IgG
antibodies appear on the 14th day and persist for life. Secondary
infections often result in high fever and in many cases with
hemorrhagic events and circulatory failure. In the present paper, a
mathematical model is proposed to simulate the succession of dengue
disease transmission in pregnancy and infancy. Stability analysis of
the equilibrium points is carried out and a simulation is given for the
different sets of parameter. Moreover, the bifurcation diagrams of our
model are discussed. The controlling of this disease in infant cases is
introduced in the term of the threshold condition.
Abstract: Pleurotus ostreatus is a common edible mushroom with a number of properties that can help to solve the nutritional and economical problems of people in Chiapas, Mexico. The objective of this project was to produce the mushroom under a sustainable management in which only regional products were allowed as a way to promote the cultivation and consumption of Pleurotus ostreatus; 5 different substrates were tested as well as 2 sanitation methods. The obtained results showed that the highest yields were obtained using corn husk and a thermal sanitation method. Pests and diseases were not a problem during the project but they appeared more in the substrates sanitized with calcium hydroxide.
Abstract: In this paper, we propose disease diagnosis hardware
architecture by using Hypernetworks technique. It can be used to
diagnose 3 different diseases (SPECT Heart, Leukemia, Prostate
cancer). Generally, the disparate diseases require specified diagnosis
hardware model for each disease. Using similarities of three diseases
diagnosis processor, we design diagnosis processor that can diagnose
three different diseases. Our proposed architecture that is combining
three processors to one processor can reduce hardware size without
decrease of the accuracy.
Abstract: The plant world is the source of many medicines.
Recently, researchers have estimated that there are approximately
400,000 plant species worldwide, of which about a quarter or a third
have been used by societies for medicinal purposes. The human uses
of plants for thousands of years to treat various ailments, in many
developing countries, much of the population trust in traditional
doctors and their collections of medicinal plants to treat them.
Essential oils have many therapeutic properties. In herbal medicine,
they are used for their antiseptic properties against infectious
diseases of fungal origin, against dermatophytes, those of bacterial
origin. The aim of our study is to determine the antimicrobial effect
of essential oils of the plant Trigonella focnum greacum on some
pathogenic bacteria, it is a medicinal plant used in traditional
therapy. The test adopted is based on the diffusion method on solid
medium (Antibiogram), this method determines the sensitivity or
resistance of a microorganism vis-à-vis the extract studied. Our study
reveals that the essential oil of the plant Trigonella focnum greacum
has a different effect on the resistance of germs. For staphiloccocus
Pseudomonnas aeroginosa and Krebsilla, are moderately sensitive
strains, also Escherichia coli and Candida albicans represents a high
sensitivity. By against Proteus is a strain that represents a weak
sensitivity.
Abstract: Human genome is not only the evolutionary
summation of all advantageous events, but also houses lesions of
deleterious foot prints. A single gene mutation sometimes may
express multiple consequences in numerous tissues and a linear
relationship of the genotype and the phenotype may often be obscure.
ß Thalassemia minor, a transfusion independent mild anaemia,
coupled with environment among other factors may articulate into
phenotypic pleotropy with Hypocholesterolemia, Vitamin D
deficiency, Tissue hypoxia, Hyper-parathyroidism and Psychological
alterations. Occurrence of Pancreatic insufficiency, resultant
steatorrhoea, Vitamin-D (25-OH) deficiency (13.86 ngm/ml) with
Hypocholesterolemia (85mg/dl) in a 30 years old male ß Thal-minor
patient (Hemoglobin 11mg/dl with Fetal Hemoglobin 2.10%, Hb A2
4.60% and Hb Adult 84.80% and altered Hemogram) with increased
Para thyroid hormone (62 pg/ml) & moderate Serum Ca+2
(9.5mg/ml) indicate towards a cascade of phenotypic pleotropy
where the ß Thalassemia mutation ,be it in the 5’ cap site of the
mRNA , differential splicing etc in heterozygous state is effecting
several metabolic pathways. Compensatory extramedulary
hematopoiesis may not coped up well with the stressful life style of
the young individual and increased erythropoietic stress with high
demand for cholesterol for RBC membrane synthesis may have
resulted in Hypocholesterolemia.Oxidative stress and tissue hypoxia
may have caused the pancreatic insufficiency, leading to Vitamin D
deficiency. This may in turn have caused the secondary
hyperparathyroidism to sustain serum Calcium level. Irritability and
stress intolerance of the patient was a cumulative effect of the vicious
cycle of metabolic compromises. From these findings we propose
that the metabolic deficiencies in the ß Thalassemia mutations may
be considered as the phenotypic display of the pleotropy to explain
the genetic epidemiology.
