Abstract: Various nanomaterials can be used as a drug delivery
vehicles in nanomedicine, called nanocarriers. They can either be
organic or inorganic, synthetic or natural-based. Although synthetic
nanocarriers are easier to produce, they can often be toxic for the
organism and thus not suitable for use in treatment. From naturalbased
nanocarriers, the most commonly used are protein cages or
viral capsids. In this work, virus bacteriophage λ was used for
delivery of different cytotoxic drugs (cisplatin, carboplatin,
oxaliplatin and doxorubicin). Large quantities of phage λ were
obtained from phage λ-producing strain of E. coli cultivated in
medium with 0.2% maltose. After killing of E. coli with chloroform
and its removal by centrifugation, the phage was concentrated by
ultracentrifugation at 130 000×g and 4°C for 3 h. The encapsulation
of the drugs was performed by infusion method and four different
concentrations of the drugs were encapsulated (200; 100; 50; 25
μg·mL-1). Free drug molecules were removed by filtration. The
encapsulation was verified using the absorbance for doxorubicin and
atomic absorption spectrometry for platinum cytostatics. The amount
of encapsulated drug linearly increased with the increasing
concentration of applied drug with the determination coefficient
R2=0.989 for doxorubicin; R2=0.967 for cisplatin; R2=0.989 for
carboplatin and R2=0.996 for oxaliplatin. The overall encapsulation
efficiency was calculated as 50% for doxorubicin; 8% for cisplatin;
6% for carboplatin and 10% for oxaliplatin.
Abstract: Chatter vibrations, occurring during cutting process,
cause vibration between the cutting tool and workpiece, which
deteriorates surface roughness and reduces tool life. The purpose of
this study is to investigate the influence of cutting parameters and
tool construction on surface roughness and vibration in turning of
aluminum alloy AA2024. A new design of cutting tool is proposed,
which is filled up with epoxy granite in order to improve damping
capacity of the tool. Experiments were performed at the lathe using
carbide cutting insert coated with TiC and two different cutting tools
made of AISI 5140 steel. Taguchi L9 orthogonal array was applied to
design of experiment and to optimize cutting conditions. By the help
of signal-to-noise ratio and analysis of variance the optimal cutting
condition and the effect of the cutting parameters on surface
roughness and vibration were determined. Effectiveness of Taguchi
method was verified by confirmation test. It was revealed that new
cutting tool with epoxy granite has reduced vibration and surface
roughness due to high damping properties of epoxy granite in
toolholder.
Abstract: High Performance Liquid Chromatography (HPLC)
method was developed and validated for simultaneous estimation of
6-Gingerol(6G) and 6-Shogaol(6S) in joint pain relief gel containing
ginger extract. The chromatographic separation was achieved by
using C18 column, 150 x 4.6mm i.d., 5μ Luna, mobile phase
containing acetonitrile and water (gradient elution). The flow rate
was 1.0 ml/min and the absorbance was monitored at 282 nm. The
proposed method was validated in terms of the analytical parameters
such as specificity, accuracy, precision, linearity, range, limit of
detection (LOD), limit of quantification (LOQ), and determined
based on the International Conference on Harmonization (ICH)
guidelines. The linearity ranges of 6G and 6S were obtained over 20-
60 and 6-18 μg/ml respectively. Good linearity was observed over the
above-mentioned range with linear regression equation Y= 11016x-
23778 for 6G and Y = 19276x-19604 for 6S (x is concentration of
analytes in μg/ml and Y is peak area). The value of correlation
coefficient was found to be 0.9994 for both markers. The limit of
detection (LOD) and limit of quantification (LOQ) for 6G were
0.8567 and 2.8555 μg/ml and for 6S were 0.3672 and 1.2238 μg/ml
respectively. The recovery range for 6G and 6S were found to be
91.57 to 102.36 % and 84.73 to 92.85 % for all three spiked levels.
The RSD values from repeated extractions for 6G and 6S were 3.43
and 3.09% respectively. The validation of developed method on
precision, accuracy, specificity, linearity, and range were also
performed with well-accepted results.
