Abstract: Bones are dynamic and responsive organs, they
regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/β-catenin pathway has profound
effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/β-catenin signaling, which results in the generation of new bone mass.
Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3β (Glycogen synthase kinase 3 beta) to cease the phosphorylation of β-catenin. β-catenin accumulation in the cytoplasm, followed by its
transport into the nucleus, binding to transcription factors (TCF/LEF)
that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter
β-galactosidase) mice in an experiment in which cyclic loads were
applied to the forearm. TOPGAL mice are reporters for cells effected
by the Wnt/β-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of β-
catenin, results in the production of an enzyme, β-galactosidase. The
presence of this enzyme allows us to localize transcriptional
activation of β-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/β-catenin pathway and new bone formation. The ulnae of loaded TOPGAL
mice were excised and transverse slices along different parts of the
ulnar shaft were assayed for the presence of β-galactosidase.
Our results indicate that loading increases β-catenin transcriptional
activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent
manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation.
Abstract: This paper presents a hybrid fuzzy-PD plus PID
(HFPP) controller and its application to steam distillation process for
essential oil extraction system. Steam temperature is one of the most
significant parameters that can influence the composition of essential
oil yield. Due to parameter variations and changes in operation
conditions during distillation, a robust steam temperature controller becomes nontrivial to avoid the degradation of essential oil quality.
Initially, the PRBS input is triggered to the system and output of steam temperature is modeled using ARX model structure. The
parameter estimation and tuning method is adopted by simulation
using HFPP controller scheme. The effectiveness and robustness of
proposed controller technique is validated by real time
implementation to the system. The performance of HFPP using 25 and 49 fuzzy rules is compared. The experimental result demonstrates the proposed HFPP using 49 fuzzy rules achieves a
better, consistent and robust controller compared to PID when considering the test on tracking the set point and the effects due to disturbance.
Abstract: We introduce an adaptive technique for the joint mitigation of transients and continuous-wave radio-frequency co-channel interference (CW RFI) in high-frequency (HF) over-the-horizon radars (OTHRs). The performance of this technique is illustrated using data from an operational surface-wave radar (SECAR) and from recent experimental trials with sky-wave (SW) and sky-wave–line-of-sight (SKYLOS) HF OTHRs.
Abstract: In this study, a longitudinal joint connection was
proposed for the short-span slab-type modular bridges with rapid
construction. The slab-type modular bridge consists of a number of
precast slab modules and has the joint connection between the
modules in the longitudinal direction of the bridge. A finite element
based parameter analysis was conducted to design the shape and the
dimensions of the longitudinal joint connection. Numbers of shear
keys within the joint, height and depth of the shear key, tooth angle,
and the spacing were considered as the design parameters. Using the
local cracking load at the corner of the shear key and the
cross-sectional area of the joint, an efficiency factor was proposed to
evaluate the effectiveness of the longitudinal joint connection. The
dimensions of shear key were determined by comparing the cracking
loads and the efficiency factors obtained from the finite element
analysis.
Abstract: Many foreign and Lithuanian scientists, analyzing the
evaluation of the tax system in respect of the burden of taxation,
agree that the latter, in principle, depends on how many individuals
and what units of the residents constitute a household. Therefore, the
aim of scientific research is to substantiate or to deny the significance
of a household, but not a resident, as a statistical unit, during the
evaluation of tax system, to be precise, determination of the value of
the burden of taxation. A performed scientific research revealed that
evaluation of the tax system in respect of a household, but not a
resident, as a statistical unit, allows not only to evaluate the
efficiency of the tax system more objectively, but also to forecast
practicably existing poverty line, burden of taxation, and to
capacitate the initiation of efficient decisions in social and tax fields
creating the environment of existence.
Abstract: Crime is a major societal problem for most of the
world's nations. Consequently, the police need to develop new
methods to improve their efficiency in dealing with these ever increasing crime rates. Two of the common difficulties that the police
face in crime control are crime investigation and the provision of crime information to the general public to help them protect themselves. Crime control in police operations involves the use of
spatial data, crime data and the related crime data from different organizations (depending on the nature of the analysis to be made).
These types of data are collected from several heterogeneous sources
in different formats and from different platforms, resulting in a lack of standardization. Moreover, there is no standard framework for
crime data collection, integration and dissemination through mobile
devices. An investigation into the current situation in crime control was carried out to identify the needs to resolve these issues. This
paper proposes and investigates the use of service oriented
architecture (SOA) and the mobile spatial information service in crime control. SOA plays an important role in crime control as an
appropriate way to support data exchange and model sharing from
heterogeneous sources. Crime control also needs to facilitate mobile
spatial information services in order to exchange, receive, share and release information based on location to mobile users anytime and
anywhere.
Abstract: The possibility of using cassava residue containing
49.66% starch, 21.47% cellulose, 12.97% hemicellulose, and 21.86%
lignin as a raw material to produce glucose using enzymatic
hydrolysis was investigated. In the experiment, each reactor
contained the cassava residue, bacteria cells, and production medium.