According to the recommendations from the NIH Workshop on
Gene-Environment Interplay in Common Complex Diseases: Forging
an Integrative Model, study design of observations should be
informed by gene-environment hypotheses and results of a study
(genetic diseases) should be published to inform future hypotheses.
Variety of approaches is needed to capture data on all possible
aspects, each of which is likely to contribute to the etiology of
disease. Speakers also agreed that there is a need for development of
new statistical methods and measurement tools to appraise
information that may be missed out by conventional method where
large sample size is needed to segregate considerable effect.
A meta analytic cohort study in future may bring about significant
insight on to the title comment.
Abstract: This paper presents the work of signal discrimination
specifically for Electrocardiogram (ECG) waveform. ECG signal is
comprised of P, QRS, and T waves in each normal heart beat to
describe the pattern of heart rhythms corresponds to a specific
individual. Further medical diagnosis could be done to determine any
heart related disease using ECG information. The emphasis on QRS
Complex classification is further discussed to illustrate the
importance of it. Pan-Tompkins Algorithm, a widely known
technique has been adapted to realize the QRS Complex
classification process. There are eight steps involved namely
sampling, normalization, low pass filter, high pass filter (build a band
pass filter), derivation, squaring, averaging and lastly is the QRS
detection. The simulation results obtained is represented in a
Graphical User Interface (GUI) developed using MATLAB.
Abstract: This study was designed to investigate the role of serum nitric oxide and sialic acid in the development of diabetic nephropathy as disease marker. Total 210 diabetic patients (age and sex matched) were selected followed by informed consent and divided into four groups (70 each) as I: control; II: diabetic; III: diabetic hypertensive; IV: diabetic nephropathy. The blood samples of all subjects were collected and analyzed for serum nitric oxide, sialic acid, fasting blood glucose, serum urea, creatinine, HbA1c and GFR. The BMI, systolic and diastolic blood pressures, blood glucose, HbA1c and serum sialic acid levels were high (p
Abstract: Principally, plants grown in soilless culture may be
attacked by the same pests and diseases as cultivated traditionally in
soil. The most destructive phytopathogens are fungi, such as
Phythium, Phytophthora and Fusarium, followed by viruses, bacteria
and nematodes. We investigated effect of carbon nanotube filters on
disease management of soilless culture. Tomato seedlings transplant
in plastic pots filled with a soilless media of vermiculite. The crop
irrigated and fertilized using a hydroponic nutrient solution. We used
carbon nanotube filters for nutrient solution disinfection. Our results
show that carbon nanotube filtration significantly reduces pathogens
on tomato plants. Fungal elimination (Fusarium oxysporum and
Pythium spp.) was usually successful at about 96 to 99.9% all over
the cultural season. It is seem that in tomato soilless culture,
nanofiltration constitutes a reliable method that allows control of the
development of diseases caused by pathogenic fungi
Abstract: Dietary macro and micro nutrients in their respective proportion and fractions present a practical potential tool to fabricate milk constituents since cells of lactating mammary glands obtain about 80 % of milk synthesis nutrients from blood, reflecting the existence of an isotonic equilibrium between blood and milk. Diverting milk biosynthetic activities through manipulation of nutrients towards producing milk not only keeping in view its significance as natural food but also as food item which prevents or dilutes the adverse effects of some diseases (like cardiovascular problem by saturated milk fat intake) has been area of interest in the last decade. Nutritional modification / supplementation has been reported to enhance conjugated linoleic acid, fatty acid type and concentration, essential fatty acid concentration, vitamin B12& C, Se, Cu, I and Fe which are involved to counter the health threats to human well being. Synchronizing dietary nutrients aimed to modify rumen dynamics towards synthesis of nutrients or their precursors to make their drive towards formulated milk constituents presents a practical option. Formulating dietary constituents to design milk constituents will let the farmers, consumers and investors know about the real potential and profit margins associated with this enterprise. This article briefly recapitulates the ways and means to modify milk constituents keeping an eye on human health and well being issues, which allows milk to serve more than a food item.
