Abstract: For the treatment of acute and chronic lung diseases it is preferred to deliver medicaments by inhalation. The drug is delivered directly to tracheobronchial tree. This way allows the given medicament to get directly into the place of action and it makes rapid onset of action and maximum efficiency. The transport of aerosol particles in the particular part of the lung is influenced by their size, anatomy of the lungs, breathing pattern and airway resistance. This article deals with calculation of airway resistance in the lung model of Horsfield. It solves the problem of determination of the pressure losses in bifurcation and thus defines the pressure drop at a given location in the bronchial tree. The obtained data will be used as boundary conditions for transport of aerosol particles in a central part of bronchial tree realized by Computational Fluid Dynamics (CFD) approach. The results obtained from CFD simulation will allow us to provide information on the required particle size and optimal inhalation technique for particle transport into particular part of the lung.
Abstract: Vegetation affects the mean and turbulent flow
structure. It may increase flood risks and sediment transport.
Therefore, it is important to develop analytical approaches for the bed
shear stress on vegetated bed, to predict resistance caused by
vegetation. In the recent years, experimental and numerical models
have both been developed to model the effects of submerged
vegetation on open-channel flow. In this paper, different analytic
models are compared and tested using the criteria of deviation, to
explore their capacity for predicting the mean velocity and select the
suitable one that will be applied in real case of rivers. The
comparison between the measured data in vegetated flume and
simulated mean velocities indicated, a good performance, in the case
of rigid vegetation, whereas, Huthoff model shows the best
agreement with a high coefficient of determination (R2=80%) and the
smallest error in the prediction of the average velocities.
Abstract: A strain of Monascus purpureus CMU001 was used to
prepare red yeast rice from Thai glutinous rice Korkor 6 (RD 6).
Adding of different amounts of histidine (156, 312, 625 and 1250 mg
in 100 g of rice grains)) under aerobic and air limitation (air-lock)
condition were used in solid fermentation. Determination of the yield
as well as monacolin K content was done. Citrinin content was also
determined in order to confirm the safety use of prepared red yeast
rice. It was found that under air-lock condition with 1250 mg of
histidine addition gave the highest yield of 37.40 g of dried red yeast
rice prepared from 100 g of rice. Highest 5.72 mg content of
monacolin K was obtained under air-lock condition with 312 mg
histidine addition. In the other hand, citrinin content was found to be
less than 24462 ng/g of all dried red yeast rice samples under the
experimental methods used in this work.
Abstract: In this study which has been conducted in Akçasu
Forest Range District of Devrek Forest Directorate; 3 methods (weed
control with labourer power, cover removal with Hitachi F20
Excavator, and weed control with agricultural equipment mounted on
a Ferguson 240S agriculture tractor) were utilized in weed control
efforts in regeneration of degraded oriental beech forests have been
compared. In this respect, 3 methods have been compared by
determining certain work hours and standard durations of unit areas
(1 hectare). For this purpose, evaluating the tasks made with human
and machine force from the aspects of duration, productivity and
costs, it has been aimed to determine the most productive method in
accordance with the actual ecological conditions of research field.
Within the scope of the study, the time studies have been conducted
for 3 methods used in weed control efforts. While carrying out those
studies, the performed implementations have been evaluated by
dividing them into business stages. Also, the actual data have been
used while calculating the cost accounts. In those calculations, the
latest formulas and equations which are also used in developed
countries have been utilized. The variance of analysis (ANOVA) was
used in order to determine whether there is any statistically
significant difference among obtained results, and the Duncan test
was used for grouping if there is significant difference. According to
the measurements and findings carried out within the scope of this
study, it has been found during living cover removal efforts in
regeneration efforts in demolished oriental beech forests that the
removal of weed layer in 1 hectare of field has taken 920 hours with
labourer force, 15.1 hours with excavator and 60 hours with an
equipment mounted on a tractor. On the other hand, it has been
determined that the cost of removal of living cover in unit area (1
hectare) was 3220.00 TL for labourer power, 1250 TL for excavator
and 1825 TL for equipment mounted on a tractor.
