Abstract: This paper presents results of the survey regarding the
awareness about HIV/AIDS among HIV-infected individuals. A
questionnaire covering various aspects of HIV-infection was
conducted among 110 HIV-infected individuals who attended the
G.A. Zaharyan Moscow Tuberculosis Clinic, Department for
treatment of TB patients with HIV. The questionnaire included
questions about modes of HIV transmission and preventive measures
against HIV/AIDS, as well as questions about age, gender, education
and employment status. The survey revealed that the respondents in
the whole had a good knowledge regarding modes of HIV
transmission and preventive measures against HIV/AIDS: about
83,6% male respondents and 85,7% female respondents gave an
accurate answers regarding the HIV-infection. However, the
overwhelming majority of the study participants, that is, 88,5% men
and 98% women, was quite ignorant about the risk of acquiring HIV
through saliva and toothbrush of HIV-infected individual. Though
that risk is rather insignificant, it is still biologically possible. And
this gap in knowledge needs to be filled. As the study showed another
point of concern was the fact, that despite the knowledge of HIV
transmission risk through unprotected sex about 40% percent of HIVpositive
men and 25% of HIV-positive women did not insist on using
condoms with their sexual partners. These findings indicate that there
are still some aspects about HIV-infection which needed to be
clarified and explained through more detailed and specific
educational programs.
Abstract: Phonocardiography is important in appraisal of
congenital heart disease and pulmonary hypertension as it reflects the
duration of right ventricular systoles. The systolic murmur in patients
with intra-cardiac shunt decreases as pulmonary hypertension
develops and may eventually disappear completely as the pulmonary
pressure reaches systemic level. Phonocardiography and auscultation
are non-invasive, low-cost, and accurate methods to assess heart
disease. In this work an objective signal processing tool to extract
information from phonocardiography signal using Wavelet is
proposed to classify the murmur as normal or abnormal. Since the
feature vector is large, a Binary Particle Swarm Optimization (PSO)
with mutation for feature selection is proposed. The extracted
features improve the classification accuracy and were tested across
various classifiers including Naïve Bayes, kNN, C4.5, and SVM.
Abstract: The goal of this paper is to present the diagnostic
contribution that the screening instrument, Mini-Mental State
Examination-2: Expanded Version (MMSE-2:EV), brings in
detecting the cognitive impairment or in monitoring the progress of
degenerative disorders. The diagnostic signification is underlined by
the interpretation of the MMSE-2:EV scores, resulted from the test
application to patients with mild and major neurocognitive disorders.
The cases were selected from current practice, in order to cover vast
and significant neurocognitive pathology: mild cognitive impairment,
Alzheimer’s disease, vascular dementia, mixed dementia, Parkinson’s
disease, conversion of the mild cognitive impairment into
Alzheimer’s disease. The MMSE-2:EV version was used: it was
applied one month after the initial assessment, three months after the
first reevaluation and then every six months, alternating the blue and
red forms. Correlated with age and educational level, the raw scores
were converted in T scores and then, with the mean and the standard
deviation, the z scores were calculated. The differences of raw scores
between the evaluations were analyzed from the point of view of
statistic signification, in order to establish the progression in time of
the disease. The results indicated that the psycho-diagnostic approach
for the evaluation of the cognitive impairment with MMSE-2:EV is
safe and the application interval is optimal. In clinical settings with a
large flux of patients, the application of the MMSE-2:EV is a safe
and fast psychodiagnostic solution. The clinicians can draw objective
decisions and for the patients: it does not take too much time and
energy, it does not bother them and it doesn’t force them to travel
frequently.
