Abstract: The p53 tumor suppressor gene plays two important
roles in genomic stability: blocking cell proliferation after DNA
damage until it has been repaired, and starting apoptosis if the
damage is too critical. Codon 72 exon4 polymorphism (Arg72Pro) of
the P53 gene has been implicated in cancer risk. Various studies have
been done to investigate the status of p53 at codon 72 for arginine
(Arg) and proline (Pro) alleles in different populations and also the
association of this codon 72 polymorphism with various tumors. Our
objective was to investigate the possible association between P53
Arg72Pro polymorphism and susceptibility to colorectal cancer
among Isfahan and Chaharmahal Va Bakhtiari (a part of south west
of Iran) population. We investigated the status of p53 at codon 72 for
Arg/Arg, Arg/Pro and Pro/Pro allele polymorphisms in blood
samples from 145 colorectal cancer patients and 140 controls by
Nested-PCR of p53 exon 4 and digestion with BstUI restriction
enzyme and the DNA fragments were then resolved by
electrophoresis in 2% agarose gel. The Pro allele was 279 bp, while
the Arg allele was restricted into two fragments of 160 and 119 bp.
Among the 145 colorectal cancer cases 49 cases (33.79%) were
homozygous for the Arg72 allele (Arg/Arg), 18 cases (12.41%) were
homozygous for the Pro72 allele (Pro/Pro) and 78 cases (53.8%)
found in heterozygous (Arg/Pro).
In conclusion, it can be said that p53Arg/Arg genotype may be
correlated with possible increased risk of this kind of cancers in south
west of Iran.
Abstract: The use of power system stabilizers (PSSs) to damp
power system swing mode of oscillations is practical important. Our
purpose is to retune the power system stabilizer (PSS1A) parameters
in Unitrol D produced by ABB– was installed in 1995in Benghazi
North Power Plants (BNPPs) at General Electricity Company of
Libya (GECOL). The optimal values of the power system stabilizer
(PSS1A) parameters are determined off-line by a particle swarm
optimization technique (PSO). The objective is to damp the local and
inter-area modes of oscillations that occur following power system
disturbances. The retuned power system stabilizer (PSS1A) can cope
with large disturbance at different operating points and has enhanced
power system stability.
Abstract: Levan, an exopolysaccharide, was produced by
Microbacterium laevaniformans and its yield was characterized as a
function of concentrations of date syrup, sucrose and the fermentation
time. The optimum condition for levan production from sucrose was
at concentration of 20% sucrose for 48 h and for date syrup was 25%
for 48 h. The results show that an increase in fermentation time
caused a decrease in the levan production at all concentrations of date
syrup tested. Under these conditions after 48 h in sucrose medium,
levan production reached 48.9 g/L and for date syrup reached 10.48
g/L . The effect of pH on the yield of the purified levan was examined
and the optimum pH for levan production was determined to be 6.0.
Levan was composed mainly of fructose residues when analyzed by
TLC and FT-IR spectroscopy. Date syrup is a cheap substrate widely
available in Iran and has potential for levan production. The thermal
stability of levan was assessed by Thermo Gravimetric Analysis
(TGA) that revealed the onset of decomposition near to 49°C for the
levan produced from sucrose and 51°C for the levan from date syrup.
DSC results showed a single Tg at 98°C for levan produced from
sucrose and 206 °C for levan from date syrup.
Abstract: In this paper, the modified optimal sliding mode control with a proposed method to design a sliding surface is presented. Because of the inability of the previous approach of the sliding mode method to design a bounded and suitable input, the new variation is proposed in the sliding manifold to obviate problems in a structural system. Although the sliding mode control is a powerful method to reject disturbances and noises, the chattering problem is not good for actuators. To decrease the chattering phenomena, the optimal control is added to the sliding mode control. Not only the proposed method can decline the intense variations in the inputs of the system but also it can produce the efficient responses respect to the sliding mode control and optimal control that are shown by performing some numerical simulations.
Abstract: We study dynamic instability in high-rise steel moment
resisting frames (SMRFs) subjected to synthetic long-period ground
motions caused by hypothetical huge subduction earthquakes. Since
long duration as well as long dominant periods is a characteristic of
long-period ground motions, interstory drifts may enter the negative
postyield stiffness range many times when high-rise buildings are
subjected to long-period ground motions. Through the case studies of
9 high-rise SMRFs designed in accordance with the Japanese design
practice in 1980s, we demonstrate that drifting, or accumulation of
interstory drifts in one direction, occurs at the lower stories of the
SMRFs, if their natural periods are close to the dominant periods of the
long-period ground motions. The drifting led to residual interstory
drift ratio over 0.01, or to collapse if the design base shear was small.