According to the obtained results, it has been found that the
utilization of excavator in weed control effort in regeneration of
degraded oriental beech regions under actual ecological conditions of
research field has been found to be more productive from both of
aspects of duration and costs. These determinations carried out
should be repeated in weed control efforts in degraded forest fields
with different ecological conditions, it is compulsory for finding the
most efficient weed control method. These findings will light the way
of technical staff of forestry directorate in determination of the most
effective and economic weed control method. Thus, the more actual
data will be used while preparing the weed control budgets, and there
will be significant contributions to national economy. Also the results of this and similar studies are very important for developing the policies for our forestry in short and long term.
Abstract: Logistics distributors face the issue of having to
provide increasing service levels while being forced to reduce costs at
the same time. Same-day delivery, quick order processing and rapidly
growing ranges of articles are only some of the prevailing challenges.
One key aspect of the performance of an intra-logistics system is how
often and in which amplitude congestions and dysfunctions affect the
processing operations. By gaining knowledge of the so called
‘performance availability’ of such a system during the planning stage,
oversizing and wasting can be reduced whereas planning
transparency is increased. State of the art for the determination of this
KPI is simulation studies. However, their structure and therefore their
results may vary unforeseeably. This article proposes a concept for
the establishment of ‘certified’ and hence reliable and comparable
simulation models.
Abstract: Brown seaweeds are abundant in Portuguese coastline
and represent an almost unexploited marine economic resource. One
of the most common species, easily available for harvesting in the
northwest coast, is Saccorhiza polyschides grows in the lowest shore
and costal rocky reefs. It is almost exclusively used by local farmers
as natural fertilizer, but contains a substantial amount of valuable
compounds, particularly alginates, natural biopolymers of high
interest for many industrial applications.
Alginates are natural polysaccharides present in cell walls of
brown seaweed, highly biocompatible, with particular properties that
make them of high interest for the food, biotechnology, cosmetics
and pharmaceutical industries. Conventional extraction processes are
based on thermal treatment. They are lengthy and consume high
amounts of energy and solvents. In recent years, microwave-assisted
extraction (MAE) has shown enormous potential to overcome major
drawbacks that outcome from conventional plant material extraction
(thermal and/or solvent based) techniques, being also successfully
applied to the extraction of agar, fucoidans and alginates. In the
present study, acid pretreatment of brown seaweed Saccorhiza
polyschides for subsequent microwave-assisted extraction (MAE) of
alginate was optimized. Seaweeds were collected in Northwest
Portuguese coastal waters of the Atlantic Ocean between May and
August, 2014. Experimental design was used to assess the effect of
temperature and acid pretreatment time in alginate extraction.
Response surface methodology allowed the determination of the
optimum MAE conditions: 40 mL of HCl 0.1 M per g of dried
seaweed with constant stirring at 20ºC during 14h. Optimal acid
pretreatment conditions have enhanced significantly MAE of
alginates from Saccorhiza polyschides, thus contributing for the
development of a viable, more environmental friendly alternative to
conventional processes.
Abstract: The extermination and proper disposal of
pharmaceutical wastes from expired and unused medications remains
a disputable issue due to their specific nature and characteristics.
Even though the hazards from these wastes are already well known in
terms of environment and human health, people still treat them as
usual wastes. At a national level, in many countries the management
of pharmaceutical and medical wastes has been one of the main
objectives in order to protect people’s health and the environment.
Even though many legal regulations exist in this respect, there has not
been a single law that would clearly explain the procedures of
returning medicines, ways of selection, treatment and extermination
of pharmaceutical wastes. This paper aims at analyzing the practices
of pharmaceutical waste management and treatment in some
European countries as well as a review of the legislation and official
guidelines in managing these kinds of wastes and protecting the
environment and human health. A suitable treatment and
management of expired medications and other similar wastes would
be in the interest of public health in the first place, as well as in the
interest of healthcare institutions and other bodies engaged in
environment protection.
Abstract: Learner motivation is considered to be an important
component for the Blended e-Learning (BL) Method. BL is an
effective learning method in multiple domains, which opens several
opportunities for its participants to engage in the learning
environment. This research explores the learners’ perspective of BL
according to the Self-Determination Theory (SDT). It identifies the
opportunities and challenges for using the BL in Logistics Education
(LE) in Egyptian Higher Education (HE). SDT is approached from
different perspectives within the relationship between Intrinsic
Motivation (IM), Extrinsic Motivation (EM) and Amotivation (AM).
