Abstract: Autologous Chondrocyte Implantation (ACI) is used worldwide since 1998 to treat cartilage defect. GEL based ACI is a new tissue-engineering technique to treat full thickness cartilage defect with fibrin and thrombin as scaffold for chondrocytes. Purpose of this study is to see safety and efficacy of gel based ACI for knee cartilage defect in multiple centres with different surgeons. Gel-based Autologous Chondrocyte Implantation (GACI) has shown effectiveness in treating isolated cartilage defect of knee joint. Long term results are still needed to be studied. This study was followed-up up to two years and showed benefit to patients. All enrolled patients with a mean age of 28.5 years had an average defect size of3 square centimeters, and were grade IV as per ICRS grading. All patients were followed up several times and at several intervals at 6th week, 8th week, 11th week, 17th week, 29th week, 57th week after surgery. The outcomes were measured based on the IKDC (subjective and objective) and MOCART scores.
Abstract: The exploitation of flow pulsation in micro- and
mini-channels is a potentially useful technique for enhancing cooling
of high-end photonics and electronics systems. It is thought that
pulsation alters the thickness of the hydrodynamic and thermal
boundary layers, and hence affects the overall thermal resistance
of the heat sink. Although the fluid mechanics and heat transfer
are inextricably linked, it can be useful to decouple the parameters
to better understand the mechanisms underlying any heat transfer
enhancement. Using two-dimensional, two-component particle image
velocimetry, the current work intends to characterize the heat transfer
mechanisms in pulsating flow with a mean Reynolds number of
48 by experimentally quantifying the hydrodynamics of a generic
liquid-cooled channel geometry. Flows circulated through the test
section by a gear pump are modulated using a controller to achieve
sinusoidal flow pulsations with Womersley numbers of 7.45 and
2.36 and an amplitude ratio of 0.75. It is found that the transient
characteristics of the measured velocity profiles are dependent on the
speed of oscillation, in accordance with the analytical solution for
flow in a rectangular channel. A large velocity overshoot is observed
close to the wall at high frequencies, resulting from the interaction
of near-wall viscous stresses and inertial effects of the main fluid
body. The steep velocity gradients at the wall are indicative of
augmented heat transfer, although the local flow reversal may reduce
the upstream temperature difference in heat transfer applications.
While unsteady effects remain evident at the lower frequency, the
annular effect subsides and retreats from the wall. The shear rate at
the wall is increased during the accelerating half-cycle and decreased
during deceleration compared to steady flow, suggesting that the flow
may experience both enhanced and diminished heat transfer during
a single period. Hence, the thickness of the hydrodynamic boundary
layer is reduced for positively moving flow during one half of the
pulsation cycle at the investigated frequencies. It is expected that the
size of the thermal boundary layer is similarly reduced during the
cycle, leading to intervals of heat transfer enhancement.
Abstract: Strategic investment decisions are characterized by
high innovation potential and long-term effects on the
competitiveness of enterprises. Due to the uncertainty and risks
involved in this complex decision making process, the need arises for
well-structured support activities. A method that considers cost and
the long-term added value is the cost-benefit effectiveness estimation.
One of those methods is the “profitability estimation focused on
benefits – PEFB”-method developed at the Institute of Management
Cybernetics at RWTH Aachen University. The method copes with
the challenges associated with strategic investment decisions by
integrating long-term non-monetary aspects whilst also mapping the
chronological sequence of an investment within the organization’s
target system. Thus, this method is characterized as a holistic
approach for the evaluation of costs and benefits of an investment.
This participation-oriented method was applied to business
environments in many workshops. The results of the workshops are a
library of more than 96 cost aspects, as well as 122 benefit aspects.
These aspects are preprocessed and comparatively analyzed with
regards to their alignment to a series of risk levels. For the first time,
an accumulation and a distribution of cost and benefit aspects
regarding their impact and probability of occurrence are given. The
results give evidence that the PEFB-method combines precise
measures of financial accounting with the incorporation of benefits.
Finally, the results constitute the basics for using information
technology and data science for decision support when applying
within the PEFB-method.
