Abstract: Aurein 1.2 is a 13-residue amphipathic peptide with antibacterial and anticancer activity. Aurein1.2 and its retro analog were synthesized to study the activity of the peptides in relation to their structure. The antibacterial test result showed the retro-analog is inactive. The secondary structural analysis by CD spectra indicated that both of the peptides at TFE/Water adopt alpha-helical conformation. MD simulation was performed on aurein 1.2 and retro-analog in water and TFE in order to analyse the factors that are involved in the activity difference between retro and the native peptide. The simulation results are discussed and validated in the light of experimental data from the CD experiment. Both of the peptides showed a relatively similar pattern for their hydrophobicity, hydrophilicity, solvent accessible surfaces, and solvent accessible hydrophobic surfaces. However, they showed different in directions of dipole moment of peptides. Also, Our results further indicate that the reversion of the amino acid sequence affects flexibility .The data also showed that factors causing structural rigidity may decrease the activity. Consequently, our finding suggests that in the case of sequence-reversed peptide strategy, one has to pay attention to the role of amino acid sequence order in making flexibility and role of dipole moment direction in peptide activity. KeywordsAntimicrobial peptides, retro, molecular dynamic, circular dichroism.
Abstract: This research was conducted in the Pua Watershed whereas located in the Upper Nan River Basin in Nan province, Thailand. Nan River basin originated in Nan province that comprises of many tributary streams to produce as inflow to the Sirikit dam provided huge reservoir with the storage capacity of 9510 million cubic meters. The common problems of most watersheds were found i.e. shortage water supply for consumption and agriculture utilizations, deteriorate of water quality, flood and landslide including debris flow, and unstable of riverbank. The Pua Watershed is one of several small river basins that flow through the Nan River Basin. The watershed includes 404 km2 representing the Pua District, the Upper Nan Basin, or the whole Nan River Basin, of 61.5%, 18.2% or 1.2% respectively. The Pua River is a main stream producing all year streamflow supplying the Pua District and an inflow to the Upper Nan Basin. Its length approximately 56.3 kilometers with an average slope of the channel by 1.9% measured. A diversion weir namely Pua weir bound the plain and mountainous areas with a very steep slope of the riverbed to 2.9% and drainage area of 149 km2 as upstream watershed while a mild slope of the riverbed to 0.2% found in a river reach of 20.3 km downstream of this weir, which considered as a gauged basin. However, the major branch streams of the Pua River are ungauged catchments namely: Nam Kwang and Nam Koon with the drainage area of 86 and 35 km2 respectively. These upstream watersheds produce runoff through the 3-streams downstream of Pua weir, Jao weir, and Kang weir, with an averaged annual runoff of 578 million cubic meters. They were analyzed using both statistical data at Pua weir and simulated data resulted from the hydrologic modeling system (HEC–HMS) which applied for the remaining ungauged basins. Since the Kwang and Koon catchments were limited with lack of hydrological data included streamflow and rainfall. Therefore, the mathematical modeling: HEC-HMS with the Snyder-s hydrograph synthesized and transposed methods were applied for those areas using calibrated hydrological parameters from the upstream of Pua weir with continuously daily recorded of streamflow and rainfall data during 2008-2011. The results showed that the simulated daily streamflow and sum up as annual runoff in 2008, 2010, and 2011 were fitted with observed annual runoff at Pua weir using the simple linear regression with the satisfied correlation R2 of 0.64, 062, and 0.59, respectively. The sensitivity of simulation results were come from difficulty using calibrated parameters i.e. lag-time, coefficient of peak flow, initial losses, uniform loss rates, and missing some daily observed data. These calibrated parameters were used to apply for the other 2-ungauged catchments and downstream catchments simulated.
