Scholarly

High Efficiency, Selectivity against Cancer Cell Line of Purified L-Asparaginase from Pathogenic Escherichia coli

Year: 2010 Volume: 4 Issue: 5 242 - 247 Pages

Abstract: L-asparaginase was extracted from pathogenic Escherichia coli which was isolated from urinary tract infection patients. L-asparaginase was purified 96-fold by ultrafiltration, ion exchange and gel filtration giving 39.19% yield with final specific activity of 178.57 IU/mg. L-asparaginase showed 138,356±1,000 Dalton molecular weight with 31024±100 Dalton molecular mass. Kinetic properties of enzyme resulting 1.25×10-5 mM Km and 2.5×10-3 M/min Vmax. L-asparaginase showed a maximum activity at pH 7.5 when incubated at 37 ºC for 30 min and illustrated its full activity (100%) after 15 min incubation at 20-37 ºC, while 70% of its activity was lost when incubated at 60 ºC. L-asparaginase showed cytotoxicity to U937 cell line with IC50 0.5±0.19 IU/ml, and selectivity index (SI=7.6) about 8 time higher selectivity over the lymphocyte cells. Therefore, the local pathogenic E. coli strains may be used as a source of high yield of L-asparaginase to produce anti cancer agent with high selectivity.

Denial of Service (DOS) Attack and Its Possible Solutions in VANET

Year: 2010 Volume: 4 Issue: 5 906 - 910 Pages

Abstract: Vehicular Ad-hoc Network (VANET) is taking more attention in automotive industry due to the safety concern of human lives on roads. Security is one of the safety aspects in VANET. To be secure, network availability must be obtained at all times since availability of the network is critically needed when a node sends any life critical information to other nodes. However, it can be expected that security attacks are likely to increase in the coming future due to more and more wireless applications being developed and deployed onto the well-known expose nature of the wireless medium. In this respect, the network availability is exposed to many types of attacks. In this paper, Denial of Service (DOS) attack on network availability is presented and its severity level in VANET environment is elaborated. A model to secure the VANET from the DOS attacks has been developed and some possible solutions to overcome the attacks have been discussed.

An Improved Genetic Algorithm to Solve the Traveling Salesman Problem

Year: 2009 Volume: 3 Issue: 4 1228 - 1231 Pages

Abstract: The Genetic Algorithm (GA) is one of the most important methods used to solve many combinatorial optimization problems. Therefore, many researchers have tried to improve the GA by using different methods and operations in order to find the optimal solution within reasonable time. This paper proposes an improved GA (IGA), where the new crossover operation, population reformulates operation, multi mutation operation, partial local optimal mutation operation, and rearrangement operation are used to solve the Traveling Salesman Problem. The proposed IGA was then compared with three GAs, which use different crossover operations and mutations. The results of this comparison show that the IGA can achieve better results for the solutions in a faster time.

Feature Based Unsupervised Intrusion Detection

Year: 2014 Volume: 8 Issue: 9 1635 - 1639 Pages

Abstract: The goal of a network-based intrusion detection system is to classify activities of network traffics into two major categories: normal and attack (intrusive) activities. Nowadays, data mining and machine learning plays an important role in many sciences; including intrusion detection system (IDS) using both supervised and unsupervised techniques. However, one of the essential steps of data mining is feature selection that helps in improving the efficiency, performance and prediction rate of proposed approach. This paper applies unsupervised K-means clustering algorithm with information gain (IG) for feature selection and reduction to build a network intrusion detection system. For our experimental analysis, we have used the new NSL-KDD dataset, which is a modified dataset for KDDCup 1999 intrusion detection benchmark dataset. With a split of 60.0% for the training set and the remainder for the testing set, a 2 class classifications have been implemented (Normal, Attack). Weka framework which is a java based open source software consists of a collection of machine learning algorithms for data mining tasks has been used in the testing process. The experimental results show that the proposed approach is very accurate with low false positive rate and high true positive rate and it takes less learning time in comparison with using the full features of the dataset with the same algorithm.

