Abstract: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the conversion of HMG-CoA to mevalonate using NADPH and the enzyme is involved in rate-controlling step of mevalonate. Inhibition of HMGR is considered as effective way to lower cholesterol levels so it is drug target to treat hypercholesterolemia, major risk factor of cardiovascular disease. To discover novel HMGR inhibitor, we performed structure-based pharmacophore modeling combined with molecular dynamics (MD) simulation. Four HMGR inhibitors were used for MD simulation and representative structure of each simulation were selected by clustering analysis. Four structure-based pharmacophore models were generated using the representative structure. The generated models were validated used in virtual screening to find novel scaffolds for inhibiting HMGR. The screened compounds were filtered by applying drug-like properties and used in molecular docking. Finally, four hit compounds were obtained and these complexes were refined using energy minimization. These compounds might be potential leads to design novel HMGR inhibitor.
Abstract: The P-Bigram method is a string comparison methods
base on an internal two characters-based similarity measure. The edit
distance between two strings is the minimal number of elementary
editing operations required to transform one string into the other. The
elementary editing operations include deletion, insertion, substitution
two characters. In this paper, we address the P-Bigram method to
sole the similarity problem in DNA sequence. This method provided
an efficient algorithm that locates all minimum operation in a string.
We have been implemented algorithm and found that our program
calculated that smaller distance than one string. We develop PBigram
edit distance and show that edit distance or the similarity and
implementation using dynamic programming. The performance of
the proposed approach is evaluated using number edit and percentage
similarity measures.
Abstract: The separation of dissolved gas including dissolved oxygen can be used in breathing for a human under water. When one is suddenly wrecked or meets a tsunami, one is instantly drowned and cannot breathe under water. To avoid this crisis, when we meet waves, the dissolved gas separated from water by wave is used, while air can be used to breathe when we are about to escape from water. In this thesis, we investigated the separation characteristics of dissolved gas using the pipe type of hollow fiber membrane with polypropylene and the nude type of one with polysulfone. The hollow fiber membranes with good characteristics under water are used to separate the dissolved gas. The hollow fiber membranes with good characteristics in an air are used to transfer air. The combination of membranes with good separation characteristics under water and good transferring one in an air is used to breathe instantly under water to be alive at crisis. These results showed that polypropylene represented better performance than polysulfone under both of air and water conditions.
Abstract: This work considered the thermodynamic feasibility
of scrubbing volatile organic compounds into biodiesel in view of
designing a gas treatment process with this absorbent. A detailed
vapour – liquid equilibrium investigation was performed using the
original UNIFAC group contribution method. The four biodiesels
studied in this work are methyl oleate, methyl palmitate, methyl
linolenate and ethyl stearate. The original UNIFAC procedure was
used to estimate the infinite dilution activity coefficients of 13
selected volatile organic compounds in the biodiesels. The
calculations were done at the VOC mole fraction of 9.213x10-8. Ethyl
stearate gave the most favourable phase equilibrium. A close
agreement was found between the infinite dilution activity coefficient
of toluene found in this work and those reported in literature.
Thermodynamic models can efficiently be used to calculate vast
amount of phase equilibrium behaviour using limited number of
experimental data.
Abstract: Based on a non-linear single track model which
describes the dynamics of vehicle, an optimal path planning strategy
is developed. Real time optimization is used to generate reference
control values to allow leading the vehicle alongside a calculated lane
which is optimal for different objectives such as energy consumption,
run time, safety or comfort characteristics. Strict mathematic
formulation of the autonomous driving allows taking decision on
undefined situation such as lane change or obstacle avoidance. Based
on position of the vehicle, lane situation and obstacle position, the
optimization problem is reformulated in real-time to avoid the
obstacle and any car crash.
Abstract: This paper presents an algorithm which
combining ant colony optimization in the dynamic
programming for solving a dynamic facility layout problem.
The problem is separated into 2 phases, static and dynamic
phase. In static phase, ant colony optimization is used to find
the best ranked of layouts for each period. Then the dynamic
programming (DP) procedure is performed in the dynamic
phase to evaluate the layout set during multi-period planning
horizon. The proposed algorithm is tested over many
problems with size ranging from 9 to 49 departments, 2 and 4
periods. The experimental results show that the proposed
method is an alternative way for the plant layout designer to
determine the layouts during multi-period planning horizon.