The effects of particles size (40 mesh and 60 mesh) and strains of
bacteria (A002 and M015) isolated from Thai higher termites,
Microcerotermes sp., on the glucose concentration at 37°C were
focused. High performance liquid chromatography (HPLC) with a
refractive index detector was used to determine the quantity of
glucose. The maximum glucose concentration obtained at 37°C using
strain A002 and 60 mesh of the cassava residue was 1.51 g/L at 10 h.
Abstract: EGOTHOR is a search engine that indexes the Web
and allows us to search the Web documents. Its hit list contains URL
and title of the hits, and also some snippet which tries to shortly
show a match. The snippet can be almost always assembled by an
algorithm that has a full knowledge of the original document (mostly
HTML page). It implies that the search engine is required to store
the full text of the documents as a part of the index.
Such a requirement leads us to pick up an appropriate compression
algorithm which would reduce the space demand. One of the solutions
could be to use common compression methods, for instance gzip or
bzip2, but it might be preferable if we develop a new method which
would take advantage of the document structure, or rather, the textual
character of the documents.
There already exist a special compression text algorithms and
methods for a compression of XML documents. The aim of this
paper is an integration of the two approaches to achieve an optimal
level of the compression ratio
Abstract: The aim of this paper is to express the input-output
matrix as a linear ordering problem which is classified as an NP-hard
problem. We then use a Tabu search algorithm to find the best
permutation among sectors in the input-output matrix that will give
an optimal solution. This optimal permutation can be useful in
designing policies and strategies for economists and government in
their goal of maximizing the gross domestic product.
Abstract: With the rapid development in the field of life
sciences and the flooding of genomic information, the need for faster
and scalable searching methods has become urgent. One of the
approaches that were investigated is indexing. The indexing methods
have been categorized into three categories which are the lengthbased
index algorithms, transformation-based algorithms and mixed
techniques-based algorithms. In this research, we focused on the
transformation based methods. We embedded the N-gram method
into the transformation-based method to build an inverted index
table. We then applied the parallel methods to speed up the index
building time and to reduce the overall retrieval time when querying
the genomic database. Our experiments show that the use of N-Gram
transformation algorithm is an economical solution; it saves time and
space too. The result shows that the size of the index is smaller than
the size of the dataset when the size of N-Gram is 5 and 6. The
parallel N-Gram transformation algorithm-s results indicate that the
uses of parallel programming with large dataset are promising which
can be improved further.
Abstract: Business process modeling has become an accepted
means for designing and describing business operations. Thereby,
consistency of business process models, i.e., the absence of modeling
faults, is of upmost importance to organizations. This paper presents
a concept and subsequent implementation for detecting faults in
business process models and for computing a measure of their
consistency. It incorporates not only syntactic consistency but also
semantic consistency, i.e., consistency regarding the meaning of
model elements from a business perspective.
Abstract: Exclusive breastfeeding is the feeding of a baby on no other milk apart from breast milk. Exclusive breastfeeding during the first 6 months of life is of fundamental importance because it supports optimal growth and development during infancy and reduces the risk of obliterating diseases and problems. Moreover, in developed countries, exclusive breastfeeding has decreased the incidence and/or severity of diarrhea, lower respiratory infection and urinary tract infection. In this paper, we study the factors that influence exclusive breastfeeding and use the Generalized Poisson regression model to analyze the practices of exclusive breastfeeding in Mauritius. We develop two sets of quasi-likelihood equations (QLE)to estimate the parameters.
Abstract: This study was conducted to explore the effects of two
countries model comparison program in Taiwan and Singapore in
TIMSS database. The researchers used Multi-Group Hierarchical
Linear Modeling techniques to compare the effects of two different
country models and we tested our hypotheses on 4,046 Taiwan
students and 4,599 Singapore students in 2007 at two levels: the class
level and student (individual) level. Design quality is a class level
variable. Student level variables are achievement and self-confidence.
The results challenge the widely held view that retention has a positive
impact on self-confidence. Suggestions for future research are
discussed.
Abstract: This paper presents an effective traffic lights
recognition method at the daytime. First, Potential Traffic Lights
Detector (PTLD) use whole color source of YCbCr channel image and
make each binary image of green and red traffic lights. After PTLD
step, Shape Filter (SF) use to remove noise such as traffic sign, street
tree, vehicle, and building. At this time, noise removal properties
consist of information of blobs of binary image; length, area, area of
boundary box, etc. Finally, after an intermediate association step witch
goal is to define relevant candidates region from the previously
detected traffic lights, Adaptive Multi-class Classifier (AMC) is
executed. The classification method uses Haar-like feature and
Adaboost algorithm. For simulation, we are implemented through Intel
Core CPU with 2.80 GHz and 4 GB RAM and tested in the urban and
rural roads. Through the test, we are compared with our method and
standard object-recognition learning processes and proved that it
reached up to 94 % of detection rate which is better than the results
achieved with cascade classifiers. Computation time of our proposed
method is 15 ms.