Active Suspension - Case Study on Robust Control

Year: 2011 Volume: 5 Issue: 6 695 - 700 Pages

Abstract: Automotive suspension system is important part of car comfort and safety. In this article automotive active suspension with linear motor as actuator is designed using H-infinity control. This paper is focused on comparison of different controller designed for quart, half or full-car model (and always used for “full" car). Special attention is placed on energy demand of the whole system. Each controller configuration is simulated and then verified on the hydraulic quarter car test bed.

Manipulation of Probiotics Fermentation of Yogurt by Cinnamon and Licorice: Effects on Yogurt Formation and Inhibition of Helicobacter Pylori Growth in vitro

Year: 2009 Volume: 3 Issue: 12 586 - 590 Pages

Abstract: Probiotic bacteria especially Lactobacillus spp. and Bifidobacterium exert suppressive effect on Helicobacter pylori. Cinnamon and licorice have been traditionally used for the treatment of gastric ulcer. The objectives of this study were to determine the effects of herbs on yogurt fermentation, the level of probiotic bacteria in yogurt during 28 days storage and the effect of herbal yogurt on the growth of H. pylori in vitro. Cinnamon or licorice was mixed with milk and the mixture was fermented with probiotic bacteria to form herbal-yogurt. Changes of pH and total titratable acids were monitored and the viability of probiotic bacteria was evaluated during and after refrigerated storage. The in vitro inhibition of H. pylori growth was determined using agar diffusion and minimum inhibitory concentration (MIC) method. The presence of herbs did not affect the probiotic population during storage. There were no significant differences in pH and TTA between herbal-yogurts and plain-yogurt during fermentation and storage. Water extract of cinnamon-yogurt showed the highest inhibition effect (13.5mm) on H. pylori growth in comparison with licorice-yogurt (11.2mm). The present findings indicate cinnamon and licorice has bioactive components to decrease the growth of H. pylori.

Pathological Truth: The Use of Forensic Science in Kenya’s Criminal Justice System

Year: 2013 Volume: 7 Issue: 6 1884 - 1894 Pages

Authors:
Peter Ndichu Muriuki

Abstract: Assassination of politicians, school mass murders, purported suicides, aircraft crash, mass shootings by police, sinking of sea ferries, mysterious car accidents, mass fire deaths and horrificterror attacks are some of the cases that bring forth scientific and legal conflicts. Questions about truth, justice and human rights are raised by both victims and perpetrators/offenders as they seek to understand why and how it happened to them. This kind of questioning manifests itself in medical-criminological-legalpsychological and scientific realms. An agreement towards truthinvestigations for possible legal-political-psychological transitory issues such as prosecution, victim-offender mediation, healing, reconciliation, amnesty, reparation, restitution, and policy formulations is seen as one way of transforming these conflicts. Forensic scientists and pathologists in particular have formed professional groups where the complexities between legal truth and scientific truth are dramatized and elucidated within the anatomy of courtrooms. This paper focuses on how pathological truth and legal truth interact with each other in Kenya’s criminal justice system.

Gastroprotective Activity of Swietenia Mahagoni Seed Extract on Ethanol-Induced Gastric Mucosal Injury in Rats

Year: 2010 Volume: 4 Issue: 7 304 - 308 Pages

Abstract: Swietenia mahagoni have been used in traditional medicine for treatment of different diseases. Present study was performed to evaluate anti-ulcerogenic activity of ethanol seed extract against ethanol induced gastric mucosal injury in rats. Six groups of rats were orally pre-treated respectively with carboxymethyl cellulose, omeprazole 20 mg/kg, 50, 100, 200 and 400 mg/kg plant extract one hour before oral administration of absolute ethanol to generate gastric mucosal injury. After additional hour, rats were sacrificed and ulcer areas of gastric walls were determined. Grossly, carboxymethyl cellulose group exhibited severe mucosal injury, whereas pre-treatment with plant extract exhibited significant protection of gastric mucosa. Histology, carboxymethyl cellulose group exhibited severe damage of gastric mucosa; edema and leucocytes infiltration of sub mucosa compared to plant extract which showed gastric protection. Acute toxicity study did not manifest any toxicological signs in rats. Conclusions, results suggest that S. mahagoni promotes ulcer protection as ascertained grossly and histologically.