Abstract: Present paper enumerates highlights of seasonal
variation in floristic composition and ecological strategies for the
management of ‘Gujar Tal’ at Jaunpur in tropical semi-arid region of
eastern U.P. (India). Total composition of macrophytes recorded was
47 from 26 families with maximum 6 plant species of Cyperaceae
from April, 2012 to March, 2013 at certain periodic intervals.
Maximum number of plants (39) was present during winter followed
by (37) rainy and (27) summer seasons. The distribution pattern
depicted that maximum number of plants (27) was of marshy and
swampy habitats usually transitional between land and water.
Abstract: The irradiation of polymeric materials has received
much attention because it can produce diverse changes in chemical
structure and physical properties. Thus, studying the chemical and
structural changes of polymers is important in practice to achieve
optimal conditions for the modification of polymers. The effect of
gamma irradiation on the crystalline structure of poly(vinylidene
fluoride) (PVDF) has been investigated using differential scanning
calorimetry (DSC) and X-ray diffraction techniques (XRD). Gamma
irradiation was carried out in atmosphere air with doses between 100
kGy at 3,000 kGy with a Co-60 source. In the melting thermogram of
the samples irradiated can be seen a bimodal melting endotherm is
detected with two melting temperature. The lower melting
temperature is attributed to melting of crystals originally present and
the higher melting peak due to melting of crystals reorganized upon
heat treatment. These results are consistent with those obtained by
XRD technique showing increasing crystallinity with increasing
irradiation dose, although the melting latent heat is decreasing.
Abstract: The combination of multi–walled carbon nanotubes
(MWCNTs) with polymers offers an attractive route to reinforce the
macromolecular compounds as well as the introduction of new
properties based on morphological modifications or electronic
interactions between the two constituents. As they are only a few
nanometers in dimension, it offers ultra-large interfacial area per
volume between the nano-element and polymer matrix. Nevertheless,
the use of MWCNTs as a rough material in different applications has
been largely limited by their poor processability, insolubility, and
infusibility. Studies concerning the nanofiller reinforced polymer
composites are justified in an attempt to overcome these limitations.
This work presents one preliminary study of MWCNTs dispersion
into the PVDF homopolymer. For preparation, the composite
components were diluted in n,n-dimethylacetamide (DMAc) with
mechanical agitation assistance. After complete dilution, followed by
slow evaporation of the solvent at 60°C, the samples were dried.
Films of about 80 μm were obtained. FTIR and UV-Vis
spectroscopic techniques were used to characterize the
nanocomposites. The appearance of absorption bands in the FTIR
spectra of nanofilled samples, when compared to the spectrum of
pristine PVDF samples, are discussed and compared with the UV-Vis
measurements.
Abstract: The adjoint method has been used as a successful tool to
obtain sensitivity gradients in aerodynamic design and optimisation
for many years. This work presents an alternative approach to the
continuous adjoint formulation that enables one to compute gradients
of a given measure of merit with respect to control parameters other
than those pertaining to geometry. The procedure is then applied to
the steady 2–D compressible Euler and incompressible Navier–Stokes
flow equations. Finally, the results are compared with sensitivities
obtained by finite differences and theoretical values for validation.
Abstract: This paper analyzes the institutionalization of social
protest in Spain. In the current crisis Podemos party seems to
represent the political positions of the most affected citizens by the
economic situation. It studies using quantitative techniques (statistical
bivariate analysis), focusing on the exploitation of several bases of
statistics data from the Center for Sociological and Research of
Spanish Government, 15M movement characterization to its
institutionalization in the Podemos party. Making a comparison
between the participant's profile by the 15M and the social bases of
Podemos votes. Data on the transformation of the socio-demographic
profile of the fans, connoisseurs and 15M participants and voters are
given.
Abstract: Debts reconstruction under some of moratorium
projects is one of important method that highly benefits to both the
Banks and farmers. The method can reduce probabilities for nonprofits
loan. This paper discuss about debts reconstruction and career
development training for farmers in Thailand between 2011 and
2013. The research designed is mix-method between quantitative
survey and qualitative survey. Sample size for quantitative method is
1003 cases. Data gathering procedure is between October and
December 2013. Main results affirmed that debts reconstruction is
needed. And there are numerous benefits from farmers’ career
development training. Many of farmers who attend field school
activities able to bring knowledge learned to apply for the farms’
work. They can reduce production costs. Framers’ quality of life and
their household well-being also improve. This program should apply
in any countries where farmers have highly debts and highly risks for
not return the debts.
