Abstract: Rheumatoid arthritis (RA) is a chronic, progressive, systemic inflammatory disorder affecting the synovial joints and typically producing symmetrical arthritis that leads to joint destruction, which is responsible for the deformity and disability. Despite improvements in the treatment of RA over the past decade, there still is a need for new therapeutic agents that are efficacious, less expensive, and free of severe adverse reactions. The present study aimed to investigate role of inflammatory markers in arthritic rats treated with ethanolic bark extract of Albizia procera. The protective effect of ethanolic bark extract of Albizia procera against complete Freund’s adjuvant (CFA) induced arthritis in rats. Arthritis was induced by an intradermal injection of 0.1 ml FCA in the foot pad of left hind limb of rats. ETBE (100 and 200 mg/kg b.wt./p.o) and the reference drug diclofenac (25 mg/kg b.wt./p.o) were administered to arthritic rats. Paw volume was measured for all the animals before inducing arthritis and thereafter once in seven days by using plethysmometer for 42 days. Gene expression of inflammatory markers such as IL-1β and IL-10 were investigated in paw tissues. Up regulation of IL-1β and Down regulation IL-10 were observed in CFA injected rats when compared to normal rats. ETBE attenuated these alterations dose dependently when compared to the vehicle treated rats. These results provide insights into the mechanism of anti-arthritic activity, and unravel potential therapeutic use of Albizia procera in arthritis.
Abstract: In this paper, monitoring and control of tap changer
mechanism of a transformer implementation in an Intelligent
Electronic Device (IED) is discussed. It has been a custom for
decades to provide a separate panel for on load tap changer control
for monitoring the tap position. However, this facility cannot either
record or transfer the information to remote control centers. As there
is a technology shift towards the smart grid protection and control
standards, the need for implementing remote control and monitoring
has necessitated the implementation of this feature in numerical
relays. This paper deals with the programming, settings and logic
implementation which is applicable to both IEC 61850 compatible
and non-compatible IEDs thereby eliminating the need for separate
tap changer control equipment. The monitoring mechanism has been
implemented in a 28MVA, 110 /6.9kV transformer with 16 tap
position with GE make T60 IED at Ultratech cement limited
Gulbarga, Karnataka and is in successful service.