Pushing the Limits of Address Based Authentication: How to Avoid MAC Address Spoofing in Wireless LANs

Year: 2008 Volume: 2 Issue: 6 1289 - 1298 Pages

Abstract: It is well-known that in wireless local area networks, authenticating nodes by their MAC addresses is not secure since it is very easy for an attacker to learn one of the authorized addresses and change his MAC address accordingly. In this paper, in order to prevent MAC address spoofing attacks, we propose to use dynamically changing MAC addresses and make each address usable for only one session. The scheme we propose does not require any change in 802.11 protocols and incurs only a small performance overhead. One of the nice features of our new scheme is that no third party can link different communication sessions of the same user by monitoring MAC addresses therefore our scheme is preferable also with respect to user privacy.

Implementation of an Improved Secure System Detection for E-passport by using EPC RFID Tags

Year: 2009 Volume: 3 Issue: 12 2954 - 2958 Pages

Abstract: Current proposals for E-passport or ID-Card is similar to a regular passport with the addition of tiny contactless integrated circuit (computer chip) inserted in the back cover, which will act as a secure storage device of the same data visually displayed on the photo page of the passport. In addition, it will include a digital photograph that will enable biometric comparison, through the use of facial recognition technology at international borders. Moreover, the e-passport will have a new interface, incorporating additional antifraud and security features. However, its problems are reliability, security and privacy. Privacy is a serious issue since there is no encryption between the readers and the E-passport. However, security issues such as authentication, data protection and control techniques cannot be embedded in one process. In this paper, design and prototype implementation of an improved E-passport reader is presented. The passport holder is authenticated online by using GSM network. The GSM network is the main interface between identification center and the e-passport reader. The communication data is protected between server and e-passport reader by using AES to encrypt data for protection will transferring through GSM network. Performance measurements indicate a 19% improvement in encryption cycles versus previously reported results.

Optimization of Microwave-Assisted Extraction of Cherry Laurel (Prunus laurocerasus L.) Fruit Using Response Surface Methodology

Year: 2012 Volume: 6 Issue: 11 1042 - 1047 Pages

Abstract: Optimization of a microwave-assisted extraction of cherry laurel (Prunus laurocerasus) fruit using methanol was studied. The influence of process parameters (microwave power, plant material-to-solvent ratio and the extraction time) on the extraction efficiency were optimized by using response surface methodology. The predicted maximum yield of extractive substances (41.85 g/100 g fresh plant material) was obtained at microwave power of 600 W and plant material to solvent ratio of 0.2 g/cm3 after 26 minutes of extraction, while a mean value of 40.80±0.41 g/100 g fresh plant material was obtained from laboratory experiments. This proves applicability of the model in predicting optimal extraction conditions with minimal laborious and time consuming. The results indicated that all process parameters were effective on the extraction efficiency, while the most important factor was extraction time. In order to rationalize production the optimal economical condition which gave a large total extract yield with minimal energy and solvent consumption was found.

Calculating the Efficiency of Steam Boilers Based on Its Most Effecting Factors: A Case Study

Year: 2012 Volume: 6 Issue: 3 746 - 749 Pages

Abstract: This paper is concerned with calculating boiler efficiency as one of the most important types of performance measurements in any steam power plant. That has a key role in determining the overall effectiveness of the whole system within the power station. For this calculation, a Visual-Basic program was developed, and a steam power plant known as El-Khmus power plant, Libya was selected as a case study. The calculation of the boiler efficiency was applied by using heating balance method. The findings showed how the maximum heat energy which produced from the boiler increases the boiler efficiency through increasing the temperature of the feed water, and decreasing the exhaust temperature along with humidity levels of the of fuel used within the boiler.