Abstract: Background: The change in foot posture can possibly
generate changes in the pelvic alignment. There is still a lack of
evidence about the effects of bilateral and unilateral flatfoot on
possible changes in pelvic alignment. The purpose of this study was
to investigate the effect of flatfoot on the sagittal and frontal planes of
pelvic postures. Materials and Methods: 56 subjects, aged 18–40
years, were assigned into three groups: 20 healthy subjects, 19
subjects with bilateral flexible second-degree flat foot, and 17
subjects with unilateral flexible second-degree flat foot. 3D
assessment of the pelvis using the formetric-II device was used to
evaluate pelvic alignment in the frontal and sagittal planes by
measuring pelvic inclination and pelvic tilt angles. Results: ANOVA
test with LSD test were used for statistical analysis. Both Unilateral
and bilateral second degree flatfoot produced significant (P
Abstract: This paper presents the design, development and
evaluation of an application prototype developed to support
tuberculosis (TB) patients’ treatment adherence. The system makes
use of graphics and voice reminders as opposed to text messaging to
encourage patients to follow their medication routine. To evaluate the
effect of the prototype applications, participants were given mobile
phones on which the reminder system was installed. Thirty-eight
people, including TB health workers and patients from Zanzibar,
Tanzania, participated in the evaluation exercises. The results
indicate that the participants found the mobile image-based
application is useful to support TB treatment. All participants
understood and interpreted the intended meaning of every image
correctly. The study findings revealed that the use of a mobile visualbased
application may have potential benefit to support TB patients
(both literate and illiterate) in their treatment processes.
Abstract: Breast cancer is in the top rate of cancer. We analyzed
the prevalence of obesity and its association with breast cancer and
finally we reviewed 25 article that 320 patient and 320 control which
enrolled to our study. The distribution of breast cancer patients and
controls with respect to their anthropometric indices in patients with
higher weight, which was statistically significant (60.2 ± 10.2 kg)
compared with control group (56.1 ± 11.3 kg). The body mass index
of patients was (26.06+/-3.42) and significantly higher than the
control group (24.1+/-1.7). Obesity leads to increased levels of
adipose tissue in the body that can be stored toxins and carcinogens
to produce a continuous supply. Due to the high level of fat and the
role of estrogen in a woman which is endogenous estrogen of the
tumor and regulates the activities of growth steroids, obesity has
confirmed as a risk factor for breast cancer. Our study and other
studies have shown that obesity is a risk factor for breast cancer. And
it can be prevented with a weight loss intervention for breast cancer
in the future.
Abstract: This study, for its research subjects, uses patients who
had undergone total knee replacement surgery from the database of the
National Health Insurance Administration. Through the review of
literatures and the interviews with physicians, important factors are
selected after careful screening. Then using Cross Entropy Method,
Genetic Algorithm Logistic Regression, and Particle Swarm
Optimization, the weight of each factor is calculated and obtained. In
the meantime, Excel VBA and Case Based Reasoning are combined
and adopted to evaluate the system. Results show no significant
difference found through Genetic Algorithm Logistic Regression and
Particle Swarm Optimization with over 97% accuracy in both
methods. Both ROC areas are above 0.87. This study can provide
critical reference to medical personnel as clinical assessment to
effectively enhance medical care quality and efficiency, prevent
unnecessary waste, and provide practical advantages to resource
allocation to medical institutes.