A self-administered face-to-face questionnaire was used to collect
data from learners who were geographically widely spread around
three colleges of International Transport and Logistics (CILTs) at the
Arab Academy for Science, Technology and Maritime Transport
(AAST&MT) in Egypt. Six hundred and sixteen undergraduates
responded to a questionnaire survey. Respondents were drawn from
three branches in Greater Cairo, Alexandria, and Port Said. The data
analysis used was SPSS 22 and AMOS 18.
Abstract: In this paper the CVA computation of interest rate
swap is presented based on its rating. Rating and probability default
given by Moody’s Investors Service are used to calculate our CVA
for a specific swap with different maturities. With this computation
the influence of rating variation can be shown on CVA. Application
is made to the analysis of Greek CDS variation during the period of
Greek crisis between 2008 and 2011. The main point is the
determination of correlation between the fluctuation of Greek CDS
cumulative value and the variation of swap CVA due to change of
rating.
Abstract: Due to the determination of the pollution status of
fresh resources in the Egyptian territorial waters is very important for
public health; this study was carried out to reveal the levels of heavy
metals in the shellfish and their environment and its relation to the
highly developed industrial activities in those areas. A total of 100
shellfish samples from the Rosetta, Edku, El-Maadiya, Abo-Kir and
El-Max coasts [10 crustaceans (shrimp) and 10 mollusks (oysters)]
were randomly collected from each coast. Additionally, 10 samples
from both the water and the sediment were collected from each coast.
Each collected sample was analyzed for cadmium, chromium,
copper, lead and zinc residues using a Perkin Elmer atomic
absorption spectrophotometer (AAS). The results showed that the
levels of heavy metals were higher in the water and sediment from
Abo-Kir. The heavy metal levels decreased successively for the
Rosetta, Edku, El-Maadiya, and El-Max coasts, and the
concentrations of heavy metals, except copper and zinc, in shellfish
exhibited the same pattern. For the concentration of heavy metals in
shellfish tissue, the highest was zinc and the concentrations decreased
successively for copper, lead, chromium and cadmium for all coasts,
except the Abo-Kir coast, where the chromium level was highest and
the other metals decreased successively for zinc, copper, lead and
cadmium. In Rosetta, chromium was higher only in the mollusks,
while the level of this metal was lower in the crustaceans; this trend
was observed at the Edku, El-Maadiya and El-Max coasts as well.
Herein, we discuss the importance of such contamination for public
health and the sources of shellfish contamination with heavy metals.
We suggest measures to minimize and prevent these pollutants in the
aquatic environment and, furthermore, how to protect humans from
excessive intake.
Abstract: Pesticides and drugs used in agriculture and veterinary
medicine may end up in aquatic environments and bioaccumulate in
the food chain, thus causing serious problems for fauna and human
health. For determination of the toxic effects of atrazine herbicide on
Caspian kutum, Rutilus frisii kutum larvae, the 96-h LC50 of atrazine
was measured for newly hatched larvae as 18.53 ppm. Toxicity of
atrazine herbicide on Caspian kutum larvae was investigated using
concentrations: 9.25ppm, 4.62 ppm and 2.31 ppm for 7 days.
Comparison of the length, weight and condition factor showed that
no significant differences between atrazine exposed and control
groups. The concentration of Na+, K+, Ca2+, Mg2+ and Cl- in whole
body of larvae in control and atrazine exposure groups were
measured and the results showed that concentrations of all these ions
is higher in atrazine exposure group than control group. It is obvious
from this study that atrazine negatively affects osmoregulation
process and changes ion compositions of the body even at sublethal
concentration and acute exposure but have no effects on growth
parameters of the body.