Abstract: In this paper, a delayed physiological control system is investigated. The sufficient conditions for stability of positive equilibrium and existence of local Hopf bifurcation are derived. Furthermore, global existence of periodic solutions is established by using the global Hopf bifurcation theory. Finally, numerical examples are given to support the theoretical analysis.
Abstract: The purpose of this work is fast design optimization of
the seal chamber. The study includes the mass transfer between lower
and upper chamber on seal chamber for hot water application pumps.
The use of Fluent 12.1 commercial code made it possible to capture
complex flow with heat-mass transfer, radiation, Tailor instability,
and buoyancy effect. Realizable k-epsilon model was used for
turbulence modeling. Radiation heat losses were taken into account.
The temperature distribution at seal region is predicted with respect
to heat addition.
Results show the possibilities of the model simplifications by
excluding the water domain in low chamber from calculations. CFD
simulations permit to improve seal chamber design to meet target
water temperature around the seal. This study can be used for the
analysis of different seal chamber configurations.
Abstract: As originally designed for wired networks, TCP (transmission control protocol) congestion control mechanism is triggered into action when packet loss is detected. This implicit assumption for packet loss mostly due to network congestion does not work well in Mobile Ad Hoc Network, where there is a comparatively high likelihood of packet loss due to channel errors and node mobility etc. Such non-congestion packet loss, when dealt with by congestion control mechanism, causes poor TCP performance in MANET. In this study, we continue to investigate the impact of the interaction between transport protocols and on-demand routing protocols on the performance and stability of 802.11 multihop networks. We evaluate the important wireless networking events caused routing change, and propose a cross layer method to delay the unnecessary routing changes, only need to add a sensitivity parameter α , which represents the on-demand routing-s reaction to link failure of MAC layer. Our proposal is applicable to the plain 802.11 networking environment, the simulation results that this method can remarkably improve the stability and performance of TCP without any modification on TCP and MAC protocol.
Abstract: The dynamics of a delayed mathematical model for
Hes1 oscillatory expression are investigated. The linear stability of
positive equilibrium and existence of local Hopf bifurcation are
studied. Moreover, the global existence of large periodic solutions
has been established due to the global bifurcation theorem.
Abstract: In this paper, the issue of pth moment exponential stability of stochastic recurrent neural network with distributed time delays is investigated. By using the method of variation parameters, inequality techniques, and stochastic analysis, some sufficient conditions ensuring pth moment exponential stability are obtained. The method used in this paper does not resort to any Lyapunov function, and the results derived in this paper generalize some earlier criteria reported in the literature. One numerical example is given to illustrate the main results.
Abstract: The presented article deals with the description of a
numerical model of a corridor at a Central Interim Spent Fuel Storage
Facility (hereinafter CISFSF). The model takes into account the
effect of air flows on the temperature of stored waste. The
computational model was implemented in the ANSYS/CFX
programming environment in the form of a CFD task solution, which
was compared with an approximate analytical calculation. The article
includes a categorization of the individual alternatives for the
ventilation of such underground systems. The aim was to evaluate a
ventilation system for a CISFSF with regard to its stability and
capacity to provide sufficient ventilation for the removal of heat
produced by stored casks with spent nuclear fuel.
Abstract: Series compensators have been used for many years,
to increase the stability and load ability of transmission line. They
compensate retarded or advanced volt drop of transmission lines
by placing advanced or retarded voltage in series with them to
compensate the effective reactance, which cause to increase load
ability of transmission lines. In this paper, two method of fuzzy
controller, based on power reference tracking and impedance
reference tracking have been developed on TCSC controller in
order to increase load ability and improving power oscillation
damping of system. In these methods, fire angle of thyristors are
determined directly through the special Rule-bases with the error
and change of error as the inputs. The simulation results of two
area four- machines power system show the good performance of
power oscillation damping in system. Comparison of this method
with classical PI controller shows the increasing speed of system
response in power oscillation damping.
Abstract: Transition prediction of boundary layers has always
been an important problem in fluid mechanics both theoretically and
practically, yet notwithstanding the great effort made by many
investigators, there is no satisfactory answer to this problem. The most
popular method available is so-called e-N method which is heavily
dependent on experiments and experience. The author has proposed
improvements to the e-N method, so to reduce its dependence on
experiments and experience to a certain extent. One of the key
assumptions is that transition would occur whenever the velocity
amplitude of disturbance reaches 1-2% of the free stream velocity.
