Abstract: Cerebellar ataxia is a steadily progressive
neurodegenerative disease associated with loss of motor control,
leaving patients unable to walk, talk, or perform activities of daily
living. Direct motor instruction in cerebella ataxia patients has limited
effectiveness, presumably because an inappropriate closed-loop
cerebellar response to the inevitable observed error confounds motor
learning mechanisms. Could the use of EEG based BCI provide
advanced biofeedback to improve motor imagery and provide a
“backdoor” to improving motor performance in ataxia patients? In
order to determine the feasibility of using EEG-based BCI control in
this population, we compare the ability to modulate mu-band power
(8-12 Hz) by performing a cued motor imagery task in an ataxia
patient and healthy control.
Abstract: In this study, firstly democratic thoughts which
directly or indirectly affect economic development and/or the
interaction between authoritarian regimes and the economic
development and the direction and channels of this interaction were
studied and then the study tried to determine how democracy affects
economic development. It was concluded that the positive
contributions of democracy to economic development were more
determinant than the effects that were either negative or restrictive in
terms of development. When compared to autocracy, since
democracy is more successful in managing social conflicts, ensuring
political stability and preventing social disasters such as famine, it
contributes more to economic development. Democracy also
facilitates delegation of authority, provides a stable investment
environment and accelerates mobilization of resources in accordance
with economic growth/development. Democracy leads to an increase
in human capital accumulation and increases the growth rate through
reducing income inequality. It can be said that democratic regimes
are the most appropriate ones in terms of increasing economic
performance and supporting economic development through their
strong institutional structures and the assurance they will ensure in
property rights.
Abstract: Purpose: The study aimed to assess the depressant or
antidepressant effects of several Nonsteroidal Anti-Inflammatory
Drugs (NSAIDs) in mice: the selective cyclooxygenase-2 (COX-2)
inhibitor meloxicam, and the non-selective COX-1 and COX-2
inhibitors lornoxicam, sodium metamizole, and ketorolac. The
current literature data regarding such effects of these agents are
scarce.
Materials and methods: The study was carried out on NMRI mice
weighing 20-35 g, kept in a standard laboratory environment. The
study was approved by the Ethics Committee of the University of
Medicine and Pharmacy „Carol Davila”, Bucharest. The study agents
were injected intraperitoneally, 10 mL/kg body weight (bw) 1 hour
before the assessment of the locomotor activity by cage testing (n=10
mice/ group) and 2 hours before the forced swimming tests (n=15).
The study agents were dissolved in normal saline (meloxicam,
sodium metamizole), ethanol 11.8% v/v in normal saline (ketorolac),
or water (lornoxicam), respectively. Negative and positive control
agents were also given (amitryptilline in the forced swimming test).
The cage floor used in the locomotor activity assessment was divided
into 20 equal 10 cm squares. The forced swimming test involved
partial immersion of the mice in cylinders (15/9cm height/diameter)
filled with water (10 cm depth at 28C), where they were left for 6
minutes. The cage endpoint used in the locomotor activity assessment
was the number of treaded squares. Four endpoints were used in the
forced swimming test (immobility latency for the entire 6 minutes,
and immobility, swimming, and climbing scores for the final 4
minutes of the swimming session), recorded by an observer that was
„blinded” to the experimental design. The statistical analysis used the
Levene test for variance homogeneity, ANOVA and post-hoc
analysis as appropriate, Tukey or Tamhane tests.
Results: No statistically significant increase or decrease in the
number of treaded squares was seen in the locomotor activity
assessment of any mice group. In the forced swimming test,
amitryptilline showed an antidepressant effect in each experiment, at
the 10 mg/kg bw dosage. Sodium metamizole was depressant at 100
mg/kg bw (increased the immobility score, p=0.049, Tamhane test),
but not in lower dosages as well (25 and 50 mg/kg bw). Ketorolac
showed an antidepressant effect at the intermediate dosage of 5
mg/kg bw, but not so in the dosages of 2.5 and 10 mg/kg bw,
respectively (increased the swimming score, p=0.012, Tamhane test).
Meloxicam and lornoxicam did not alter the forced swimming
endpoints at any dosage level.
Discussion: 1) Certain NSAIDs caused changes in the forced
swimming patterns without interfering with locomotion. 2) Sodium
metamizole showed a depressant effect, whereas ketorolac proved
antidepressant. Conclusion: NSAID-induced mood changes are not
class effects of these agents and apparently are independent of the
type of inhibited cyclooxygenase (COX-1 or COX-2).