Abstract: Distributed Generation (DG) can help in reducing the
cost of electricity to the costumer, relieve network congestion and
provide environmentally friendly energy close to load centers. Its
capacity is also scalable and it provides voltage support at distribution
level. Hence, DG placement and penetration level is an important
problem for both the utility and DG owner. DG allocation and capacity
determination is a nonlinear optimization problem. The objective
function of this problem is the minimization of the total loss of the
distribution system. Also high levels of penetration of DG are a new
challenge for traditional electric power systems. This paper presents a
new methodology for the optimal placement of DG and penetration
level of DG in distribution system based on General Algebraic
Modeling System (GAMS) and Genetic Algorithm (GA).
Abstract: Assertion-Based software testing has been shown to
be a promising tool for generating test cases that reveal program
faults. Because the number of assertions may be very large for
industry-size programs, one of the main concerns to the applicability
of assertion-based testing is the amount of search time required to
explore a large number of assertions. This paper presents a new
approach for assertions exploration during the process of Assertion-
Based software testing. Our initial exterminations with the proposed
approach show that the performance of Assertion-Based testing may
be improved, therefore, making this approach more efficient when
applied on programs with large number of assertions.
Abstract: Preparation of nanoparticles of cerium oxide and
adsorption of bovine serum albumin on them were studied. Particle
size distribution and influence of pH on zeta potential of prepared
CeO2 were determined. Average size of prepared cerium oxide
nanoparticles was 9 nm. The simultaneous measurements of the
bovine serum albumin adsorption and zeta potential determination of
the (adsorption) suspensions were carried out. The adsorption
isotherms were found to be of typical Langmuir type; values of the
bovine serum albumin adsorption capacities were calculated.
Increasing of pH led to decrease of zeta potential and decrease of
adsorption capacity of cerium oxide nanoparticles. The maximum
adsorption capacity was found for strongly acid suspension (am =
118 mg/g). The samples of nanoceria with positive zeta potential
adsorbed more bovine serum albumin on the other hand, the samples
with negative zeta potential showed little or no protein adsorption.
Surface charge or better say zeta potential of CeO2 nanoparticles
plays the key role in adsorption of proteins on such type of materials.
Abstract: One of the most important tasks in the risk
management is the correct determination of probability of default
(PD) of particular financial subjects. In this paper a possibility of
determination of financial institution’s PD according to the creditscoring
models is discussed. The paper is divided into the two parts.
The first part is devoted to the estimation of the three different
models (based on the linear discriminant analysis, logit regression
and probit regression) from the sample of almost three hundred US
commercial banks. Afterwards these models are compared and
verified on the control sample with the view to choose the best one.
The second part of the paper is aimed at the application of the chosen
model on the portfolio of three key Czech banks to estimate their
present financial stability. However, it is not less important to be able
to estimate the evolution of PD in the future. For this reason, the
second task in this paper is to estimate the probability distribution of
the future PD for the Czech banks. So, there are sampled randomly
the values of particular indicators and estimated the PDs’ distribution,
while it’s assumed that the indicators are distributed according to the
multidimensional subordinated Lévy model (Variance Gamma model
and Normal Inverse Gaussian model, particularly). Although the
obtained results show that all banks are relatively healthy, there is
still high chance that “a financial crisis” will occur, at least in terms
of probability. This is indicated by estimation of the various quantiles
in the estimated distributions. Finally, it should be noted that the
applicability of the estimated model (with respect to the used data) is
limited to the recessionary phase of the financial market.
Abstract: Different services based on different switching
techniques in wireless networks leads to drastic changes in the
properties of network traffic. Because of these diversities in services,
network traffic is expected to undergo qualitative and quantitative
variations. Hence, assumption of traffic characteristics and the
prediction of network events become more complex for the wireless
networks. In this paper, the traffic characteristics have been studied
by collecting traces from the mobile switching centre (MSC). The
traces include initiation and termination time, originating node, home
station id, foreign station id. Traffic parameters namely, call interarrival
and holding times were estimated statistically. The results
show that call inter-arrival and distribution time in this wireless
network is heavy-tailed and follow gamma distributions. They are
asymptotically long-range dependent. It is also found that the call
holding times are best fitted with lognormal distribution. Based on
these observations, an analytical model for performance estimation is
also proposed.
