Abstract: The presence of heavy metals in the environment
could constitute a hazard to food security and public health. These
can be accumulated in aquatic animals such as fish. Samples of four
popular brands of canned fish in the Iranian market (yellowfin tuna,
common Kilka, Kawakawa and longtail tuna) were analyzed for level
of Cr after wet digestion with acids using graphite furnace atomic
absorption spectrophotometry. The mean concentrations for Cr in the
different brands were: 2.57, 3.24, 3.16 and 1.65 μg/g for brands A, B,
C and D respectively. Significant differences were observed in the Cr
levels between all of the different brands of canned fish evaluated in
this study. The Cr concentrations for the varieties of canned fishes
were generally within the FAO/WHO, U.S. FDA and U.S. EPA
recommended limits for fish.
Abstract: This article addresses feature selection for breast
cancer diagnosis. The present process contains a wrapper approach
based on Genetic Algorithm (GA) and case-based reasoning (CBR).
GA is used for searching the problem space to find all of the possible
subsets of features and CBR is employed to estimate the evaluation
result of each subset. The results of experiment show that the
proposed model is comparable to the other models on Wisconsin
breast cancer (WDBC) dataset.
Abstract: A mathematical model of the surface roughness
has been developed by using response surface methodology
(RSM) in grinding of AISI D2 cold work tool steels. Analysis
of variance (ANOVA) was used to check the validity of the
model. Low and high value for work speed and feed rate are
decided from design of experiment. The influences of all
machining parameters on surface roughness have been
analyzed based on the developed mathematical model. The
developed prediction equation shows that both the feed rate
and work speed are the most important factor that influences
the surface roughness. The surface roughness was found to be
the lowers with the used of low feed rate and low work speed.
Accuracy of the best model was proved with the testing data.
Abstract: Finite element method was applied to model damage
development in the femoral neck during a sideways fall. The femoral
failure was simulated using the maximum principal strain criterion.
The evolution of damage was consistent with previous studies. It was
initiated by compressive failure at the junction of the superior aspect
of the femoral neck and the greater trochanter. It was followed by
tensile failure that occurred at the inferior aspect of the femoral neck
before a complete transcervical fracture was observed. The estimated
failure line was less than 50° from the horizontal plane (Pauwels type
II).
Abstract: The importance of machining process in today-s
industry requires the establishment of more practical approaches to
clearly represent the intimate and severe contact on the tool-chipworkpiece
interfaces. Mathematical models are developed using the
measured force signals to relate each of the tool-chip friction
components on the rake face to the operating cutting parameters in
rough turning operation using multilayers coated carbide inserts.
Nonlinear modeling proved to have high capability to detect the
nonlinear functional variability embedded in the experimental data.
While feedrate is found to be the most influential parameter on the
friction coefficient and its related force components, both cutting
speed and depth of cut are found to have slight influence. Greater
deformed chip thickness is found to lower the value of friction
coefficient as the sliding length on the tool-chip interface is reduced.
Abstract: The PAX6, a transcription factor, is essential for the morphogenesis of the eyes, brain, pituitary and pancreatic islets. In rodents, the loss of Pax6 function leads to central nervous system defects, anophthalmia, and nasal hypoplasia. The haplo-insufficiency of Pax6 causes microphthalmia, aggression and other behavioral abnormalities. It is also required in brain patterning and neuronal plasticity. In human, heterozygous mutation of Pax6 causes loss of iris [aniridia], mental retardation and glucose intolerance. The 3- deletion in Pax6 leads to autism and aniridia. The phenotypes are variable in peneterance and expressivity. However, mechanism of function and interaction of PAX6 with other proteins during development and associated disease are not clear. It is intended to explore interactors of PAX6 to elucidated biology of PAX6 function in the tissues where it is expressed and also in the central regulatory pathway. This report describes In-silico approaches to explore interacting proteins of PAX6. The models show several possible proteins interacting with PAX6 like MITF, SIX3, SOX2, SOX3, IPO13, TRIM, and OGT. Since the Pax6 is a critical transcriptional regulator and master control gene of eye and brain development it might be interacting with other protein involved in morphogenesis [TGIF, TGF, Ras etc]. It is also presumed that matricelluar proteins [SPARC, thrombospondin-1 and osteonectin etc] are likely to interact during transport and processing of PAX6 and are somewhere its cascade. The proteins involved in cell survival and cell proliferation can also not be ignored.