Comparison between Haar and Daubechies Wavelet Transformations on FPGA Technology

Year: 2008 Volume: 2 Issue: 1 170 - 175 Pages

Abstract: Recently, the Field Programmable Gate Array (FPGA) technology offers the potential of designing high performance systems at low cost. The discrete wavelet transform has gained the reputation of being a very effective signal analysis tool for many practical applications. However, due to its computation-intensive nature, current implementation of the transform falls short of meeting real-time processing requirements of most application. The objectives of this paper are implement the Haar and Daubechies wavelets using FPGA technology. In addition, the Bit Error Rate (BER) between the input audio signal and the reconstructed output signal for each wavelet is calculated. From the BER, it is seen that the implementations execute the operation of the wavelet transform correctly and satisfying the perfect reconstruction conditions. The design procedure has been explained and designed using the stat-ofart Electronic Design Automation (EDA) tools for system design on FPGA. Simulation, synthesis and implementation on the FPGA target technology has been carried out.

Study of a Four-Bed Pressure Swing Adsorption for Oxygen Separation from Air

Year: 2008 Volume: 2 Issue: 11 362 - 366 Pages

Abstract: This article is presented an experimental and modeling study of a four-bed pressure swing adsorption process using zeolite13X to provide oxygen-enriched air. The binary mixture N2/O2 (79/21 vol %) was used as a feed stream. The effects of purge/feed ratio (P/F), adsorption pressure, cyclic time and product flow rate on product purity and recovery under nonisothermal condition were studied. The adsorption dynamics of process were determined using a mathematical model incorporated mass and energy balances. A Mathlab code using finite difference method was developed to solve the set of coupled differential-algebraic equations, and the simulation results are agreed well with experimental results.

Feature Subset Selection approach based on Maximizing Margin of Support Vector Classifier

Year: 2008 Volume: 2 Issue: 6 2275 - 2280 Pages

Abstract: Identification of cancer genes that might anticipate the clinical behaviors from different types of cancer disease is challenging due to the huge number of genes and small number of patients samples. The new method is being proposed based on supervised learning of classification like support vector machines (SVMs).A new solution is described by the introduction of the Maximized Margin (MM) in the subset criterion, which permits to get near the least generalization error rate. In class prediction problem, gene selection is essential to improve the accuracy and to identify genes for cancer disease. The performance of the new method was evaluated with real-world data experiment. It can give the better accuracy for classification.

Study on Crater Detection Using FLDA

Year: 2012 Volume: 6 Issue: 11 1544 - 1548 Pages

Abstract: In this paper, we validate crater detection in moon surface image using FLDA. This proposal assumes that it is applied to SLIM (Smart Lander for Investigating Moon) project aiming at the pin-point landing to the moon surface. The point where the lander should land is judged by the position relations of the craters obtained via camera, so the real-time image processing becomes important element. Besides, in the SLIM project, 400kg-class lander is assumed, therefore, high-performance computers for image processing cannot be equipped. We are studying various crater detection methods such as Haar-Like features, LBP, and PCA. And we think these methods are appropriate to the project, however, to identify the unlearned images obtained by actual is insufficient. In this paper, we examine the crater detection using FLDA, and compare with the conventional methods.

A Preliminary X-Ray Study on Human-Hair Microstructures for a Health-State Indicator