Abstract: In recent years a new method of combination
treatment for cancer has been developed and studied that has led to
significant advancements in the field of cancer therapy. Hyperthermia
is a traditional therapy that, along with a creation of a medically
approved level of heat with the help of an alternating magnetic AC
current, results in the destruction of cancer cells by heat. This paper
gives details regarding the production of the spherical nanocomposite
PVA/γ-Fe2O3 in order to be used for medical purposes such as tumor
treatment by hyperthermia. To reach a suitable and evenly distributed
temperature, the nanocomposite with core-shell morphology and
spherical form within a 100 to 200 nanometer size was created using
phase separation emulsion, in which the magnetic nano-particles γ-
Fe2O3 with an average particle size of 20 nano-meters and with
different percentages of 0.2, 0.4, 0.5 and 0.6 were covered by
polyvinyl alcohol. The main concern in hyperthermia and heat
treatment is achieving desirable specific absorption rate (SAR) and
one of the most critical factors in SAR is particle size. In this project
all attempts has been done to reach minimal size and consequently
maximum SAR. The morphological analysis of the spherical
structure of the nanocomposite PVA/γ-Fe2O3 was achieved by SEM
analyses and the study of the chemical bonds created was made
possible by FTIR analysis. To investigate the manner of magnetic
nanocomposite particle size distribution a DLS experiment was
conducted. Moreover, to determine the magnetic behavior of the γ-
Fe2O3 particle and the nanocomposite PVA/γ-Fe2O3 in different
concentrations a VSM test was conducted. To sum up, creating
magnetic nanocomposites with a spherical morphology that would be
employed for drug loading opens doors to new approaches in
developing nanocomposites that provide efficient heat and a
controlled release of drug simultaneously inside the magnetic field,
which are among their positive characteristics that could significantly
improve the recovery process in patients.
Abstract: The future and the development of science is therefore
seen in interdisciplinary areas such as biomedical engineering. Selfassembled
structures, similar to stem cell niches would inhibit fast
division process and subsequently capture the stem cells from the
blood flow. By means of surface topography and the stiffness as well
as microstructure progenitor cells should be differentiated towards
the formation of endothelial cells monolayer which effectively will
inhibit activation of the coagulation cascade. The idea of the material
surface development met the interest of the clinical institutions,
which support the development of science in this area and are waiting
for scientific solutions that could contribute to the development of
heart assist systems. This would improve the efficiency of the
treatment of patients with myocardial failure, supported with artificial
heart assist systems. Innovative materials would enable the redesign,
in the post project activity, construction of ventricular heart assist.
Abstract: Hemoglobin (HB) indicates anemia level and by
extension may reflect the nutritional level and perhaps the immunity
of an individual. Some antiretroviral drugs like Zidovudine are
known to cause anemia in people living with HIV/AIDS (PLWHA).
A cross sectional study using demographic data and blood specimen
from 218 female commercial sex workers attending antiretroviral
therapy (ART) clinics was conducted between December, 2009 and
July, 2011 to assess the effect of zidovudine on hematologic, and
RNA viral load of female sex workers receiving antiretroviral
treatment in north western Nigeria. Anemia is a common and serious
complication of both HIV infection and its treatment. In the setting of
HIV infection, anemia has been associated with decreased quality of
life, functional status, and survival. Antiretroviral therapy,
particularly the highly active antiretroviral therapy (HAART), has
been associated with a decrease in the incidence and severity of
anemia in HIV-infected patients who have received a HAART
regimen for at least 1 year. In this study, result has shown that of the
218 patients, 26 with hemoglobin count between 5.1 – 10g/dl were
observed to have the highest viral load count of 300,000 –
350,000copies/ml. It was also observed that most patients (190) with
HB of 10.1 – 15.0g/dl had viral load count of 200,000 – 250,000
copies /ml. An inverse relationship therefore exists i.e. the lower the
hemoglobin level, the higher the viral load count even though the test
statistics did not show any significance between the two (P = 0.206).
This shows that multivariate logistic regression analysis
demonstrated that anemia was associated with a CD4 + cell count
below 50/μL, female sex workers with a viral load above 100,000
copies/mL, who use zidovudine.
Severe anemia was less prevalent in this study population than in
historical comparators; however, mild to moderate anemia rates
remain high. The study therefore recommends that hematological and
virologic parameters be monitored closely in patients receiving first
line ART regimen.
Abstract: Obesity and osteoporosis are the two diseases whose
increasing prevalence and high impact on the global morbidity and
mortality, during the two recent decades, have gained a status of
major health threats worldwide. Obesity purports to affect the bone
metabolism through complex mechanisms. Debated data on the
connection between the bone mineral density and fracture prevalence
in the obese patients are widely presented in literature. There is
evidence that the correlation of weight and fracture risk is sitespecific.