Abstract: The purpose of this project is to carry out an analysis
and determine the profile of actual lean manufacturing processes in
the Metropolitan Area of Bucaramanga. Through the analysis of
qualitative and quantitative variables it was possible to establish how
these manufacturers develop production practices that ensure their
competitiveness and productivity in the market.
In this study, a random sample of metallurgic and wrought iron
companies was applied, following which a quantitative focus and
analysis was used to formulate a qualitative methodology for
measuring the level of lean manufacturing procedures in the industry.
A qualitative evaluation was also carried out through a multivariate
analysis using the Numerical Taxonomy System (NTSYS) program
which should allow for the determination of Lean Manufacturing
profiles.
Through the results it was possible to observe how the companies
in the sector are doing with respect to Lean Manufacturing Practices,
as well as identify the level of management that these companies
practice with respect to this topic. In addition, it was possible to
ascertain that there is no one dominant profile in the sector when it
comes to Lean Manufacturing.
It was established that the companies in the metallurgic and
wrought iron industry show low levels of Lean Manufacturing
implementation. Each one carries out diverse actions that are
insufficient to consolidate a sectoral strategy for developing a
competitive advantage which enables them to tie together a
production strategy.
Abstract: Characterization of the engineering behavior of
unsaturated soil is dependent on the soil-water characteristic curve
(SWCC), a graphical representation of the relationship between water
content or degree of saturation and soil suction. A reasonable
description of the SWCC is thus important for the accurate prediction
of unsaturated soil parameters. The measurement procedures for
determining the SWCC, however, are difficult, expensive, and timeconsuming.
During the past few decades, researchers have laid a
major focus on developing empirical equations for predicting the
SWCC, with a large number of empirical models suggested. One of
the most crucial questions is how precisely existing equations can
represent the SWCC. As different models have different ranges of
capability, it is essential to evaluate the precision of the SWCC
models used for each particular soil type for better SWCC estimation.
It is expected that better estimation of SWCC would be achieved via
a thorough statistical analysis of its distribution within a particular
soil class. With this in view, a statistical analysis was conducted in
order to evaluate the reliability of the SWCC prediction models
against laboratory measurement. Optimization techniques were used
to obtain the best-fit of the model parameters in four forms of SWCC
equation, using laboratory data for relatively coarse-textured (i.e.,
sandy) soil. The four most prominent SWCCs were evaluated and
computed for each sample. The result shows that the Brooks and
Corey model is the most consistent in describing the SWCC for sand
soil type. The Brooks and Corey model prediction also exhibit
compatibility with samples ranging from low to high soil water
content in which subjected to the samples that evaluated in this study.
Abstract: This article presents a new vibration diagnostic
method designed to (PM) machines with permanent magnets. Those
devices are commonly used in small wind and water systems or
vehicles drives. The author’s method is very innovative and unique.
Specific structural properties of PM machines are used in this method
- electromotive force (EMF) generated due to vibrations. There was
analysed number of publications which describe vibration diagnostic
methods and tests of electrical PM machines and there was no
method found to determine the technical condition of such machine
basing on their own signals. In this article will be discussed: the
method genesis, the similarity of machines with permanent magnet to
vibration sensor and simulation and laboratory tests results. The
method of determination the technical condition of electrical machine
with permanent magnets basing on its own signals is the subject of
patent application and it is the main thesis of author’s doctoral
dissertation.
Abstract: In order to efficiently solve the problems created by the deepening energy crisis affecting Europe and the world,
governments cannot neglect the opportunities of using the energy
produced by sun collectors. In many of the EU countries there are sun
collectors producing heat energy, e.g. in 2011 in the area of EU27
(countries which belong to European Union) + Switzerland altogether
37519126 m2 were operated, which are capable of producing 26.3
GWh heat energy. The energy produced by these sun collectors is
utilized at the place of production. In the near future governments
will have to focus more on spreading and using sun collectors.
Among the complex problems of operating sun collectors, this article
deals with determining the optimal tilt angle, directions of sun
collectors. We evaluate the contamination of glass surface of sun
collector to the produced energy. Our theoretically results are confirmed by laboratory measurements. The purpose of our work is to help users and engineers in determination of optimal operation
parameters of sun collectors.