Abstract: Transcription factor p53 has a powerful tumor
suppressing function that is associated with many cancers. However,
p53 of the molecular weight was higher make the limitation across to
skin or cell membrane. Thymidine dinucleotide (pTT), an
oligonucleotide, can activate the p53 transcription factor. pTT is a
hydrophilic and negative charge oligonucleotide, which delivery in to
cell membrane need an appropriate carrier. The aim of this study was
to improve the bioavailability of the nucleotide fragment, thymidine
dinucleotide (pTT), using elasic liposome carriers to deliver the drug
into the skin. The study demonstrate that dioleoylphosphocholine
(DOPC) incorporated with sodium cholate at molar ratio 1:1 can
archived the particle size about 220 nm. This elastic liposome could
penetration through skin from stratum corneum to whole epidermis by
confocal laser scanning microscopy (CLSM). Moreover, we observed
the the slight increase in generation of p53 by western blot.
Abstract: This paper reports the three-phase (gas + liquid +
hydrate) equilibrium pressure versus temperature data for a (O3 + O2 +
CO2 + H2O) system for developing the hydrate-based technology to
preserve ozone, a chemically unstable substance, for various
industrial, medical and consumer uses. These data cover the
temperature range from 272 K to 277 K, corresponding to pressures
from 1.6 MPa to 3.1 MPa, for each of the three different (O3 +
O2)-to-CO2 or O2-to-CO2 molar ratios in the gas phase, which are
approximately 4 : 6, 5 : 5, respectively. The mole fraction of ozone in
the gas phase was ~0.03 , which are the densest ozone fraction to
artificially form O3 containing hydrate ever reported in the literature.
Based on these data, the formation of hydrate containing
high-concentration ozone, as high as 1 mass %, will be expected.
Abstract: The main aim of Supply Chain Management (SCM) is
to produce, distribute, logistics and deliver goods and equipment in
right location, right time, right amount to satisfy costumers, with
minimum time and cost waste. So implementing techniques that
reduce project time and cost, and improve productivity and
performance is very important. Emerging technologies such as the
Radio Frequency Identification (RFID) are now making it possible to
automate supply chains in a real time manner and making them more
efficient than the simple supply chain of the past for tracing and
monitoring goods and products and capturing data on movements of
goods and other events. This paper considers concepts, components
and RFID technology characteristics by concentration of warehouse
and inventories management. Additionally, utilization of RFID in the
role of improving information management in supply chain is
discussed. Finally, the facts of installation and this technology-s
results in direction with warehouse and inventory management and
business development will be presented.
Abstract: Improvement in CAE methods has an important role for shortening of the vehicle product development time. It is provided that validation of the design and improvements in terms of durability can be done without hardware prototype production. In recent years, several different methods have been developed in order to investigate fatigue damage of the vehicle. The intended goal among these methods is prediction of fatigue damage in a short time with reduced costs. This study developed a new fatigue damage prediction method in the automotive sector using power spectrum densities of accelerations. This study also confirmed that the weak region in vehicle can be easily detected with the method developed in this study which results were compared with conventional method.
Abstract: Both the minimum energy consumption and
smoothness, which is quantified as a function of jerk, are generally
needed in many dynamic systems such as the automobile and the
pick-and-place robot manipulator that handles fragile equipments.
Nevertheless, many researchers come up with either solely
concerning on the minimum energy consumption or minimum jerk
trajectory. This research paper proposes a simple yet very interesting
when combining the minimum energy and jerk of indirect jerks
approaches in designing the time-dependent system yielding an
alternative optimal solution. Extremal solutions for the cost functions
of the minimum energy, the minimum jerk and combining them
together are found using the dynamic optimization methods together
with the numerical approximation. This is to allow us to simulate
and compare visually and statistically the time history of state inputs
employed by combining minimum energy and jerk designs. The
numerical solution of minimum direct jerk and energy problem are
exactly the same solution; however, the solutions from problem of
minimum energy yield the similar solution especially in term of
tendency.