Abstract: This article presents a current-mode quadrature
oscillator using differential different current conveyor (DDCC) and
voltage differencing transconductance amplifier (VDTA) as active
elements. The proposed circuit is realized fro m a non-inverting
lossless integrator and an inverting second order low-pass filter. The
oscillation condition and oscillation frequency can be
electronically/orthogonally controlled via input bias currents. The
circuit description is very simple, consisting of merely 1 DDCC, 1
VDTA, 1 grounded resistor and 3 grounded capacitors. Using only
grounded elements, the proposed circuit is then suitable for IC
architecture. The proposed oscillator has high output impedance
which is easy to cascade or dive the external load without the buffer
devices. The PSPICE simulation results are depicted, and the given
results agree well with the theoretical anticipation. The power
consumption is approximately 1.76mW at ±1.25V supply voltages.
Abstract: In Multiple Sclerosis, pathological changes in the
brain results in deviations in signal intensity on Magnetic Resonance
Images (MRI). Quantitative analysis of these changes and their
correlation with clinical finding provides important information for
diagnosis. This constitutes the objective of our work. A new approach
is developed. After the enhancement of images contrast and the brain
extraction by mathematical morphology algorithm, we proceed to the
brain segmentation. Our approach is based on building statistical
model from data itself, for normal brain MRI and including clustering
tissue type. Then we detect signal abnormalities (MS lesions) as a
rejection class containing voxels that are not explained by the built
model. We validate the method on MR images of Multiple Sclerosis
patients by comparing its results with those of human expert
segmentation.
Abstract: Topics Disaster and Emergency Management are highly debated among experts. Fast communication will help to deal with emergencies. Problem is with the network connection and data exchange. The paper suggests a solution, which allows possibilities and perspectives of new flexible communication platform to the protection of communication systems for crisis management. This platform is used for everyday communication and communication in crisis situations too.
Abstract: The crop rice is the staple food of most Sierra Leone
with no close substitute. However, its cultivation has been on its last
legs over the years. The decline in the domestic rice cultivation has
had vicious socio-economic implications such as hiking consumer
prices, balance of payment dilemmas with debt burden. The objective
of this study is thus, to assess the effect of the shift of rural labour
towards non-agricultural sectors on rice cultivation. The tools utilized
for analyzing the problem under consideration involved a thorough
descriptive statistics and generalized linear model using OLS
technique. Increased rural population was established positive and
significant in affecting rice cultivation. Fertilizer utilization was
insignificant in rice cultivation. For reducing the shift of rural labor
force towards nonagricultural sectors, the government should make
the agricultural sector very lucrative.
Abstract: When the foundations of structures under cyclic
loading with amplitudes less than their permissible load, the concern exists often for the amount of uniform and non-uniform settlement of
such structures. Storage tank foundations with numerous filling and discharging and railways ballast course under repeating
transportation loads are examples of such conditions. This paper
deals with the effects of using the new generation of reinforcements,
Grid-Anchor, for the purpose of reducing the permanent settlement
of these foundations under the influence of different proportions of
the ultimate load. Other items such as the type and the number of
reinforcements as well as the number of loading cycles are studied numerically. Numerical models were made using the Plaxis3D
Tunnel finite element code. The results show that by using gridanchor
and increasing the number of their layers in the same
proportion as that of the cyclic load being applied, the amount of
permanent settlement decreases up to 42% relative to unreinforced
condition depends on the number of reinforcement layers and percent
of applied load and the number of loading cycles to reach a constant
value of dimensionless settlement decreases up to 20% relative to
unreinforced condition.
Abstract: Minimally invasive surgery (MIS) is now being widely used as a preferred choice for various types of operations. The need to detect various tactile properties, justifies the key role of tactile sensing that is currently missing in MIS. In this regard, Laparoscopy is one of the methods of minimally invasive surgery that can be used in kidney stone removal surgeries. At this moment, determination of the exact location of stone during laparoscopy is one of the limitations of this method that no scientific solution has been found for so far. Artificial tactile sensing is a new method for obtaining the characteristics of a hard object embedded in a soft tissue. Artificial palpation is an important application of artificial tactile sensing that can be used in different types of surgeries. In this study, a new method for determining the exact location of stone during laparoscopy is presented. In the present study, the effects of stone existence on the surface of kidney were investigated using conceptual 3D model of kidney containing a simulated stone. Having imitated palpation and modeled it conceptually, indications of stone existence that appear on the surface of kidney were determined. A number of different cases were created and solved by the software and using stress distribution contours and stress graphs, it is illustrated that the created stress patterns on the surface of kidney show not only the existence of stone inside, but also its exact location. So three-dimensional analysis leads to a novel method of predicting the exact location of stone and can be directly applied to the incorporation of tactile sensing in artificial palpation, helping surgeons in non-invasive procedures.