Abstract: Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular concentrations and pharmacokinetics of intravitreally injected drugs. A finite volume model was created to predict distribution of two drugs with different physiochemical properties in the rabbit eye. The model parameters were obtained from literature review. To validate this numeric model, the in vivo data of spatial concentration profile from the lens to the retina were compared with the numeric data. The difference was less than 5% between the numerical and experimental data. This validation provides strong support for the numerical methodology and associated assumptions of the current study.
Abstract: In this study, a software has been developed to predict
the optimum conditions for drying of cotton based yarn bobbins in a
hot air dryer. For this purpose, firstly, a suitable drying model has
been specified using experimental drying behavior for different
values of drying parameters. Drying parameters in the experiments
were drying temperature, drying pressure, and volumetric flow rate of
drying air. After obtaining a suitable drying model, additional curve
fittings have been performed to obtain equations for drying time and
energy consumption taking into account the effects of drying
parameters. Then, a software has been developed using Visual Basic
programming language to predict the optimum drying conditions for
drying time and energy consumption.