Abstract: To decompose organochlorides by bioremediation, co-culture biohydrogen producer and dehalogenation microorganisms is a useful method. In this study, we combined these two characteristics from a biohydrogen producer, Rhodopseudomonas palustris, and a dehalogenation microorganism, Pseudomonas putida, to enchance halorespiration in R. palustris. The genes encoding cytochrome P450cam system (camC, camA, and camB) from P. putida were expressed in R. palustris with designated expression plasmid. All tested strains were cultured to log phase then presented pentachloroethane (PCA) in media. The vector control strain could degrade PCA about 78% after 16 hours, however, the cytochrome P450cam system expressed strain, CGA-camCAB, could completely degrade PCA in 12 hours. While taking chlorinated aromatic, 3-chlorobenzoate, as sole carbon source or present benzoate as co-substrate, CGA-camCAB presented faster growth rate than vector control strain.
Abstract: This paper is intended to assist anyone with some general technical experience, but perhaps limited specific knowledge of heat transfer equipment. A characteristic of heat exchanger design is the procedure of specifying a design, heat transfer area and pressure drops and checking whether the assumed design satisfies all requirements or not. The purpose of this paper is how to design the oil cooler (heat exchanger) especially for shell-and-tube heat exchanger which is the majority type of liquid-to-liquid heat exchanger. General design considerations and design procedure are also illustrated in this paper and a flow diagram is provided as an aid of design procedure. In design calculation, the MatLAB and AutoCAD software are used. Fundamental heat transfer concepts and complex relationships involved in such exchanger are also presented in this paper. The primary aim of this design is to obtain a high heat transfer rate without exceeding the allowable pressure drop. This computer program is highly useful to design the shell-and-tube type heat exchanger and to modify existing deign.
Abstract: In view of the good properties of nonstationary wavelet frames and the better flexibility of wavelets in Sobolev spaces, the nonstationary dual wavelet frames in a pair of dual Sobolev spaces are studied in this paper. We mainly give the oblique extension principle and the mixed extension principle for nonstationary dual wavelet frames in a pair of dual Sobolev spaces Hs(Rd) and H-s(Rd).
Abstract: Metallic micro parts are playing an important role in micro-fabrication industry. Recently, we have demonstrated a new deformation mechanism for micro-formability of polycrystalline materials. Different depressed micro-features smaller than the grain size have been successfully fabricated on 6061 aluminum alloy (AA6061) substrates with good fidelity. To further verify this proposed deformation mechanism that grain size is not a limiting factor, we demonstrate here that in addition of depressed features, protruded micro-features on a polycrystalline substrate can similarly be fabricated.
Abstract: Nowadays, under developed countries for progress in
science and technology and decreasing the technologic gap with
developed countries, increasing the capacities and technology
transfer from developed countries. To remain competitive, industry is
continually searching for new methods to evolve their products.
Business model is one of the latest buzzwords in the Internet and
electronic business world. To be successful, organizations must look
into the needs and wants of their customers. This research attempts to
identify a specific feature of the company with a strong competitive
advantage by analyzing the cause of Customer satisfaction. Due to
the rapid development of knowledge and information technology,
business environments have become much more complicated.
Information technology can help a firm aiming to gain a competitive
advantage. This study explores the role and effect of Information
Communication Technology in Business Models and Customer
satisfaction on firms and also relationships between ICTs and
Outsourcing strategic.
Abstract: In this paper, the effects of thermodynamic,
hydrodynamic and geometric of an air cooled condenser on COP of
vapor compression cycle are investigated for a fixed condenser facing
surface area. The system is utilized with a scroll compressor,
modeled based on thermodynamic and heat transfer equations
employing Matlab software. The working refrigerant is R134a whose
thermodynamic properties are called from Engineering Equation
Software. This simulation shows that vapor compression cycle can
be designed by different configurations and COPs, economical and
optimum working condition can be obtained via considering these
parameters.
Abstract: The theory of Groebner Bases, which has recently been
honored with the ACM Paris Kanellakis Theory and Practice Award,
has become a crucial building block to computer algebra, and is
widely used in science, engineering, and computer science. It is wellknown
that Groebner bases computation is EXP-SPACE in a general
setting. In this paper, we give an algorithm to show that Groebner
bases computation is P-SPACE in Boolean rings. We also show that
with this discovery, the Groebner bases method can theoretically be
as efficient as other methods for automated verification of hardware
and software. Additionally, many useful and interesting properties of
Groebner bases including the ability to efficiently convert the bases
for different orders of variables making Groebner bases a promising
method in automated verification.
