Abstract: Malaria is a serious, acute and chronic relapsing
infection to humans. It is characterized by periodic attacks of chills,
fever, nausea, vomiting, back pain, increased sweating anemia,
splenomegaly (enlargement of the spleen) and often-fatal
complications.The malaria disease is caused by the multiplication of
protozoa parasite of the genus Plasmodium. Malaria in humans is due
to 4 types of malaria parasites such that Plasmodium falciparum,
Plasmodium vivax, Plasmodium malariae and Plasmodium ovale.
P.vivax malaria differs from P. falciparum malaria in that a person
suffering from P. vivax malaria can experience relapses of the
disease. Between the relapses, the malaria parasite will remain
dormant in the liver of the patient, leading to the patient being
classified as being in the dormant class. A mathematical model for
the transmission of P. vivax is developed in which the human
population is divided into four classes, the susceptible, the infected,
the dormant and the recovered. In this paper, we formulate the
dynamical model of P. vivax malaria to see the distribution of this
disease at the district level.
Abstract: In order to find the particular interaction energy
between cylcloguanil and the amino acids surrounding the pocket of
wild type and quadruple mutant type PfDHFR enzymes, the MP2
method with basis set 6-31G(d,p) level of calculations was
performed. The obtained interaction energies found that Asp54 has
the strongest interaction energy to both wild type and mutant type of -
12.439 and -11.250 kcal/mol, respectively and three amino acids;
Asp54, Ile164 and Ile14 formed the H-bonding with cycloguanil
drug. Importantly, the mutation at Ser108Asn was the key important
of cycloguanil resistant with showing repulsive interaction energy.