Abstract: This paper discusses the thematic structure of Yoruba
popular music of Southwest Nigeria. It examines the use of themes
and variations in early and contemporary Juju music. The work is an
outcome of a research developed by the author in his doctoral studies
at the University of Lagos, Nigeria, with the aim of analyzing the
thematic and motivic developments in Yoruba popular genres.
Observations, interviews, live recordings and CDs were used as
methods for eliciting information. Field recordings and CDs of
selected musical samples were also transcribed and notated. The
research established the prevalent use of string of themes by Juju
musicians as a compositional technique in moving from one musical
section to another, as they communicate the verbal messages in their
song. These themes consist of the popular ‘call and response’ form
found in most African music, analogous to the western ‘subject and
answer’ style of the fugue or sonata form, although without the tonic–
dominant relations. Due to the short and repetitive form of African
melodies and rhythms, a theme is restated as a variation, where its
rhythmic and melodic motifs are stylistically developed and repeated,
but still retaining its recognizable core musical structure. The
findings of this study showed that Juju musicians generally often
employ a thematic plan where new themes are used to arrange the
songs into sections, and each theme is developed into variations in
order to further expand the music, eliminate monotony, and create
musical aesthetics, serving as hallmark of its musical identity. The
study established the musical and extra-musical attributes of the
genre, while recommending further research towards analyzing the
various compositional techniques employed in African popular
genres.
Abstract: The effects of the contact ball-lens on the soda lime
glass in laser thermal cleavage with a cw Nd-YAG laser were
investigated in this study. A contact ball-lens was adopted to generate
a bending force on the crack formation of the soda-lime glass in the
laser cutting process. The Nd-YAG laser beam (wavelength of 1064
nm) was focused through the ball-lens and transmitted to the soda-lime
glass, which was coated with a carbon film on the surface with a
bending force from a ball-lens to generate a tensile stress state on the
surface cracking. The fracture was controlled by the contact ball-lens
and a straight cutting was tested to demonstrate the feasibility.
Experimental observations on the crack propagation from the leading
edge, main section and trailing edge of the glass sheet were compared
with various mechanical and thermal loadings. Further analyses on the
stress under various laser powers and contact ball loadings were made
to characterize the innovative technology. The results show that the distributions of the side crack at the
leading and trailing edges are mainly dependent on the boundary
condition, contact force, cutting speed and laser power. With the
increase of the mechanical and thermal loadings, the region of the side
cracks might be dramatically reduced with proper selection of the
geometrical constrains. Therefore the application of the contact
ball-lens is a possible way to control the fracture in laser cleavage with
improved cutting qualities.
Abstract: We consider fast and accurate solutions of scattering
problems by large perfectly conducting objects (PEC) formulated
by an optimization of the Method of Auxiliary Sources (MAS). We
present various techniques used to reduce the total computational cost
of the scattering problem. The first technique is based on replacing
the object by an array of finite number of small (PEC) object with the
same shape. The second solution reduces the problem on considering
only the half of the object.These t
Abstract: The increase of technogenic and natural accidents,
accompanied by air pollution, for example, by combustion products,
leads to the necessity of respiratory protection. This work is devoted to the development of a calorimetric method
and a device which allows investigating quickly the kinetics of
carbon dioxide sorption by chemisorbents on the base of potassium
superoxide in order to assess the protective properties of respiratory
protective closed circuit apparatus. The features of the traditional approach for determining the
sorption properties in a thin layer of chemisorbent are described, as
well as methods and devices, which can be used for the sorption
kinetics study. The authors developed an approach (as opposed to the traditional
approach) based on the power measurement of internal heat sources
in the chemisorbent layer. The emergence of the heat sources is a
result of exothermic reaction of carbon dioxide sorption. This
approach eliminates the necessity of chemical analysis of samples
and can significantly reduce the time and material expenses during
chemisorbents testing. Error of determining the volume fraction of adsorbed carbon
dioxide by the developed method does not exceed 12%. Taking into
account the efficiency of the method, we consider that it is a good
alternative to traditional methods of chemical analysis under the
assessment of the protection sorbents quality.