Abstract: While the form of crises may change, their essence
remains the same (such as a cycle of abundant liquidity, rapid credit
growth, and a low-inflation environment followed by an asset-price
bubble). The current market turbulence began in mid-2000s when the
US economy shifted to imbalanced both internal and external
macroeconomic positions. We see two key causes of these problems
– loose US monetary policy in early 2000s and US government
guarantees issued on the securities by government-sponsored
enterprises what was further fueled by financial innovations such as
structured credit products. We have discovered both negative and
positive lessons deriving from this crisis and divided the negative
lessons into three groups: financial products and valuation, processes
and business models, and strategic issues. Moreover, we address key
risk management lessons and exit strategies derived from the current
crisis and recommend policies that should help diminish the negative
impact of future potential crises.
Abstract: The major part of light weight timber constructions
consists of insulation. Mineral wool is the most commonly used
insulation due to its cost efficiency and easy handling. The fiber
orientation and porosity of this insulation material enables flowthrough.
The air flow resistance is low. If leakage occurs in the
insulated bay section, the convective flow may cause energy losses
and infiltration of the exterior wall with moisture and particles. In
particular the infiltrated moisture may lead to thermal bridges and
growth of health endangering mould and mildew. In order to prevent
this problem, different numerical calculation models have been
developed. All models developed so far have a potential for
completion. The implementation of the flow-through properties of
mineral wool insulation may help to improve the existing models.
Assuming that the real pressure difference between interior and
exterior surface is larger than the prescribed pressure difference in the
standard test procedure for mineral wool ISO 9053 / EN 29053,
measurements were performed using the measurement setup for
research on convective moisture transfer “MSRCMT".
These measurements show, that structural inhomogeneities of
mineral wool effect the permeability only at higher pressure
differences, as applied in MSRCMT. Additional microscopic
investigations show, that the location of a leak within the
construction has a crucial influence on the air flow-through and the
infiltration rate. The results clearly indicate that the empirical values
for the acoustic resistance of mineral wool should not be used for the
calculation of convective transfer mechanisms.
Abstract: Literature reveals that many investors rely on technical trading rules when making investment decisions. If stock markets are efficient, one cannot achieve superior results by using these trading rules. However, if market inefficiencies are present, profitable opportunities may arise. The aim of this study is to investigate the effectiveness of technical trading rules in 34 emerging stock markets. The performance of the rules is evaluated by utilizing White-s Reality Check and the Superior Predictive Ability test of Hansen, along with an adjustment for transaction costs. These tests are able to evaluate whether the best model performs better than a buy-and-hold benchmark. Further, they provide an answer to data snooping problems, which is essential to obtain unbiased outcomes. Based on our results we conclude that technical trading rules are not able to outperform a naïve buy-and-hold benchmark on a consistent basis. However, we do find significant trading rule profits in 4 of the 34 investigated markets. We also present evidence that technical analysis is more profitable in crisis situations. Nevertheless, this result is relatively weak.
Abstract: We have developed a database for membrane protein functions, which has more than 3000 experimental data on functionally important amino acid residues in membrane proteins along with sequence, structure and literature information. Further, we have proposed different methods for identifying membrane proteins based on their functions: (i) discrimination of membrane transport proteins from other globular and membrane proteins and classifying them into channels/pores, electrochemical and active transporters, and (ii) β-signal for the insertion of mitochondrial β-barrel outer membrane proteins and potential targets. Our method showed an accuracy of 82% in discriminating transport proteins and 68% to classify them into three different transporters. In addition, we have identified a motif for targeting β-signal and potential candidates for mitochondrial β-barrel membrane proteins. Our methods can be used as effective tools for genome-wide annotations.
Abstract: The methanolic extracts from seeds of tamarind
(Tamarindus indica) was prepared by Soxhlet apparatus extraction
and evaluated for total phenolic content by Folin-Ciocalteu method.
Then, methanolic extract was screened biological activities (In vitro)
for anti-melanogenic activity by tyrosinase inhibition test, antiinflammation
activity by cyclooxygenase 1 (COX-1) and
cyclooxygenase 2 (COX-2) inhibition test, and cytotoxic screening
test with Vero cells. The results showed that total phenolic content,
which contained in extract, was contained 27.72 mg of gallic acid
equivalent per g of dry weight. The ability to inhibit tyrosinase
enzyme, which exerted by Tamarind seed extracts (1 mg/ml) was
52.13 ± 0.42 %. The extract was not possessed inhibitory effect to
COX-1 and COX-2 enzymes and cytotoxic effect to Vero cells. The
finding is concludes that tested seed extract was possessed
antimelanogenic activity with non-toxic effects. However, there was
not exhibited anti-inflammatory activity. Further studies include the
use of advance biological models to confirm this biological activity,
as well as, the isolation and characterization of the purified
compounds that it was contained.