This study is aimed at determining the connection between
the bone mineral density (BMD) and trabecular bone score (TBS)
parameters in Ukrainian women suffering from obesity. We
examined 1025 40-89-year-old women, divided them into the groups
according to their body mass index: Group A included 360 women
with obesity whose BMI was ≥30 kg/m2, and Group B – 665 women
with no obesity and BMI of
Abstract: Auditory hallucinations among the most invalidating
and distressing experiences reported by patients diagnosed with
schizophrenia, leading to feelings of powerlessness and helplessness
towards their illness. In more severe cases, these auditory
hallucinations can take the form of commanding voices, which are
often related to high suicidality rates in these patients. Several
authors propose that the meanings attributed to the hallucinatory
experience, rather than characteristics like form and content, can be
determinant in patients’ reactions to hallucinatory activity,
particularly in the case of voice-hearing experiences. In this study, 48
patients diagnosed with paranoid schizophrenia presenting auditory
hallucinations were studied. Multiple regression analyses were
computed to study the influence of several developmental aspects,
such as family and social dynamics, bullying, depression, and sociocognitive
variables on the auditory hallucinations, on patients’
attributions and relationships with their voices, and on the resulting
invalidation of hallucinatory experience. Overall, results showed how
relationships with voices can mirror several aspects of interpersonal
relationship with others, and how self-schemas, depression and actual
social relationships help shaping the voice-hearing experience. Early
experiences of victimization and submission help predict the
attributions of omnipotence of the voices, and increased hostility
from parents seems to increase the malevolence of the voices,
suggesting that socio-cognitive factors can significantly contribute to
the etiology and maintenance of auditory hallucinations. The
understanding of the characteristics of auditory hallucinations and the
relationships patients established with their voices can allow the
development of more promising therapeutic interventions that can be
more effective in decreasing invalidation caused by this devastating
mental illness.
Abstract: Cerebellar ataxia is a steadily progressive
neurodegenerative disease associated with loss of motor control,
leaving patients unable to walk, talk, or perform activities of daily
living. Direct motor instruction in cerebella ataxia patients has limited
effectiveness, presumably because an inappropriate closed-loop
cerebellar response to the inevitable observed error confounds motor
learning mechanisms. Could the use of EEG based BCI provide
advanced biofeedback to improve motor imagery and provide a
“backdoor” to improving motor performance in ataxia patients? In
order to determine the feasibility of using EEG-based BCI control in
this population, we compare the ability to modulate mu-band power
(8-12 Hz) by performing a cued motor imagery task in an ataxia
patient and healthy control.
Abstract: Plasmin plays an important role in the human
circulatory system owing to its catalytic ability of fibrinolysis. The
immediate injection of plasmin in patients of strokes has intrigued
many scientists to design vectors that can transport plasmin to the
desired location in human body. Here we predict the structure of
human plasmin and investigate the interaction of plasmin with the
gold-nanoparticle.
Because the crystal structure of plasminogen has been solved, we
deleted N-terminal domain (Pan-apple domain) of plasminogen and
generate a mimic of the active form of this enzyme (plasmin). We
conducted a simulated annealing process on plasmin and discovered a
very large conformation occurs. Kringle domains 1, 4 and 5 had been
observed to leave its original location relative to the main body of the
enzyme and the original doughnut shape of this enzyme has been
transformed to a V-shaped by opening its two arms. This observation
of conformational change is consistent with the experimental results of
neutron scattering and centrifugation.
We subsequently docked the plasmin on the simulated gold surface
to predict their interaction. The V-shaped plasmin could utilize its
Kringle domain and catalytic domain to contact the gold surface.
Our findings not only reveal the flexibility of plasmin structure but
also provide a guide for the design of a plasmin-gold nanoparticle.