Abstract: Sub-Saharan Africa is described as the second fastest
growing in mobile phone penetration in the world more than in the
United States or the European Union. Mobile phones have been used
to provide a lot of opportunities to improve people’s lives in the
region such as in banking, marketing, entertainment, and paying for
various bills such as water, TV, and electricity. However, the
potential of mobile phones to enhance teaching and learning has not
been explored. This study presents an experience of developing and
delivering SMS based quiz questions used to assess mastery of
subject content knowledge of science and mathematics secondary
school teachers in Tanzania. The SMS quizzes were used as a follow
up support mechanism to 500 teachers who participated in a project
to upgrade subject content knowledge of teachers in science and
mathematics subjects in Tanzania. Quizzes of 10-15 questions were
sent to teachers each week for 8 weeks and the results were analyzed
using SPSS. Results show that teachers who participated in chemistry
and biology subjects have better performance compared to those who
participated in mathematics and physics subjects. Teachers reported
some challenges that led to poor performance, This research has
several practical implications for those who are implementing or
planning to use mobile phones in teaching and learning especially in
rural secondary schools in sub-Saharan Africa.
Abstract: The aim of sustainable architecture is to design
buildings with the least adverse effects on the environment and
provide better conditions for people. What building forms make the
best use of land? This question was addressed in the late 1960s at the
center of Land Use and Built Form Studies in Cambridge. This led to
a number of influential papers which had a great influence on the
practice of urban design. This paper concentrates on the results of
sustainability caused by climatic conditions in Iranian traditional
architecture in hot-arid regions. As people spent a significant amount
of their time in houses, it was very important to have such houses to
fulfill their needs physically and spiritually as well as satisfying their
cultural and religious aspects of their lifestyles. In a vast country such
as Iran with different climatic zones, traditional builders have
presented series of logical solutions for human comfort. These
solutions have been able to response to the environmental problems
for a long period of time. As a result, by considering the experience
in traditional architecture of hot–arid climate in Iran, it is possible to
attain sustainable architecture.
Abstract: This paper focuses on the questions raised through the
work of Unit 5: ‘In/Out Crisis, emergent and adaptive’; an
architectural research-based studio at [ARC] University of Nicosia. Students were asked to delve into state of Art Technologies in
order to propose sustainable Emergent and Adaptive Architectures
and Urbanities, the resulting unprecedented spatial conditions and
atmospheres of the emergent new ways of living are deemed to be the
ultimate aim of the investigation. Students explored a variety of sites
and crisis conditions seen through their primary ingredient identified
as soil, water and air and their paired combination. Within this
methodology, crisis is seen as a mechanism for allowing an
emergence of new and fascinating ultimate sustainable future cultures
and cities by taking advantage of the primary materiality of the sites.
Abstract: Internal circulation two-platen clamping system for
injection molding machine (IMM) has many potential advantages on
energy-saving. In order to estimate its properties, experiments were
carried out in this paper. Displacement and pressure of the components
were measured. In comparison, the model of hydraulic clamping
system was established by using AMESim. The related parameters as
well as the energy consumption could be calculated. According to the
analysis, the hydraulic system was optimized in order to reduce the
energy consumption.
Abstract: The fundamental issue in understanding the origin and
growth mechanism of nanomaterials, from a fundamental unit is a big
challenging problem to the scientists. Recently, an immense attention
is generated to the researchers for prediction of exceptionally stable
atomic cluster units as the building units for future smart materials.
The present study is a systematic investigation on the stability and
electronic properties of a series of bimetallic (semiconductor-alkaline
earth) clusters, viz., BxMg3 (x=1-5) is performed, in search for
exceptional and/ or unusual stable motifs. A very popular hybrid
exchange-correlation functional, B3LYP along with a higher basis
set, viz., 6-31+G[d,p] is employed for this purpose under the density
functional formalism. The magic stability among the concerned
clusters is explained using the jellium model. It is evident from the
present study that the magic stability of B4Mg3
cluster arises due to
the jellium shell closure.