Abstract: None of the processing models in the software
development has explained the software systems performance
evaluation and modeling; likewise, there exist uncertainty in the
information systems because of the natural essence of requirements,
and this may cause other challenges in the processing of software
development. By definition an extended version of UML (Fuzzy-
UML), the functional requirements of the software defined
uncertainly would be supported. In this study, the behavioral
description of uncertain information systems by the aid of fuzzy-state
diagram is crucial; moreover, the introduction of behavioral diagrams
role in F-UML is investigated in software performance modeling
process. To get the aim, a fuzzy sub-profile is used.
Abstract: This paper presents an exact analytical model for
optimizing stability of thin-walled, composite, functionally graded
pipes conveying fluid. The critical flow velocity at which divergence
occurs is maximized for a specified total structural mass in order to
ensure the economic feasibility of the attained optimum designs. The
composition of the material of construction is optimized by defining
the spatial distribution of volume fractions of the material
constituents using piecewise variations along the pipe length. The
major aim is to tailor the material distribution in the axial direction so
as to avoid the occurrence of divergence instability without the
penalty of increasing structural mass. Three types of boundary
conditions have been examined; namely, Hinged-Hinged, Clamped-
Hinged and Clamped-Clamped pipelines. The resulting optimization
problem has been formulated as a nonlinear mathematical
programming problem solved by invoking the MatLab optimization
toolbox routines, which implement constrained function
minimization routine named “fmincon" interacting with the
associated eigenvalue problem routines. In fact, the proposed
mathematical models have succeeded in maximizing the critical flow
velocity without mass penalty and producing efficient and economic
designs having enhanced stability characteristics as compared with
the baseline designs.
Abstract: To learn about China-s future energy demand, this paper first proposed GM(1,1) model group based on recursive solutions of parameters estimation, setting up a general solving-algorithm of the model group. This method avoided the problems occurred on the past researches that remodeling, loss of information and large amount of calculation. This paper established respectively all-data-GM(1,1), metabolic GM(1,1) and new information GM (1,1)model according to the historical data of energy consumption in China in the year 2005-2010 and the added data of 2011, then modeling, simulating and comparison of accuracies we got the optimal models and to predict. Results showed that the total energy demand of China will be 37.2221 billion tons of equivalent coal in 2012 and 39.7973 billion tons of equivalent coal in 2013, which are as the same as the overall planning of energy demand in The 12th Five-Year Plan.
Abstract: Kepsut-Dursunbey volcanic field (KDVF) is located
in NW Turkey and contains various products of the post-collisional
Neogene magmatic activity. Two distinct volcanic suites have been
recognized; the Kepsut volcanic suite (KVS) and the Dursunbey
volcanic suite (DVS). The KVS includes basaltic trachyandesitebasaltic
andesite-andesite lavas and associated pyroclastic rocks. The
DVS consists of dacite-rhyodacite lavas and extensive pumice-ash
fall and flow deposits. Petrographical features (i.e. existence of
xenocrysts, glomerocrysts, and mixing-compatible textures) and
mineral chemistry of phenocryst assemblages of both suites provide
evidence for magma mixing/AFC. Calculated crystallization
pressures and temperatures give values of 5.7–7.0 kbar and 927–982
°C for the KVS and 3.7–5.3 kbar and 783-787°C for the DVS,
indicating separate magma reservoirs and crystallization in magma
chambers at deep and mid crustal levels, respectively. These
observations support the establishment and evolution of KDVF
magma system promoted by episodic basaltic inputs which may
generate and mix with crustal melts.
Abstract: Catalytic converters are used for minimizing the release of pollutants to the atmosphere. It is during the warm-up period that hydrocarbons are seen to be released in appreciable quantities from these converters. In this paper the conversion of a fast oxidizing hydrocarbon propylene is analysed using two numerical methods. The quasi steady state method assumes the accumulation terms to be negligible in the gas phase mass and energy balance equations, however this term is present in the solid phase energy balance. The unsteady state model accounts for the accumulation term to be present in the gas phase mass and energy balance and in the solid phase energy balance. The results derived from the two models for gas concentration, gas temperature and solid temperature are compared.