Abstract: A composite material with carbon fiber and polymer
matrix has been used as adherent for manufacturing adhesive joints.
In order to evaluate different fiber orientations on joint performance,
the adherents with the 0°, ±15°, ±30°, ±45° fiber orientations were
used in the single lap joint configuration. The joints with an overlap
length of 25 mm were prepared according to the ASTM 1002
specifications and subjected to tensile loadings. The structural
adhesive used was a two-part epoxy to be cured at 70°C for an hour.
First, mechanical behaviors of the adherents were measured using
three point bending test. In the test, considerations were given to
stress to failure and elastic modulus. The results were compared with
theoretical ones using rule of mixture. Then, the joints were
manufactured in a specially prepared jig, after a proper surface
preparation. Experimental results showed that the fiber orientations
of the adherents affected the joint performance considerably; the
joints with ±45° adherents experienced the worst shear strength, half
of those with 0° adherents, and in general, there was a great
relationship between the fiber orientations and failure mechanisms.
Delamination problems were observed for many joints, which were
thought to be due to peel effects at the ends of the overlap. It was
proved that the surface preparation applied to the adherent surface
was adequate. For further explanation of the results, a numerical
work should be carried out using a possible non-linear analysis.
Abstract: The rising demand for format-flexible packaging
machines is caused by current market changes. Increasing the formatflexibility
is a new goal for the packaging machine manufacturers’
product development process. There are no methodical or designorientated
tools for a comprehensive consideration of this target. This
paper defines the term format-flexibility in the context of packaging
machines and shows the state-of-the-art for improving the
changeover of production machines. The requirements for a new
approach and the concept itself will be introduced, and the method
elements will be explained. Finally, the use of the concept and the
result of the development of a format-flexible packaging machine
will be shown.
Abstract: The recent instability in economy was found to be
influencing the situation in Malaysia whether directly or indirectly.
Taking that into consideration, the government needs to find the best
approach to balance its citizen’s socio-economic strata level urgently.
Through education platform is among the efforts planned and acted
upon for the purpose of balancing the effects of the influence,
through the exposure of social entrepreneurial activity towards youth
especially those in higher institution level. Armed with knowledge
and skills that they gained, with the support by entrepreneurial
culture and environment while in campus; indirectly, the students will
lean more on making social entrepreneurship as a career option when
they graduate. Following the issues of marketability and workability
of current graduates that are becoming dire, research involving how
far the willingness of student to create social innovation that
contribute to the society without focusing solely on personal gain is
relevant enough to be conducted. With that, this research is
conducted with the purpose of identifying the level of entrepreneurial
intention and social entrepreneurship among higher institution
students in Malaysia. Stratified random sampling involves 355
undergraduate students from five public universities had been made
as research respondents and data were collected through surveys. The
data was then analyzed descriptively using min score and standard
deviation. The study found that the entrepreneurial intention of higher
education students are on moderate level, however it is the contrary
for social entrepreneurship activities, where it was shown on a high
level. This means that while the students only have moderate level of
willingness to be a social entrepreneur, they are very committed to
created social innovation through the social entrepreneurship
activities conducted. The implication from this study can be
contributed towards the higher institution authorities in prediction the
tendency of student in becoming social entrepreneurs. Thus, the
opportunities and facilities for realizing the courses related to social
entrepreneurship must be created expansively so that the vision of
creating as many social entrepreneurs as possible can be achieved.
Abstract: The maintenance of work rolls in hot strip processing
has been lengthy and difficult tasks for hot strip manufacturer
because heavy work rolls have to be taken out of the production line,
which could take hours. One way to increase the time between
maintenance is to improve the effectiveness of the work roll cooling
system such that the wear and tear more slowly occurs, while the
operation cost is kept low. Therefore, this study aims to improve the
work roll cooling system by providing the manufacturer the
relationship between the work-roll temperature reduced by cooling
and the water flow that can help manufacturer determining the more
effective water flow of the cooling system. The relationship is found
using simulation with a systematic process adjustment so that the
satisfying quality of product is achieved. Results suggest that the
manufacturer could reduce the water flow by 9% with roughly the
same performance. With the same process adjustment, the feasibility
of finishing-mill-stand reduction is also investigated. Results suggest
its possibility.