Abstract: A geoelectric survey was carried out in some parts of
Angwan Gwari, an outskirt of Lapai Local Government Area on
Niger State which belongs to the Nigerian Basement Complex, with
the aim of evaluating the soil corrosivity, aquifer transmissivity and
protective capacity of the area from which aquifer characterisation
was made. The G41 Resistivity Meter was employed to obtain fifteen
Schlumberger Vertical Electrical Sounding data along profiles in a
square grid network. The data were processed using interpex 1-D
sounding inversion software, which gives vertical electrical sounding
curves with layered model comprising of the apparent resistivities,
overburden thicknesses, and depth. This information was used to
evaluate longitudinal conductance and transmissivities of the layers.
The results show generally low resistivities across the survey area
and an average longitudinal conductance variation from
0.0237Siemens in VES 6 to 0.1261Siemens in VES 15 with almost
the entire area giving values less than 1.0 Siemens. The average
transmissivity values range from 96.45 Ω.m2 in VES 4 to 299070
Ω.m2 in VES 1. All but VES 4 and VES14 had an average
overburden greater than 400 Ω.m2, these results suggest that the
aquifers are highly permeable to fluid movement within, leading to
the possibility of enhanced migration and circulation of contaminants
in the groundwater system and that the area is generally corrosive.
Abstract: Experience is what makes a man perfect. Though we
tend to learn many a different things in life through practice still we
need to go an extra mile to gain experience which would be profitable
only when it is integrated with regular practice. A clear phenomenal
idea is that every teacher is a learner. The centralized idea of this paper would focus on the integrated
practices carried out among the students of Jizan University which
enhances learning through experiences. Integrated practices like
student-directed activities, balanced curriculum, phonological based
activities and use of consistent language would enlarge the vision and
mission of students to earn experience through learning. Students
who receive explicit instruction and guidance could practice the skills
and strategies through student-directed activities such as peer tutoring
and cooperative learning. The second effective practice is to use
consistent language. Consistent language provides students a model
for talking about the new concepts which also enables them to
communicate without hindrances. Phonological awareness is an
important early reading skill for all students. Students generally have
phonemic awareness in their home language can often transfer that
knowledge to a second language. And also a balanced curriculum
requires instruction in all the elements of reading. Reading is the
most effective skill when both basic and higher-order skills are
included on a daily basis. Computer based reading and listening skills
will empower students to understand language in a better way.
English language learners can benefit from sound reading instruction
even before they are fully proficient in English as long as the
instruction is comprehensible. Thus, if students have to be well
equipped in learning they should foreground themselves in various
integrated practices through multifarious experience for which
teachers are moderators and trainers. This type of learning prepares
the students for a constantly changing society which helps them to
meet the competitive world around them for better employability
fulfilling the vision and mission of the institution.
Abstract: Green concrete are generally composed of recycling
materials as hundred or partial percent substitutes for aggregate,
cement, and admixture in concrete. To reduce greenhouse gas
emissions, efforts are needed to develop environmentally friendly
construction materials. Using of fly ash based geopolymer as an
alternative binder can help reduce CO2 emission of concrete. The
binder of geopolymer concrete is different from the ordinary Portland
cement concrete. Geopolymer Concrete specimens were prepared
with different concentration of NaOH solution M10, M14, and, M16
and cured at 60ºC in duration of 24 hours and 8 hours, in addition to
the curing in direct sunlight. Thus, it is necessary to study the effects
of the geopolymer binder on the behavior of concrete. Concrete is
made by using geopolymer technology is environmental friendly and
could be considered as part of the sustainable development. In this
study, the Local Alkaline Activator in Egypt and crashed stone as
coarse aggregate in fly ash based-geopolymer concrete was
investigated. This paper illustrates the development of mechanical
properties. Since the gained compressive strength for geopolymer
concrete at 28 days was in the range of 22.5MPa – 43.9MPa.