Disclosure: This paper was co-financed from the European Social
Fund, through the Sectorial Operational Programme Human Resources Development 2007-2013, project number POSDRU /159
/1.5 /S /138907 "Excellence in scientific interdisciplinary research,
doctoral and postdoctoral, in the economic, social and medical fields
-EXCELIS", coordinator The Bucharest University of Economic
Studies.
Abstract: Waste load allocation (WLA) policies may use multiobjective
optimization methods to find the most appropriate and
sustainable solutions. These usually intend to simultaneously
minimize two criteria, total abatement costs (TC) and environmental
violations (EV). If other criteria, such as inequity, need for
minimization as well, it requires introducing more binary
optimizations through different scenarios. In order to reduce the
calculation steps, this study presents value index as an innovative
decision making approach. Since the value index contains both the
environmental violation and treatment costs, it can be maximized
simultaneously with the equity index. It implies that the definition of
different scenarios for environmental violations is no longer required.
Furthermore, the solution is not necessarily the point with minimized
total costs or environmental violations. This idea is testified for Haraz
River, in north of Iran. Here, the dissolved oxygen (DO) level of river
is simulated by Streeter-Phelps equation in MATLAB software. The
WLA is determined for fish farms using multi-objective particle
swarm optimization (MOPSO) in two scenarios. At first, the trade-off
curves of TC-EV and TC-Inequity are plotted separately as the
conventional approach. In the second, the Value-Equity curve is
derived. The comparative results show that the solutions are in a
similar range of inequity with lower total costs. This is due to the
freedom of environmental violation attained in value index. As a
result, the conventional approach can well be replaced by the value
index particularly for problems optimizing these objectives. This
reduces the process to achieve the best solutions and may find better
classification for scenario definition. It is also concluded that decision
makers are better to focus on value index and weighting its contents
to find the most sustainable alternatives based on their requirements.
Abstract: In this work, we explore the capability of the mean
shift algorithm as a powerful preprocessing tool for improving the
quality of spatial data, acquired from airborne scanners, from densely
built urban areas. On one hand, high resolution image data corrupted
by noise caused by lossy compression techniques are appropriately
smoothed while at the same time preserving the optical edges and, on
the other, low resolution LiDAR data in the form of normalized
Digital Surface Map (nDSM) is upsampled through the joint mean
shift algorithm. Experiments on both the edge-preserving smoothing
and upsampling capabilities using synthetic RGB-z data show that the
mean shift algorithm is superior to bilateral filtering as well as to
other classical smoothing and upsampling algorithms. Application of
the proposed methodology for 3D reconstruction of buildings of a
pilot region of Athens, Greece results in a significant visual
improvement of the 3D building block model.
Abstract: The development of adaptive user interfaces (UI)
presents for a long time an important research area in which
researcher attempt to call upon the full resources and skills of several
disciplines, The adaptive UI community holds a thorough knowledge
regarding the adaptation of UIs with users and with contexts of use.
Several solutions, models, formalisms, techniques and mechanisms
were proposed to develop adaptive UI. In this paper, we propose an
approach based on the fuzzy set theory for modeling the concept of
the appropriateness of different solutions of UI adaptation with
different situations for which interactive systems have to adapt their
UIs.
Abstract: Theory of Mind (ToM) refers to the ability to infer
another’s mental state. With appropriate ToM, one can behave well in
social interactions. A growing body of evidence has demonstrated that
patients with temporal lobe epilepsy (TLE) may damage ToM by
affecting on regions of the underlying neural network of ToM.
However, the question of whether there is cerebral laterality for ToM
functions remains open. This study aimed to examine whether there is
cerebral lateralization for ToM abilities in TLE patients. Sixty-seven
adult TLE patients and 30 matched healthy controls (HC) were
recruited. Patients were classified into right (RTLE), left (LTLE), and
bilateral (BTLE) TLE groups on the basis of a consensus panel review
of their seizure semiology, EEG findings, and brain imaging results.
All participants completed an intellectual test and four tasks measuring
basic and advanced ToM. The results showed that, on all ToM tasks,
(1) each patient group performed worse than HC; (2) there were no
significant differences between LTLE and RTLE groups; and (3) the
BTLE group performed the worst. It appears that the neural network
responsible for ToM is distributed evenly between the cerebral
hemispheres.