Abstract: Failure modes and effects analysis (FMEA) is an effective technique for preventing potential problems and actions needed to error cause removal. On the other hand, the oil producing companies paly a critical role in the oil industry of Iran as a developing country out of which, Sepahan Oil Co. has a considerable contribution. The aim of this research is to show how FMEA could be applied and improve the quality of products at Sepahan Oil Co. For this purpose, the four liter production line of the company has been selected for investigation. The findings imply that the application of FMEA has reduced the scraps from 50000 ppm to 5000 ppm and has resulted in a 0.92 percent decrease of the oil waste.
Abstract: Neighborhood Rough Sets (NRS) has been proven to
be an efficient tool for heterogeneous attribute reduction. However,
most of researches are focused on dealing with complete and noiseless
data. Factually, most of the information systems are noisy, namely,
filled with incomplete data and inconsistent data. In this paper, we
introduce a generalized neighborhood rough sets model, called
VPTNRS, to deal with the problem of heterogeneous attribute
reduction in noisy system. We generalize classical NRS model with
tolerance neighborhood relation and the probabilistic theory.
Furthermore, we use the neighborhood dependency to evaluate the
significance of a subset of heterogeneous attributes and construct a
forward greedy algorithm for attribute reduction based on it.
Experimental results show that the model is efficient to deal with noisy
data.
Abstract: In today-s new technology era, cluster has become a
necessity for the modern computing and data applications since many
applications take more time (even days or months) for computation.
Although after parallelization, computation speeds up, still time
required for much application can be more. Thus, reliability of the
cluster becomes very important issue and implementation of fault
tolerant mechanism becomes essential. The difficulty in designing a
fault tolerant cluster system increases with the difficulties of various
failures. The most imperative obsession is that the algorithm, which
avoids a simple failure in a system, must tolerate the more severe
failures. In this paper, we implemented the theory of watchdog timer
in a parallel environment, to take care of failures. Implementation of
simple algorithm in our project helps us to take care of different
types of failures; consequently, we found that the reliability of this
cluster improves.
Abstract: Object-oriented programming is a wonderful way to
make programming of huge real life tasks much easier than by using
procedural languages. In order to teach those ideas to students, it
is important to find a good task that shows the advantages of OOprogramming
very naturally. This paper gives an example, the game
Battleship, which seems to work excellent for teaching the OO ideas
(using Java, [1], [2], [3], [4]).
A three-step task is presented for how to teach OO-programming
using just one example suitable to convey many of the OO ideas.
Observations are given at the end and conclusions about how the
whole teaching course worked out.
Abstract: This paper has presented research in progress
concerning the contribution of target costing approach to
achievement competitive price in the Iraqi firm. The title of the
paper is one of the subjects that get large concerns in the finance and
business world in the present time. That is because many competitive
firms have appeared in the regional and global markets and the rapid
changes that covered all fields of life. On the other hand, this paper
concentrated on lack knowledge of the industrial firms, regarding the
significant role of target cost for achieving the competitive prices.
The paper depends on the main supposition, using the competitive
price to get the target cost in the industrial firms. In order to achieve
competitive advantage in business world the firms should rely on
modern methods to manage cost and profit. From strategic
perspective the target cost achieves a so powerful competitive
advantage represented in cost reduction. Nevertheless the target cost
does not exclude the calculation and survey of costs during the
production process. Products- estimated costs are calculated and
compared with the target costs.
Abstract: In this study, how affects the narrative of Positive
Psychothreapy which is named “The Three Small Gold Statues "the
adloescent-s perception is investigated The sample included 90
adolescents who were high school students. Firstly the narrative was
read. Then three questions which were about the narrative were
asked. The questions were: What kind of things did you recall what
kind of results did you conculde, and also how could you use this
narrative in your real life problems. Responds were analyzed by
content analysis method. According to research findings the narrative
had a great effect for adolescent perceptions, and also the tale could
be used at school counselling programs.