Abstract: Synchrophasor technology is fast being deployed in
electric power grids all over the world and is fast changing the way
the grids are managed. This trend is to continue until the entire
power grids are fully connected so they can be monitored and
controlled in real-time. Much achievement has been made in the
synchrophasor technology development and deployment, and there
are still much more to be achieved. For instance, real-time power
grid control and protection potentials of synchrophasor are yet to be
explored. It is of necessity that researchers keep in view the various
challenges that still need to be overcome in expanding the frontiers
of synchrophasor technology. This paper outlines the major
challenges that should be dealt with in order to achieve the goal of
total power grid visualization, monitoring, and control using
synchrophasor technology.
Abstract: A method of effective planning and control of
industrial facility energy consumption is offered. The method allows
optimally arranging the management and full control of complex
production facilities in accordance with the criteria of minimal
technical and economic losses at the forecasting control. The method
is based on the optimal construction of the power efficiency
characteristics with the prescribed accuracy. The problem of optimal
designing of the forecasting model is solved on the basis of three
criteria: maximizing the weighted sum of the points of forecasting
with the prescribed accuracy; the solving of the problem by the
standard principles at the incomplete statistic data on the basis of
minimization of the regularized function; minimizing the technical
and economic losses due to the forecasting errors.
Abstract: The liberalisation of the education industry has
exposed the institute of higher learning (IHL) in Malaysia to the
financial challenges. Without good financial standing, public
institution will rely on the government funding. Ostensibly, this
contradicts with the government’s aspiration to make universities
self-sufficient. With stiff competition from private institutes of higher
learning, IHL need to be prepared at the forefront level. The
corporate identity itself is the entrance to the world of higher learning
and it is in this uniqueness, it will be able to distinguish itself from
competitors. This paper examined the perception of the stakeholders
at one of the public universities in the east coast region in Malaysia
on the perceived reputation and how the university communicate its
preparedness for self-sustainability through corporate identity. The
findings indicated while the stakeholders embraced the challenges in
facing the stiff competition and struggling market conditions, most of
them felt the university should put more efforts in mobilising the
corporate identity to its constituencies.
Abstract: Electrical Muscle Stimulation (EMS) has been
introduced and globally gained increasing attention on its usefulness.
Continuous application of EMS may lead to the increment of muscle
mass and indirectly will increase the strength. This study can be used
as an alternative to help people especially those living a sedentary
lifestyle to improve their muscle activity without having to go
through a heavy workout session. Therefore, this study intended to
investigate the effectiveness of EMS training program in 5 weeks
interventions towards male body composition. It was a quasiexperimental
design, held at the Impulse Studio Bangsar, which
examined the effects of EMS training towards skeletal muscle mass
among the subjects. Fifteen subjects (n = 15) were selected to assist
in this study. The demographic data showed that, the average age of
the subjects was 43.07 years old ± 9.90, height (173.4 cm ± 9.09) and
weight was (85.79 kg ± 18.07). Results showed that there was a
significant difference on the skeletal muscle mass (p = 0.01 < 0.05),
upper body (p = 0.01 < 0.05) and lower body (p = 0.00 < 0.05).
Therefore, the null hypothesis has been rejected in this study. As a
conclusion, the application of EMS towards body composition can
increase the muscle size and strength. This method has been proven
to be able to improve athlete strength and thus, may be implemented
in the sports science area of knowledge.
Abstract: Recently, many users have begun to frequently share
their opinions on diverse issues using various social media. Therefore,
numerous governments have attempted to establish or improve
national policies according to the public opinions captured from
various social media. In this paper, we indicate several limitations of
the traditional approaches to analyze public opinion on science and
technology and provide an alternative methodology to overcome these
limitations. First, we distinguish between the science and technology
analysis phase and the social issue analysis phase to reflect the fact that
public opinion can be formed only when a certain science and
technology is applied to a specific social issue. Next, we successively
apply a start list and a stop list to acquire clarified and interesting
results. Finally, to identify the most appropriate documents that fit
with a given subject, we develop a new logical filter concept that
consists of not only mere keywords but also a logical relationship
among the keywords. This study then analyzes the possibilities for the
practical use of the proposed methodology thorough its application to
discover core issues and public opinions from 1,700,886 documents
comprising SNS, blogs, news, and discussions.