Abstract: The aim of the current study was to develop and
validate a Response to Stressful Situations Scale (RSSS) for the
Portuguese population. This scale assesses the degree of stress
experienced in scenarios that can constitute positive, negative and
more neutral stressors, and also describes the physiological,
emotional and behavioral reactions to those events according to their
intensity. These scenarios include typical stressor scenarios relevant
to patients with schizophrenia, which are currently absent from most
scales, assessing specific risks that these stressors may bring on
subjects, which may prove useful in non-clinical and clinical
populations (i.e. Patients with mood or anxiety disorders,
schizophrenia). Results from Principal Components Analysis and
Confirmatory Factor Analysis of two adult samples from general
population allowed to confirm a three-factor model with good fit
indices: χ2 (144)= 370.211, p = 0.000; GFI = 0.928; CFI = 0.927; TLI =
0.914, RMSEA = 0.055, P(rmsea ≤0.005) = .096; PCFI = .781.
Further data analysis of the scale revealed that RSSS is an adequate
assessment tool of stress response in adults to be used in further
research and clinical settings, with good psychometric characteristics,
adequate divergent and convergent validity, good temporal stability
and high internal consistency.
Abstract: Kidney cancer is the most lethal urological cancer
accounting for 3% of adult malignancies. VHL, a tumor-suppressor
gene, is best known to be associated with renal cell carcinoma
(RCC). The VHL functions as negative regulator of hypoxia inducible
factors. Recent sequencing efforts have identified several novel
frequent mutations of histone modifying and chromatin remodeling
genes in ccRCC (clear cell RCC) including PBRM1 and SETD2. The
PBRM1 gene encodes the BAF180 protein, which involved in
transcriptional activation and repression of selected genes. SETD2
encodes a histone methyltransferase, which may play a role in
suppressing tumor development. In this study, RNAs of 30 paired
tumor and normal samples that were grouped according to the types
of kidney cancer and clinical characteristics of patients, including
gender and average age were examined by RT-PCR, SSCP and
sequencing techniques. VHL, PBRM1 and SETD2 expressions were
relatively down-regulated. However, statistically no significance was
found (Wilcoxon signed rank test, p>0.05). Interestingly, no mutation
was observed on the contrary of previous studies. Understanding the
molecular mechanisms involved in the pathogenesis of RCC has
aided the development of molecular-targeted drugs for kidney cancer.
Further analysis is required to identify the responsible genes rather
than VHL, PBRM1 and SETD2 in kidney cancer.
Abstract: Theory of Mind (ToM) refers to the ability to infer
another’s mental state. With appropriate ToM, one can behave well in
social interactions. A growing body of evidence has demonstrated that
patients with temporal lobe epilepsy (TLE) may damage ToM by
affecting on regions of the underlying neural network of ToM.
However, the question of whether there is cerebral laterality for ToM
functions remains open. This study aimed to examine whether there is
cerebral lateralization for ToM abilities in TLE patients. Sixty-seven
adult TLE patients and 30 matched healthy controls (HC) were
recruited. Patients were classified into right (RTLE), left (LTLE), and
bilateral (BTLE) TLE groups on the basis of a consensus panel review
of their seizure semiology, EEG findings, and brain imaging results.
All participants completed an intellectual test and four tasks measuring
basic and advanced ToM. The results showed that, on all ToM tasks,
(1) each patient group performed worse than HC; (2) there were no
significant differences between LTLE and RTLE groups; and (3) the
BTLE group performed the worst. It appears that the neural network
responsible for ToM is distributed evenly between the cerebral
hemispheres.
Abstract: Availability of different genetic tests after completion
of Human Genome Project increases the physicians’ responsibility to
keep themselves update on the potential implementation of these
genetic tests in their daily practice. However, due to numbers of
barriers, still many of physicians are not either aware of these tests or
are not willing to offer or refer their patients for genetic tests. This
study was conducted an anonymous, cross-sectional, mailed-based
survey to develop a primary data of Malaysian physicians’ level of
knowledge and perception of gene profiling. Questionnaire had 29
questions. Total scores on selected questions were used to assess the
level of knowledge. The highest possible score was 11. Descriptive
statistics, one way ANOVA and chi-squared test was used for
statistical analysis. Sixty three completed questionnaires were
returned by 27 general practitioners (GPs) and 36 medical specialists.