Abstract: Cloud computing can reduce the start-up expenses of implementing EHR (Electronic Health Records). However, many of the healthcare institutions are yet to implement cloud computing due to the associated privacy and security issues. In this paper, we analyze the challenges and opportunities of implementing cloud computing in healthcare. We also analyze data of over 5000 US hospitals that use Telemedicine applications. This analysis helps to understand the importance of smart phones over the desktop systems in different departments of the healthcare institutions. The wide usage of smartphones and cloud computing allows ubiquitous and affordable access to the health data by authorized persons, including patients and doctors. Cloud computing will prove to be beneficial to a majority of the departments in healthcare. Through this analysis, we attempt to understand the different healthcare departments that may benefit significantly from the implementation of cloud computing.
Abstract: Growth and remodeling of biological structures have
gained lots of attention over the past decades. Determining the
response of living tissues to mechanical loads is necessary for a wide
range of developing fields such as prosthetics design or computerassisted
surgical interventions. It is a well-known fact that biological
structures are never stress-free, even when externally unloaded. The
exact origin of these residual stresses is not clear, but theoretically,
growth is one of the main sources. Extracting body organ’s shapes
from medical imaging does not produce any information regarding
the existing residual stresses in that organ. The simplest cause of such
stresses is gravity since an organ grows under its influence from
birth. Ignoring such residual stresses might cause erroneous results in
numerical simulations. Accounting for residual stresses due to tissue
growth can improve the accuracy of mechanical analysis results. This
paper presents an original computational framework based on gradual
growth to determine the residual stresses due to growth. To illustrate
the method, we apply it to a finite element model of a healthy human
face reconstructed from medical images. The distribution of residual
stress in facial tissues is computed, which can overcome the effect of
gravity and maintain tissues firmness. Our assumption is that tissue
wrinkles caused by aging could be a consequence of decreasing
residual stress and thus not counteracting gravity. Taking into
account these stresses seems therefore extremely important in
maxillofacial surgery. It would indeed help surgeons to estimate
tissues changes after surgery.
Abstract: Mumbai, being traditionally the epicenter of India's
trade and commerce, the existing major ports such as Mumbai and
Jawaharlal Nehru Ports (JN) situated in Thane estuary are also
developing its waterfront facilities. Various developments over the
passage of decades in this region have changed the tidal flux
entering/leaving the estuary. The intake at Pir-Pau is facing the
problem of shortage of water in view of advancement of shoreline,
while jetty near Ulwe faces the problem of ship scheduling due to
existence of shallower depths between JN Port and Ulwe Bunder. In
order to solve these problems, it is inevitable to have information
about tide levels over a long duration by field measurements.
However, field measurement is a tedious and costly affair;
application of artificial intelligence was used to predict water levels
by training the network for the measured tide data for one lunar tidal
cycle. The application of two layered feed forward Artificial Neural
Network (ANN) with back-propagation training algorithms such as
Gradient Descent (GD) and Levenberg-Marquardt (LM) was used to
predict the yearly tide levels at waterfront structures namely at Ulwe
Bunder and Pir-Pau. The tide data collected at Apollo Bunder, Ulwe,
and Vashi for a period of lunar tidal cycle (2013) was used to train,
validate and test the neural networks. These trained networks having
high co-relation coefficients (R= 0.998) were used to predict the tide
at Ulwe, and Vashi for its verification with the measured tide for the
year 2000 & 2013. The results indicate that the predicted tide levels
by ANN give reasonably accurate estimation of tide. Hence, the
trained network is used to predict the yearly tide data (2015) for
Ulwe. Subsequently, the yearly tide data (2015) at Pir-Pau was
predicted by using the neural network which was trained with the
help of measured tide data (2000) of Apollo and Pir-Pau. The analysis of measured data and study reveals that: The
measured tidal data at Pir-Pau, Vashi and Ulwe indicate that there is
maximum amplification of tide by about 10-20 cm with a phase lag
of 10-20 minutes with reference to the tide at Apollo Bunder
(Mumbai). LM training algorithm is faster than GD and with increase
in number of neurons in hidden layer and the performance of the
network increases. The predicted tide levels by ANN at Pir-Pau and
Ulwe provides valuable information about the occurrence of high and
low water levels to plan the operation of pumping at Pir-Pau and
improve ship schedule at Ulwe.