Abstract: The first part of the paper analyzes the dynamics of
the total fertility rate both at the national and regional level, pointing
out the regional disparities in the distribution of this indicator. At the
same time, we also focus on the collapse of the number of live births,
on the changes in the fertility rate by birth rank, as well as on the
failure of acquiring the desired number of children. The second part
of the study centres upon a survey applied to urban families with 3
and more than 3 offspring. The preliminary analysis highlights the
fact that an increased fertility (more than 3rd rank) is triggered by the
parents’ above the average material condition and superior education.
The current situation of Romania, which is still passing through a
period of relatively rapid demographic changes, marked by numerous
convulsions, requires a new approach, in compliance with the recent
interpretations appropriate to a new post-transitional demographic
regime.
Abstract: The Aptima® HIV-1 Quant Dx Assay is a fully
automated assay on the Panther system. It is based on Transcription-
Mediated Amplification and real time detection technologies. This
assay is intended for monitoring HIV-1 viral load in plasma
specimens and for the detection of HIV-1 in plasma and serum
specimens.
Nine-hundred and seventy nine specimens selected at random
from routine testing at St Thomas’ Hospital, London were
anonymised and used to compare the performance of the Aptima
HIV-1 Quant Dx assay and Roche COBAS® AmpliPrep/COBAS®
TaqMan® HIV-1 Test, v2.0. Two-hundred and thirty four specimens
gave quantitative HIV-1 viral load results in both assays. The
quantitative results reported by the Aptima Assay were comparable to
those reported by the Roche COBAS AmpliPrep/COBAS TaqMan
HIV-1 Test, v2.0 with a linear regression slope of 1.04 and an
intercept on -0.097.
The Aptima assay detected HIV-1 in more samples than the
COBAS assay. This was not due to lack of specificity of the Aptima
assay because this assay gave 99.83% specificity on testing plasma
specimens from 600 HIV-1 negative individuals. To understand the
reason for this higher detection rate a side-by-side comparison of low
level panels made from the HIV-1 3rd international standard
(NIBSC10/152) and clinical samples of various subtypes were tested
in both assays. The Aptima assay was more sensitive than the
COBAS assay.
The good sensitivity, specificity and agreement with other
commercial assays make the HIV-1 Quant Dx Assay appropriate for
both viral load monitoring and detection of HIV-1 infections.
Abstract: A large amount of blast furnace slag is generated in
China. Most ground granulated blast furnace slag (GGBS) however
ends up in low-grade applications. Blast furnace slag, ground to an
appropriate fineness, can be used as a partial replacement of
cementitious material in concrete. The potential for using GGBS in
structural concrete, e.g. concrete beams and columns is investigated
at Xi’an Jiaotong-Liverpool University (XJTLU). With 50% of CEM
I cement replaced with GGBS, peak hydration temperatures
determined in a suspended concrete slab reduced by 20%. This
beneficiary effect has not been further improved with 70% of CEM I
replaced with GGBS. Partial replacement of CEM I with GGBS has a
retardation effect on the early-age strength of concrete. More GGBS
concrete mixes will be conducted to identify an ‘optimum’
replacement level which will lead to a reduced thermal loading,
without significantly compromising the early-age strength of
concrete.
Abstract: Family has a crucial role in maintaining the
physical, social and mental health of the children. Most of the
mental and anxiety problems of children reflect the complex
interpersonal situations among family members, especially parents.
In other words, anxiety problems of the children are correlated
with deficit relationships of family members and improper
childrearing styles. The parental child rearing styles leads to
positive and negative consequences which affect the children’s
mental health. Therefore, the present research was aimed to
compare the parental childrearing styles and anxiety of children
with stuttering and normal population. It was also aimed to study
the relationship between parental child rearing styles and anxiety
of children. The research sample included 54 boys with stuttering
and 54 normal boys who were selected from the children (boys) of
Tehran, Iran in the age range of 5 to 8 years in 2013. In order to
collect data, Baum-rind Childrearing Styles Inventory and Spence
Parental Anxiety Inventory were used. Appropriate descriptive
statistical methods and multivariate variance analysis and t test for
independent groups were used to test the study hypotheses.
Statistical data analyses demonstrated that there was a significant
difference between stuttering boys and normal boys in anxiety (t =
7.601, p< 0.01); but there was no significant difference between
stuttering boys and normal boys in parental childrearing styles (F =
0.129). There was also not found significant relationship between
parental childrearing styles and children anxiety (F = 0.135, p<
0.05). It can be concluded that the influential factors of children’s
society are parents, school, teachers, peers and media. So, parental
childrearing styles are not the only influential factors on anxiety of
children, and other factors including genetic, environment and
child experiences are effective in anxiety as well. Details are
discussed.