Responders’ age ranges from 24 to 55 years old (mean 30.2 ± 6.4).
About 40% of the participants rated themselves as having poor level
of knowledge in genetics in general whilst 60% believed that they
have fair level of knowledge; however, almost half (46%) of the
respondents felt that they were not knowledgeable about available
genetic tests. A majority (94%) of the responders were not aware of
any lab or company which is offering gene profiling services in
Malaysia. Only 4% of participants were aware of using gene profiling
for detection of dosage of some drugs. Respondents perceived greater
utility of gene profiling for breast cancer (38%) compared to the
colorectal familial cancer (3%). The score of knowledge ranged from
2 to 8 (mean 4.38 ± 1.67). Non- significant differences between score
of knowledge of GPs and specialists were observed, with score of
4.19 and 4.58 respectively. There was no significant association
between any demographic factors and level of knowledge. However,
those who graduated between years 2001 to 2005 had higher level of
knowledge. Overall, 83% of participants showed relatively high level
of perception on value of gene profiling to detect patient’s risk of
disease. However, low perception was observed for both statements
of using gene profiling for general population in order to alter their
lifestyle (25%) as well as having the full sequence of a patient
genome for the purpose of determining a patient’s best match for
treatment (18%). The lack of clinical guidelines, limited provider
knowledge and awareness, lack of time and resources to educate
patients, lack of evidence-based clinical information and cost of tests
were the most barriers of ordering gene profiling mentioned by
physicians. In conclusion Malaysian physicians who participate in
this study had mediocre level of knowledge and awareness in gene
profiling. The low exposure to the genetic questions and problems
might be a key predictor of lack of awareness and knowledge on
available genetic tests. Educational and training workshop might be useful in helping Malaysian physicians incorporate genetic profiling
into practice for eligible patients.
Abstract: Moving into a new era of healthcare, new tools and
devices are developed to extend and improve health services, such as
remote patient monitoring and risk prevention. In this concept,
Internet of Things (IoT) and Cloud Computing present great
advantages by providing remote and efficient services, as well as
cooperation between patients, clinicians, researchers and other health
professionals. This paper focuses on patients suffering from bipolar
disorder, a brain disorder that belongs to a group of conditions
called affective disorders, which is characterized by great mood
swings. We exploit the advantages of Semantic Web and Cloud
Technologies to develop a patient monitoring system to support
clinicians. Based on intelligently filtering of evidence-knowledge and
individual-specific information we aim to provide treatment
notifications and recommended function tests at appropriate times or
concluding into alerts for serious mood changes and patient’s nonresponse
to treatment. We propose an architecture as the back-end
part of a cloud platform for IoT, intertwining intelligence devices
with patients’ daily routine and clinicians’ support.
Abstract: Taiwan is a hyper endemic area for the Hepatitis B
virus (HBV). The estimated total number of HBsAg carriers in the
general population who are more than 20 years old is more than 3
million. Therefore, a case record review is conducted from January
2003 to June 2007 for all patients with a diagnosis of acute hepatitis
who were admitted to the Emergency Department (ED) of a
well-known teaching hospital. The cost for the use of medical
resources is defined as the total medical fee. In this study, principal
component analysis (PCA) is firstly employed to reduce the number of
dimensions. Support vector regression (SVR) and artificial neural
network (ANN) are then used to develop the forecasting model. A total
of 117 patients meet the inclusion criteria. 61% patients involved in
this study are hepatitis B related. The computational result shows that
the proposed PCA-SVR model has superior performance than other
compared algorithms. In conclusion, the Child-Pugh score and
echogram can both be used to predict the cost of medical resources for
patients with acute hepatitis in the ED.