Abstract: The extermination and proper disposal of
pharmaceutical wastes from expired and unused medications remains
a disputable issue due to their specific nature and characteristics.
Even though the hazards from these wastes are already well known in
terms of environment and human health, people still treat them as
usual wastes. At a national level, in many countries the management
of pharmaceutical and medical wastes has been one of the main
objectives in order to protect people’s health and the environment.
Even though many legal regulations exist in this respect, there has not
been a single law that would clearly explain the procedures of
returning medicines, ways of selection, treatment and extermination
of pharmaceutical wastes. This paper aims at analyzing the practices
of pharmaceutical waste management and treatment in some
European countries as well as a review of the legislation and official
guidelines in managing these kinds of wastes and protecting the
environment and human health. A suitable treatment and
management of expired medications and other similar wastes would
be in the interest of public health in the first place, as well as in the
interest of healthcare institutions and other bodies engaged in
environment protection.
Abstract: In this study, cometabolic biodegradation of
chloroform was experimented with mixed cultures in the presence of
various organic solvents like methanol, ethanol, isopropanol, acetone,
acetonitrile and toluene as these are predominant discharges in
pharmaceutical industries. Toluene and acetone showed higher
specific chloroform degradation rate when compared to other
compounds. Cometabolic degradation of chloroform was further
confirmed by observation of free chloride ions in the medium. An
extended Haldane model, incorporating the inhibition due to
chloroform and the competitive inhibition between primary
substrates, was developed to predict the biodegradation of primary
substrates, cometabolic degradation of chloroform and the biomass
growth. The proposed model is based on the use of biokinetic
parameters obtained from single substrate degradation studies. The
model was able to satisfactorily predict the experimental results of
ternary and quaternary mixtures. The proposed model can be used for
predicting the performance of bioreactors treating discharges from
pharmaceutical industries.
Abstract: Ciprofloxacin (CIP) and Carbamazepine (CBZ), nonbiodegradable pharmaceutical residues, were become emerging pollutants in several aquatic environments. The objectives of this research were to study the possibility to recover these pharmaceuticals residues from pharmaceutical wastewater by increasing the selective adsorption on synthesized functionalized porous silicate, comparing with powdered activated carbon (PAC). Hexagonal mesoporous silicate (HMS), functionalized HMSs (3- aminopropyltriethoxy, 3- mercaptopropyltrimethoxy and noctyldimethyl) were synthesized and characterized physico-chemical characteristics. Obtained adsorption kinetics and isotherms showed that 3-mercaptopropyltrimethoxy functional groups grafted on HMS provided highest CIP and CBZ adsorption capacities; however, it was still lower than that of PAC. The kinetic results were compatible with pseudo-second order. The hydrophobicity and hydrogen bonding might play a key role on the adsorption. Furthermore, the capacities were affected by varying pH values due to the strength of hydrogen bonding between targeted compounds and adsorbents. Electrostatic interaction might not affect the adsorption capacities.
Abstract: Pharmaceutical industries and effluents of sewage treatment plants are the main sources of residual pharmaceuticals in water resources. These emergent pollutants may adversely impact the biophysical environment. Pharmaceutical industries often generate wastewater that changes in characteristics and quantity depending on the used manufacturing processes. Carbamazepine (CBZ), {5Hdibenzo [b,f]azepine-5-carboxamide, (C15H12N2O)}, is a significant non-biodegradable pharmaceutical contaminant in the Jordanian pharmaceutical wastewater, which is not removed by the activated sludge processes in treatment plants. Activated carbon may potentially remove that pollutant from effluents, but the high cost involved suggests that more attention should be given to the potential use of low-cost materials in order to reduce cost and environmental contamination. Powders of Jordanian non-metallic raw materials namely, Azraq Bentonite (AB), Kaolinite (K), and Zeolite (Zeo) were activated (acid and thermal treatment) and evaluated by removing CBZ. The results of batch and column techniques experiments showed around 46% and 67% removal of CBZ respectively.