Abstract: In the recent past Learning Classifier Systems have
been successfully used for data mining. Learning Classifier System
(LCS) is basically a machine learning technique which combines
evolutionary computing, reinforcement learning, supervised or
unsupervised learning and heuristics to produce adaptive systems. A
LCS learns by interacting with an environment from which it
receives feedback in the form of numerical reward. Learning is
achieved by trying to maximize the amount of reward received. All
LCSs models more or less, comprise four main components; a finite
population of condition–action rules, called classifiers; the
performance component, which governs the interaction with the
environment; the credit assignment component, which distributes the
reward received from the environment to the classifiers accountable
for the rewards obtained; the discovery component, which is
responsible for discovering better rules and improving existing ones
through a genetic algorithm. The concatenate of the production rules
in the LCS form the genotype, and therefore the GA should operate
on a population of classifier systems. This approach is known as the
'Pittsburgh' Classifier Systems. Other LCS that perform their GA at
the rule level within a population are known as 'Mitchigan' Classifier
Systems. The most predominant representation of the discovered
knowledge is the standard production rules (PRs) in the form of IF P
THEN D. The PRs, however, are unable to handle exceptions and do
not exhibit variable precision. The Censored Production Rules
(CPRs), an extension of PRs, were proposed by Michalski and
Winston that exhibit variable precision and supports an efficient
mechanism for handling exceptions. A CPR is an augmented
production rule of the form: IF P THEN D UNLESS C, where
Censor C is an exception to the rule. Such rules are employed in
situations, in which conditional statement IF P THEN D holds
frequently and the assertion C holds rarely. By using a rule of this
type we are free to ignore the exception conditions, when the
resources needed to establish its presence are tight or there is simply
no information available as to whether it holds or not. Thus, the IF P
THEN D part of CPR expresses important information, while the
UNLESS C part acts only as a switch and changes the polarity of D
to ~D. In this paper Pittsburgh style LCSs approach is used for
automated discovery of CPRs. An appropriate encoding scheme is
suggested to represent a chromosome consisting of fixed size set of
CPRs. Suitable genetic operators are designed for the set of CPRs
and individual CPRs and also appropriate fitness function is proposed
that incorporates basic constraints on CPR. Experimental results are
presented to demonstrate the performance of the proposed learning
classifier system.
Abstract: 17α-ethynylestradiol (EE2) is a synthetic estrogen
used as a key ingredient in an oral contraceptives pill. EE2 is an
endocrine disrupting compound, high in estrogenic potency.
Although EE2 exhibits low degree of biodegradability with common
microorganisms in wastewater treatment plants (WWTPs), this
compound can be biotransformed by ammonia-oxidizing bacteria
(AOB) via a co-metabolism mechanism in WWTPs. This study
aimed to investigate the effect of real wastewater on
biotransformation of EE2 by AOB. A preliminary experiment on the
effect of nitrite and pH levels on abiotic transformation of EE2
suggested that the abiotic transformation occurred at only pH
Abstract: We aimed to investigate how can target and optimize
pulmonary delivery distribution by changing physicochemical
characteristics of instilled liquid.Therefore, we created a new liquids
group:
a. eligible for desired distribution within lung because of
assorted physicochemical characteristics
b. capable of being augmented with a broad range of
chemicals inertly
c. no interference on respiratory function
d. compatible with airway surface liquid
We developed forty types of new liquid,were composed of
Carboxymethylcellulose sodium,Glycerin and different types of
Polysorbates.Viscosity was measured using a Programmable
Rheometer and surface tension by KRUSS Tensiometer.We
subsequently examined the liquids and delivery protocols by simple
and branched glass capillary tube models of airways.Eventually,we
explored pulmonary distribution of liquids being augmented with
technetium-99m in mechanically ventilated rabbits.We used a single
head large field of view gamma camera.Kinematic viscosity between
0.265Stokes and 0.289Stokes,density between 1g/cm3 and 1.5g/cm3
and surface tension between 25dyn/cm and 35dyn/cm were the most
acceptable.
Abstract: The technology usages of high speed Internet leads to
establish and start new era of online education. With the
advancement of the information technology and communication
systems new opportunities have been created. This leads universities
to have various online education channels to meet the demand of
different learners- needs. One of these channels is M-learning, which
can be used to improve the online education environment. With using
such mobile technology in learning both students and instructors can
easily access educational courses anytime from anywhere. The paper
first presents literature about mobile learning and to what extent this
approach can be utilized to enhance the overall learning system. It
provides a comparison between mobile learning and traditional elearning
showing the wide array of benefits of the new generation of
technology. The possible challenges and potential advantages of Mlearning
in the online education system are also discussed.