Abstract: There are three distinct stages in the evolution of
economic thought, namely:
1. in the first stage, the major concern was to accelerate
economic growth with increased availability of material
goods, especially in developing economies with very low
living standards, because poverty eradication meant faster
economic growth.
2. in the second stage, economists made distinction between
growth and development. Development was seen as going
beyond economic growth, and bringing certain changes in
the structure of the economy with more equitable
distribution of the benefits of growth, with the growth
coming automatic and sustained.
3. the third stage is now reached. Our concern is now with
“sustainable development", that is, development not only
for the present but also of the future.
Thus the focus changed from “sustained growth" to “sustained
development". Sustained development brings to the fore the long
term relationship between the ecology and economic development.
Since the creation of UNEP in 1972 it has worked for
development without destruction for environmentally sound and
sustained development. It was realised that the environment cannot
be viewed in a vaccum, it is not separate from development, nor is it
competing. It suggested for the integration of the environment with
development whereby ecological factors enter development planning,
socio-economic policies, cost-benefit analysis, trade, technology
transfer, waste management, educational and other specific areas.
Industrialisation has contributed to the growth of economy of
several countries. It has improved the standards of living of its people
and provided benefits to the society. It has also created in the process
great environmental problems like climate change, forest destruction
and denudation, soil erosion and desertification etc.
On the other hand, industry has provided jobs and improved the
prospects of wealth for the industrialists. The working class
communities had to simply put up with the high levels of pollution in
order to keep up their jobs and also to save their income.
There are many roots of the environmental problem. They may be
political, economic, cultural and technological conditions of the
modern society. The experts concede that industrial growth lies
somewhere close to the heart of the matter. Therefore, the objective
of this paper is not to document all roots of an environmental crisis
but rather to discuss the effects of industrial growth and
development.
We have come to the conclusion that although public intervention
is often unnecessary to ensure that perfectly competitive markets will
function in society-s best interests, such intervention is necessary
when firms or consumers pollute.
Abstract: Mathematical programming has been applied to various
problems. For many actual problems, the assumption that the parameters
involved are deterministic known data is often unjustified. In
such cases, these data contain uncertainty and are thus represented
as random variables, since they represent information about the
future. Decision-making under uncertainty involves potential risk.
Stochastic programming is a commonly used method for optimization
under uncertainty. A stochastic programming problem with recourse
is referred to as a two-stage stochastic problem. In this study, we
consider a stochastic programming problem with simple integer
recourse in which the value of the recourse variable is restricted to a
multiple of a nonnegative integer. The algorithm of a dynamic slope
scaling procedure for solving this problem is developed by using a
property of the expected recourse function. Numerical experiments
demonstrate that the proposed algorithm is quite efficient. The
stochastic programming model defined in this paper is quite useful
for a variety of design and operational problems.
Abstract: Grid computing provides an effective infrastructure for massive computation among flexible and dynamic collection of individual system for resource discovery. The major challenge for grid computing is to prevent breaches and secure the data from trespassers. To overcome such conflicts a semantic approach can be designed which will filter the access requests of peers by checking the resource description specifying the data and the metadata as factual statements. Between every node in the grid a semantic firewall as a middleware will be present The intruder will be required to present an application specifying there needs to the firewall and hence accordingly the system will grant or deny the application request.
Abstract: This paper presents a very simple and efficient
algorithm for codebook search, which reduces a great deal of
computation as compared to the full codebook search. The algorithm
is based on sorting and centroid technique for search. The results
table shows the effectiveness of the proposed algorithm in terms of
computational complexity. In this paper we also introduce a new
performance parameter named as Average fractional change in pixel
value as we feel that it gives better understanding of the closeness of
the image since it is related to the perception. This new performance
parameter takes into consideration the average fractional change in
each pixel value.