Abstract: Previous research has demonstrated that negative
attitudes towards people with physical disabilities and obesity are
predicted by a component of perceived vulnerability to disease; germ
aversion. These findings have been suggested as illustrations of an
evolved but over-active mechanism which promotes the avoidance of
pathogen-carrying individuals. To date, this interpretation of attitude
formation has not been explored with regard to people with
intellectual disability, and no attempts have been made to examine
possible mediating factors. This study examined attitudes in 333
adults and demonstrated that the moderate positive relationship
between germ aversion and negative attitudes toward people with
intellectual disability is fully mediated by social dominance
orientation, a general preference for hierarchies and inequalities
among social groups. These findings have implications for the
design of programs which attempt to promote community acceptance
and inclusion of people with disabilities.
Abstract: Medical image modalities such as computed
tomography (CT), magnetic resonance imaging (MRI), ultrasound
(US), X-ray are adapted to diagnose disease. These modalities
provide flexible means of reviewing anatomical cross-sections and
physiological state in different parts of the human body. The raw
medical images have a huge file size and need large storage
requirements. So it should be such a way to reduce the size of those
image files to be valid for telemedicine applications. Thus the image
compression is a key factor to reduce the bit rate for transmission or
storage while maintaining an acceptable reproduction quality, but it is
natural to rise the question of how much an image can be compressed
and still preserve sufficient information for a given clinical
application. Many techniques for achieving data compression have
been introduced. In this study, three different MRI modalities which
are Brain, Spine and Knee have been compressed and reconstructed
using wavelet transform. Subjective and objective evaluation has
been done to investigate the clinical information quality of the
compressed images. For the objective evaluation, the results show
that the PSNR which indicates the quality of the reconstructed image
is ranging from (21.95 dB to 30.80 dB, 27.25 dB to 35.75 dB, and
26.93 dB to 34.93 dB) for Brain, Spine, and Knee respectively. For
the subjective evaluation test, the results show that the compression
ratio of 40:1 was acceptable for brain image, whereas for spine and
knee images 50:1 was acceptable.
Abstract: Tumor classification is a key area of research in the
field of bioinformatics. Microarray technology is commonly used in
the study of disease diagnosis using gene expression levels. The
main drawback of gene expression data is that it contains thousands
of genes and a very few samples. Feature selection methods are used
to select the informative genes from the microarray. These methods
considerably improve the classification accuracy. In the proposed
method, Genetic Algorithm (GA) is used for effective feature
selection. Informative genes are identified based on the T-Statistics,
Signal-to-Noise Ratio (SNR) and F-Test values. The initial candidate
solutions of GA are obtained from top-m informative genes. The
classification accuracy of k-Nearest Neighbor (kNN) method is used
as the fitness function for GA. In this work, kNN and Support Vector
Machine (SVM) are used as the classifiers. The experimental results
show that the proposed work is suitable for effective feature
selection. With the help of the selected genes, GA-kNN method
achieves 100% accuracy in 4 datasets and GA-SVM method
achieves in 5 out of 10 datasets. The GA with kNN and SVM
methods are demonstrated to be an accurate method for microarray
based tumor classification.
Abstract: The relevance of the study of everyday life in Almaty
and Kyzylorda are associated with the emergence of the modern
trends in historiography and socializing areas of government reform.
The relevance is due to the fact that in the early twentieth century
Kyzylorda and Almaty began to develop as a city and this period has
a special place in the life of the state. An interesting aspect of the
everyday life of the inhabitants of the new city, which was built in the
era of Stalin's Five-Year Plans, can be examined through the eyes of
the Soviet people living in a specific environment, reflecting the life
of the citizens. The study of industrialization of the Soviet Union and
the attention paid to new developments in the first five years of
everyday aspects as the impact of the modernization of the 1930s was
one of the decisive factors in the lives of residents. Among these
factors, we would like to highlight the medical field, which is the
basis of all human life, specifically focusing on the state of medicine
in Alma-Ata in the first 20-30-years of the twentieth century, and
analyze the different aspects of human life, determining the quality of
medical care to the population during this period.
Abstract: Weblogs are resource of social structure to discover and track the various type of information written by blogger. In this paper, we proposed to use mining weblogs technique for identifying the trends of influenza where blogger had disseminated their opinion for the anomaly disease. In order to identify the trends, web crawler is applied to perform a search and generated a list of visited links based on a set of influenza keywords. This information is used to implement the analytics report system for monitoring and analyzing the pattern and trends of influenza (H1N1). Statistical and graphical analysis reports are generated. Both types of the report have shown satisfactory reports that reflect the awareness of Malaysian on the issue of influenza outbreak through blogs.