Abstract: Substandard and counterfeit antimalarials is a major problem in malaria endemic areas. The availability of counterfeit/ substandard medicines is not only decreasing the efficacy in patients, but it is also one of the contributing factors for developing antimalarial drug resistance. Owing to this, a pilot study was conducted to survey quality of drugs collected from different malaria endemic areas of India. Artesunate+Sulphadoxine-Pyrimethamine (AS+SP), Artemether-Lumefantrine (AL), Chloroquine (CQ) tablets were randomly picked from public health facilities in selected states of India. The quality of antimalarial drugs from these areas was assessed by using Global Pharma Health Fund Minilab test kit. This includes physical/visual inspection and disintegration test. Thin-layer chromatography (TLC) was carried out for semi-quantitative assessment of active pharmaceutical ingredients. A total of 45 brands, out of which 21 were for CQ, 14 for AL and 10 for AS+SP were tested from Uttar Pradesh (U.P.), Mizoram, Meghalaya and Gujrat states. One out of 45 samples showed variable disintegration and retension factor. The variable disintegration and retention factor which would have been due to substandard quality or other factors including storage. However, HPLC analysis confirms standard active pharmaceutical ingredient, but may be due to humid temperature and moisture in storage may account for the observed result.
Abstract: The paper deals with the analysis of hazards and sensitivity of potential resource of emergency water supply of population in a selected region of the Czech Republic. The procedure of identification and analysis of hazards and sensitivity is carried out on the basis of a unique methodology of classifying the drinking water resources earmarked for emergency supply of population. The hazard identification is based on a general register of hazards for individual parts of hydrological structure and the elements of technological equipment. It is followed by a semi-quantitative point indexation for the activation of each identified hazard, i.e. fires of anthropogenic origin, flood and the increased radioactive background accompanied by the leak of radon. Point indexation of sensitivity has been carried out at the same time. The analysis is the basis for a risk assessment of potential resource of emergency supply of population and the subsequent classification of such resource within the system of crisis planning.
Abstract: The paper presents the case study of hazard
identification and sensitivity of potential resource of emergency
water supply as part of the application of methodology classifying
the resources of drinking water for emergency supply of population.
The case study has been carried out on a selected resource of
emergency water supply in one region of the Czech Republic. The
hazard identification and sensitivity of potential resource of
emergency water supply is based on a unique procedure and
developed general registers of selected types of hazards and
sensitivities. The registers have been developed with the help of the
“Fault Tree Analysis” method in combination with the “What if
method”. The identified hazards for the assessed resource include
hailstorms and torrential rains, drought, soil erosion, accidents of
farm machinery, and agricultural production. The developed registers
of hazards and vulnerabilities and a semi-quantitative assessment of
hazards for individual parts of hydrological structure and
technological elements of presented drilled wells are the basis for a
semi-quantitative risk assessment of potential resource of emergency
supply of population and the subsequent classification of such
resource within the system of crisis planning.