However, the reliability of this assumption needs to be verified. In this
paper, transition prediction on a flat plate is investigated by using both
the improved e-N method and the parabolized stability equations (PSE)
methods. The results show that the transition locations predicted by
both methods agree reasonably well with each other, under the above
assumption. For the supersonic case, the critical velocity amplitude in
the improved e-N method should be taken as 0.013, whereas in the
subsonic case, it should be 0.018, both are within the range 1-2%.
Abstract: This paper studies dynamic stability of homogeneous
beams with piezoelectric layers subjected to periodic axial
compressive load that is simply supported at both ends lies on a
continuous elastic foundation. The displacement field of beam is
assumed based on Bernoulli-Euler beam theory. Applying the
Hamilton's principle, the governing dynamic equation is established.
The influences of applied voltage, foundation coefficient and
piezoelectric thickness on the unstable regions are presented. To
investigate the accuracy of the present analysis, a compression study
is carried out with a known data.
Abstract: This paper describes the historical development of
interethnic concord in the Republic of Kazakhstan, and emphasizes
the role of tolerance mentality of the Kazakh people in ethno-political
policy of the country. Moreover, pointing out interethnic concord as a
powerful stabilizing factor, it analyses the specifics of interethnic
policy in multinational Kazakh society. It summarizes that the culture
of interethnic concord can be a model of ethno- political policy of
Kazakhstan.
Abstract: This paper considers the influence of promotion
instruments for renewable energy sources (RES) on a multi-energy
modeling framework. In Europe, so called Feed-in Tariffs are
successfully used as incentive structures to increase the amount of
energy produced by RES. Because of the stochastic nature of large
scale integration of distributed generation, many problems have
occurred regarding the quality and stability of supply. Hence, a
macroscopic model was developed in order to optimize the power
supply of the local energy infrastructure, which includes electricity,
natural gas, fuel oil and district heating as energy carriers. Unique
features of the model are the integration of RES and the adoption of
Feed-in Tariffs into one optimization stage. Sensitivity studies are
carried out to examine the system behavior under changing profits
for the feed-in of RES. With a setup of three energy exchanging
regions and a multi-period optimization, the impact of costs and
profits are determined.
Abstract: Single side band modulation is a widespread technique in communication with significant impact on communication technologies such as DSL modems and ATSC TV. Its widespread utilization is due to its bandwidth and power saving characteristics. In this paper, we present a new scheme for SSB signal generation which is cost efficient and enjoys superior characteristics in terms of frequency stability, selectivity, and robustness to noise. In the process, we develop novel Hilbert transform properties.
Abstract: In present work the problem of the ITER fusion
plasma neutron source parameter reconstruction using only the
Vertical Neutron Camera data was solved. The possibility of neutron
source parameter reconstruction was estimated by the numerical
simulations and the analysis of adequateness of mathematic model
was performed. The neutron source was specified in a parametric
form. The numerical analysis of solution stability with respect to data
distortion was done. The influence of the data errors on the
reconstructed parameters is shown:
• is reconstructed with errors less than 4% at all examined values
of δ (until 60%);
• is determined with errors less than 10% when δ do not overcome
5%;
• is reconstructed with relative error more than 10 %;
• integral intensity of the neutron source is determined with error
10% while δ error is less than 15%;
where -error of signal measurements, (R0,Z0), the plasma center
position,- /parameter of neutron source profile.
Abstract: As is known, one of the priority directions of research
works of natural sciences is introduction of applied section of
contemporary mathematics as approximate and numerical methods to
solving integral equation into practice. We fare with the solving of
integral equation while studying many phenomena of nature to whose
numerically solving by the methods of quadrature are mainly applied.
Taking into account some deficiency of methods of quadrature for
finding the solution of integral equation some sciences suggested of
the multistep methods with constant coefficients. Unlike these papers,
here we consider application of hybrid methods to the numerical
solution of Volterra integral equation. The efficiency of the suggested
method is proved and a concrete method with accuracy order p = 4
is constructed. This method in more precise than the corresponding
known methods.
Abstract: In this paper, delay-dependent stability analysis for
neutral type neural networks with uncertain paramters and
time-varying delay is studied. By constructing new
Lyapunov-Krasovskii functional and dividing the delay interval into
multiple segments, a novel sufficient condition is established to
guarantee the globally asymptotically stability of the considered
system. Finally, a numerical example is provided to illustrate the
usefulness of the proposed main results.