Abstract: The paper presents a new method for efficient
innovation process management. Even though the innovation
management methods, tools and knowledge are well established and
documented in literature, most of the companies still do not manage it
efficiently. Especially in SMEs the front end of innovation - problem
identification, idea creation and selection - is often not optimally
performed. Our eMIPS methodology represents a sort of "umbrella
methodology" - a well-defined set of procedures, which can be
dynamically adapted to the concrete case in a company. In daily
practice, various methods (e.g. for problem identification and idea
creation) can be applied, depending on the company's needs. It is
based on the proactive involvement of the company's employees
supported by the appropriate methodology and external experts. The
presented phases are performed via a mixture of face-to-face
activities (workshops) and online (eLearning) activities taking place
in eLearning Moodle environment and using other e-communication
channels. One part of the outcomes is an identified set of
opportunities and concrete solutions ready for implementation. The
other also very important result is connected to innovation
competences for the participating employees related with concrete
tools and methods for idea management. In addition, the employees
get a strong experience for dynamic, efficient and solution oriented
managing of the invention process. The eMIPS also represents a way
of establishing or improving the innovation culture in the
organization. The first results in a pilot company showed excellent
results regarding the motivation of participants and also as to the
results achieved.
Abstract: This paper deals with the theoretical and numerical
investigation of magneto hydrodynamic boundary layer flow of a
nanofluid past a wedge shaped wick in heat pipe used for the cooling
of electronic components and different type of machines. To
incorporate the effect of nanoparticle diameter, concentration of
nanoparticles in the pure fluid, nanothermal layer formed around the
nanoparticle and Brownian motion of nanoparticles etc., appropriate
models are used for the effective thermal and physical properties of
nanofluids. To model the rotation of nanoparticles inside the base
fluid, microfluidics theory is used. In this investigation ethylene
glycol (EG) based nanofluids, are taken into account. The non-linear
equations governing the flow and heat transfer are solved by using a
very effective particle swarm optimization technique along with
Runge-Kutta method. The values of heat transfer coefficient are
found for different parameters involved in the formulation viz.
nanoparticle concentration, nanoparticle size, magnetic field and
wedge angle etc. It is found that, the wedge angle, presence of
magnetic field, nanoparticle size and nanoparticle concentration etc.
have prominent effects on fluid flow and heat transfer characteristics
for the considered configuration.
Abstract: Moving into a new era of healthcare, new tools and
devices are developed to extend and improve health services, such as
remote patient monitoring and risk prevention. In this concept,
Internet of Things (IoT) and Cloud Computing present great
advantages by providing remote and efficient services, as well as
cooperation between patients, clinicians, researchers and other health
professionals. This paper focuses on patients suffering from bipolar
disorder, a brain disorder that belongs to a group of conditions
called affective disorders, which is characterized by great mood
swings. We exploit the advantages of Semantic Web and Cloud
Technologies to develop a patient monitoring system to support
clinicians. Based on intelligently filtering of evidence-knowledge and
individual-specific information we aim to provide treatment
notifications and recommended function tests at appropriate times or
concluding into alerts for serious mood changes and patient’s nonresponse
to treatment. We propose an architecture as the back-end
part of a cloud platform for IoT, intertwining intelligence devices
with patients’ daily routine and clinicians’ support.
Abstract: The main objective of this paper is to provide a new
methodology for road safety assessment in Oman through the
development of suitable accident prediction models. GLM technique
with Poisson or NBR using SAS package was carried out to develop
these models. The paper utilized the accidents data of 31 un-signalized
T-intersections during three years. Five goodness-of-fit
measures were used to assess the overall quality of the developed
models. Two types of models were developed separately; the flow-based
models including only traffic exposure functions, and the full
models containing both exposure functions and other significant
geometry and traffic variables.
The results show that, traffic exposure functions produced much
better fit to the accident data. The most effective geometric variables
were major-road mean speed, minor-road 85th percentile speed,
major-road lane width, distance to the nearest junction, and right-turn
curb radius.
The developed models can be used for intersection treatment or
upgrading and specify the appropriate design parameters of T-intersections.
Finally, the models presented in this thesis reflect the intersection
conditions in Oman and could represent the typical conditions in
several countries in the middle east area, especially gulf countries.
Abstract: Experimental production methods of Chevreul’s salt
being an intermediate stage product in copper recovery were
investigated on this article. Chevreul’s salt, Cu2SO3.CuSO3.2H2O,
being a mixed valence copper sulphite compound, has been obtained
by using different methods and reagents. Chevreul’s salt has an
intense brick-red color. It is highly stable and expensive. The
production of Chevreul’s salt plays a key role in hydrometallurgy.