Abstract: A novel PDE solver using the multidimensional wave
digital filtering (MDWDF) technique to achieve the solution of a 2D
seismic wave system is presented. In essence, the continuous physical
system served by a linear Kirchhoff circuit is transformed to an
equivalent discrete dynamic system implemented by a MD wave
digital filtering (MDWDF) circuit. This amounts to numerically
approximating the differential equations used to describe elements of a
MD passive electronic circuit by a grid-based difference equations
implemented by the so-called state quantities within the passive
MDWDF circuit. So the digital model can track the wave field on a
dense 3D grid of points. Details about how to transform the continuous
system into a desired discrete passive system are addressed. In
addition, initial and boundary conditions are properly embedded into
the MDWDF circuit in terms of state quantities. Graphic results have
clearly demonstrated some physical effects of seismic wave (P-wave
and S–wave) propagation including radiation, reflection, and
refraction from and across the hard boundaries. Comparison between
the MDWDF technique and the finite difference time domain (FDTD)
approach is also made in terms of the computational efficiency.
Abstract: The objective of this paper was to designing a
ventilation system to enhance the performance of roof solar collector
(RSC) for reducing heat accumulation inside the house. The RSC has
1.8 m2 surface area made of CPAC monier roof tiles on the upper part
and gypsum board on the lower part. The space between CPAC
monier and gypsum board was fixed at 14 cm.
Ventilation system of modified roof solar collector (modified
RSC) consists of 9 tubes of 0.15m diameter and installed in the
lower part of RSC. Experimental result showed that the temperature
of the room, and attic temperature. The average temperature
reduction of room of house used modified RSC is about 2oC. and the
percentage of room temperature reduction varied between 0 to 10%.
Therefore, modified RSC is an interesting option in the sense that it
promotes solar energy and conserve energy.
Abstract: Every day human life experiences new equipments
more automatic and with more abilities. So the need for faster
processors doesn-t seem to finish. Despite new architectures and
higher frequencies, a single processor is not adequate for many
applications. Parallel processing and networks are previous solutions
for this problem. The new solution to put a network of resources on a
chip is called NOC (network on a chip). The more usual topology for
NOC is mesh topology. There are several routing algorithms suitable
for this topology such as XY, fully adaptive, etc. In this paper we
have suggested a new algorithm named Intermittent X, Y (IX/Y). We
have developed the new algorithm in simulation environment to
compare delay and power consumption with elders' algorithms.
Abstract: Concept maps can be generated manually or
automatically. It is important to recognize differences of the two
types of concept maps. The automatically generated concept maps
are dynamic, interactive, and full of associations between the terms
on the maps and the underlying documents. Through a specific
concept mapping system, Visual Concept Explorer (VCE), this paper
discusses how automatically generated concept maps are different
from manually generated concept maps and how different
applications and learning opportunities might be created with the
automatically generated concept maps. The paper presents several
examples of learning strategies that take advantages of the
automatically generated concept maps for concept learning and
exploration.
Abstract: Long term rainfall analysis and prediction is a
challenging task especially in the modern world where the impact of
global warming is creating complications in environmental issues.
These factors which are data intensive require high performance
computational modeling for accurate prediction. This research paper
describes a prototype which is designed and developed on grid
environment using a number of coupled software infrastructural
building blocks. This grid enabled system provides the demanding
computational power, efficiency, resources, user-friendly interface,
secured job submission and high throughput. The results obtained
using sequential execution and grid enabled execution shows that
computational performance has enhanced among 36% to 75%, for
decade of climate parameters. Large variation in performance can be
attributed to varying degree of computational resources available for
job execution.
Grid Computing enables the dynamic runtime selection, sharing
and aggregation of distributed and autonomous resources which plays
an important role not only in business, but also in scientific
implications and social surroundings. This research paper attempts to
explore the grid enabled computing capabilities on weather indices
from HOAPS data for climate impact modeling and change
detection.