Year: 2011 Volume: 5 Issue: 11 632 - 636 Pages

Abstract: We present a preliminary x-ray study on human-hair microstructures for a health-state indicator, in particular a cancer case. As an uncomplicated and low-cost method of x-ray technique, the human-hair microstructure was analyzed by wide-angle x-ray diffractions (XRD) and small-angle x-ray scattering (SAXS). The XRD measurements exhibited the simply reflections at the d-spacing of 28 Å, 9.4 Å and 4.4 Å representing to the periodic distance of the protein matrix of the human-hair macrofibrous and the diameter and the repeated spacing of the polypeptide alpha helixes of the photofibrils of the human-hair microfibrous, respectively. When compared to the normal cases, the unhealthy cases including to the breast- and ovarian-cancer cases obtained higher normalized ratios of the x-ray diffracting peaks of 9.4 Å and 4.4 Å. This likely resulted from the varied distributions of microstructures by a molecular alteration. As an elemental analysis by x-ray fluorescence (XRF), the normalized quantitative ratios of zinc(Zn)/calcium(Ca) and iron(Fe)/calcium(Ca) were determined. Analogously, both Zn/Ca and Fe/Ca ratios of the unhealthy cases were obtained higher than both of the normal cases were. Combining the structural analysis by XRD measurements and the elemental analysis by XRF measurements exhibited that the modified fibrous microstructures of hair samples were in relation to their altered elemental compositions. Therefore, these microstructural and elemental analyses of hair samples will be benefit to associate with a diagnosis of cancer and genetic diseases. This functional method would lower a risk of such diseases by the early diagnosis. However, the high-intensity x-ray source, the highresolution x-ray detector, and more hair samples are necessarily desired to develop this x-ray technique and the efficiency would be enhanced by including the skin and fingernail samples with the human-hair analysis.

Temperature Variation Effects on I-V Characteristics of Cu-Phthalocyanine based OFET

Year: 2011 Volume: 5 Issue: 10 1644 - 1648 Pages

Abstract: In this study we present the effect of elevated temperatures from 300K to 400K on the electrical properties of copper Phthalocyanine (CuPc) based organic field effect transistors (OFET). Thin films of organic semiconductor CuPc (40nm) and semitransparent Al (20nm) were deposited in sequence, by vacuum evaporation on a glass substrate with previously deposited Ag source and drain electrodes with a gap of 40 μm. Under resistive mode of operation, where gate was suspended it was observed that drain current of this organic field effect transistor (OFET) show an increase with temperature. While in grounded gate condition metal (aluminum) – semiconductor (Copper Phthalocyanine) Schottky junction dominated the output characteristics and device showed switching effect from low to high conduction states like Zener diode at higher bias voltages. This threshold voltage for switching effect has been found to be inversely proportional to temperature and shows an abrupt decrease after knee temperature of 360K. Change in dynamic resistance (Rd = dV/dI) with respect to temperature was observed to be -1%/K.

Fuzzy Sliding Mode Control of an MR Mount for Vibration Attenuation

Year: 2009 Volume: 3 Issue: 12 1631 - 1636 Pages

Abstract: In this paper, an magnetorheological (MR) mount with fuzzy sliding mode controller (FSMC) is studied for vibration suppression when the system is subject to base excitations. In recent years, magnetorheological fluids are becoming a popular material in the field of the semi-active control. However, the dynamic equation of an MR mount is highly nonlinear and it is difficult to identify. FSMC provides a simple method to achieve vibration attenuation of the nonlinear system with uncertain disturbances. This method is capable of handling the chattering problem of sliding mode control effectively and the fuzzy control rules are obtained by using the Lyapunov stability theory. The numerical simulations using one-dimension and two-dimension FSMC show effectiveness of the proposed controller for vibration suppression. Further, the well-known skyhook control scheme and an adaptive sliding mode controller are also included in the simulation for comparison with the proposed FSMC.

Flagging Critical Components to Prevent Transient Faults in Real-Time Systems

Year: 2008 Volume: 2 Issue: 2 339 - 343 Pages

Abstract: This paper proposes the use of metrics in design space exploration that highlight where in the structure of the model and at what point in the behaviour, prevention is needed against transient faults. Previous approaches to tackle transient faults focused on recovery after detection. Almost no research has been directed towards preventive measures. But in real-time systems, hard deadlines are performance requirements that absolutely must be met and a missed deadline constitutes an erroneous action and a possible system failure. This paper proposes the use of metrics to assess the system design to flag where transient faults may have significant impact. These tools then allow the design to be changed to minimize that impact, and they also flag where particular design techniques – such as coding of communications or memories – need to be applied in later stages of design.

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