Abstract: The source of the jet noise is generated by rocket exhaust plume during rocket engine testing. A domain decomposition approach is applied to the jet noise prediction in this paper. The aerodynamic noise coupling is based on the splitting into acoustic sources generation and sound propagation in separate physical domains. Large Eddy Simulation (LES) is used to simulate the supersonic jet flow. Based on the simulation results of the flow-fields, the jet noise distribution of the sound pressure level is obtained by applying the Ffowcs Williams-Hawkings (FW-H) acoustics equation and Fourier transform. The calculation results show that the complex structures of expansion waves, compression waves and the turbulent boundary layer could occur due to the strong interaction between the gas jet and the ambient air. In addition, the jet core region, the shock cell and the sound pressure level of the gas jet increase with the nozzle size increasing. Importantly, the numerical simulation results of the far-field sound are in good agreement with the experimental measurements in directivity.
Abstract: Our purpose is to investigate how the relationship
between employees and innovation management processes can drive
organizations to successful innovations. This research is deeply
related to a new way of thinking about human resources management
practices. It’s not simply about improving the employees’
engagement, but rather about a different and more radical
commitment: the employee can take on the role traditionally played
by the customer, namely to become the first tester of an innovative
product or service, the first user/customer and eventually the first
investor in the innovation. This new perception of employees could
create the basis of a novelty in the innovation process where
innovation is taken to a next level when the problems with customer
driven innovation on the one hand, and employees driven innovation
on the other can be balanced. This research identifies an effective
approach to innovation where the employees will participate
throughout the whole innovation process, not only in the idea
creation but also in the idea definition and development by giving
feedback in parallel to that provided by customers and lead-users.
Abstract: Discussing the nexus between global health policy and local practices, this article addresses the recent Ebola outbreak as a role model for narrative co-constructions of epidemic risk. We will demonstrate in how far a theory-driven and methodologically rooted analysis of narrativity can help to improve mechanisms of prevention and intervention whenever epidemic risk needs to be addressed locally in order to contribute to global health. Analyzing the narrative transformation of Ebola, we will also address issues of transcultural problem-solving and of normative questions at stake. In this regard, we seek to contribute to a better understanding of a key question of global health and justice as well as to the underlying ethical questions. By highlighting and analyzing the functions of narratives, this paper provides a translational approach to refine our practices by which we address epidemic risk, be it on the national, the transnational or the global scale.
Abstract: The increasing availability of information about earth
surface elevation (Digital Elevation Models DEM) generated from
different sources (remote sensing, Aerial Images, Lidar) poses the
question about how to integrate and make available to the most than
possible audience this huge amount of data. In order to exploit the potential of 3D elevation representation the
quality of data management plays a fundamental role. Due to the high
acquisition costs and the huge amount of generated data, highresolution
terrain surveys tend to be small or medium sized and
available on limited portion of earth. Here comes the need to merge
large-scale height maps that typically are made available for free at
worldwide level, with very specific high resolute datasets. One the
other hand, the third dimension increases the user experience and the
data representation quality, unlocking new possibilities in data
analysis for civil protection, real estate, urban planning, environment
monitoring, etc. The open-source 3D virtual globes, which are
trending topics in Geovisual Analytics, aim at improving the
visualization of geographical data provided by standard web services
or with proprietary formats. Typically, 3D Virtual globes like do not
offer an open-source tool that allows the generation of a terrain
elevation data structure starting from heterogeneous-resolution terrain
datasets. This paper describes a technological solution aimed to set
up a so-called “Terrain Builder”. This tool is able to merge
heterogeneous-resolution datasets, and to provide a multi-resolution
worldwide terrain services fully compatible with CesiumJS and
therefore accessible via web using traditional browser without any
additional plug-in.