Abstract: this paper presents a novel neural network controller
with composite adaptation low to improve the trajectory tracking
problems of biped robots comparing with classical controller. The
biped model has 5_link and 6 degrees of freedom and actuated by
Plated Pneumatic Artificial Muscle, which have a very high power to
weight ratio and it has large stoke compared to similar actuators. The
proposed controller employ a stable neural network in to approximate
unknown nonlinear functions in the robot dynamics, thereby
overcoming some limitation of conventional controllers such as PD
or adaptive controllers and guarantee good performance. This NN
controller significantly improve the accuracy requirements by
retraining the basic PD/PID loop, but adding an inner adaptive loop
that allows the controller to learn unknown parameters such as
friction coefficient, therefore improving tracking accuracy.
Simulation results plus graphical simulation in virtual reality show
that NN controller tracking performance is considerably better than
PD controller tracking performance.
Abstract: An end-member selection method for spectral unmixing that is based on Particle Swarm Optimization (PSO) is developed in this paper. The algorithm uses the K-means clustering algorithm and a method of dynamic selection of end-members subsets to find the appropriate set of end-members for a given set of multispectral images. The proposed algorithm has been successfully applied to test image sets from various platforms such as LANDSAT 5 MSS and NOAA's AVHRR. The experimental results of the proposed algorithm are encouraging. The influence of different values of the algorithm control parameters on performance is studied. Furthermore, the performance of different versions of PSO is also investigated.
Abstract: With the advent of inexpensive 32 bit floating point digital signal processor-s availability in market, many computationally intensive algorithms such as Kalman filter becomes feasible to implement in real time. Dynamic simulation of a self excited DC motor using second order state variable model and implementation of Kalman Filter in a floating point DSP TMS320C6713 is presented in this paper with an objective to introduce and implement such an algorithm, for beginners. A fractional hp DC motor is simulated in both Matlab® and DSP and the results are included. A step by step approach for simulation of DC motor in Matlab® and “C" routines in CC Studio® is also given. CC studio® project file details and environmental setting requirements are addressed. This tutorial can be used with 6713 DSK, which is based on floating point DSP and CC Studio either in hardware mode or in simulation mode.
Abstract: This article provides empirical evidence on the effect
of domestic and international factors on the U.S. current account
deficit. Linear dynamic regression and vector autoregression models
are employed to estimate the relationships during the period from 1986
to 2011. The findings of this study suggest that the current and lagged
private saving rate and foreign current account for East Asian
economies have played a vital role in affecting the U.S. current
account. Additionally, using Granger causality tests and variance
decompositions, the change of the productivity growth and foreign
domestic demand are determined to influence significantly the change
of the U.S. current account. To summarize, the empirical relationship
between the U.S. current account deficit and its determinants is
sensitive to alternative regression models and specifications.
Abstract: The present study was designed to investigate the
cardio protective role of chronic oral administration of alcoholic
extract of Terminalia arjuna in in-vivo ischemic reperfusion injury
and the induction of HSP72. Rabbits, divided into three groups, and
were administered with the alcoholic extract of the bark powder of
Terminalia arjuna (TAAE) by oral gavage [6.75mg/kg: (T1) and
9.75mg/kg: (T2), 6 days /week for 12 weeks]. In open-chest
Ketamine pentobarbitone anaesthetized rabbits, the left anterior
descending coronary artery was occluded for 15 min of ischemia
followed by 60 min of reperfusion. In the vehicle-treated group,
ischemic-reperfusion injury (IRI) was evidenced by depression of
global hemodynamic function (MAP, HR, LVEDP, peak LV (+) & (-
) (dP/dt) along with depletion of HEP compounds. Oxidative stress
in IRI was evidenced by, raised levels of myocardial TBARS and
depletion of endogenous myocardial antioxidants GSH, SOD and
catalase. Western blot analysis showed a single band corresponding
to 72 kDa in homogenates of hearts from rabbits treated with both the
doses. In the alcoholic extract of the bark powder of Terminalia
arjuna treatment groups, both the doses had better recovery of
myocardial hemodynamic function, with significant reduction in
TBARS, and rise in SOD, GSH, catalase were observed. The results
of the present study suggest that the alcoholic extract of the bark
powder of Terminalia arjuna in rabbit induces myocardial HSP 72
and augments myocardial endogenous antioxidants, without causing
any cellular injury and offered better cardioprotection against
oxidative stress associated with myocardial IR injury.