Thermodynamic tendency on precipitation of Chevreul’s salt is
related to pH and temperature. Besides, SO2 gaseous is a versatile
reagent for precipitating of copper sulphites, Using of SO2 for
selective precipitation can be made by appropriate adjustments of pH
and temperature. Chevreul’s salt does not form in acidic solutions if
those solutions contains considerable amount of sulfurous acid. It is
necessary to maintain between pH 2–4.5, because, solubility of
Chevreul’s salt increases with decreasing of pH values. Also, the
region which Chevreul’s salt is stable can be seen from the potentialpH
diagram.
Abstract: The problem of toughening in brittle materials
reinforced by fibers is complex, involving all of the mechanical
properties of fibers, matrix and the fiber/matrix interface, as well as
the geometry of the fiber. Development of new numerical methods
appropriate to toughening simulation and analysis is necessary. In
this work, we have performed simulations and analysis of toughening
in brittle matrix reinforced by randomly distributed fibers by means
of the discrete elements method. At first, we put forward a
mechanical model of toughening contributed by random fibers. Then
with a numerical program, we investigated the stress, damage and
bridging force in the composite material when a crack appeared in the
brittle matrix. From the results obtained, we conclude that: (i) fibers
of high strength and low elasticity modulus are beneficial to
toughening; (ii) fibers of relatively high elastic modulus compared to
the matrix may result in substantial matrix damage due to spalling
effect; (iii) employment of high-strength synthetic fibers is a good
option for toughening. We expect that the combination of the discrete
element method (DEM) with the finite element method (FEM) can
increase the versatility and efficiency of the software developed. The
present work can guide the design of ceramic composites of high
performance through the optimization of the parameters.
Abstract: In this paper, a direct power control (DPC)
strategies have been investigated in order to control a high
power AC/DC converter with time variable load. This converter
is composed of a three level three phase neutral point clamped
(NPC) converter as rectifier and an H-bridge four quadrant
current control converter. In the high power application,
controller not only must adjust the desire outputs but also
decrease the level of distortions which are injected to the network
from the converter. Regarding to this reason and nonlinearity
of the power electronic converter, the conventional controllers
cannot achieve appropriate responses. In this research, the
precise mathematical analysis has been employed to design the
appropriate controller in order to control the time variable
load. A DPC controller has been proposed and simulated using
Matlab/ Simulink. In order to verify the simulation result, a real
time simulator- OPAL-RT- has been employed. In this paper,
the dynamic response and stability of the high power NPC
with variable load has been investigated and compared with
conventional types using a real time simulator. The results proved
that the DPC controller is more stable and has more precise
outputs in comparison with conventional controller.
Abstract: Modeling and forecasting dynamics of rainfall
occurrences constitute one of the major topics, which have been
largely treated by statisticians, hydrologists, climatologists and many
other groups of scientists. In the same issue, we propose, in the
present paper, a new hybrid method, which combines Extreme
Values and fractal theories. We illustrate the use of our methodology
for transformed Emberger Index series, constructed basing on data
recorded in Oujda (Morocco).
The index is treated at first by Peaks Over Threshold (POT)
approach, to identify excess observations over an optimal threshold u.
In the second step, we consider the resulting excess as a fractal object
included in one dimensional space of time. We identify fractal
dimension by the box counting. We discuss the prospect descriptions
of rainfall data sets under Generalized Pareto Distribution, assured by
Extreme Values Theory (EVT). We show that, despite of the
appropriateness of return periods given by POT approach, the
introduction of fractal dimension provides accurate interpretation
results, which can ameliorate apprehension of rainfall occurrences.
Abstract: Data mining idea is mounting rapidly in admiration
and also in their popularity. The foremost aspire of data mining
method is to extract data from a huge data set into several forms that
could be comprehended for additional use. The data mining is a
technology that contains with rich potential resources which could be
supportive for industries and businesses that pay attention to collect
the necessary information of the data to discover their customer’s
performances. For extracting data there are several methods are
available such as Classification, Clustering, Association,
Discovering, and Visualization… etc., which has its individual and
diverse algorithms towards the effort to fit an appropriate model to
the data. STATISTICA mostly deals with excessive groups of data
that imposes vast rigorous computational constraints. These results
trials challenge cause the emergence of powerful STATISTICA Data
Mining technologies. In this survey an overview of the STATISTICA
software is illustrated along with their significant features.